LOCUS       NM_011722               1182 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus dynactin 6 (Dctn6), transcript variant 2, mRNA.
ACCESSION   NM_011722
VERSION     NM_011722.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1182)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1182)
  AUTHORS   Sharoar,M.G., Zhou,J., Benoit,M., He,W. and Yan,R.
  TITLE     Dynactin 6 deficiency enhances aging-associated dystrophic neurite
            formation in mouse brains
  JOURNAL   Neurobiol Aging 107, 21-29 (2021)
   PUBMED   34371284
  REMARK    GeneRIF: Dynactin 6 deficiency enhances aging-associated dystrophic
            neurite formation in mouse brains.
REFERENCE   3  (bases 1 to 1182)
  AUTHORS   Yeh,T.Y., Kowalska,A.K., Scipioni,B.R., Cheong,F.K., Zheng,M.,
            Derewenda,U., Derewenda,Z.S. and Schroer,T.A.
  TITLE     Dynactin helps target Polo-like kinase 1 to kinetochores via its
            left-handed beta-helical p27 subunit
  JOURNAL   EMBO J 32 (7), 1023-1035 (2013)
   PUBMED   23455152
  REMARK    GeneRIF: Dynactin helps target Polo-like kinase 1 to kinetochores
            via its left-handed beta-helical p27 subunit.
REFERENCE   4  (bases 1 to 1182)
  AUTHORS   Nelson,P.S., Pritchard,C., Abbott,D. and Clegg,N.
  TITLE     The human (PEDB) and mouse (mPEDB) Prostate Expression Databases
  JOURNAL   Nucleic Acids Res 30 (1), 218-220 (2002)
   PUBMED   11752298
REFERENCE   5  (bases 1 to 1182)
  AUTHORS   Eckley,D.M., Gill,S.R., Melkonian,K.A., Bingham,J.B., Goodson,H.V.,
            Heuser,J.E. and Schroer,T.A.
  TITLE     Analysis of dynactin subcomplexes reveals a novel actin-related
            protein associated with the arp1 minifilament pointed end
  JOURNAL   J Cell Biol 147 (2), 307-320 (1999)
   PUBMED   10525537
REFERENCE   6  (bases 1 to 1182)
  AUTHORS   Murdock,D.G., Boone,B.E., Esposito,L.A. and Wallace,D.C.
  TITLE     Up-regulation of nuclear and mitochondrial genes in the skeletal
            muscle of mice lacking the heart/muscle isoform of the adenine
            nucleotide translocator
  JOURNAL   J Biol Chem 274 (20), 14429-14433 (1999)
   PUBMED   10318868
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CA573939.1, AK003618.1 and BU756370.1.
            
            On Jun 19, 2014 this sequence version replaced NM_011722.3.
            
            Transcript Variant: This variant (2) lacks an alternate exon
            compared to variant 1. The resulting isoform (2) has a shorter and
            distinct N-terminus compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BY703880.1, DV065891.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-261               CA573939.1         1-261
            262-1160            AK003618.1         2-900
            1161-1182           BU756370.1         1-22                c
FEATURES             Location/Qualifiers
     source          1..1182
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6NCrl"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 20.9 cM"
     gene            1..1182
                     /gene="Dctn6"
                     /gene_synonym="p27; WS-3"
                     /note="dynactin 6"
                     /db_xref="GeneID:22428"
                     /db_xref="MGI:MGI:1343154"
     exon            1..294
                     /gene="Dctn6"
                     /gene_synonym="p27; WS-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             272..844
                     /gene="Dctn6"
                     /gene_synonym="p27; WS-3"
                     /note="isoform 2 is encoded by transcript variant 2; RGD
