LOCUS       NM_001190449            1350 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus DDAH family member 2, ADMA independent (Ddah2),
            transcript variant 1, mRNA.
ACCESSION   NM_001190449
VERSION     NM_001190449.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1350)
  AUTHORS   Ragavan,V.N., Nair,P.C., Jarzebska,N., Angom,R.S., Ruta,L.,
            Bianconi,E., Grottelli,S., Tararova,N.D., Ryazanskiy,D.,
            Lentz,S.R., Tommasi,S., Martens-Lobenhoffer,J., Suzuki-Yamamoto,T.,
            Kimoto,M., Rubets,E., Chau,S., Chen,Y., Hu,X., Bernhardt,N.,
            Spieth,P.M., Weiss,N., Bornstein,S.R., Mukhopadhyay,D.,
            Bode-Boger,S.M., Maas,R., Wang,Y., Macchiarulo,A., Mangoni,A.A.,
            Cellini,B. and Rodionov,R.N.
  TITLE     A multicentric consortium study demonstrates that dimethylarginine
            dimethylaminohydrolase 2 is not a dimethylarginine
            dimethylaminohydrolase
  JOURNAL   Nat Commun 14 (1), 3392 (2023)
   PUBMED   37296100
  REMARK    GeneRIF: A multicentric consortium study demonstrates that
            dimethylarginine dimethylaminohydrolase 2 is not a dimethylarginine
            dimethylaminohydrolase.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1350)
  AUTHORS   Wu,Y., Shen,S., Chen,J., Ni,W., Wang,Q., Zhou,H., Chen,J.,
            Zhang,H., Mei,Z., Sun,X., Shen,P., Jie,Z., Xu,W., Hong,Z., Ma,Y.,
            Wang,K., Wan,S., Wu,H., Xie,Z., Qin,A. and Fan,S.
  TITLE     Metabolite asymmetric dimethylarginine (ADMA) functions as a
            destabilization enhancer of SOX9 mediated by DDAH1 in
            osteoarthritis
  JOURNAL   Sci Adv 9 (6), eade5584 (2023)
   PUBMED   36753544
REFERENCE   3  (bases 1 to 1350)
  AUTHORS   Xie,Z., Hou,L., Shen,S., Wu,Y., Wang,J., Jie,Z., Zhao,X., Li,X.,
            Zhang,X., Chen,J., Xu,W., Ning,L., Ma,Q., Wang,S., Wang,H.,
            Yuan,P., Fang,X., Qin,A. and Fan,S.
  TITLE     Mechanical force promotes dimethylarginine dimethylaminohydrolase
            1-mediated hydrolysis of the metabolite asymmetric dimethylarginine
            to enhance bone formation
  JOURNAL   Nat Commun 13 (1), 50 (2022)
   PUBMED   35013196
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1350)
  AUTHORS   Huang,S., Li,Z., Wu,Z., Liu,C., Yu,M., Wen,M., Zhang,L. and Wang,X.
  TITLE     DDAH2 suppresses RLR-MAVS-mediated innate antiviral immunity by
            stimulating nitric oxide-activated, Drp1-induced mitochondrial
            fission
  JOURNAL   Sci Signal 14 (678) (2021)
   PUBMED   33850055
  REMARK    GeneRIF: DDAH2 suppresses RLR-MAVS-mediated innate antiviral
            immunity by stimulating nitric oxide-activated, Drp1-induced
            mitochondrial fission.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1350)
  AUTHORS   Zhu,Z.D., Ye,J.M., Fu,X.M., Wang,X.C., Ye,J.Y., Wu,X.R., Hua,P.,
            Liao,Y.Q., Xuan,W., Duan,J.L., Li,W.Y., Fu,H., Xia,Z.H. and
            Zhang,X.
  TITLE     DDAH2 alleviates myocardial fibrosis in diabetic cardiomyopathy
            through activation of the DDAH/ADMA/NOS/NO pathway in rats
  JOURNAL   Int J Mol Med 43 (2), 749-760 (2019)
   PUBMED   30569164
  REMARK    GeneRIF: the overexpression of DDAH2 attenuates myocardial fibrosis
            and protects against Diabetic cardiomyopathy DCM through activation
            of the DDAH/ADMA/NOS/NO pathway
REFERENCE   6  (bases 1 to 1350)
  AUTHORS   Palm,F., Onozato,M.L., Luo,Z. and Wilcox,C.S.
  TITLE     Dimethylarginine dimethylaminohydrolase (DDAH): expression,
            regulation, and function in the cardiovascular and renal systems
  JOURNAL   Am J Physiol Heart Circ Physiol 293 (6), H3227-H3245 (2007)
   PUBMED   17933965
  REMARK    Review article
REFERENCE   7  (bases 1 to 1350)
  AUTHORS   Hasegawa,K., Wakino,S., Tatematsu,S., Yoshioka,K., Homma,K.,
            Sugano,N., Kimoto,M., Hayashi,K. and Itoh,H.
