LOCUS       NM_001357462            3821 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus dynactin 4 (Dctn4), transcript variant 2, mRNA.
ACCESSION   NM_001357462 XM_006526189
VERSION     NM_001357462.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3821)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3821)
  AUTHORS   Butterfield,N.C., Curry,K.F., Steinberg,J., Dewhurst,H.,
            Komla-Ebri,D., Mannan,N.S., Adoum,A.T., Leitch,V.D., Logan,J.G.,
            Waung,J.A., Ghirardello,E., Southam,L., Youlten,S.E.,
            Wilkinson,J.M., McAninch,E.A., Vancollie,V.E., Kussy,F.,
            White,J.K., Lelliott,C.J., Adams,D.J., Jacques,R., Bianco,A.C.,
            Boyde,A., Zeggini,E., Croucher,P.I., Williams,G.R. and
            Bassett,J.H.D.
  TITLE     Accelerating functional gene discovery in osteoarthritis
  JOURNAL   Nat Commun 12 (1), 467 (2021)
   PUBMED   33473114
  REMARK    Erratum:[Nat Commun. 2021 May 28;12(1):3302. doi:
            10.1038/s41467-021-23768-8.. PMID: 34050183]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3821)
  AUTHORS   Watanabe,K., Takebayashi,H., Bepari,A.K., Esumi,S., Yanagawa,Y. and
            Tamamaki,N.
  TITLE     Dpy19l1, a multi-transmembrane protein, regulates the radial
            migration of glutamatergic neurons in the developing cerebral
            cortex
  JOURNAL   Development 138 (22), 4979-4990 (2011)
   PUBMED   22028030
  REMARK    Erratum:[Development. 2012 Mar;139(6):1225]
REFERENCE   4  (bases 1 to 3821)
  AUTHORS   Ayalon,G., Hostettler,J.D., Hoffman,J., Kizhatil,K., Davis,J.Q. and
            Bennett,V.
  TITLE     Ankyrin-B interactions with spectrin and dynactin-4 are required
            for dystrophin-based protection of skeletal muscle from exercise
            injury
  JOURNAL   J Biol Chem 286 (9), 7370-7378 (2011)
   PUBMED   21186323
  REMARK    GeneRIF: Ankyrin-B then interacts with dynactin-4 and dystrophin,
            whereas dynactin-4 collaborates with dystrophin in coordinating
            costamere-aligned microtubules
REFERENCE   5  (bases 1 to 3821)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB856653.1, AK034292.1, AK160813.1, AC135638.5 and CJ308131.1.
            
            On Oct 28, 2017 this sequence version replaced XM_006526189.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK034292.1, AK141855.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-31                BB856653.1         2-32
            32-2979             AK034292.1         2-2949
            2980-3231           AK160813.1         2898-3149
            3232-3233           AC135638.5         10777-10778         c
            3234-3797           AK160813.1         3150-3713
            3798-3821           CJ308131.1         405-428
FEATURES             Location/Qualifiers
     source          1..3821
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 34.36 cM"
     gene            1..3821
                     /gene="Dctn4"
                     /gene_synonym="1110001K06Rik; 4930547K17Rik;
                     C130039E17Rik; p62"
                     /note="dynactin 4"
                     /db_xref="GeneID:67665"
                     /db_xref="MGI:MGI:1914915"
     exon            1..212
                     /gene="Dctn4"
                     /gene_synonym="1110001K06Rik; 4930547K17Rik;
                     C130039E17Rik; p62"
                     /inference="alignment:Splign:2.1.0"
     exon            213..283
                     /gene="Dctn4"
                     /gene_synonym="1110001K06Rik; 4930547K17Rik;
                     C130039E17Rik; p62"
                     /inference="alignment:Splign:2.1.0"
     exon            284..462
                     /gene="Dctn4"
                     /gene_synonym="1110001K06Rik; 4930547K17Rik;
                     C130039E17Rik; p62"
                     /inference="alignment:Splign:2.1.0"
     exon            463..506
                     /gene="Dctn4"
                     /gene_synonym="1110001K06Rik; 4930547K17Rik;
