LOCUS       NM_007835               4440 bp    mRNA    linear   ROD 17-JUL-2024
DEFINITION  Mus musculus dynactin 1 (Dctn1), transcript variant 1, mRNA.
ACCESSION   NM_007835 XM_977604
VERSION     NM_007835.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4440)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4440)
  AUTHORS   Pierga,A., Matusiak,R., Cauhape,M., Branchu,J., Danglot,L.,
            Boutry,M. and Darios,F.
  TITLE     Spatacsin regulates directionality of lysosome trafficking by
            promoting the degradation of its partner AP5Z1
  JOURNAL   PLoS Biol 21 (10), e3002337 (2023)
   PUBMED   37871017
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4440)
  AUTHORS   He,S., Gillies,J.P., Zang,J.L., Cordoba-Beldad,C.M., Yamamoto,I.,
            Fujiwara,Y., Grantham,J., DeSantis,M.E. and Shibuya,H.
  TITLE     Distinct dynein complexes defined by DYNLRB1 and DYNLRB2 regulate
            mitotic and male meiotic spindle bipolarity
  JOURNAL   Nat Commun 14 (1), 1715 (2023)
   PUBMED   36973253
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4440)
  AUTHORS   Yu,J., Yang,X., Zheng,J., Sgobio,C., Sun,L. and Cai,H.
  TITLE     Deficiency of Perry syndrome-associated p150Glued in midbrain
            dopaminergic neurons leads to progressive neurodegeneration and
            endoplasmic reticulum abnormalities
  JOURNAL   NPJ Parkinsons Dis 9 (1), 35 (2023)
   PUBMED   36879021
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4440)
  AUTHORS   Sapir,T., Kshirsagar,A., Gorelik,A., Olender,T., Porat,Z.,
            Scheffer,I.E., Goldstein,D.B., Devinsky,O. and Reiner,O.
  TITLE     Heterogeneous nuclear ribonucleoprotein U (HNRNPU) safeguards the
            developing mouse cortex
  JOURNAL   Nat Commun 13 (1), 4209 (2022)
   PUBMED   35864088
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4440)
  AUTHORS   Jiang,C.H., Tsien,J.Z., Schultz,P.G. and Hu,Y.
  TITLE     The effects of aging on gene expression in the hypothalamus and
            cortex of mice
  JOURNAL   Proc Natl Acad Sci U S A 98 (4), 1930-1934 (2001)
   PUBMED   11172053
REFERENCE   7  (bases 1 to 4440)
  AUTHORS   Weber,J.S., Jang,W., Simin,K., Lu,W., Yu,J. and Meisler,M.H.
  TITLE     High-resolution genetic, physical, and transcript map of the mnd2
            region of mouse chromosome 6
  JOURNAL   Genomics 54 (1), 107-115 (1998)
   PUBMED   9806835
REFERENCE   8  (bases 1 to 4440)
  AUTHORS   Abe,T.K., Tanaka,H., Iwanaga,T., Odani,S. and Kuwano,R.
  TITLE     The presence of the 50-kDa subunit of dynactin complex in the nerve
            growth cone
  JOURNAL   Biochem Biophys Res Commun 233 (2), 295-299 (1997)
   PUBMED   9144527
REFERENCE   9  (bases 1 to 4440)
  AUTHORS   Jang,W., Weber,J.S., Tokito,M.K., Holzbaur,E.L. and Meisler,M.H.
  TITLE     Mouse p150Glued (dynactin 1) cDNA sequence and evaluation as a
            candidate for the neuromuscular disease mutation mnd2
  JOURNAL   Biochem Biophys Res Commun 231 (2), 344-347 (1997)
   PUBMED   9070275
REFERENCE   10 (bases 1 to 4440)
  AUTHORS   Vaughan,K.T., Mikami,A., Paschal,B.M., Holzbaur,E.L., Hughes,S.M.,
            Echeverri,C.J., Moore,K.J., Gilbert,D.J., Copeland,N.G.,
            Jenkins,N.A. and Vallee,R.B.
  TITLE     Multiple mouse chromosomal loci for dynein-based motility
  JOURNAL   Genomics 36 (1), 29-38 (1996)
   PUBMED   8812413
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC160400.12.
