LOCUS       NM_023203                648 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus dCTP pyrophosphatase 1 (Dctpp1), mRNA.
ACCESSION   NM_023203
VERSION     NM_023203.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 648)
  AUTHORS   Nonaka,M., Tsuchimoto,D., Sakumi,K. and Nakabeppu,Y.
  TITLE     Mouse RS21-C6 is a mammalian 2'-deoxycytidine 5'-triphosphate
            pyrophosphohydrolase that prefers 5-iodocytosine
  JOURNAL   FEBS J 276 (6), 1654-1666 (2009)
   PUBMED   19220460
REFERENCE   2  (bases 1 to 648)
  AUTHORS   Wu,B., Liu,Y., Zhao,Q., Liao,S., Zhang,J., Bartlam,M., Chen,W. and
            Rao,Z.
  TITLE     Crystal structure of RS21-C6, involved in nucleoside triphosphate
            pyrophosphohydrolysis
  JOURNAL   J Mol Biol 367 (5), 1405-1412 (2007)
   PUBMED   17320107
  REMARK    GeneRIF: Several key residues involved in the substrate binding of
            RS21-C6 have been identified.
REFERENCE   3  (bases 1 to 648)
  AUTHORS   Taniwaki,T., Haruna,K., Nakamura,H., Sekimoto,T., Oike,Y.,
            Imaizumi,T., Saito,F., Muta,M., Soejima,Y., Utoh,A., Nakagata,N.,
            Araki,M., Yamamura,K. and Araki,K.
  TITLE     Characterization of an exchangeable gene trap using pU-17 carrying
            a stop codon-beta geo cassette
  JOURNAL   Dev Growth Differ 47 (3), 163-172 (2005)
   PUBMED   15840001
REFERENCE   4  (bases 1 to 648)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF110764.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF110764.1, BC004623.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN01164137
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..648
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="BALB/c"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 69.42 cM"
     gene            1..648
                     /gene="Dctpp1"
                     /gene_synonym="2410015N17Rik; RS21-C6"
                     /note="dCTP pyrophosphatase 1"
                     /db_xref="GeneID:66422"
                     /db_xref="MGI:MGI:1913672"
     exon            1..145
                     /gene="Dctpp1"
                     /gene_synonym="2410015N17Rik; RS21-C6"
                     /inference="alignment:Splign:2.1.0"
     CDS             45..557
                     /gene="Dctpp1"
                     /gene_synonym="2410015N17Rik; RS21-C6"
                     /EC_number="3.6.1.12"
                     /note="dCTPase 1; deoxycytidine-triphosphatase 1;
                     XTP3-transactivated gene A protein homolog"
                     /codon_start=1
                     /product="dCTP pyrophosphatase 1"
                     /protein_id="NP_075692.1"
                     /db_xref="CCDS:CCDS21862.1"
                     /db_xref="GeneID:66422"
                     /db_xref="MGI:MGI:1913672"
                     /translation="MSTAGDGERGTVGQEDSAAARPFRFSPEPTLEDIRRLHAEFAAE
                     RDWEQFHQPRNLLLALVGEVGELAELFQWKSDTEPGPQAWPPKERAALQEELSDVLIY
                     LVALAARCHVDLPQAVISKMDTNRQRYPVHLSRGSACKYTDLPRGTISENQAVGAGDP
                     ASELRDQAST"
     exon            146..256
                     /gene="Dctpp1"
                     /gene_synonym="2410015N17Rik; RS21-C6"
                     /inference="alignment:Splign:2.1.0"
     exon            257..634
                     /gene="Dctpp1"
                     /gene_synonym="2410015N17Rik; RS21-C6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      612..617
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dctpp1"
                     /gene_synonym="2410015N17Rik; RS21-C6"
                     /note="hexamer: AATAAA"
     polyA_site      634
                     /gene="Dctpp1"
                     /gene_synonym="2410015N17Rik; RS21-C6"
                     /note="major polyA site"
ORIGIN      
        1 gcggcgcggg gtccgctccc gcgcgggttg gactagtggg cggaatgtcc acggctggtg
       61 acggtgagcg cggtactgtg ggacaagaag actctgctgc tgcccgcccg ttcagattca
      121 gtccggagcc cacgcttgag gacatccgac gcctccatgc agagtttgca gctgagcggg
      181 actgggagca gttccaccag cctcggaacc tgctgctagc cttggtggga gaagtgggcg
      241 agctggcaga actcttccag tggaagtctg atacagagcc tggtcctcaa gcatggccac
      301 caaaggagag agcagccctt caggaggagc ttagcgacgt cctcatctac ctggtagcat
      361 tagcagcccg ctgccatgtg gatttacctc aagcagtaat ctccaaaatg gacaccaacc
      421 gccaacgtta cccagtccac ctgtcccgag gttctgcctg caagtacact gacttgcccc
      481 gtgggaccat ctctgaaaac caggctgtgg gggctggaga ccctgcctcg gagctgagag
      541 accaggcttc cacataaaaa cgaggtgcta atctggcctt attaagtctg ggcccaagtg
      601 ttttctctct caataaaatg acttaaggca aaaaaaaaaa aaaaaaaa
//
