LOCUS       NM_026993               3747 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus dimethylarginine dimethylaminohydrolase 1 (Ddah1),
            mRNA.
ACCESSION   NM_026993 XM_131205
VERSION     NM_026993.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3747)
  AUTHORS   Yuan,J., Yu,Z., Zhang,P., Luo,K., Xu,Y., Lan,T., Zhang,M., Chen,Y.
            and Lu,Z.
  TITLE     DDAH1 recruits peroxiredoxin 1 and sulfiredoxin 1 to preserve its
            activity and regulate intracellular redox homeostasis
  JOURNAL   Redox Biol 70, 103080 (2024)
   PUBMED   38354630
  REMARK    GeneRIF: DDAH1 recruits peroxiredoxin 1 and sulfiredoxin 1 to
            preserve its activity and regulate intracellular redox homeostasis.
REFERENCE   2  (bases 1 to 3747)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3747)
  AUTHORS   Kozlova,A.A., Rubets,E., Vareltzoglou,M.R., Jarzebska,N.,
            Ragavan,V.N., Chen,Y., Martens-Lobenhoffer,J., Bode-Boger,S.M.,
            Gainetdinov,R.R., Rodionov,R.N. and Bernhardt,N.
  TITLE     Knock-out of the critical nitric oxide synthase regulator DDAH1 in
            mice impacts amphetamine sensitivity and dopamine metabolism
  JOURNAL   J Neural Transm (Vienna) 130 (9), 1097-1112 (2023)
   PUBMED   36792833
  REMARK    GeneRIF: Knock-out of the critical nitric oxide synthase regulator
            DDAH1 in mice impacts amphetamine sensitivity and dopamine
            metabolism.
REFERENCE   4  (bases 1 to 3747)
  AUTHORS   Ragavan,V.N., Nair,P.C., Jarzebska,N., Angom,R.S., Ruta,L.,
            Bianconi,E., Grottelli,S., Tararova,N.D., Ryazanskiy,D.,
            Lentz,S.R., Tommasi,S., Martens-Lobenhoffer,J., Suzuki-Yamamoto,T.,
            Kimoto,M., Rubets,E., Chau,S., Chen,Y., Hu,X., Bernhardt,N.,
            Spieth,P.M., Weiss,N., Bornstein,S.R., Mukhopadhyay,D.,
            Bode-Boger,S.M., Maas,R., Wang,Y., Macchiarulo,A., Mangoni,A.A.,
            Cellini,B. and Rodionov,R.N.
  TITLE     A multicentric consortium study demonstrates that dimethylarginine
            dimethylaminohydrolase 2 is not a dimethylarginine
            dimethylaminohydrolase
  JOURNAL   Nat Commun 14 (1), 3392 (2023)
   PUBMED   37296100
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3747)
  AUTHORS   Wu,Y., Shen,S., Chen,J., Ni,W., Wang,Q., Zhou,H., Chen,J.,
            Zhang,H., Mei,Z., Sun,X., Shen,P., Jie,Z., Xu,W., Hong,Z., Ma,Y.,
            Wang,K., Wan,S., Wu,H., Xie,Z., Qin,A. and Fan,S.
  TITLE     Metabolite asymmetric dimethylarginine (ADMA) functions as a
            destabilization enhancer of SOX9 mediated by DDAH1 in
            osteoarthritis
  JOURNAL   Sci Adv 9 (6), eade5584 (2023)
   PUBMED   36753544
REFERENCE   6  (bases 1 to 3747)
  AUTHORS   Leiper,J., Nandi,M., Torondel,B., Murray-Rust,J., Malaki,M.,
            O'Hara,B., Rossiter,S., Anthony,S., Madhani,M., Selwood,D.,
            Smith,C., Wojciak-Stothard,B., Rudiger,A., Stidwill,R.,
            McDonald,N.Q. and Vallance,P.