            
            On Jul 20, 2022 this sequence version replaced NM_007835.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U60312.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849379, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-317               AC160400.12        105420-105736
            318-563             AC160400.12        108355-108600
            564-642             AC160400.12        108890-108968
            643-677             AC160400.12        109130-109164
            678-698             AC160400.12        109767-109787
            699-716             AC160400.12        112259-112276
            717-737             AC160400.12        113595-113615
            738-929             AC160400.12        114908-115099
            930-1127            AC160400.12        115379-115576
            1128-1332           AC160400.12        115732-115936
            1333-1411           AC160400.12        116034-116112
            1412-1571           AC160400.12        116252-116411
            1572-1676           AC160400.12        116524-116628
            1677-1868           AC160400.12        116800-116991
            1869-1985           AC160400.12        117076-117192
            1986-2138           AC160400.12        117397-117549
            2139-2299           AC160400.12        118291-118451
            2300-2468           AC160400.12        118565-118733
            2469-2537           AC160400.12        119538-119606
            2538-2600           AC160400.12        119790-119852
            2601-2750           AC160400.12        119951-120100
            2751-2912           AC160400.12        120261-120422
            2913-3044           AC160400.12        120505-120636
            3045-3170           AC160400.12        120819-120944
            3171-3313           AC160400.12        121379-121521
            3314-3480           AC160400.12        121772-121938
            3481-3495           AC160400.12        123150-123164
            3496-3629           AC160400.12        123322-123455
            3630-3822           AC160400.12        123587-123779
            3823-3902           AC160400.12        124413-124492
            3903-3992           AC160400.12        125019-125108
            3993-4440           AC160400.12        125505-125952
FEATURES             Location/Qualifiers
     source          1..4440
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 35.94 cM"
     gene            1..4440
                     /gene="Dctn1"
                     /gene_synonym="DAP-150; DP-150; Glued; p150; p150-glued;
                     p150<glued>"
                     /note="dynactin 1"
                     /db_xref="GeneID:13191"
                     /db_xref="MGI:MGI:107745"
     exon            1..317
                     /gene="Dctn1"
                     /gene_synonym="DAP-150; DP-150; Glued; p150; p150-glued;
                     p150<glued>"
                     /inference="alignment:Splign:2.1.0"
     CDS             285..4130
                     /gene="Dctn1"
                     /gene_synonym="DAP-150; DP-150; Glued; p150; p150-glued;
                     p150<glued>"
                     /note="isoform 1 is encoded by transcript variant 1;
                     dynactin subunit 1; 150 kDa dynein-associated polypeptide;
                     dynactin 1, retrograde axonal transport"
                     /codon_start=1
                     /product="dynactin subunit 1 isoform 1"
                     /protein_id="NP_031861.2"
                     /db_xref="CCDS:CCDS39532.1"
                     /db_xref="GeneID:13191"
                     /db_xref="MGI:MGI:107745"
                     /translation="MAQSRRHMSSRTPSGSRMSTEASARPLRVGSRVEVIGKGHRGTV
