LOCUS       NM_026428               1748 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus dicarbonyl L-xylulose reductase (Dcxr), transcript
            variant 1, mRNA.
ACCESSION   NM_026428
VERSION     NM_026428.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1748)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1748)
  AUTHORS   Sapir,T., Kshirsagar,A., Gorelik,A., Olender,T., Porat,Z.,
            Scheffer,I.E., Goldstein,D.B., Devinsky,O. and Reiner,O.
  TITLE     Heterogeneous nuclear ribonucleoprotein U (HNRNPU) safeguards the
            developing mouse cortex
  JOURNAL   Nat Commun 13 (1), 4209 (2022)
   PUBMED   35864088
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1748)
  AUTHORS   Hubbs,A.F., Fluharty,K.L., Edwards,R.J., Barnabei,J.L.,
            Grantham,J.T., Palmer,S.M., Kelly,F., Sargent,L.M., Reynolds,S.H.,
            Mercer,R.R., Goravanahally,M.P., Kashon,M.L., Honaker,J.C.,
            Jackson,M.C., Cumpston,A.M., Goldsmith,W.T., McKinney,W.,
            Fedan,J.S., Battelli,L.A., Munro,T., Bucklew-Moyers,W.,
            McKinstry,K., Schwegler-Berry,D., Friend,S., Knepp,A.K., Smith,S.L.
            and Sriram,K.
  TITLE     Accumulation of Ubiquitin and Sequestosome-1 Implicate Protein
            Damage in Diacetyl-Induced Cytotoxicity
  JOURNAL   Am J Pathol 186 (11), 2887-2908 (2016)
   PUBMED   27643531
REFERENCE   4  (bases 1 to 1748)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   5  (bases 1 to 1748)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (bases 1 to 1748)
  AUTHORS   Abdallah,B.M., Ditzel,N., Mahmood,A., Isa,A., Traustadottir,G.A.,
            Schilling,A.F., Ruiz-Hidalgo,M.J., Laborda,J., Amling,M. and
            Kassem,M.
  TITLE     DLK1 is a novel regulator of bone mass that mediates estrogen
            deficiency-induced bone loss in mice
  JOURNAL   J Bone Miner Res 26 (7), 1457-1471 (2011)
   PUBMED   21308776
REFERENCE   7  (bases 1 to 1748)
  AUTHORS   Sudo,T., Ishii,A., Asami,J., Uematsu,Y., Saitoh,M., Nakamura,A.,
            Tada,N., Ohnuki,T., Komurasaki,T. and Nakagawa,J.
  TITLE     Transgenic mice over-expressing dicarbonyl/L-xylulose reductase
            gene crossed with KK-Ay diabetic model mice: an animal model for
            the metabolism of renal carbonyl compounds
  JOURNAL   Exp Anim 54 (5), 385-394 (2005)
   PUBMED   16365515
  REMARK    GeneRIF: DCXR might function in the metabolism of glucose or
            carbonyl compounds, and play a protective role in a kidney which is
            under hyperglycemic pressure.
REFERENCE   8  (bases 1 to 1748)
  AUTHORS   Cheung,C.C., Martin,I.C., Zenger,K.R., Donald,J.A., Thomson,P.C.,
            Moran,C. and Buckley,M.F.
  TITLE     Quantitative trait loci for steady-state platelet count in mice
  JOURNAL   Mamm Genome 15 (10), 784-797 (2004)
   PUBMED   15520881
REFERENCE   9  (bases 1 to 1748)
  AUTHORS   Nakagawa,J., Ishikura,S., Asami,J., Isaji,T., Usami,N., Hara,A.,
            Sakurai,T., Tsuritani,K., Oda,K., Takahashi,M., Yoshimoto,M.,
            Otsuka,N. and Kitamura,K.
  TITLE     Molecular characterization of mammalian dicarbonyl/L-xylulose
            reductase and its localization in kidney
  JOURNAL   J Biol Chem 277 (20), 17883-17891 (2002)
   PUBMED   11882650
  REMARK    GeneRIF: highly expressed in kidney and liver
REFERENCE   10 (bases 1 to 1748)
  AUTHORS   Tulsiani,D.R. and Touster,O.
