LOCUS       NM_001205361            4474 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus defective in cullin neddylation 1 domain containing 1
            (Dcun1d1), transcript variant 1, mRNA.
ACCESSION   NM_001205361
VERSION     NM_001205361.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4474)
  AUTHORS   Zhao,Y., Hu,Y., Shen,Q., Xiong,R., Song,X. and Guan,C.
  TITLE     DCUN1D1, a new molecule involved in depigmentation via upregulating
            CXCL10
  JOURNAL   Exp Dermatol 32 (4), 457-468 (2023)
   PUBMED   36541112
  REMARK    GeneRIF: DCUN1D1, a new molecule involved in depigmentation via
            upregulating CXCL10.
REFERENCE   2  (bases 1 to 4474)
  AUTHORS   Huang,G., Kaufman,A.J., Ryan,R.J.H., Romin,Y., Huryn,L., Bains,S.,
            Manova-Todorova,K., Morris,P.L., Hunnicutt,G.R., Adelman,C.A.,
            Petrini,J.H.J., Ramanathan,Y. and Singh,B.
  TITLE     Mouse DCUN1D1 (SCCRO) is required for spermatogenetic
            individualization
  JOURNAL   PLoS One 14 (1), e0209995 (2019)
   PUBMED   30653527
  REMARK    GeneRIF: Spermatozoa in DCUN1D1-/- mice had multiple abnormalities,
            including globozoospermia, macrocephaly, and multiple flagella.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4474)
  AUTHORS   Huang,G., Kaufman,A.J., Xu,K., Manova,K. and Singh,B.
  TITLE     Squamous cell carcinoma-related oncogene (SCCRO) neddylates Cul3
            protein to selectively promote midbody localization and activity of
            Cul3KLHL21 protein complex during abscission
  JOURNAL   J Biol Chem 292 (37), 15254-15265 (2017)
   PUBMED   28620047
  REMARK    GeneRIF: Data (including data from studies using cells cultured
            from knockout mice) suggest that Sccro neddylates Cul3 with Nedd8,
            promoting Cul3/Klhl21 complex formation and localization of Cul3
            during telophase. (Sccro = squamous cell carcinoma-related
            oncogene; Cul3 = cullin 3; Nedd8 = neural precursor cell expressed,
            developmentally down-regulated protein 8; Klhl21 = kelch-like
            protein 21)
REFERENCE   4  (bases 1 to 4474)
  AUTHORS   Fu,W., Sun,J., Huang,G., Liu,J.C., Kaufman,A., Ryan,R.J.,
            Ramanathan,S.Y., Venkatesh,T. and Singh,B.
  TITLE     Squamous Cell Carcinoma-related Oncogene (SCCRO) Family Members
            Regulate Cell Growth and Proliferation through Their Cooperative
            and Antagonistic Effects on Cullin Neddylation
  JOURNAL   J Biol Chem 291 (12), 6200-6217 (2016)
   PUBMED   26792857
  REMARK    GeneRIF: SCCRO family members cooperatively regulate neddylation
            and cell proliferation.
REFERENCE   5  (bases 1 to 4474)
  AUTHORS   Huang,G., Towe,C.W., Choi,L., Yonekawa,Y., Bommelje,C.C., Bains,S.,
            Rechler,W., Hao,B., Ramanathan,Y. and Singh,B.
  TITLE     The ubiquitin-associated (UBA) domain of SCCRO/DCUN1D1 protein
            serves as a feedback regulator of biochemical and oncogenic
            activity
  JOURNAL   J Biol Chem 290 (1), 296-309 (2015)
   PUBMED   25411243
  REMARK    GeneRIF: The ubiquitin-associated (UBA) domain of SCCRO/DCUN1D1
            protein serves as a feedback regulator of biochemical and oncogenic
            activity.
REFERENCE   6  (bases 1 to 4474)
  AUTHORS   Broderick,S.R., Golas,B.J., Pham,D., Towe,C.W., Talbot,S.G.,
            Kaufman,A., Bains,S., Huryn,L.A., Yonekawa,Y., Carlson,D.,
            Hambardzumyan,D., Ramanathan,Y. and Singh,B.
  TITLE     SCCRO promotes glioma formation and malignant progression in mice
  JOURNAL   Neoplasia 12 (6), 476-484 (2010)
   PUBMED   20563250
  REMARK    GeneRIF: SCCRO promotes glioma formation and malignant progression.
REFERENCE   7  (bases 1 to 4474)
  AUTHORS   Kim,A.Y., Bommelje,C.C., Lee,B.E., Yonekawa,Y., Choi,L.,
            Morris,L.G., Huang,G., Kaufman,A., Ryan,R.J., Hao,B., Ramanathan,Y.
            and Singh,B.
