LOCUS       NM_029775               2436 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus defective in cullin neddylation 1 domain containing 5
            (Dcun1d5), transcript variant 2, mRNA.
ACCESSION   NM_029775
VERSION     NM_029775.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2436)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2436)
  AUTHORS   Thomas,Y., Scott,D.C., Kristariyanto,Y.A., Rinehart,J., Clark,K.,
            Cohen,P. and Kurz,T.
  TITLE     The NEDD8 E3 ligase DCNL5 is phosphorylated by IKK alpha during
            Toll-like receptor activation
  JOURNAL   PLoS One 13 (6), e0199197 (2018)
   PUBMED   29958295
  REMARK    GeneRIF: evidence that DCNL5 may be involved in innate immunity, as
            it is a direct substrate of the kinase IKKalpha during immune
            signalling.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2436)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   4  (bases 1 to 2436)
  AUTHORS   Watanabe,K., Takebayashi,H., Bepari,A.K., Esumi,S., Yanagawa,Y. and
            Tamamaki,N.
  TITLE     Dpy19l1, a multi-transmembrane protein, regulates the radial
            migration of glutamatergic neurons in the developing cerebral
            cortex
  JOURNAL   Development 138 (22), 4979-4990 (2011)
   PUBMED   22028030
  REMARK    Erratum:[Development. 2012 Mar;139(6):1225]
REFERENCE   5  (bases 1 to 2436)
  AUTHORS   Guo,G., Huss,M., Tong,G.Q., Wang,C., Li Sun,L., Clarke,N.D. and
            Robson,P.
  TITLE     Resolution of cell fate decisions revealed by single-cell gene
            expression analysis from zygote to blastocyst
  JOURNAL   Dev Cell 18 (4), 675-685 (2010)
   PUBMED   20412781
REFERENCE   6  (bases 1 to 2436)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CO801841.1, AK134862.1 and AC174457.2.
            
            On Oct 28, 2017 this sequence version replaced NM_029775.2.
            
            Transcript Variant: This variant (2) contains an alternate exon in
            the 3' coding sequence compared to variant 1, that causes a
            frameshift. The resulting isoform (2) has a shorter and distinct
            C-terminus compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK134862.1, AK013933.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849379
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                CO801841.1         1-15
            16-261              AK134862.1         2-247
            262-262             AC174457.2         126100-126100       c
            263-2434            AK134862.1         249-2420
            2435-2436           AC174457.2         102661-102662       c
FEATURES             Location/Qualifiers
     source          1..2436
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 2.46 cM"
     gene            1..2436
                     /gene="Dcun1d5"
                     /gene_synonym="3110001A18Rik; 4833420K19Rik;
                     D430047L21Rik; DCNL5"
                     /note="defective in cullin neddylation 1 domain containing
                     5"
                     /db_xref="GeneID:76863"
                     /db_xref="MGI:MGI:1924113"
     exon            1..378
                     /gene="Dcun1d5"
                     /gene_synonym="3110001A18Rik; 4833420K19Rik;
                     D430047L21Rik; DCNL5"
                     /inference="alignment:Splign:2.1.0"
     CDS             293..1006
                     /gene="Dcun1d5"
                     /gene_synonym="3110001A18Rik; 4833420K19Rik;
                     D430047L21Rik; DCNL5"
                     /note="isoform 2 is encoded by transcript variant 2;
                     DCN1-like protein 5; DCUN1 domain-containing protein 5;
                     defective in cullin neddylation protein 1-like protein 5;
                     squamous cell carcinoma-related oncogene 5; DCN1,
                     defective in cullin neddylation 1, domain containing 5"
                     /codon_start=1
                     /product="DCN1-like protein 5 isoform 2"
                     /protein_id="NP_084051.1"
                     /db_xref="CCDS:CCDS40529.1"
                     /db_xref="GeneID:76863"
                     /db_xref="MGI:MGI:1924113"
                     /translation="MPVKKKRKAPGVAAAVAEDAGLKKCKIPSYCRSQPPARLISGEE
                     DFSRKKCLAWFYEYAGPDEVVGPEGMEKFCEDIGVEPENIIMLVLAWKLEAESMGFFT
                     KEEWLKGMTSLQCDCTEKLQSRFDFLRSQLNDISSFKNIYRYAFDFARDKDQRSLDID
                     TAKSMLALLLGRTWPLFSVFYQYLEQSKYRVMNKDQWYNVLEFSRTVHADLSNYDEDG
                     AWPVLLDEFVEWQKIRQTS"
     exon            379..470
                     /gene="Dcun1d5"
                     /gene_synonym="3110001A18Rik; 4833420K19Rik;
                     D430047L21Rik; DCNL5"
                     /inference="alignment:Splign:2.1.0"
     exon            471..541
                     /gene="Dcun1d5"
                     /gene_synonym="3110001A18Rik; 4833420K19Rik;
                     D430047L21Rik; DCNL5"
                     /inference="alignment:Splign:2.1.0"
     exon            542..633
