LOCUS       NM_001347310            4065 bp    mRNA    linear   ROD 17-JUL-2024
DEFINITION  Mus musculus dynactin 1 (Dctn1), transcript variant 4, mRNA.
ACCESSION   NM_001347310
VERSION     NM_001347310.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4065)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4065)
  AUTHORS   Pierga,A., Matusiak,R., Cauhape,M., Branchu,J., Danglot,L.,
            Boutry,M. and Darios,F.
  TITLE     Spatacsin regulates directionality of lysosome trafficking by
            promoting the degradation of its partner AP5Z1
  JOURNAL   PLoS Biol 21 (10), e3002337 (2023)
   PUBMED   37871017
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4065)
  AUTHORS   He,S., Gillies,J.P., Zang,J.L., Cordoba-Beldad,C.M., Yamamoto,I.,
            Fujiwara,Y., Grantham,J., DeSantis,M.E. and Shibuya,H.
  TITLE     Distinct dynein complexes defined by DYNLRB1 and DYNLRB2 regulate
            mitotic and male meiotic spindle bipolarity
  JOURNAL   Nat Commun 14 (1), 1715 (2023)
   PUBMED   36973253
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4065)
  AUTHORS   Yu,J., Yang,X., Zheng,J., Sgobio,C., Sun,L. and Cai,H.
  TITLE     Deficiency of Perry syndrome-associated p150Glued in midbrain
            dopaminergic neurons leads to progressive neurodegeneration and
            endoplasmic reticulum abnormalities
  JOURNAL   NPJ Parkinsons Dis 9 (1), 35 (2023)
   PUBMED   36879021
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4065)
  AUTHORS   Sapir,T., Kshirsagar,A., Gorelik,A., Olender,T., Porat,Z.,
            Scheffer,I.E., Goldstein,D.B., Devinsky,O. and Reiner,O.
  TITLE     Heterogeneous nuclear ribonucleoprotein U (HNRNPU) safeguards the
            developing mouse cortex
  JOURNAL   Nat Commun 13 (1), 4209 (2022)
   PUBMED   35864088
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4065)
  AUTHORS   Jiang,C.H., Tsien,J.Z., Schultz,P.G. and Hu,Y.
  TITLE     The effects of aging on gene expression in the hypothalamus and
            cortex of mice
  JOURNAL   Proc Natl Acad Sci U S A 98 (4), 1930-1934 (2001)
   PUBMED   11172053
REFERENCE   7  (bases 1 to 4065)
  AUTHORS   Weber,J.S., Jang,W., Simin,K., Lu,W., Yu,J. and Meisler,M.H.
  TITLE     High-resolution genetic, physical, and transcript map of the mnd2
            region of mouse chromosome 6
  JOURNAL   Genomics 54 (1), 107-115 (1998)
   PUBMED   9806835
REFERENCE   8  (bases 1 to 4065)
  AUTHORS   Abe,T.K., Tanaka,H., Iwanaga,T., Odani,S. and Kuwano,R.
  TITLE     The presence of the 50-kDa subunit of dynactin complex in the nerve
            growth cone
  JOURNAL   Biochem Biophys Res Commun 233 (2), 295-299 (1997)
   PUBMED   9144527
REFERENCE   9  (bases 1 to 4065)
  AUTHORS   Jang,W., Weber,J.S., Tokito,M.K., Holzbaur,E.L. and Meisler,M.H.
  TITLE     Mouse p150Glued (dynactin 1) cDNA sequence and evaluation as a
            candidate for the neuromuscular disease mutation mnd2
  JOURNAL   Biochem Biophys Res Commun 231 (2), 344-347 (1997)
   PUBMED   9070275
REFERENCE   10 (bases 1 to 4065)
  AUTHORS   Vaughan,K.T., Mikami,A., Paschal,B.M., Holzbaur,E.L., Hughes,S.M.,
            Echeverri,C.J., Moore,K.J., Gilbert,D.J., Copeland,N.G.,
            Jenkins,N.A. and Vallee,R.B.
  TITLE     Multiple mouse chromosomal loci for dynein-based motility
  JOURNAL   Genomics 36 (1), 29-38 (1996)
   PUBMED   8812413
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC160400.12.
            
            On Jul 20, 2022 this sequence version replaced NM_001347310.1.