                     C130039E17Rik; p62"
                     /inference="alignment:Splign:2.1.0"
     exon            507..614
                     /gene="Dctn4"
                     /gene_synonym="1110001K06Rik; 4930547K17Rik;
                     C130039E17Rik; p62"
                     /inference="alignment:Splign:2.1.0"
     exon            615..635
                     /gene="Dctn4"
                     /gene_synonym="1110001K06Rik; 4930547K17Rik;
                     C130039E17Rik; p62"
                     /inference="alignment:Splign:2.1.0"
     exon            636..709
                     /gene="Dctn4"
                     /gene_synonym="1110001K06Rik; 4930547K17Rik;
                     C130039E17Rik; p62"
                     /inference="alignment:Splign:2.1.0"
     exon            710..822
                     /gene="Dctn4"
                     /gene_synonym="1110001K06Rik; 4930547K17Rik;
                     C130039E17Rik; p62"
                     /inference="alignment:Splign:2.1.0"
     exon            823..932
                     /gene="Dctn4"
                     /gene_synonym="1110001K06Rik; 4930547K17Rik;
                     C130039E17Rik; p62"
                     /inference="alignment:Splign:2.1.0"
     exon            933..1006
                     /gene="Dctn4"
                     /gene_synonym="1110001K06Rik; 4930547K17Rik;
                     C130039E17Rik; p62"
                     /inference="alignment:Splign:2.1.0"
     exon            1007..1061
                     /gene="Dctn4"
                     /gene_synonym="1110001K06Rik; 4930547K17Rik;
                     C130039E17Rik; p62"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1169
                     /gene="Dctn4"
                     /gene_synonym="1110001K06Rik; 4930547K17Rik;
                     C130039E17Rik; p62"
                     /inference="alignment:Splign:2.1.0"
     exon            1170..1267
                     /gene="Dctn4"
                     /gene_synonym="1110001K06Rik; 4930547K17Rik;
                     C130039E17Rik; p62"
                     /inference="alignment:Splign:2.1.0"
     exon            1268..3806
                     /gene="Dctn4"
                     /gene_synonym="1110001K06Rik; 4930547K17Rik;
                     C130039E17Rik; p62"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2271..2276
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dctn4"
                     /gene_synonym="1110001K06Rik; 4930547K17Rik;
                     C130039E17Rik; p62"
                     /note="hexamer: ATTAAA"
     polyA_site      2290
                     /gene="Dctn4"
                     /gene_synonym="1110001K06Rik; 4930547K17Rik;
                     C130039E17Rik; p62"
                     /note="major polyA site"
     regulatory      3778..3783
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dctn4"
                     /gene_synonym="1110001K06Rik; 4930547K17Rik;
                     C130039E17Rik; p62"
                     /note="hexamer: AATAAA"
     polyA_site      3799
                     /gene="Dctn4"
                     /gene_synonym="1110001K06Rik; 4930547K17Rik;
                     C130039E17Rik; p62"
                     /note="major polyA site"
ORIGIN      
        1 gtaggggacg cggggaggga agcgccgggc tgtgtcacgt gacgggtgcg ccgggcgttg
       61 gctcctccct caccaagatg gcgtccctgc tgcagtcgga gcgggttctc tatctcgtcc
      121 aaggagaaaa gaaggttcgg gctccgctct cacagctcta cttctgccgc tactgcagtg
      181 agcttcgatc gctggaatgt gtgtcgcacg aggtggactc acattattgt cccagctgct
      241 tagaaaacat gccgtcagct gaagccaaat taaaaaagaa tagatgtgcc aactgctttg
      301 actgtcctgg atgcatgcac accctttcta cccgtgcaac aagcatctcc acacagcttc
      361 ccgatgaccc agccaaaacc accatgaaga aagcctatta cttggcctgt ggattttgtc
      421 gatggacatc tagagatgtg ggcatggcag acaaatctgt cgctagtggt ggttggcaag
      481 aaccagaaaa ccctcacaca caacggatga acaagttgat tgagtattac cagcagcttg
      541 ctcagaagga aaaggtcgaa cgagatcgca agaagctggc acggcgaaga aattacatgc
      601 ctttggcttt ttcgcaacac actattcatg tagtggacaa gtacagtctt gggaccaggc