  TITLE     SCCRO (DCUN1D1) is an essential component of the E3 complex for
            neddylation
  JOURNAL   J Biol Chem 283 (48), 33211-33220 (2008)
   PUBMED   18826954
  REMARK    GeneRIF: SCCRO recruits Ubc12 approximately NEDD8 to the
            CAND1-Cul1-ROC1 complex but that this is not sufficient to
            dissociate or overcome the inhibitory effects of CAND1 on cullin
            neddylation
REFERENCE   8  (bases 1 to 4474)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 4474)
  AUTHORS   Pourcel,C., Jaubert,J., Hadchouel,M., Wu,X. and Schweizer,J.
  TITLE     A new family of genes and pseudogenes potentially expressing
            testis- and brain-specific leucine zipper proteins in man and mouse
  JOURNAL   Gene 249 (1-2), 105-113 (2000)
   PUBMED   10831844
REFERENCE   10 (bases 1 to 4474)
  AUTHORS   Mas,C., Bourgeois,F., Bulfone,A., Levacher,B., Mugnier,C. and
            Simonneau,M.
  TITLE     Cloning and expression analysis of a novel gene, RP42, mapping to
            an autism susceptibility locus on 6q16
  JOURNAL   Genomics 65 (1), 70-74 (2000)
   PUBMED   10777668
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC116677.11 and AK008657.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK155081.1, BC037431.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-164               AC116677.11        136079-136242       c
            165-1558            AK008657.1         2-1395
            1559-4474           AC116677.11        95381-98296         c
FEATURES             Location/Qualifiers
     source          1..4474
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 17.41 cM"
     gene            1..4474
                     /gene="Dcun1d1"
                     /gene_synonym="DCNL1; pTes3; Rp42; SCCRO; Tes3"
                     /note="defective in cullin neddylation 1 domain containing
                     1"
                     /db_xref="GeneID:114893"
                     /db_xref="MGI:MGI:2150386"
     exon            1..182
                     /gene="Dcun1d1"
                     /gene_synonym="DCNL1; pTes3; Rp42; SCCRO; Tes3"
                     /inference="alignment:Splign:2.1.0"
     CDS             180..959
                     /gene="Dcun1d1"
                     /gene_synonym="DCNL1; pTes3; Rp42; SCCRO; Tes3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     DCN1-like protein 1; testis-specific protein 3; DCUN1
                     domain-containing protein 1; defective in cullin
                     neddylation protein 1-like protein 1; testis derived
                     transcript 3; DCN1, defective in cullin neddylation 1,
                     domain containing 1; squamous cell carcinoma-related
                     oncogene"
                     /codon_start=1
                     /product="DCN1-like protein 1 isoform 1"
                     /protein_id="NP_001192290.1"
                     /db_xref="CCDS:CCDS57207.1"
                     /db_xref="GeneID:114893"
                     /db_xref="MGI:MGI:2150386"
                     /translation="MNKLKSSQKDKVRQFMIFTQSSEKTAVSCLSQNDWKLDVATDNF
                     FQNPELYIRESVKGSLDRKKLEQLYTRYKDPQDENKIGIDGIQQFCDDLALDPASISV
                     LIIAWKFRAATQCEFSKQEFMDGMTELGCDSIEKLKAQIPKMEQELKEPGRFKDFYQF
                     TFNFAKNPGQKGLDLEMAIAYWNLVLNGRFKFLDLWNKFLLEHHKRSIPKDTWNLLLD
                     FSSMIADDMSNYDEEGAWPVLIDDFVEFARPQIAGTKSTTV"
     exon            183..399
                     /gene="Dcun1d1"
                     /gene_synonym="DCNL1; pTes3; Rp42; SCCRO; Tes3"
                     /inference="alignment:Splign:2.1.0"
     exon            400..568
                     /gene="Dcun1d1"