            
            Transcript Variant: This variant (4) differs in the 5' UTR, lacks
            multiple exons in the coding region, and uses a novel start codon,
            compared to variant 1. Variant 4 encodes a protein (isoform 4) with
            a distinct and shorter N-terminus, compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849374,
                              SAMN00849375 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-341               AC160400.12        111936-112276
            342-362             AC160400.12        113595-113615
            363-554             AC160400.12        114908-115099
            555-752             AC160400.12        115379-115576
            753-957             AC160400.12        115732-115936
            958-1036            AC160400.12        116034-116112
            1037-1196           AC160400.12        116252-116411
            1197-1301           AC160400.12        116524-116628
            1302-1493           AC160400.12        116800-116991
            1494-1610           AC160400.12        117076-117192
            1611-1763           AC160400.12        117397-117549
            1764-1924           AC160400.12        118291-118451
            1925-2093           AC160400.12        118565-118733
            2094-2162           AC160400.12        119538-119606
            2163-2225           AC160400.12        119790-119852
            2226-2375           AC160400.12        119951-120100
            2376-2537           AC160400.12        120261-120422
            2538-2669           AC160400.12        120505-120636
            2670-2795           AC160400.12        120819-120944
            2796-2938           AC160400.12        121379-121521
            2939-3105           AC160400.12        121772-121938
            3106-3120           AC160400.12        123150-123164
            3121-3254           AC160400.12        123322-123455
            3255-3447           AC160400.12        123587-123779
            3448-3527           AC160400.12        124413-124492
            3528-3617           AC160400.12        125019-125108
            3618-4065           AC160400.12        125505-125952
FEATURES             Location/Qualifiers
     source          1..4065
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 35.94 cM"
     gene            1..4065
                     /gene="Dctn1"
                     /gene_synonym="DAP-150; DP-150; Glued; p150; p150-glued;
                     p150<glued>"
                     /note="dynactin 1"
                     /db_xref="GeneID:13191"
                     /db_xref="MGI:MGI:107745"
     exon            1..341
                     /gene="Dctn1"
                     /gene_synonym="DAP-150; DP-150; Glued; p150; p150-glued;
                     p150<glued>"
                     /inference="alignment:Splign:2.1.0"
     CDS             312..3755
                     /gene="Dctn1"
                     /gene_synonym="DAP-150; DP-150; Glued; p150; p150-glued;
                     p150<glued>"
                     /note="isoform 4 is encoded by transcript variant 4;
                     dynactin subunit 1; 150 kDa dynein-associated polypeptide;
                     dynactin 1, retrograde axonal transport"
                     /codon_start=1
                     /product="dynactin subunit 1 isoform 4"
                     /protein_id="NP_001334239.1"
                     /db_xref="GeneID:13191"
                     /db_xref="MGI:MGI:107745"
                     /translation="MMRQAPTARKTTTRRPKPTRPASTGVAGPSSSLGPSGSASAGEL
                     SSSEPSTPAQTPLAAPIIPTPALTSPGAAPPLPSPSKEEEGLRAQVRDLEEKLETLRL
                     KRSEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYM
                     EEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSD
                     GAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRE
                     RLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMN
                     EMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAH
                     LQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRH
                     MSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFDLSENCSERPGL
                     RGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLD
                     FLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDSTMQLADHIKFTQSALD
                     CMGVEVGRLRAFLQGGQEATDIALLLRDLETSCSDTRQFCKKIRRRMPGTDAPGIPAA
                     LAFGSQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLPVAALEELAFKAS
                     EQIYGSPSSSPYECLRQSCTILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALR
                     AEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAAKDADER
                     IEKVQTRLDETQTLLRKKEKDFEETMDALQADIDQLEAEKAELKQRLNSQSKRTIEGL
                     RGPPPSGIATLVSGIAGEEPQRGGAPGQAPGALPGPGLVKDSPLLLQQISAMRLHISQ
                     LQHENSILRGAQMKASLAALPPLHVAKLSLPPHEGPGGNLVAGALYRKTSQLLEKLNQ
                     LSTHTHVVDITRSSPAAKSPSAQLMEQVAQLKSLSDTIEKLKDEVLKETVTQRPGATV
                     PTDFATFPSSAFLRAKEEQQDDTVYMGKVTFSCAAGLGQRHRLVLTQEQLHQLHSRLI
                     S"
     exon            342..362
                     /gene="Dctn1"
                     /gene_synonym="DAP-150; DP-150; Glued; p150; p150-glued;
                     p150<glued>"
                     /inference="alignment:Splign:2.1.0"
     exon            363..554
                     /gene="Dctn1"
                     /gene_synonym="DAP-150; DP-150; Glued; p150; p150-glued;
                     p150<glued>"
                     /inference="alignment:Splign:2.1.0"
     exon            555..752
                     /gene="Dctn1"
                     /gene_synonym="DAP-150; DP-150; Glued; p150; p150-glued;
                     p150<glued>"
                     /inference="alignment:Splign:2.1.0"
     exon            753..957
                     /gene="Dctn1"
                     /gene_synonym="DAP-150; DP-150; Glued; p150; p150-glued;
                     p150<glued>"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1036
                     /gene="Dctn1"
                     /gene_synonym="DAP-150; DP-150; Glued; p150; p150-glued;
                     p150<glued>"
                     /inference="alignment:Splign:2.1.0"
     exon            1037..1196
                     /gene="Dctn1"
                     /gene_synonym="DAP-150; DP-150; Glued; p150; p150-glued;
                     p150<glued>"
                     /inference="alignment:Splign:2.1.0"
     exon            1197..1301
                     /gene="Dctn1"
                     /gene_synonym="DAP-150; DP-150; Glued; p150; p150-glued;
                     p150<glued>"
                     /inference="alignment:Splign:2.1.0"
     exon            1302..1493
                     /gene="Dctn1"
                     /gene_synonym="DAP-150; DP-150; Glued; p150; p150-glued;
                     p150<glued>"
                     /inference="alignment:Splign:2.1.0"
     exon            1494..1610
                     /gene="Dctn1"
                     /gene_synonym="DAP-150; DP-150; Glued; p150; p150-glued;
                     p150<glued>"
                     /inference="alignment:Splign:2.1.0"
     exon            1611..1763
                     /gene="Dctn1"
                     /gene_synonym="DAP-150; DP-150; Glued; p150; p150-glued;
                     p150<glued>"
                     /inference="alignment:Splign:2.1.0"
     exon            1764..1924
                     /gene="Dctn1"
                     /gene_synonym="DAP-150; DP-150; Glued; p150; p150-glued;
                     p150<glued>"
                     /inference="alignment:Splign:2.1.0"
     exon            1925..2093
                     /gene="Dctn1"
                     /gene_synonym="DAP-150; DP-150; Glued; p150; p150-glued;
                     p150<glued>"
                     /inference="alignment:Splign:2.1.0"
     exon            2094..2162
                     /gene="Dctn1"
                     /gene_synonym="DAP-150; DP-150; Glued; p150; p150-glued;
                     p150<glued>"
                     /inference="alignment:Splign:2.1.0"
     exon            2163..2225
                     /gene="Dctn1"
                     /gene_synonym="DAP-150; DP-150; Glued; p150; p150-glued;
                     p150<glued>"
                     /inference="alignment:Splign:2.1.0"
