LOCUS       NM_010024               2279 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus dopachrome tautomerase (Dct), mRNA.
ACCESSION   NM_010024 XM_905952 XM_919584
VERSION     NM_010024.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2279)
  AUTHORS   Nasim,S., Abujamra,B.A., Chaparro,D., Nogueira,P.D.S., Riva,A.,
            Hutcheson,J.D. and Kos,L.
  TITLE     Multiple cell types including melanocytes contribute to
            elastogenesis in the developing murine aortic valve
  JOURNAL   Sci Rep 14 (1), 25481 (2024)
   PUBMED   39461968
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2279)
  AUTHORS   Ferrena,A., Zhang,X., Shrestha,R., Zheng,D. and Liu,W.
  TITLE     Six3 and Six6 jointly control diverse target genes in multiple cell
            populations over developmental trajectories of mouse embryonic
            retinal progenitor cells
  JOURNAL   PLoS One 19 (10), e0308839 (2024)
   PUBMED   39446806
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2279)
  AUTHORS   Ghotbi,E., Tchegnon,E., Chen,Z., Li,S., Shipman,T., Wang,Y.,
            Raman,J., Zhang,Y., McKay,R.M., Liao,C.P. and Le,L.Q.
  TITLE     Transcription factor KROX20 marks epithelial stem cell ancestors
            for hair follicle formation
  JOURNAL   J Clin Invest 134 (23), e180160 (2024)
   PUBMED   39361422
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2279)
  AUTHORS   Erjavec,E., Angee,C., Hadjadj,D., Passet,B., David,P., Kostic,C.,
            Dode,E., Zanlonghi,X., Cagnard,N., Nedelec,B., Crippa,S.V.,
            Bole-Feysot,C., Zarhrate,M., Creuzet,S., Castille,J., Vilotte,J.L.,
            Calvas,P., Plaisancie,J., Chassaing,N., Kaplan,J., Rozet,J.M. and
            Fares Taie,L.
  TITLE     Congenital microcoria deletion in mouse links Sox21 dysregulation
            to disease and suggests a role for TGFB2 in glaucoma and myopia
  JOURNAL   Am J Hum Genet 111 (10), 2265-2282 (2024)
   PUBMED   39293448
REFERENCE   5  (bases 1 to 2279)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   6  (bases 1 to 2279)
  AUTHORS   Hearing,V.J., Tsukamoto,K., Urabe,K., Kameyama,K., Montague,P.M.
            and Jackson,I.J.
  TITLE     Functional properties of cloned melanogenic proteins
  JOURNAL   Pigment Cell Res 5 (5 Pt 2), 264-270 (1992)
   PUBMED   1292007
REFERENCE   7  (bases 1 to 2279)
  AUTHORS   Steel,K.P., Davidson,D.R. and Jackson,I.J.
  TITLE     TRP-2/DT, a new early melanoblast marker, shows that steel growth
            factor (c-kit ligand) is a survival factor
  JOURNAL   Development 115 (4), 1111-1119 (1992)
   PUBMED   1280558
REFERENCE   8  (bases 1 to 2279)
  AUTHORS   Jackson,I.J., Chambers,D.M., Tsukamoto,K., Copeland,N.G.,
            Gilbert,D.J., Jenkins,N.A. and Hearing,V.
  TITLE     A second tyrosinase-related protein, TRP-2, maps to and is mutated
            at the mouse slaty locus
  JOURNAL   EMBO J 11 (2), 527-535 (1992)
   PUBMED   1537334
REFERENCE   9  (bases 1 to 2279)
  AUTHORS   Tsukamoto,K., Jackson,I.J., Urabe,K., Montague,P.M. and
            Hearing,V.J.
  TITLE     A second tyrosinase-related protein, TRP-2, is a melanogenic enzyme
            termed DOPAchrome tautomerase
  JOURNAL   EMBO J 11 (2), 519-526 (1992)
   PUBMED   1537333
REFERENCE   10 (bases 1 to 2279)
  AUTHORS   Shibahara,S., Tomita,Y., Yoshizawa,M., Shibata,K. and Tagami,H.
  TITLE     Identification of mutations in the pigment cell-specific gene
            located at the brown locus in mouse
  JOURNAL   Pigment Cell Res Suppl 2, 90-95 (1992)
   PUBMED   1409444
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY733265.1, BC082330.1 and BC067064.1.