                     /gene_synonym="DCNL1; pTes3; Rp42; SCCRO; Tes3"
                     /inference="alignment:Splign:2.1.0"
     exon            569..699
                     /gene="Dcun1d1"
                     /gene_synonym="DCNL1; pTes3; Rp42; SCCRO; Tes3"
                     /inference="alignment:Splign:2.1.0"
     exon            700..782
                     /gene="Dcun1d1"
                     /gene_synonym="DCNL1; pTes3; Rp42; SCCRO; Tes3"
                     /inference="alignment:Splign:2.1.0"
     exon            783..879
                     /gene="Dcun1d1"
                     /gene_synonym="DCNL1; pTes3; Rp42; SCCRO; Tes3"
                     /inference="alignment:Splign:2.1.0"
     exon            880..4474
                     /gene="Dcun1d1"
                     /gene_synonym="DCNL1; pTes3; Rp42; SCCRO; Tes3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3569..3574
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dcun1d1"
                     /gene_synonym="DCNL1; pTes3; Rp42; SCCRO; Tes3"
                     /note="hexamer: AATAAA"
     regulatory      3581..3586
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dcun1d1"
                     /gene_synonym="DCNL1; pTes3; Rp42; SCCRO; Tes3"
                     /note="hexamer: AGTAAA"
     polyA_site      3596
                     /gene="Dcun1d1"
                     /gene_synonym="DCNL1; pTes3; Rp42; SCCRO; Tes3"
                     /note="major polyA site"
     polyA_site      3601
                     /gene="Dcun1d1"
                     /gene_synonym="DCNL1; pTes3; Rp42; SCCRO; Tes3"
                     /note="major polyA site"
ORIGIN      
        1 ggccaggccg cccaccccgg ggcccgcgcc ctccgcctcc cgcggcccgg ccgctccgcg
       61 ggccgccgca ctgcgcatga gcgggagccc ggcgagcccg tgagaggcgc cgccgccgcc
      121 gccgccgtcc attcgctgcg gagccggagg aggaggggag aggtccggag gacaccaaca
      181 tgaacaagtt gaaatcatcg cagaaggata aagttcgtca gtttatgatc ttcacacaat
      241 ctagtgagaa aactgcagta agttgtcttt ctcaaaatga ctggaagtta gatgttgcaa
      301 cagataattt ttttcaaaat ccagaacttt atatacggga gagtgtaaaa ggatcgttgg
      361 acaggaagaa gttagagcaa ctgtacacta gatacaaaga ccctcaggat gaaaataaaa
      421 ttggaataga tggtatacag cagttctgtg atgatctggc cctcgatcca gccagcatca
      481 gtgtgttgat cattgcatgg aagttcaggg cggccacaca gtgcgagttc tccaaacagg
      541 agttcatgga tggcatgaca gagttaggat gtgacagcat agaaaaacta aaggcccaaa
      601 tacccaagat ggaacaagaa ttgaaagaac caggacgatt taaggatttt taccagttta
      661 cttttaattt tgcaaagaat ccaggacaaa aaggattaga tctagaaatg gccattgctt
      721 actggaactt agtgcttaat ggaagattta aattcttaga cttatggaat aaatttttgt
      781 tggagcatca taaacgatca ataccaaaag acacgtggaa tcttctgtta gacttcagtt
      841 caatgattgc agatgacatg tccaattatg atgaagaagg agcatggcct gtccttattg
      901 atgactttgt ggaatttgca cgccctcaaa ttgctgggac aaaaagtaca acagtgtagc
      961 actaaaggaa ccttctagaa tgtacatagt ctgtacaata aatacaacgg aaaatgcaca
     1021 gtcaatttct gctggctgga ctgaagatca atcctcataa ttcaaactga gggttgagac
     1081 aaaactttta aggatacatc ttggaccata tcgtactcca ttcttctact ggtggtttgg
     1141 gcttgtcttc tagtctgggc cactctaagc atttataatt ccgacattgt ggatttcatc
     1201 ttacacctgt ggaccatctt agtctgtctt cccataagtc atagaagctt gatggtgatt
     1261 attttgaggt ttccattctt gcataaagca caatgctgtc ttcatcagaa aacagtttgg
     1321 cataagaatt aaacataata atgaacacca caacaattta taaaaacttc ttaagtatat
     1381 gctttgggct agttgcaaag actgtgctgg cagcacttca aatgagagtg atttatctga
     1441 gtgtaccgca tctgaaatgg tgtttggttg ggggaattta attttcctgg caaactacat
     1501 gtactgctgg tgtgagtaga atacctgata taagaaatat caaaataacc aacacatgaa