     exon            2226..2375
                     /gene="Dctn1"
                     /gene_synonym="DAP-150; DP-150; Glued; p150; p150-glued;
                     p150<glued>"
                     /inference="alignment:Splign:2.1.0"
     exon            2376..2537
                     /gene="Dctn1"
                     /gene_synonym="DAP-150; DP-150; Glued; p150; p150-glued;
                     p150<glued>"
                     /inference="alignment:Splign:2.1.0"
     exon            2538..2669
                     /gene="Dctn1"
                     /gene_synonym="DAP-150; DP-150; Glued; p150; p150-glued;
                     p150<glued>"
                     /inference="alignment:Splign:2.1.0"
     exon            2670..2795
                     /gene="Dctn1"
                     /gene_synonym="DAP-150; DP-150; Glued; p150; p150-glued;
                     p150<glued>"
                     /inference="alignment:Splign:2.1.0"
     exon            2796..2938
                     /gene="Dctn1"
                     /gene_synonym="DAP-150; DP-150; Glued; p150; p150-glued;
                     p150<glued>"
                     /inference="alignment:Splign:2.1.0"
     exon            2939..3105
                     /gene="Dctn1"
                     /gene_synonym="DAP-150; DP-150; Glued; p150; p150-glued;
                     p150<glued>"
                     /inference="alignment:Splign:2.1.0"
     exon            3106..3120
                     /gene="Dctn1"
                     /gene_synonym="DAP-150; DP-150; Glued; p150; p150-glued;
                     p150<glued>"
                     /inference="alignment:Splign:2.1.0"
     exon            3121..3254
                     /gene="Dctn1"
                     /gene_synonym="DAP-150; DP-150; Glued; p150; p150-glued;
                     p150<glued>"
                     /inference="alignment:Splign:2.1.0"
     exon            3255..3447
                     /gene="Dctn1"
                     /gene_synonym="DAP-150; DP-150; Glued; p150; p150-glued;
                     p150<glued>"
                     /inference="alignment:Splign:2.1.0"
     exon            3448..3527
                     /gene="Dctn1"
                     /gene_synonym="DAP-150; DP-150; Glued; p150; p150-glued;
                     p150<glued>"
                     /inference="alignment:Splign:2.1.0"
     exon            3528..3617
                     /gene="Dctn1"
                     /gene_synonym="DAP-150; DP-150; Glued; p150; p150-glued;
                     p150<glued>"
                     /inference="alignment:Splign:2.1.0"
     exon            3618..4065
                     /gene="Dctn1"
                     /gene_synonym="DAP-150; DP-150; Glued; p150; p150-glued;
                     p150<glued>"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4041..4046
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dctn1"
                     /gene_synonym="DAP-150; DP-150; Glued; p150; p150-glued;
                     p150<glued>"
                     /note="hexamer: ATTAAA"
     polyA_site      4065
                     /gene="Dctn1"
                     /gene_synonym="DAP-150; DP-150; Glued; p150; p150-glued;
                     p150<glued>"
                     /note="major polyA site"
ORIGIN      
        1 ggagctgctg ctgctgcggc cactgagaca gccatcagct taaagctgac gacccgggcc
       61 aggcaaggct ccggagcctg ctggagctcg caatcgcccg ctgacctgct gtgcacctgc
      121 cacggcctgt gtcgctgcag ccgcctttgc ctgtccggaa gctaaggctg cattgttggg
      181 atttgatgca ctaatctcct gtctccgccg cctttccctc cctcccttcg tctgtctttc
      241 ctccctgtgt ttgtctgccc tcctctgtac ctccctctct ttcctctcct tgctttctgt
      301 ggttttctgc aatgatgaga caggcaccga cagcccgaaa gaccacaact cgacggccca
      361 agcctactcg cccagccagc actggggtgg ctgggcccag tagctccctt ggcccctctg
      421 gctcagcgtc agccggggaa ctaagcagca gtgagcccag caccccagct cagactccgc
      481 tggcagcacc catcatcccc acaccggccc tcacctctcc tggagcagca cccccacttc
      541 catctccctc taaggaagag gaagggctga gggctcaggt acgggacctg gaggagaagc
      601 tggagaccct gcgcctaaaa cgctcagaag acaaagcaaa gctgaaagag ctggagaagc
      661 acaagatcca gctggagcag gtgcaggaat ggaagagcaa aatgcaggag cagcaggcag