                     AYVGATLFATGKWVGVILDEAKGKNDGTVQGRKYFTCDEGHGIFVRQSQIQVFEDGAD
                     TTSPETPDSSASKVLKREGADAAAKTSKLRGLKPKKAPTARKTTTRRPKPTRPASTGV
                     AGPSSSLGPSGSASAGELSSSEPSTPAQTPLAAPIIPTPALTSPGAAPPLPSPSKEEE
                     GLRAQVRDLEEKLETLRLKRSEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRL
                     KEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDE
                     LTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQ
                     KLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNL
                     EEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQE
                     TVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHA
                     KAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRK
                     QAQEKFDLSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVY
                     KKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPE
                     DSTMQLADHIKFTQSALDCMGVEVGRLRAFLQGGQEATDIALLLRDLETSCSDTRQFC
                     KKIRRRMPGTDAPGIPAALAFGSQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLA
                     ENEGLPVAALEELAFKASEQIYGSPSSSPYECLRQSCTILISTMNKLATAMQEGEYDA
                     ERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVR
                     LSLLEKKLDSAAKDADERIEKVQTRLDETQTLLRKKEKDFEETMDALQADIDQLEAEK
                     AELKQRLNSQSKRTIEGLRGPPPSGIATLVSGIAGEEPQRGGAPGQAPGALPGPGLVK
                     DSPLLLQQISAMRLHISQLQHENSILRGAQMKASLAALPPLHVAKLSLPPHEGPGGNL
                     VAGALYRKTSQLLEKLNQLSTHTHVVDITRSSPAAKSPSAQLMEQVAQLKSLSDTIEK
                     LKDEVLKETVTQRPGATVPTDFATFPSSAFLRAKEEQQDDTVYMGKVTFSCAAGLGQR
                     HRLVLTQEQLHQLHSRLIS"
     exon            318..563
                     /gene="Dctn1"
                     /gene_synonym="DAP-150; DP-150; Glued; p150; p150-glued;
                     p150<glued>"
                     /inference="alignment:Splign:2.1.0"
     exon            564..642
                     /gene="Dctn1"
                     /gene_synonym="DAP-150; DP-150; Glued; p150; p150-glued;
                     p150<glued>"
                     /inference="alignment:Splign:2.1.0"
     exon            643..677
                     /gene="Dctn1"
                     /gene_synonym="DAP-150; DP-150; Glued; p150; p150-glued;
                     p150<glued>"
                     /inference="alignment:Splign:2.1.0"
     exon            678..698
                     /gene="Dctn1"
                     /gene_synonym="DAP-150; DP-150; Glued; p150; p150-glued;
                     p150<glued>"
                     /inference="alignment:Splign:2.1.0"
     exon            699..716
                     /gene="Dctn1"
                     /gene_synonym="DAP-150; DP-150; Glued; p150; p150-glued;
                     p150<glued>"
                     /inference="alignment:Splign:2.1.0"
     exon            717..737
                     /gene="Dctn1"
                     /gene_synonym="DAP-150; DP-150; Glued; p150; p150-glued;
                     p150<glued>"
                     /inference="alignment:Splign:2.1.0"
     exon            738..929
                     /gene="Dctn1"
                     /gene_synonym="DAP-150; DP-150; Glued; p150; p150-glued;
                     p150<glued>"
                     /inference="alignment:Splign:2.1.0"
     exon            930..1127
                     /gene="Dctn1"
                     /gene_synonym="DAP-150; DP-150; Glued; p150; p150-glued;
                     p150<glued>"
                     /inference="alignment:Splign:2.1.0"
     exon            1128..1332
                     /gene="Dctn1"
                     /gene_synonym="DAP-150; DP-150; Glued; p150; p150-glued;
                     p150<glued>"