     1561 aaaaaaaaag gataatctgg ggactccctg aaatatgtct tgtgtttcag acgctcagaa
     1621 aggttctaca gaacaggtct gtggttatct tacccatgtt tatacagtgt cctgcagtga
     1681 acttttattt aaaaaaatat tgtaatgaga tcagatgtta gactccacac tcgtgcatca
     1741 cacaccacat aatcggattt cattgtgctc tgaaatactt ctatgccttc tgaataagtt
     1801 aaactatttc atttgttttg aatgttttgg attgctatac aatataatat tctaaattta
     1861 ggcatgaggg tattaggttt gtttgttttt ttttttaatt ttttgtcatc gcactatgga
     1921 acacaatgca attcacttaa tttataagaa gatagtaaga tttagatttt gaaaatggtt
     1981 gtgatgagcc gtgaagttca acctttctcc catggcactg ctctttgagg cgtggtccag
     2041 ccatgttggc tgctgactgt tgagatggct tactgctaaa tcactgtggt tgccaagtct
     2101 actccagaag cagagattgt cagacaggcg agcactggtg cagataccaa tggcttctgt
     2161 tctataaatt atttgacttt tgactgtttt tgtctcactt gcatttgcta tttccacatc
     2221 acagcagaat gcagtcttga ttggttttgt tttttgtttt tccatgacag gactcatgcc
     2281 ttgctctcct gctgaaaatg cttgtttctc tgataacata ctgacatgtg aaaggggtgt
     2341 attcatacat atttccatga ggaagttaaa atgatgaact aaatgttggg tgactggtct
     2401 tcaataggaa cagattttgc ttcatgtatc caggtcctct gcagggtacc aaggaatgtt
     2461 cttcaggata gcggaacaat ttatgcagat atggaaatga ttaaaactgc tttttagtca
     2521 catgatttgg aaaatgcatt gaaagcttac cttacagata tatcattaat ccaatcataa
     2581 ctttaattta ggaatgcatt tctaccaaaa gaagcttaga gtaaatttct attcacgtta
     2641 cagggattgg tcattaaaag gaaaagaatc ttgctgtttt cagtatttct tgatttcatt
     2701 ttttgtaaat ataaagaact tcaattatga aaaaaattaa agatatatgt atatatatct
     2761 ttaaaagttt tacagaccta tattgtttat tccctacatg gaacattttg agttttggta
     2821 ttgttttcag attgattgat tcagatatga tttgttttca aatgagactc cattagcttc
     2881 tttccctgcc tcataaattt tttttcataa aaatcttgat atttgtgtgt ggcctaatgc
     2941 tttgggtttt acagatttta tttttaaatg caagactttt taacaaaata gtgtttgtca
     3001 tcagtttggt actaaacatt tacaattact gtgtaattat aaacaaaaat atataaagct
     3061 tttattatgt agcaaaaaga gttaaggttg ttcaccatga tggcatctta gaattaaaca
     3121 agacttgcta gggctccaag agaaaattga tttaatgtgt ttattctgag ggtgactgtc
     3181 tggttctagg aaatgttttg taatacaaat gcttacccta ttgggggcgg ggcgtcgggg
     3241 agtcttccag aggaagggca cactcactca cacacagcca gctattgccg gcagaggatc
     3301 atggggttca gtcttcgtgt gggtcaggtc tccaagctga ttcttttctt tccagacaga
     3361 accataggga gagtttactt tttgccaaat gtcagaacag gtacacattt ttaaatgtaa
     3421 tgctttttaa atagtaaact gtataaaatg agaagtaccc acatataaaa atacttgagg
     3481 tcaaggttct cttgagtgac tatcatctgc atatctctgt aagttcaagt gtgtcgtttc
     3541 caatccctgt catattaccc acagaggcaa taaaagcttc agtaaatttg ccatgactaa
     3601 atcttctccc atattatttc agtgttttag tgtttcacat aactagacta gacttgaaga
     3661 cttttcatgg ccgagcgctg taatggcaca tctgggggaa gagaagctac gccacgtgtt
     3721 tgctccgtaa tgtttacaat gtgctcagct gtgttgttta tttaactgcg ttagttgtat
     3781 actgcggcac tgtgagtgca cccctcatcg aacttttaaa aagttttagt gttggtaaat
     3841 tcgctcactg aaaccatcgg gagcctttta tgtaatctct ttcctgaata attcttaaac
     3901 aaggttgaca ttttttcccc cctcaaggat ctgagtgcag agttcttttt ttattttttt
     3961 ctttgatgat aagtttttga gccattccat gcccaccctg cttgtgtgtt tacgtgtgtt
     4021 gctgttaagg actgtttgga aacctgtcat tttggcatac aaataggagc aagttgacct
     4081 aagagaataa tttggggatg aaaaatggaa aatggtgttg ggaaaagtta tacttgttta
     4141 caaagtatgc ccttgtaaca tgaatgaccg ttcagtgagc gtttatgtgg ctctgaatgt
     4201 taaattgtgt ctttaatagg aaatatttac ctgacacctc tgggcttttt gttgttgttg
     4261 ttaccttaaa cttttaataa tatggtttat attgaatgct gagatgtttt gataagagtt
     4321 taccaaattt gataatgtaa tgataaatgt tttaaaatgt gaactattta tcatatatct
     4381 taataattga actgtggctt ttatatgaca gatgatgaat agggtcaaat tatggctcac
     4441 cctttaattg attataaact tgagtgtatt tctg
//