  TITLE     Studies on dehydrogenases of the glucuronate-xylulose cycle in the
            livers of diabetic mice and rats
  JOURNAL   Diabetes 28 (9), 793-798 (1979)
   PUBMED   38160
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL663030.12, AK007627.1, AK153521.1 and BY500715.1.
            
            On May 3, 2018 this sequence version replaced NM_026428.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BI219348.1, AK004023.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AL663030.12        183096-183098       c
            4-23                AK007627.1         13-32
            24-890              AK153521.1         2-868
            891-921             BY500715.1         383-413
            922-1748            AL663030.12        180360-181186       c
FEATURES             Location/Qualifiers
     source          1..1748
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 84.47 cM"
     gene            1..1748
                     /gene="Dcxr"
                     /gene_synonym="0610038K04Rik; 1810027P18Rik; XR"
                     /note="dicarbonyl L-xylulose reductase"
                     /db_xref="GeneID:67880"
                     /db_xref="MGI:MGI:1915130"
     exon            1..107
                     /gene="Dcxr"
                     /gene_synonym="0610038K04Rik; 1810027P18Rik; XR"
                     /inference="alignment:Splign:2.1.0"
     CDS             56..790
                     /gene="Dcxr"
                     /gene_synonym="0610038K04Rik; 1810027P18Rik; XR"
                     /EC_number="1.1.1.10"
                     /note="isoform 1 is encoded by transcript variant 1;
                     diacetyl/L-xylulose reductase"
                     /codon_start=1
                     /product="L-xylulose reductase isoform 1"
                     /protein_id="NP_080704.2"
                     /db_xref="CCDS:CCDS25755.1"
                     /db_xref="GeneID:67880"
                     /db_xref="MGI:MGI:1915130"
                     /translation="MDLGLAGRRALVTGAGKGIGRSTVLALKAAGAQVVAVSRTREDL
                     DDLVRECPGVEPVCVDLADWEATEQALSNVGPVDLLVNNAAVALLQPFLEVTKEACDT
                     SFNVNLRAVIQVSQIVAKGMIARGVPGAIVNVSSQASQRALTNHTVYCSTKGALDMLT
                     KMMALELGPHKIRVNAVNPTVVMTPMGRTNWSDPHKAKAMLDRIPLGKFAEVENVVDT
                     ILFLLSNRSGMTTGSTLPVDGGFLAT"
     exon            108..205
                     /gene="Dcxr"
                     /gene_synonym="0610038K04Rik; 1810027P18Rik; XR"
                     /inference="alignment:Splign:2.1.0"
     exon            206..360
                     /gene="Dcxr"
                     /gene_synonym="0610038K04Rik; 1810027P18Rik; XR"
                     /inference="alignment:Splign:2.1.0"
     exon            361..403
                     /gene="Dcxr"
                     /gene_synonym="0610038K04Rik; 1810027P18Rik; XR"
                     /inference="alignment:Splign:2.1.0"
     exon            404..503
                     /gene="Dcxr"
                     /gene_synonym="0610038K04Rik; 1810027P18Rik; XR"
                     /inference="alignment:Splign:2.1.0"
     exon            504..568
                     /gene="Dcxr"
                     /gene_synonym="0610038K04Rik; 1810027P18Rik; XR"
                     /inference="alignment:Splign:2.1.0"
     exon            569..686
                     /gene="Dcxr"