                     /inference="alignment:Splign:2.1.0"
     exon            1333..1411
                     /gene="Dctn1"
                     /gene_synonym="DAP-150; DP-150; Glued; p150; p150-glued;
                     p150<glued>"
                     /inference="alignment:Splign:2.1.0"
     exon            1412..1571
                     /gene="Dctn1"
                     /gene_synonym="DAP-150; DP-150; Glued; p150; p150-glued;
                     p150<glued>"
                     /inference="alignment:Splign:2.1.0"
     exon            1572..1676
                     /gene="Dctn1"
                     /gene_synonym="DAP-150; DP-150; Glued; p150; p150-glued;
                     p150<glued>"
                     /inference="alignment:Splign:2.1.0"
     exon            1677..1868
                     /gene="Dctn1"
                     /gene_synonym="DAP-150; DP-150; Glued; p150; p150-glued;
                     p150<glued>"
                     /inference="alignment:Splign:2.1.0"
     exon            1869..1985
                     /gene="Dctn1"
                     /gene_synonym="DAP-150; DP-150; Glued; p150; p150-glued;
                     p150<glued>"
                     /inference="alignment:Splign:2.1.0"
     exon            1986..2138
                     /gene="Dctn1"
                     /gene_synonym="DAP-150; DP-150; Glued; p150; p150-glued;
                     p150<glued>"
                     /inference="alignment:Splign:2.1.0"
     exon            2139..2299
                     /gene="Dctn1"
                     /gene_synonym="DAP-150; DP-150; Glued; p150; p150-glued;
                     p150<glued>"
                     /inference="alignment:Splign:2.1.0"
     exon            2300..2468
                     /gene="Dctn1"
                     /gene_synonym="DAP-150; DP-150; Glued; p150; p150-glued;
                     p150<glued>"
                     /inference="alignment:Splign:2.1.0"
     exon            2469..2537
                     /gene="Dctn1"
                     /gene_synonym="DAP-150; DP-150; Glued; p150; p150-glued;
                     p150<glued>"
                     /inference="alignment:Splign:2.1.0"
     exon            2538..2600
                     /gene="Dctn1"
                     /gene_synonym="DAP-150; DP-150; Glued; p150; p150-glued;
                     p150<glued>"
                     /inference="alignment:Splign:2.1.0"
     exon            2601..2750
                     /gene="Dctn1"
                     /gene_synonym="DAP-150; DP-150; Glued; p150; p150-glued;
                     p150<glued>"
                     /inference="alignment:Splign:2.1.0"
     exon            2751..2912
                     /gene="Dctn1"
                     /gene_synonym="DAP-150; DP-150; Glued; p150; p150-glued;
                     p150<glued>"
                     /inference="alignment:Splign:2.1.0"
     exon            2913..3044
                     /gene="Dctn1"
                     /gene_synonym="DAP-150; DP-150; Glued; p150; p150-glued;
                     p150<glued>"
                     /inference="alignment:Splign:2.1.0"
     exon            3045..3170
                     /gene="Dctn1"
                     /gene_synonym="DAP-150; DP-150; Glued; p150; p150-glued;
                     p150<glued>"
                     /inference="alignment:Splign:2.1.0"
     exon            3171..3313
                     /gene="Dctn1"
                     /gene_synonym="DAP-150; DP-150; Glued; p150; p150-glued;
                     p150<glued>"
                     /inference="alignment:Splign:2.1.0"
     exon            3314..3480
                     /gene="Dctn1"
                     /gene_synonym="DAP-150; DP-150; Glued; p150; p150-glued;
                     p150<glued>"