  TITLE     Disruption of methylarginine metabolism impairs vascular
            homeostasis
  JOURNAL   Nat Med 13 (2), 198-203 (2007)
   PUBMED   17273169
REFERENCE   7  (bases 1 to 3747)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   8  (bases 1 to 3747)
  AUTHORS   Dayoub,H., Achan,V., Adimoolam,S., Jacobi,J., Stuehlinger,M.C.,
            Wang,B.Y., Tsao,P.S., Kimoto,M., Vallance,P., Patterson,A.J. and
            Cooke,J.P.
  TITLE     Dimethylarginine dimethylaminohydrolase regulates nitric oxide
            synthesis: genetic and physiological evidence
  JOURNAL   Circulation 108 (24), 3042-3047 (2003)
   PUBMED   14638548
REFERENCE   9  (bases 1 to 3747)
  AUTHORS   Knipp,M., Braun,O., Gehrig,P.M., Sack,R. and Vasak,M.
  TITLE     Zn(II)-free dimethylargininase-1 (DDAH-1) is inhibited upon
            specific Cys-S-nitrosylation
  JOURNAL   J Biol Chem 278 (5), 3410-3416 (2003)
   PUBMED   12441345
REFERENCE   10 (bases 1 to 3747)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK148907.1, AK149185.1 and AK010970.1.
            
            On Dec 2, 2008 this sequence version replaced NM_026993.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK149185.1, SRR1660813.239923.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-348               AK148907.1         2-349
            349-3745            AK149185.1         1-3397
            3746-3747           AK010970.1         356-357
FEATURES             Location/Qualifiers
     source          1..3747
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 70.63 cM"
     gene            1..3747
                     /gene="Ddah1"
                     /gene_synonym="2410006N07Rik; 2510015N06Rik"
                     /note="dimethylarginine dimethylaminohydrolase 1"
                     /db_xref="GeneID:69219"
                     /db_xref="MGI:MGI:1916469"
     exon            1..473
                     /gene="Ddah1"
                     /gene_synonym="2410006N07Rik; 2510015N06Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             171..1028
                     /gene="Ddah1"
                     /gene_synonym="2410006N07Rik; 2510015N06Rik"
                     /EC_number="3.5.3.18"
                     /note="DDAHI; DDAH-1; dimethylargininase-1"
                     /codon_start=1
                     /product="N(G),N(G)-dimethylarginine
                     dimethylaminohydrolase 1"
                     /protein_id="NP_081269.1"
                     /db_xref="CCDS:CCDS17896.1"
                     /db_xref="GeneID:69219"
                     /db_xref="MGI:MGI:1916469"
                     /translation="MAGLGHPSAFGRATHAVVRAPPESLCRHALRRSQGEEVDFARAE
                     RQHELYVGVLGSKLGLQVVQLPADESLPDCVFVEDVAVVCEETALITRPGAPSRRKEV
                     DMMKEALEKLQLNIVEMKDENATLDGGDVLFTGREFFVGLSKRTNQRGAEILADTFKD
                     YAVSTVPVADSLHLKSFCSMAGPNLIAIGSSESAQKALKIMQQMSDHRYDKLTVPDDM
                     AANCIYLNIPSKGHVLLHRTPEEYPESAKVYEKLKDHLLIPVSNSEMEKVDGLLTCCS
                     VFINKKIDS"
     exon            474..573
                     /gene="Ddah1"