  TITLE     Role of asymmetric dimethylarginine in vascular injury in
            transgenic mice overexpressing dimethylarginie
            dimethylaminohydrolase 2
  JOURNAL   Circ Res 101 (2), e2-e10 (2007)
   PUBMED   17601800
  REMARK    GeneRIF: DDAH2/ADMA pathway can be a novel therapeutic target for
            vasculopathy in the ADMA or angiotensin II-induced
            pathophysiological conditions
REFERENCE   8  (bases 1 to 1350)
  AUTHORS   Allcock,R.J., Martin,A.M. and Price,P.
  TITLE     The mouse as a model for the effects of MHC genes on human disease
  JOURNAL   Immunol Today 21 (7), 328-332 (2000)
   PUBMED   10871872
  REMARK    Review article
REFERENCE   9  (bases 1 to 1350)
  AUTHORS   Leiper,J.M., Santa Maria,J., Chubb,A., MacAllister,R.J.,
            Charles,I.G., Whitley,G.S. and Vallance,P.
  TITLE     Identification of two human dimethylarginine
            dimethylaminohydrolases with distinct tissue distributions and
            homology with microbial arginine deiminases
  JOURNAL   Biochem J 343 Pt 1 (Pt 1), 209-214 (1999)
   PUBMED   10493931
REFERENCE   10 (bases 1 to 1350)
  AUTHORS   Spanjaard,R.A., Lee,P.J., Sarkar,S., Goedegebuure,P.S. and
            Eberlein,T.J.
  TITLE     Clone 10d/BM28 (CDCL1), an early S-phase protein, is an important
            growth regulator of melanoma
  JOURNAL   Cancer Res 57 (22), 5122-5128 (1997)
   PUBMED   9371513
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC087117.9.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from genomic sequence
            data to make the sequence consistent with the reference genome
            assembly. The genomic coordinates used for the transcript record
            were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC003328.1, BI410085.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-238               AC087117.9         167652-167889
            239-597             AC087117.9         168720-169078
            598-697             AC087117.9         169220-169319
            698-771             AC087117.9         169450-169523
            772-891             AC087117.9         169622-169741
            892-1041            AC087117.9         170093-170242
            1042-1350           AC087117.9         170408-170716
FEATURES             Location/Qualifiers
     source          1..1350
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 18.59 cM"
     gene            1..1350
                     /gene="Ddah2"
                     /gene_synonym="1110003M04Rik; Ddah; DDAH-2; DDAHII; G6a;
                     NG30"
                     /note="DDAH family member 2, ADMA independent"
                     /db_xref="GeneID:51793"
                     /db_xref="MGI:MGI:1859016"
     exon            1..238
                     /gene="Ddah2"
                     /gene_synonym="1110003M04Rik; Ddah; DDAH-2; DDAHII; G6a;
                     NG30"
                     /inference="alignment:Splign:2.1.0"
     exon            239..597
                     /gene="Ddah2"
                     /gene_synonym="1110003M04Rik; Ddah; DDAH-2; DDAHII; G6a;
                     NG30"
                     /inference="alignment:Splign:2.1.0"
     CDS             301..1158
                     /gene="Ddah2"
                     /gene_synonym="1110003M04Rik; Ddah; DDAH-2; DDAHII; G6a;
                     NG30"
                     /EC_number="3.5.3.18"
                     /note="isoform 1 is encoded by transcript variant 1;
                     N(G),N(G)-dimethylarginine dimethylaminohydrolase 2;
                     dimethylargininase-2; Clone 7u; inactive dimethylarginine
                     dimethylaminohydrolase 2; inactive
                     N(G),N(G)-dimethylarginine dimethylaminohydrolase 2;
                     putative hydrolase DDAH2"
                     /codon_start=1
                     /product="putative hydrolase DDAH2 isoform 1"
                     /protein_id="NP_001177378.1"
                     /db_xref="CCDS:CCDS50082.1"
                     /db_xref="GeneID:51793"
                     /db_xref="MGI:MGI:1859016"