                     /inference="alignment:Splign:2.1.0"
     exon            3481..3495
                     /gene="Dctn1"
                     /gene_synonym="DAP-150; DP-150; Glued; p150; p150-glued;
                     p150<glued>"
                     /inference="alignment:Splign:2.1.0"
     exon            3496..3629
                     /gene="Dctn1"
                     /gene_synonym="DAP-150; DP-150; Glued; p150; p150-glued;
                     p150<glued>"
                     /inference="alignment:Splign:2.1.0"
     exon            3630..3822
                     /gene="Dctn1"
                     /gene_synonym="DAP-150; DP-150; Glued; p150; p150-glued;
                     p150<glued>"
                     /inference="alignment:Splign:2.1.0"
     exon            3823..3902
                     /gene="Dctn1"
                     /gene_synonym="DAP-150; DP-150; Glued; p150; p150-glued;
                     p150<glued>"
                     /inference="alignment:Splign:2.1.0"
     exon            3903..3992
                     /gene="Dctn1"
                     /gene_synonym="DAP-150; DP-150; Glued; p150; p150-glued;
                     p150<glued>"
                     /inference="alignment:Splign:2.1.0"
     exon            3993..4440
                     /gene="Dctn1"
                     /gene_synonym="DAP-150; DP-150; Glued; p150; p150-glued;
                     p150<glued>"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4416..4421
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dctn1"
                     /gene_synonym="DAP-150; DP-150; Glued; p150; p150-glued;
                     p150<glued>"
                     /note="hexamer: ATTAAA"
     polyA_site      4440
                     /gene="Dctn1"
                     /gene_synonym="DAP-150; DP-150; Glued; p150; p150-glued;
                     p150<glued>"
                     /note="major polyA site"
ORIGIN      
        1 agtctagagc agcactagcg cagagtgaga ctcatcagct ggcaagcggg gctcagtgtc
       61 tctgggttca ggaatccttg ggcagtagaa gggacttact cctcagcccc atcactgctc
      121 ctgcccctcc agagggagga ccatggacgg agggaggtcc gtggctaacg gcttctgagc
      181 cgtccgtcca tgcaggccca tcaccctgac ccctcctgcc taggtttctg ccttttctct
      241 gtctttggct agctggggga gggggtagag tccgggtgag caacatggcc cagagcagga
      301 ggcacatgtc cagtcggacg ccgagtggca gcaggatgag tacggaggca agcgcccggc
      361 ccctgcgggt tggctcccgc gtggaggtga ttgggaaggg ccaccgaggc actgtggcct
      421 atgttggagc cacactcttt gccactggca aatgggtggg cgtgattctg gatgaagcaa
      481 aaggcaaaaa tgatggcact gtccagggaa ggaagtattt cacatgtgat gaaggccacg
      541 gcatctttgt acgccagtcc cagatccaag tatttgaaga tggagcagat actacttccc
      601 cagagactcc tgattcttct gcttcaaagg tcctcaagag agagggagcc gatgcagctg
      661 caaagaccag caaactgcgg ggactgaagc ctaagaaggc accgacagcc cgaaagacca
      721 caactcgacg gcccaagcct actcgcccag ccagcactgg ggtggctggg cccagtagct
      781 cccttggccc ctctggctca gcgtcagccg gggaactaag cagcagtgag cccagcaccc
      841 cagctcagac tccgctggca gcacccatca tccccacacc ggccctcacc tctcctggag
      901 cagcaccccc acttccatct ccctctaagg aagaggaagg gctgagggct caggtacggg
      961 acctggagga gaagctggag accctgcgcc taaaacgctc agaagacaaa gcaaagctga
     1021 aagagctgga gaagcacaag atccagctgg agcaggtgca ggaatggaag agcaaaatgc
     1081 aggagcagca ggcagacctg cagcggcgcc tcaaggaggc tcggaaggaa gccaaggagg
     1141 cgctagaggc aaaggaacgc tacatggagg agatggccga cacagccgac gctatcgaga
     1201 tggccactct ggacaaggag atggctgaag agcgcgctga gtctctgcag caagaggtgg
     1261 aggcactgaa ggaacgggta gacgagctca ccacagacct ggagattctc aaggctgaaa
     1321 tcgaagagaa aggctctgat ggggccgcat caagctacca gctcaagcag ctggaggagc
     1381 agaatgcccg cctgaaggat gccctggtga ggatgcgaga cctctcttcc tcagagaagc