            
            On Mar 27, 2008 this sequence version replaced NM_010024.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC067064.1, X63349.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138, SAMN02415132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-365               BY733265.1         2-366
            366-995             BC082330.1         1-630
            996-2279            BC067064.1         830-2113
FEATURES             Location/Qualifiers
     source          1..2279
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 61.6 cM"
     gene            1..2279
                     /gene="Dct"
                     /gene_synonym="DT; slaty; slt; TRP-2; TRP2; Tyrp-2; Tyrp2"
                     /note="dopachrome tautomerase"
                     /db_xref="GeneID:13190"
                     /db_xref="MGI:MGI:102563"
     exon            1..763
                     /gene="Dct"
                     /gene_synonym="DT; slaty; slt; TRP-2; TRP2; Tyrp-2; Tyrp2"
                     /inference="alignment:Splign:2.1.0"
     CDS             469..2022
                     /gene="Dct"
                     /gene_synonym="DT; slaty; slt; TRP-2; TRP2; Tyrp-2; Tyrp2"
                     /EC_number="5.3.3.12"
                     /note="L-dopachrome tautomerase; SLATY locus protein;
                     L-dopachrome Delta-isomerase; tyrosinase-related protein
                     2; DOPAchrome isomerase; DOPAchrome oxidoreductase;
                     DOPAchrome conversion factor"
                     /codon_start=1
                     /product="L-dopachrome tautomerase precursor"
                     /protein_id="NP_034154.2"
                     /db_xref="CCDS:CCDS27331.1"
                     /db_xref="GeneID:13190"
                     /db_xref="MGI:MGI:102563"
                     /translation="MGLVGWGLLLGCLGCGILLRARAQFPRVCMTLDGVLNKECCPPL
                     GPEATNICGFLEGRGQCAEVQTDTRPWSGPYILRNQDDREQWPRKFFNRTCKCTGNFA
                     GYNCGGCKFGWTGPDCNRKKPAILRRNIHSLTAQEREQFLGALDLAKKSIHPDYVITT
                     QHWLGLLGPNGTQPQIANCSVYDFFVWLHYYSVRDTLLGPGRPYKAIDFSHQGPAFVT
                     WHRYHLLWLERELQRLTGNESFALPYWNFATGKNECDVCTDELLGAARQDDPTLISRN
                     SRFSTWEIVCDSLDDYNRRVTLCNGTYEGLLRRNKVGRNNEKLPTLKNVQDCLSLQKF
                     DSPPFFQNSTFSFRNALEGFDKADGTLDSQVMNLHNLAHSFLNGTNALPHSAANDPVF
                     VVLHSFTDAIFDEWLKRNNPSTDAWPQELAPIGHNRMYNMVPFFPPVTNEELFLTAEQ
                     LGYNYAVDLSEEEAPVWSTTLSVVIGILGAFVLLLGLLAFLQYRRLRKGYAPLMETGL
                     SSKRYTEEA"
     exon            764..1063
                     /gene="Dct"
                     /gene_synonym="DT; slaty; slt; TRP-2; TRP2; Tyrp-2; Tyrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1164
                     /gene="Dct"
                     /gene_synonym="DT; slaty; slt; TRP-2; TRP2; Tyrp-2; Tyrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1165..1331
                     /gene="Dct"
                     /gene_synonym="DT; slaty; slt; TRP-2; TRP2; Tyrp-2; Tyrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1332..1511
                     /gene="Dct"
                     /gene_synonym="DT; slaty; slt; TRP-2; TRP2; Tyrp-2; Tyrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1512..1647
                     /gene="Dct"
                     /gene_synonym="DT; slaty; slt; TRP-2; TRP2; Tyrp-2; Tyrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1648..1849
                     /gene="Dct"