                     /translation="MGTPGEGLGRCSHALIRGVPESLASGEGAGAGLPALDLAKAQRE
                     HGVLGGKLRQRLGLQLLELPPEESLPLGPLLGDTAVIQGDTALITRPWSPARRPEVDG
                     VRKALQDLGLRIVEMGDENATLDGTDVLFTGREFFVGLSKWTNHRGAEIVADTFRDFA
                     VSTVPVSGSSHLRGLCGMGGPRTVVAGSSEAAQKAVRAMAALTDHPYASLTLPDDAAS
                     DCLFLRPGLPGATPFLLHRGGGDLPNSQEALQKLSDVTLVPVSCSELEKAGAGLSSLC
                     LVLSTRPHC"
     exon            598..697
                     /gene="Ddah2"
                     /gene_synonym="1110003M04Rik; Ddah; DDAH-2; DDAHII; G6a;
                     NG30"
                     /inference="alignment:Splign:2.1.0"
     exon            698..771
                     /gene="Ddah2"
                     /gene_synonym="1110003M04Rik; Ddah; DDAH-2; DDAHII; G6a;
                     NG30"
                     /inference="alignment:Splign:2.1.0"
     exon            772..891
                     /gene="Ddah2"
                     /gene_synonym="1110003M04Rik; Ddah; DDAH-2; DDAHII; G6a;
                     NG30"
                     /inference="alignment:Splign:2.1.0"
     exon            892..1041
                     /gene="Ddah2"
                     /gene_synonym="1110003M04Rik; Ddah; DDAH-2; DDAHII; G6a;
                     NG30"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1350
                     /gene="Ddah2"
                     /gene_synonym="1110003M04Rik; Ddah; DDAH-2; DDAHII; G6a;
                     NG30"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1319..1324
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ddah2"
                     /gene_synonym="1110003M04Rik; Ddah; DDAH-2; DDAHII; G6a;
                     NG30"
                     /note="hexamer: AATAAA"
     regulatory      1324..1329
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ddah2"
                     /gene_synonym="1110003M04Rik; Ddah; DDAH-2; DDAHII; G6a;
                     NG30"
                     /note="hexamer: AATAAA"
     polyA_site      1341
                     /gene="Ddah2"
                     /gene_synonym="1110003M04Rik; Ddah; DDAH-2; DDAHII; G6a;
                     NG30"
     polyA_site      1346
                     /gene="Ddah2"
                     /gene_synonym="1110003M04Rik; Ddah; DDAH-2; DDAHII; G6a;
                     NG30"
                     /note="major polyA site"
ORIGIN      
        1 gggcgtggtc ttagaaggtc ccgccccgtc ccgcttagac aatgccccgg agccgccaga
       61 ccatcgcgcc cccgccccat cgtcgtacgt gagctcgcct accctgggaa cccctcaaaa
      121 gcccgagcta tccgtctctc cagcttgagg actcagactc ccatcttcat taactctctc
      181 ctctgggggt ggggccaagg ctgaaatcac aaggctgcag gagtggaggt ggccgctgac
      241 cagtgaagtc aagagaaaaa acaaaacagc ttggctggaa ggggcttcgg tgtggatgtg
      301 atggggacgc cgggggaggg gctgggtcgt tgttcccatg ccctgatccg gggtgtcccc
      361 gagagcttgg catccgggga aggtgctggc gctggtcttc cggctctgga cctggctaaa
      421 gctcaaaggg agcatggagt actaggaggt aaactgaggc aacgactagg gctgcagctg
      481 cttgaactgc ctcctgagga gtcactgccg ctgggaccac tgcttggtga cacggctgtg
      541 atccaaggag acacggccct aatcacaagg ccctggagcc cagcacgtag gcctgaggtt
      601 gatggagtgc gtaaagccct ccaggacttg ggactccgaa ttgtggagat gggggatgag
      661 aatgcgacgc tggacggcac cgacgtcctc ttcaccggcc gggagttttt cgtaggcctc
      721 tccaagtgga ccaatcatcg aggagctgag atcgtggcag acacgttccg ggacttcgct
      781 gtctcaacgg taccggtctc aggctcctcg cacctgcgcg gcctctgtgg catgggggga
      841 cctcgcaccg tggtggctgg aagcagcgag gctgcccaaa aagcagtcag ggcaatggca
      901 gcgctgactg atcaccccta cgcctctctg accctcccag atgatgcagc tagtgactgt
      961 ctctttctgc gtcctgggtt gcctggtgcc acacctttcc tcctgcaccg cggaggtggg
     1021 gacctgccca acagccagga ggctctgcag aagctctctg atgtcaccct ggtacctgtg
     1081 tcctgctcag aactggagaa ggctggagct ggcctcagct ccctctgcct ggtgctcagc
     1141 acacgccccc actgctgagg gcctggattt ggggatccca ctggttagga atagagctgt
     1201 atagtgggta gaatcagcta atagaggctg ggtagttgtg gggagatgcc ccaggatagg
     1261 gaaggactta gtgtggaaaa gaatagaagc cattgggtga gtcctctctg tcaaaaccaa
     1321 taaaataaaa ttgacctttt agataagggc
//