     1441 aggagcacgt gaagctgcag aaactcatgg aaaagaaaaa ccaggagctg gaggtcgtgc
     1501 ggcagcagcg cgagcgtctt caggaggagc tgagccaggc tgagagcacc atcgatgagc
     1561 tcaaagagca ggtggacgcc gctctgggag ccgaggagat ggtggagatg ctgaccgacc
     1621 ggaacctgaa tctagaggag aaagtgcggg agttacggga gactgtgggg gacttggaag
     1681 ccatgaacga gatgaacgat gagctgcagg agaacgcacg ggagacggag ctggaactcc
     1741 gagagcagct ggacatggcg ggcgcccgag tgagggaagc gcagaagcga gtggaagccg
     1801 cccaggagac agtcgccgac taccagcaga ccatcaagaa gtaccgccag ttgactgccc
     1861 acctacagga tgtcaatcgg gagctgacaa accagcagga agcgtctgta gagaggcagc
     1921 agcagccgcc gccagagact tttgatttca aaatcaagtt tgctgagacc aaggctcatg
     1981 ccaaggccat tgagatggag ttgagacaga tggaagttgc ccaggccaac cggcacatgt
     2041 ccctgctgac agcctttatg cctgacagct tccttcggcc aggtggagac cacgactgtg
     2101 tcctggtgct gctgctcatg ccccgactca tttgcaaggc agagctcatc cggaagcagg
     2161 cccaggagaa gtttgacctg agcgagaact gttcggagcg gcccgggctg cggggagctg
     2221 ccggggagca gctgagcttt gctgctggac tggtgtactc gctgagtctg ctgcaggcca
     2281 cgctgcaccg ctatgagcat gccctctctc agtgcagtgt ggacgtgtat aagaaggtcg
     2341 gcagcctgta ccccgagatg agcgcccacg agcgctcctt agatttcctc attgagctgc
     2401 tgcacaagga tcagctggat gagactgtca acgtggagcc cctcaccaag gccatcaagt
     2461 attaccagca tctgtacagc atccacctcg ctgaacaacc cgaggactcc accatgcagc
     2521 tggctgacca catcaagttc acccagagtg ccctggactg catgggcgtg gaggtggggc
     2581 ggctgcgtgc cttcttgcag ggtgggcagg aggcaacaga tattgccctt cttctccgag
     2641 acctggaaac atcatgtagt gacacccgtc agttctgcaa gaagatccga aggcggatgc
     2701 cggggacgga tgctcctggg atcccagcag cgctggcctt tggctcacag gtatccgaca
     2761 cactcctgga ctgcaggaag cacttgacgt gggtggtagc tgttctgcag gaggtggcag
     2821 ctgcagccgc ccagcttatt gcccccttgg cagagaacga ggggctgcct gtggctgcac
     2881 tggaggagct ggccttcaaa gcaagcgagc agatctacgg gagcccctcc agcagcccct
     2941 atgagtgtct acgccagtca tgcaccatcc tcatcagcac gatgaacaag ctggccacag
     3001 ccatgcaaga aggcgagtat gacgcagagc gacccccgag caagcctcct ccggttgaac
     3061 ttcgggctgc agccctgcgt gcagagatca cagatgctga aggtctgggt ttgaagcttg
     3121 aggatcgaga gacagttatc aaggagttaa agaagtcact caagattaag ggagaggagc
     3181 tgagtgaggc caacgtgcgg ctcagcctcc tggagaagaa gttggacagc gctgccaagg
     3241 atgcagacga gcgaatcgag aaagttcaga cacggctgga cgagactcag accctgctgc
     3301 ggaagaagga gaaagacttt gaggagacaa tggacgcact ccaggctgac atcgaccagc
     3361 tggaggcaga gaaggcagag ctcaagcagc gcctgaacag ccagtccaag cgcacaatcg
     3421 aggggctccg gggcccccct ccgtcaggca tcgctaccct ggtctctggc atcgctggtg
     3481 aggaaccaca gcgagggggc gctcctgggc aggctccggg cgccttgcca ggcccggggc
     3541 tggtgaagga ctccccactg ctgcttcagc agatctctgc tatgaggcta cacatctctc
     3601 agctccagca tgagaacagc atcctcagag gagcccagat gaaggcgtcc ttggcagctc
     3661 tgccccctct gcatgttgca aagctttccc tcccacccca tgagggcccc ggtggtaacc
     3721 tagtggctgg ggcactgtac cgcaagacca gccagctcct ggagaaacta aaccagctga
     3781 gtacccacac ccacgtggtg gatatcactc ggagcagccc agctgccaag agcccgtcag
     3841 ctcagcttat ggaacaagtg gctcagctca agtccctgag tgacaccatt gagaagctca
     3901 aggatgaggt cctcaaggag acagtgactc agcgccctgg agccactgtg cccaccgact
     3961 ttgccacttt cccttcatct gccttcctca gggccaagga agagcagcaa gatgacacag
     4021 tctacatggg caaagtgacc ttttcatgcg cggcaggcct aggacagcga caccgcctgg
     4081 tgctgaccca ggagcagctg caccagcttc acagtcgcct catctcctaa gcactccttc
     4141 cctgccttcc ctgtggtccc actgcgcagg gcacagccac ctcagccact cccaggctgg
     4201 accacacgct aacctcctga gtggttcagc tgcgtctggt ctggtcaggg tcctgctgct
     4261 tccgtaacct gggtttgcct gtccacccct ggcctcttcc gtatttgctg ttatctgctc
     4321 cctctttcct gaggggcctc agggcattgg agggggccga cacccctcca ctaaagattg
     4381 agtgaggtct ccctgactga ggacttcacc ccttgattaa agcaacttgt gcttcactgc
//