                     /gene_synonym="2410006N07Rik; 2510015N06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            574..647
                     /gene="Ddah1"
                     /gene_synonym="2410006N07Rik; 2510015N06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            648..767
                     /gene="Ddah1"
                     /gene_synonym="2410006N07Rik; 2510015N06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            768..911
                     /gene="Ddah1"
                     /gene_synonym="2410006N07Rik; 2510015N06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            912..3747
                     /gene="Ddah1"
                     /gene_synonym="2410006N07Rik; 2510015N06Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2718..2723
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ddah1"
                     /gene_synonym="2410006N07Rik; 2510015N06Rik"
                     /note="hexamer: AAGAAA"
     polyA_site      2738
                     /gene="Ddah1"
                     /gene_synonym="2410006N07Rik; 2510015N06Rik"
     regulatory      3725..3730
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ddah1"
                     /gene_synonym="2410006N07Rik; 2510015N06Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3747
                     /gene="Ddah1"
                     /gene_synonym="2410006N07Rik; 2510015N06Rik"
                     /note="major polyA site"
ORIGIN      
        1 agggctccgg gcgcgagccg ggctcccgca gcagcacatt catcggctgc caagaggagc
       61 cgccgggcgc tcgcaggctc gcaggctcgc aggctgggcg cgcgctgctc tcgggaggac
      121 cgagccaccg actcaaaccc agccaccgtc gcctcctctc cgcgcgaacc atggccggcc
      181 tcggccaccc ctccgccttc ggccgggcca cccacgccgt ggtgcgggct ccgcccgagt
      241 ccctgtgccg ccacgcgctg aggcgctcgc agggcgagga ggtggatttc gctcgcgccg
      301 agcgccagca cgagctctac gtgggcgtgc tgggcagcaa gctggggctg caggtggtgc
      361 agctgcccgc cgacgagagc ctgcccgact gcgtgttcgt ggaggacgtg gccgtcgtgt
      421 gcgaggagac ggccctcatc acccgccccg gggcgcccag ccgcaggaag gaggttgaca
      481 tgatgaaaga ggctttggaa aaacttcagc tcaacatagt agagatgaaa gatgaaaatg
      541 caactttgga tggtggggac gtcctattca caggcagaga attttttgtg ggcctttcca
      601 aaagaacaaa tcaacgaggt gctgaaatct tggctgatac ttttaaggac tacgcagtct
      661 ctacagtccc tgtggccgat tctttgcatt taaagagttt ctgcagcatg gccggaccca
      721 acctgattgc aatagggtcc agcgaatctg cacagaaggc cctcaagatc atgcaacaga
      781 tgagtgacca tcgttatgac aagctcactg tacccgacga catggccgcc aactgcatat
      841 atctaaatat ccccagcaaa gggcatgtct tgctgcaccg aaccccagaa gagtacccag
      901 aaagcgcaaa ggtctatgag aaactcaagg accatctact gatccctgtg agcaactcgg
      961 agatggaaaa ggtggacggc ttgctcacct gctgctccgt ttttattaac aagaagatag
     1021 actcctgagc cagagagtcc cttccctgtg gccagcaagt ggccgaggcc aggctgatgg
     1081 ctctgtacct attcctcctt tttcctttga caatctactg ggccactgtg ctactaactc
     1141 ttgtttacaa aaaaagaaaa gaaaaactaa ttccaatttt aatcacctca ttccccacac
     1201 cctccttttc ctcacggtgg tacctaacct gtgcattcgc taaaagaatt aagcaaccta
     1261 ggaaatacag aactaacgaa tcattggaat gcaattgata gcgtggaagc ccctcacttc