      721 acctgcagcg gcgcctcaag gaggctcgga aggaagccaa ggaggcgcta gaggcaaagg
      781 aacgctacat ggaggagatg gccgacacag ccgacgctat cgagatggcc actctggaca
      841 aggagatggc tgaagagcgc gctgagtctc tgcagcaaga ggtggaggca ctgaaggaac
      901 gggtagacga gctcaccaca gacctggaga ttctcaaggc tgaaatcgaa gagaaaggct
      961 ctgatggggc cgcatcaagc taccagctca agcagctgga ggagcagaat gcccgcctga
     1021 aggatgccct ggtgaggatg cgagacctct cttcctcaga gaagcaggag cacgtgaagc
     1081 tgcagaaact catggaaaag aaaaaccagg agctggaggt cgtgcggcag cagcgcgagc
     1141 gtcttcagga ggagctgagc caggctgaga gcaccatcga tgagctcaaa gagcaggtgg
     1201 acgccgctct gggagccgag gagatggtgg agatgctgac cgaccggaac ctgaatctag
     1261 aggagaaagt gcgggagtta cgggagactg tgggggactt ggaagccatg aacgagatga
     1321 acgatgagct gcaggagaac gcacgggaga cggagctgga actccgagag cagctggaca
     1381 tggcgggcgc ccgagtgagg gaagcgcaga agcgagtgga agccgcccag gagacagtcg
     1441 ccgactacca gcagaccatc aagaagtacc gccagttgac tgcccaccta caggatgtca
     1501 atcgggagct gacaaaccag caggaagcgt ctgtagagag gcagcagcag ccgccgccag
     1561 agacttttga tttcaaaatc aagtttgctg agaccaaggc tcatgccaag gccattgaga
     1621 tggagttgag acagatggaa gttgcccagg ccaaccggca catgtccctg ctgacagcct
     1681 ttatgcctga cagcttcctt cggccaggtg gagaccacga ctgtgtcctg gtgctgctgc
     1741 tcatgccccg actcatttgc aaggcagagc tcatccggaa gcaggcccag gagaagtttg
     1801 acctgagcga gaactgttcg gagcggcccg ggctgcgggg agctgccggg gagcagctga
     1861 gctttgctgc tggactggtg tactcgctga gtctgctgca ggccacgctg caccgctatg
     1921 agcatgccct ctctcagtgc agtgtggacg tgtataagaa ggtcggcagc ctgtaccccg
     1981 agatgagcgc ccacgagcgc tccttagatt tcctcattga gctgctgcac aaggatcagc
     2041 tggatgagac tgtcaacgtg gagcccctca ccaaggccat caagtattac cagcatctgt
     2101 acagcatcca cctcgctgaa caacccgagg actccaccat gcagctggct gaccacatca
     2161 agttcaccca gagtgccctg gactgcatgg gcgtggaggt ggggcggctg cgtgccttct
     2221 tgcagggtgg gcaggaggca acagatattg cccttcttct ccgagacctg gaaacatcat
     2281 gtagtgacac ccgtcagttc tgcaagaaga tccgaaggcg gatgccgggg acggatgctc
     2341 ctgggatccc agcagcgctg gcctttggct cacaggtatc cgacacactc ctggactgca
     2401 ggaagcactt gacgtgggtg gtagctgttc tgcaggaggt ggcagctgca gccgcccagc
     2461 ttattgcccc cttggcagag aacgaggggc tgcctgtggc tgcactggag gagctggcct
     2521 tcaaagcaag cgagcagatc tacgggagcc cctccagcag cccctatgag tgtctacgcc
     2581 agtcatgcac catcctcatc agcacgatga acaagctggc cacagccatg caagaaggcg
     2641 agtatgacgc agagcgaccc ccgagcaagc ctcctccggt tgaacttcgg gctgcagccc
     2701 tgcgtgcaga gatcacagat gctgaaggtc tgggtttgaa gcttgaggat cgagagacag
     2761 ttatcaagga gttaaagaag tcactcaaga ttaagggaga ggagctgagt gaggccaacg
     2821 tgcggctcag cctcctggag aagaagttgg acagcgctgc caaggatgca gacgagcgaa
     2881 tcgagaaagt tcagacacgg ctggacgaga ctcagaccct gctgcggaag aaggagaaag
     2941 actttgagga gacaatggac gcactccagg ctgacatcga ccagctggag gcagagaagg
     3001 cagagctcaa gcagcgcctg aacagccagt ccaagcgcac aatcgagggg ctccggggcc
     3061 cccctccgtc aggcatcgct accctggtct ctggcatcgc tggtgaggaa ccacagcgag
     3121 ggggcgctcc tgggcaggct ccgggcgcct tgccaggccc ggggctggtg aaggactccc
     3181 cactgctgct tcagcagatc tctgctatga ggctacacat ctctcagctc cagcatgaga
     3241 acagcatcct cagaggagcc cagatgaagg cgtccttggc agctctgccc cctctgcatg
     3301 ttgcaaagct ttccctccca ccccatgagg gccccggtgg taacctagtg gctggggcac
     3361 tgtaccgcaa gaccagccag ctcctggaga aactaaacca gctgagtacc cacacccacg
     3421 tggtggatat cactcggagc agcccagctg ccaagagccc gtcagctcag cttatggaac
     3481 aagtggctca gctcaagtcc ctgagtgaca ccattgagaa gctcaaggat gaggtcctca
     3541 aggagacagt gactcagcgc cctggagcca ctgtgcccac cgactttgcc actttccctt
     3601 catctgcctt cctcagggcc aaggaagagc agcaagatga cacagtctac atgggcaaag
     3661 tgaccttttc atgcgcggca ggcctaggac agcgacaccg cctggtgctg acccaggagc
     3721 agctgcacca gcttcacagt cgcctcatct cctaagcact ccttccctgc cttccctgtg
     3781 gtcccactgc gcagggcaca gccacctcag ccactcccag gctggaccac acgctaacct
     3841 cctgagtggt tcagctgcgt ctggtctggt cagggtcctg ctgcttccgt aacctgggtt
     3901 tgcctgtcca cccctggcct cttccgtatt tgctgttatc tgctccctct ttcctgaggg
     3961 gcctcagggc attggagggg gccgacaccc ctccactaaa gattgagtga ggtctccctg
     4021 actgaggact tcaccccttg attaaagcaa cttgtgcttc actgc
//