                     /gene_synonym="0610038K04Rik; 1810027P18Rik; XR"
                     /inference="alignment:Splign:2.1.0"
     exon            687..1748
                     /gene="Dcxr"
                     /gene_synonym="0610038K04Rik; 1810027P18Rik; XR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      854..859
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dcxr"
                     /gene_synonym="0610038K04Rik; 1810027P18Rik; XR"
                     /note="hexamer: AATAAA"
     polyA_site      894
                     /gene="Dcxr"
                     /gene_synonym="0610038K04Rik; 1810027P18Rik; XR"
                     /note="major polyA site"
     polyA_site      924
                     /gene="Dcxr"
                     /gene_synonym="0610038K04Rik; 1810027P18Rik; XR"
     regulatory      1067..1072
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dcxr"
                     /gene_synonym="0610038K04Rik; 1810027P18Rik; XR"
                     /note="hexamer: AACAAA"
     polyA_site      1093
                     /gene="Dcxr"
                     /gene_synonym="0610038K04Rik; 1810027P18Rik; XR"
ORIGIN      
        1 ctcgattccg gaactccagg tccatcttgc ccaggcagga ccaggctcaa gcaccatgga
       61 cctggggctt gcaggtcggc gggcgctggt caccggcgcg ggcaaaggca tcgggcgcag
      121 cactgtgctg gcgttgaagg cggctggtgc acaggttgtg gcggtgagtc ggacgcgaga
      181 ggacctggac gacctggtcc gcgagtgtcc tggtgtggag cctgtgtgtg tggacctggc
      241 cgactgggag gccacagagc aggccctaag caatgtggga cccgtggacc ttctggtgaa
      301 caatgctgct gtggctctgt tgcagccctt cctggaggtc accaaggagg cctgtgacac
      361 atccttcaat gtgaatcttc gggctgtcat ccaggtgtct cagattgtgg ccaagggcat
      421 gatagctcgg ggagttccag gagccattgt gaatgtctcc agccaggcct cccaacgtgc
      481 actgaccaac catactgtct actgttccac caagggtgct ctggacatgt tgaccaagat
      541 gatggcccta gagcttgggc cccacaagat ccgtgtgaat gcagtaaacc ccacagtagt
      601 gatgacaccc atgggccgga ccaactggag tgacccccac aaagctaagg ccatgctgga
      661 tcgtatccca ctgggcaagt tcgctgaggt ggagaacgtc gtggacacca ttctcttcct
      721 gctgagcaac cggagtggca tgaccactgg ctccactttg ccagtggatg ggggcttcct
      781 ggctacctga gccccctgcc caccgacact ctgctcagct ctctgctcag gacactgtgc
      841 cctccgcccc tgcaataaag ctctctgctc agcctgtgtg ctgattctcc aggaggcaca
      901 gatctgtgct atctgtgacc caaagcaggt gttgcctggt tctcacactt tcagccttga
      961 cagcttgggg tggaaggtag tcggatcttc cagaaggctg gatcctcacg aggttgatca
     1021 acctgtctaa agatagcttg tccagaaatt gtggattttt ggtaagaaca aaaccagctc
     1081 catgtgtttt tgacatggct tcccggtgac tctgcttaca catcagcgac aaccccacac
     1141 accaggagaa gataggtggt agacattact catttgccaa tgaactgaat aactctgtgg
     1201 ggctggaggc agagctgttt cgaacacgtg aacattccca caacttcttt ctctgctatt
     1261 tacaacatgg tgagaatcct ggtgtattgt ttgcaatatc tcacttccaa cagcctgggc
     1321 cactgaaggt ccagccctgg ttggtttgct gcaccgcacg gtgcagaact cccaccagaa
     1381 ctgacttttt gttttgtttt gttttgtttc gagacagggt ttctctgtgt agtcctggct
     1441 gtcctggaac tcactttgta gaccaggctg gcctcaaact cagaaatcca cctggctctg
     1501 cctcccgagt gctgggacta aaggtgtgcg ccaccacgcc cggccagagc tgacttttaa
     1561 actgtttatc tgacatcatt tgatgaggag ttgaggggga catggagctg agggggtcca
     1621 tagtagcacc ccatacacac actgtcatga gatatagagg ctagcgacat atattaatca
     1681 aggaagtgaa gaatttgtta attttgttct cagcacaact aattacaaac tgatatgatt
     1741 taattatt
//