                     /gene_synonym="DT; slaty; slt; TRP-2; TRP2; Tyrp-2; Tyrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1850..2263
                     /gene="Dct"
                     /gene_synonym="DT; slaty; slt; TRP-2; TRP2; Tyrp-2; Tyrp2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2243..2248
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dct"
                     /gene_synonym="DT; slaty; slt; TRP-2; TRP2; Tyrp-2; Tyrp2"
                     /note="hexamer: ATTAAA"
     polyA_site      2263
                     /gene="Dct"
                     /gene_synonym="DT; slaty; slt; TRP-2; TRP2; Tyrp-2; Tyrp2"
                     /note="major polyA site"
ORIGIN      
        1 gaactgagtt caaggcaatt aaggtcaagg gctagggaga gaaggaggag gcttagaaac
       61 agcagcataa taagcagtat ggctggagca ctctgtaaat taactcaatt agacagagcc
      121 tgatttaaca aggaagactg gcgagaagcg ctcccctcat taaacctgat gttagaggag
      181 cttcggatga aattaaatca gtgttagttg tttgagtcac ataaaattgc atgtgcgtgt
      241 acacatgtgc acacgtgtag gctctgtgat ttaggtggga attttgagag gagaggaaag
      301 ggctagaact aaacccaaag aaaaggaaag aagagaagag gaaaggaaag aaaaaagaaa
      361 aggcaatttg agtgagtaaa ggttccagaa ctcaggagtg gaagacaagg agtaaagtca
      421 gacagaaacc aggtgggacg ccgggccagg cctcccaatt aagaaggcat gggccttgtg
      481 ggatgggggc ttctgctggg ttgtctgggc tgcggaattc tgctcagagc tcgggctcag
      541 tttccccgag tctgcatgac cttggatggc gtgctgaaca aggaatgctg cccgcctctg
      601 ggtcccgagg caaccaacat ctgtggattt ctagagggca gggggcagtg cgcagaggtg
      661 caaacagaca ccagaccctg gagtggccct tatatccttc gaaaccagga tgaccgtgag
      721 caatggccga gaaaattctt caaccggaca tgcaaatgca caggaaactt tgctggttat
      781 aattgtggag gctgcaagtt cggctggacc ggccccgact gtaatcggaa gaagccggcc
      841 atcctaagac ggaatatcca ttccctgact gcccaggaga gggagcagtt cttgggcgcc
      901 ttagacctgg ccaagaagag tatccatcca gactacgtga tcaccacgca acactggctg
      961 gggctgctcg gacccaacgg gacccagccc cagatcgcca actgcagcgt gtatgacttt
     1021 tttgtgtggc tccattatta ttctgttcga gacacattat taggtccagg acgcccctat
     1081 aaggccattg atttctctca ccaagggcct gcctttgtca cgtggcacag gtaccatctg
     1141 ttgtggctgg aaagagaact ccagagactc actggcaatg agtcctttgc gttgccctac
     1201 tggaactttg caaccgggaa gaacgagtgt gacgtgtgca cagacgagct gcttggagca
     1261 gcaagacaag atgacccaac gctgattagt cggaactcga gattctctac ctgggagatt
     1321 gtgtgcgaca gcttggatga ctacaaccgc cgggtcacac tgtgtaatgg aacctatgaa
     1381 ggtttgctga gaagaaacaa agtaggcaga aataatgaga aactgccaac cttaaaaaat
     1441 gtgcaagatt gcctgtctct ccagaagttt gacagccctc ccttcttcca gaactctacc
     1501 ttcagcttca ggaatgcact ggaagggttt gataaagcag acggaacact ggactctcaa
     1561 gtcatgaacc ttcataactt ggctcactcc ttcctgaatg ggaccaatgc cttgccacac
     1621 tcagcagcca acgaccctgt gtttgtggtc ctccactctt ttacagacgc catctttgat
     1681 gagtggctga agagaaacaa cccttccaca gatgcctggc ctcaggaact ggcacccatt
     1741 ggtcacaacc gaatgtataa catggtcccc ttcttcccac cggtgactaa tgaggagctc
     1801 ttcctaaccg cagagcaact tggctacaat tacgccgttg atctgtcaga ggaagaagct
     1861 ccagtttggt ccacaactct ctcagtggtc attggaatcc tgggagcttt cgtcttgctc
     1921 ttggggttgc tggcttttct tcaatacaga aggcttcgca aaggctatgc gcccttaatg
     1981 gagacaggtc tcagcagcaa gagatacacg gaggaagcct agcatgctcc tacctggcct
     2041 gacctgggta gtaactaatt acaccgtcgc tcatcttgag acaggtggaa ctcttcagcg
     2101 tgtgctcttt agtagtgatg atgatgatgc cttagcaatg acaattatct ctagttgctg
     2161 ctttgcttat tgtacacaga caaaatgctt gggtcattca ccacggtcaa agtaaggtgt
     2221 ggctagttat atgtgacctt tgattaaaag tccttatatt gaaaaaaaaa aaaaaaaaa
//