      661 ttcagcgacc acgagctggt gcatccatca gtacacttgc tggactttcc cttagagaag
      721 gagaagatca gaaagaggtg aagattgagc cggctcaggc tgtcgctgaa gtggagcctc
      781 tgcctgaaga ctattacacg cggccagtga acctaacaga agtgaccacc cttcagcagc
      841 gcctcttaca gcccgaccta cagccagtct ctgcttcaca gctttatcct cgacacaagc
      901 accttctgat caaacggtcc ctgcgctgtc ggaaatgtga gcacaacttg agcaagccag
      961 aatttaatcc aacatctatc aaattcaaaa tccagttggt tgctgtcaat tatattccag
     1021 aagtgagaat catgtcaatc cccaaccttc gctacatgaa ggagagccag gtcctcttga
     1081 ctcttacaaa tccagtggag aacctcaccc atgtgactct gttggagtgt gacgaggggg
     1141 accctgataa tatcaacagc actgctaagg tggtggtgcc tcccaaagag ctcatcttag
     1201 ccggcaagga tgcagcagca gaatatgatg agctggcaga gccccaggac ttccaggatg
     1261 accctgacat cgtagctttc agaaaagcca acaaagtggg catcttcatc aaagtcaccc
     1321 cacagcgtga ggaaggggaa gtgaccgtgt gcttcaagat gaaacacgat tttaaaaacc
     1381 tggctgcccc catccgccca gtggaagaag gtgaccaagg cacagaggtc atctggctca
     1441 cgcagcacgt ggagctgagc tttggccctc ttcttcctta aaacacagtg accccaccca
     1501 cagctgtgtc aacacaactc taacagtgga agccgctgct tcaccagtcg tgtttataaa
     1561 gatgtaccca tcactactga atcctgtgga ggggggaaca ggccagggtt gggagcacag
     1621 agtaactgct gttgacacca ggaagcctgt gtctctgaca cttgcacatt gagtaacagc
     1681 atggctccat cccagtgaag gagtggctgt tcctcagagg ggcgttagat ttactcccta
     1741 agacatgtgc tgtgtgcctg tcacagtctg acagagaacc ttaggacggt aatccagagc
     1801 acacctggtc ttcatgccgc agcattggcc tcggtgttga aaggcttcct gcattccact
     1861 aaggataacc ctgtaatgat aacccttcat agccttggct ctcactttgc cactgctttc
     1921 catttgacag agcagtagga ctgtcagtgt gtctttaact ttgtgatgac agggcaacct
     1981 gtcactttcc taaggcactt tgtttcttcc aaaagaacac agtatacctg tcacttgctt
     2041 gtcattttcc tcactagtat atgggacttt taagaatttg agtggcaagc aattacatgt
     2101 catgaaattc tatttgtttc aatattacaa tacccagggg ataacgctgc caaggggaga
     2161 cagttatgta tctcactatc tgcccttctc tattctgttt tctgttggtt tgtttttcag
     2221 ataggctcgc tccatgtaac tcttgctggc ctggaactca gcctgctagg attaaagata
     2281 cttgccacca tgcccatgcc ctgttctata aatcaaggga ttcgctaacg ttggggcttt
     2341 tagagcaggg atgggttgta tgggcacttt gctacatcac ttctgggata cagaaaacat
     2401 tttaaactag acttttagca tgatccaaac taatgttctt tctactgaat tgaaggacaa
     2461 attaactgtc aatcccttaa attcaaaact ggacacaaag aaaaagaacc tttcccttca
     2521 tgaatgtaag acttctagtt ctgtatgaag tgaggccatt ttgattgtaa gccatagaag
     2581 ttcagcaagt agccaggatg ccagcctaac tctagacttg ctgttgttct cagatactaa
     2641 cattgagttg caaaccttaa tttctgcgac gtgttctgct gcacttttcc ttaaagtact
     2701 cctagtatgt ggccagcaga ccttggaaga gaacgctcct gcttacaaac cctgctttgg
     2761 ttttcatttt aagtctgcgg agttttgttt tgtattaagg aatgtataga ctgtactaca
     2821 gatagaaaat agtctttgtt tgttctactt aagagaaacc gcttaggaag ctattgaaag
     2881 acactttgtt ctttaaagat cttaagatca agccaatttc atgaaacaat attcccagag
     2941 agtaatatat gtactagagt aaagaagaaa atactgacct aatacaacga gaacaataat
     3001 gtctgcctct tagaagctgg agctgaagct tgggtaattg caagtttcag actatagaaa
     3061 aagtgatttt ctgtaatccc ataaagcctc aagttaatgc ctactatgaa accacaactc
     3121 agtatctttt ggccgggcag cgcatcaaag tgctgatggc ctcagttgtg cacatattgt
     3181 gaagcctggc atagttacct gtctgcctgc cttttttttt tttttttttt tttgtctgcc
     3241 tgcctttatg cagtgacacc gatacttatt ccctaggaaa acattgaagg acggggctct
     3301 ttactcctgg ggaacaaaca cttgtgggtt tgtttttgtt ttttttaaga agtcaagtta
     3361 acttacaaat accagctgtt ggctgtttca aggtaagttt agtgcaagct ggccttgttt
     3421 gtgttcttag aaaaggttca acacttggtg gtgattagga attgtgactg tcacccttct
     3481 tgtattagat caggtgcagg gttcttattt ctagtcagtg tgcaccaaga cacagagtca
     3541 ggcatcctta gcacttgaaa ctacaatttt ggatgcttaa agctaagtta ctttgggttt
     3601 gtgagctgat tcacactcaa atttttcttt tgttccaaat acatgttata ggcatactgc
     3661 cctgaatgcc cttgcatcgt tgtaatgagc atcctccttg gtccctctgg ggggtgagag
     3721 gcactccttg acttatgaat aacaggttac tgttttgcct tattgcttaa tgtagtgaat
     3781 aaagcagaca aagctcgtgt gtcttcaaaa aaaaaaaaaa a
//