                     containing protein; dynactin subunit 6; protein WS-3;
                     dynactin subunit p27; p27 dynactin subunit"
                     /codon_start=1
                     /product="dynactin subunit 6 isoform 2"
                     /protein_id="NP_035852.1"
                     /db_xref="CCDS:CCDS22238.1"
                     /db_xref="GeneID:22428"
                     /db_xref="MGI:MGI:1343154"
                     /translation="MAEKTQKSVKIAPGAVVCVESEIRGDVTIGPRTVIHPKARIIAE
                     AGPIIIGEGNLIEEQALIINAHPDNIIPDTEDTEPKPMIIGTNNVFEVGCHSQAMKMG
                     DNNVIESKAYVGRNVILTSGCIIGACCSLNTFEAIPENTVIYGADCLRRVQTERPQPQ
                     TLQLDFLMKILPNYHHLKKTMKGSSTPVKN"
     exon            295..359
                     /gene="Dctn6"
                     /gene_synonym="p27; WS-3"
                     /inference="alignment:Splign:2.1.0"
     exon            360..465
                     /gene="Dctn6"
                     /gene_synonym="p27; WS-3"
                     /inference="alignment:Splign:2.1.0"
     exon            466..554
                     /gene="Dctn6"
                     /gene_synonym="p27; WS-3"
                     /inference="alignment:Splign:2.1.0"
     exon            555..602
                     /gene="Dctn6"
                     /gene_synonym="p27; WS-3"
                     /inference="alignment:Splign:2.1.0"
     exon            603..745
                     /gene="Dctn6"
                     /gene_synonym="p27; WS-3"
                     /inference="alignment:Splign:2.1.0"
     exon            746..1168
                     /gene="Dctn6"
                     /gene_synonym="p27; WS-3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1133..1138
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dctn6"
                     /gene_synonym="p27; WS-3"
                     /note="hexamer: AATAAA"
     polyA_site      1168
                     /gene="Dctn6"
                     /gene_synonym="p27; WS-3"
                     /note="major polyA site"
ORIGIN      
        1 aggatcaggg ctgatggggt taggatagac ttggtaaaca ctgtcaagtg gaaaaaacga
       61 ctttccagga ggcagaagcg aagcaagcca agccaacccc gaaaagcaaa ccatcctcag
      121 cacgcaagcg cgaacctgga aagcagaagg cgggtctctc aggccccgcc tctcccaggc
      181 cgtgccaggc tctgcaatcc catgcagaga tcatcgctct agccaggctg caaaaatcga
      241 tctcagctct tcctgagacc cgggcttgac gatggcggag aagacgcaaa agagtgtgaa
      301 gattgctccc ggagcagtag tgtgtgtaga aagcgaaatc agaggagatg taaccatagg
      361 cccgaggacg gtgatccacc ctaaagcacg aattatcgcg gaggccgggc caataatcat
      421 cggtgaagga aacctgatag aagagcaggc cctcatcata aatgctcatc cggataacat
      481 catcccagat actgaagata cagagcccaa acctatgatt attggcacca acaacgtatt
      541 tgaagtgggc tgtcattccc aagccatgaa aatgggagac aataatgtca ttgagtcaaa
      601 agcctacgtg ggcaggaatg tcatcctgac cagcggctgc atcattgggg cttgctgcag
      661 cctcaacacc tttgaagcca tccctgagaa cacggtgatc tacggcgcgg actgcctgcg
      721 gcgggtacag acagagcggc cacagcccca gactctacaa ctggatttcc tgatgaagat
      781 cttgcccaat taccaccacc tgaagaagac gatgaaaggc agctcaaccc cagttaagaa
      841 ctgagaagat gtcagtggtg ctcggttctg ccagctgtca gcgggcccgg ctgttagcac
      901 cgtgctgact ttccattgga gacttgagtt ggagagaggt gggtcctatt gtaacaaccg
      961 ctataattta tatggactat attgtctccc tgtccttgtt ctgataatgt acagactcag
     1021 tttttcttat gttatacaaa atattagcca tgcatttatt atgtaaagga ctacccatga
     1081 taacatgcca tattatgtgt ttatattcta atgtaaccat ataccataac taaataaaag
     1141 tttggctact tgcactaatc ttcccaaaaa aaaaaaaaaa aa
//