                     /gene="Dcun1d5"
                     /gene_synonym="3110001A18Rik; 4833420K19Rik;
                     D430047L21Rik; DCNL5"
                     /inference="alignment:Splign:2.1.0"
     exon            634..742
                     /gene="Dcun1d5"
                     /gene_synonym="3110001A18Rik; 4833420K19Rik;
                     D430047L21Rik; DCNL5"
                     /inference="alignment:Splign:2.1.0"
     exon            743..847
                     /gene="Dcun1d5"
                     /gene_synonym="3110001A18Rik; 4833420K19Rik;
                     D430047L21Rik; DCNL5"
                     /inference="alignment:Splign:2.1.0"
     exon            848..950
                     /gene="Dcun1d5"
                     /gene_synonym="3110001A18Rik; 4833420K19Rik;
                     D430047L21Rik; DCNL5"
                     /inference="alignment:Splign:2.1.0"
     exon            951..2436
                     /gene="Dcun1d5"
                     /gene_synonym="3110001A18Rik; 4833420K19Rik;
                     D430047L21Rik; DCNL5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1235..1240
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dcun1d5"
                     /gene_synonym="3110001A18Rik; 4833420K19Rik;
                     D430047L21Rik; DCNL5"
                     /note="hexamer: AATAAA"
     polyA_site      1273
                     /gene="Dcun1d5"
                     /gene_synonym="3110001A18Rik; 4833420K19Rik;
                     D430047L21Rik; DCNL5"
                     /note="major polyA site"
     regulatory      2412..2417
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dcun1d5"
                     /gene_synonym="3110001A18Rik; 4833420K19Rik;
                     D430047L21Rik; DCNL5"
                     /note="hexamer: AGTAAA"
     polyA_site      2436
                     /gene="Dcun1d5"
                     /gene_synonym="3110001A18Rik; 4833420K19Rik;
                     D430047L21Rik; DCNL5"
ORIGIN      
        1 ttccggtcca gagccatccg cttccgggtc aggctaagcc gcctgctctt cgctgctact
       61 gtaggtgccg cgctgtcggc gttcgctgct cctggaaaag cccgagccgc gacaccgccg
      121 gccttagcgc tgcgctgccc ggaaccgccc ctaaagagga gacccggggc ggggtcgcgc
      181 ctcgggcctc cgctgcggtc cccggcaggc gggagccggc gctgcggggc ctgcggcgga
      241 gcgcgatacc cctccccggc cgccctgtct accttgccgg ggaaggcgga agatgccagt
      301 gaagaagaag agaaaagctc ccggagtggc agcggcggtc gcggaagacg cgggcctcaa
      361 aaagtgtaaa atccccagct attgcagatc ccagcctcct gctagactca tcagtggaga
      421 ggaagatttt tcaagaaaga agtgcctggc ttggttttat gagtatgcag gtcctgatga
      481 agttgtaggg ccagaaggaa tggaaaaatt ttgtgaagac attggtgttg aacctgaaaa
      541 cattattatg ttagttttag catggaaatt ggaggctgaa agcatgggat tttttaccaa
      601 ggaagaatgg ttaaagggaa tgacctcatt acagtgtgac tgcacagaaa agttacagag
      661 caggtttgat tttctgcgct ctcagctgaa tgacatctca tcttttaaga atatctacag
      721 atatgccttt gattttgcaa gggataaaga tcagagaagc cttgatattg atactgcgaa
      781 gtctatgtta gctctgctgc ttgggagaac atggccactc ttttcagtat tttaccagta
      841 cctggagcaa tcaaagtatc gtgttatgaa caaagatcag tggtacaatg tattagaatt
      901 cagcagaaca gttcatgccg atcttagtaa ctacgatgaa gacggtgctt ggcctgttct
      961 tcttgatgaa tttgttgagt ggcaaaaaat ccgtcaaaca tcatagcaag aactgtcgtg
     1021 aagacaatgc aaaccttgtg aagacaatgc agagaggagg cagagtacag aaagggtgca
     1081 ttttcactca cgaaagactt ctcatagtac ttcttttcct tttttttaaa ggaagttttc
     1141 ttgttacatg tgatgggcat tgagccacat gtcttctgag actgaatatt gacatttttg
     1201 tttcaagtta tgtttttaac atttatttca gaacaataaa gattcagatt tgtgacaaag
     1261 gccttaaagt gaagatgtcc gttgagtgtc agagtggtat ttatttttgt aaatttgatt
     1321 tctttaactt ttgaagttct aaatcaccat gagtttgtag atttttaaag actttaagca
     1381 atctaaatac ttgagagtat aacttgccaa cggtgtggct actaataatt cctctttgca
     1441 taattaggaa acatagtaac cttgacttgt aggatcctgt ttttctgata gcagctaata
     1501 gtgtgggaag ggctccaact gaaggttgtt atgaaaagct atttatgcca actttatcta
     1561 aagagtatag gattggaaag attatgtcga agttgtcttt attttctaac cattaagttt
     1621 tcaataagta ttcttaatgt gaattgtaag ttttctgtat ttctgtaagt taaaaagtct
     1681 tatttctaag agtatagtca gacaacctta ggaaagcttt agaaccagta ttgaagttgt
     1741 gctctttctt accattattt agtaattagt gtgtttttag ccatgaagct atatggattt
     1801 gctgagagca ctttgtctga tttcagaata cttgagcttc agtattgtag acttggtttg
     1861 atacacactg gagaagaaga gaactataag gaagtatgag agacttgatg gaattgtaca
     1921 cctcataagg ccatttactt tgttccctgt atgaaggtca aattcaagac cttgaactat
     1981 gtgaggtact acactgagct atactcctaa ccccagggaa gcagtttaca tttacagtca
     2041 taatttgcta tttatcacag tctttggcta ctagcagaaa ggttatgaca aacatgtata
     2101 atttatgtgg aaggtacatt ttagattagc atcaggccta tatgtttatt gcttttcaga
     2161 tcacccagtg tctccttctg tgaaaactct tgagacccaa aacctgagct ccattcatat
     2221 tagtacttgt tccattgtat aagtagaaag aaatagatac attctctttt tccagaaaga
     2281 aaatgtcaat tgtgatttac agcaaaggtt gatttttttc cccttggtaa attcgtttaa
     2341 tgaatgattc ttagtactgc tttcttaagg gaaagtatca ttctgaaggt tttatttgcc
     2401 tttggttgat aagtaaaaag aacatgatta ctgctg
//