     1321 agtgtttgtg tccttaatgt gggaatgatt tagctgcagg gcattctgaa gactgtcttc
     1381 ccggccagcc agataagcaa gggactttct ctgtatcatg aatcaagctt ggctcctgtg
     1441 aaattcccta gaacgtggat tttttttccc attcccctct cttctcgccc ctaaaaacct
     1501 ttcttctggg tctttctgtg gtcttctccg cttctttcgt aatcgccttg accttggatt
     1561 tacccaagct cttgcgttct ggatgtcatc ccgaaggtcc aacctgtgtg cactcctctc
     1621 tctctgcctt acagccacct ctccaccacc agcagcaagt cagagtggct ggtcggggaa
     1681 caggaacctc acagaggcac accctgacag gctttcccat tgccacacct aggaaggtaa
     1741 atccagcctc aggtggttga tgcaggatgt tagatacaga tgcctagaaa caccccatgg
     1801 gtacatctta gagagactga gtcacatgcc atgagtttgc ctcatgacta gtcctgtagt
     1861 atggagggaa gtctttctcc actccaccac ctccgccttt ctgagcttcc ttctgactcg
     1921 ccttgtatct acccccttag aatcatcatg atcttgagaa agtcatttcc ttcaaaagag
     1981 gcagagcatg tacaatgatt gctgatggtc cggggagagc cagagggggc tgcctccacc
     2041 caggcctggg agcgcagtca ggaaatggtt cctaaggtca gcctcaaaca atgtctgagt
     2101 ctcctgtgaa atatccatga ttgtttactg tggaattcaa gtgaaacttc aaattacaca
     2161 atgctcagct ggcacaggtc gctcacagag agccatgcat gccacagcaa agaaggagag
     2221 cattcctttt tttttttttt ttcttaaaag ctgaaacaga gcagggacat ggtgctttac
     2281 aatgcacagt gacccagcca ggcatgtcat caaagttctg gtcacttcta cctttgctgt
     2341 acagtctgca gtttgtcatt cagtatttaa agttcaggag acaaagacta agtcagatct
     2401 atctctcctt tgtgatcagt gtttctcata atgaagacaa gagaggctgg tctccattgc
     2461 attcccccca gtggatagaa gtgagacaat cagggcatcc ttcatcactc ttctcatatt
     2521 tggcaatctc tctgaagaca tctccatctc ttccttgctt ctctaacttt agactcatag
     2581 cacatgcaaa tatctaactc tgtgcaccct gcgaatgaac catatcctga tcactgtcat
     2641 atttcacaac atatcatgag tgaataatta tgttttttcc agggtaaatg aatgtgagcc
     2701 agttgcctaa attaataaag aaaacttgtt ctcagcaatt atggttgcct ttgggggtta
     2761 aatttgacca tatactagta aaaacaattt ctccttgaga gaggtgacca tctcaaaatc
     2821 caccacagga aaaacagccc actgtatatg taccagcatg caactgtcac tgacgtcctt
     2881 tctctcatcc tgttacgtgc agtcagttac gagtgagtag attttccatg gcaacggttt
     2941 cttctaccag aggtggtttt ccagttcccg tttcctttgc gctcctcttt ccttgtttgt
     3001 cctgagaaat tgactagagt tgctgcctct tccccatctt actctgctct tcagaccccc
     3061 tgtgtgattc agagatgtga acacgcaaaa tacacgcagc attgcccctt cgatgttctc
     3121 atcacataac gttacctcta aaagggaaaa tcattgcccc agttcccctc tcgtccgttg
     3181 tgtctcacaa agatgggaag accaacaaaa atgcttcttg atattacaac aatgtgagga
     3241 gttacattta actaagtcta tagcttgggt aagaaggatc aggtcagtat gagttggttt
     3301 agtgaagaga tgagctagaa ggattgcata gttagcacta tgtctttaac tggtgggttg
     3361 ctgtaccaat tggttgcaga tctccacagc gtgttcattg cactaaaatg ctactaggaa
     3421 ccaaacacta aggccgtcat ctctatatct ctaagaaggg aagttaggcc aggctgtagt
     3481 ctcacagtgt ggcctgtgta gggttgcatg ctactctcta agacattcag acatagtttc
     3541 tgtgcggtgt taggtttgtg cttttttttt tctatcttct tgcctgccat cttccagcca
     3601 atgtgtggtt atccagtctg tgtgccaaag tcagccatat ctcccacgac ctgttagtcc
     3661 agaggagttc tgcaccgacg ctagttgcca gctgcctgct cctaatgtac accagtcaag
     3721 acagaataaa atgtgagttg taccgtg
//
