LOCUS       NM_029422               1999 bp    mRNA    linear   ROD 07-MAY-2024
DEFINITION  Mus musculus dendrocyte expressed seven transmembrane protein
            (Dcstamp), transcript variant 1, mRNA.
ACCESSION   NM_029422 XM_128030
VERSION     NM_029422.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1999)
  AUTHORS   Tang,Y., Li,X., Cai,Y., Bie,M., Tian,Y., Shao,Q. and Kang,F.
  TITLE     Hypoxia-induced factor 1alpha promotes osteotomy-induced regional
            acceleratory phenomenon via DC-STAMP mediated membrane fusion
  JOURNAL   Oral Dis 29 (5), 2139-2153 (2023)
   PUBMED   35445493
  REMARK    GeneRIF: Hypoxia-induced factor 1alpha promotes osteotomy-induced
            regional acceleratory phenomenon via DC-STAMP mediated membrane
            fusion.
REFERENCE   2  (bases 1 to 1999)
  AUTHORS   Garcia-Hernandez,M.L., Rangel-Moreno,J., Garcia-Castaneda,M.,
            Kenney,H.M., Paine,A., Thullen,M., Anandarajah,A.P., Schwarz,E.M.,
            Dirksen,R.T. and Ritchlin,C.T.
  TITLE     Dendritic cell-specific transmembrane protein is required for
            synovitis and bone resorption in inflammatory arthritis
  JOURNAL   Front Immunol 13, 1026574 (2022)
   PUBMED   36420272
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1999)
  AUTHORS   Choi,Y., Yoo,J.H., Lee,J.H., Lee,Y., Bae,M.K., Kim,Y.D. and
            Kim,H.J.
  TITLE     Connective tissue growth factor (CTGF) regulates the fusion of
            osteoclast precursors by inhibiting Bcl6 in periodontitis
  JOURNAL   Int J Med Sci 17 (5), 647-656 (2020)
   PUBMED   32210715
  REMARK    GeneRIF: Connective tissue growth factor (CTGF) regulates the
            fusion of osteoclast precursors by inhibiting Bcl6 in
            periodontitis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1999)
  AUTHORS   Il'in,D.A. and Shkurupy,V.A.
  TITLE     In Vitro Analysis of the Expression of CD11, CD29, CD36, and
            DC-STAMP Molecules during the Formation of Multinuclear Macrophages
            in BCG-Infected Mice
  JOURNAL   Bull Exp Biol Med 167 (5), 653-655 (2019)
   PUBMED   31641985
  REMARK    GeneRIF: Multinuclear macrophages of BCG-infected mice express CD
            antigens and DC-STAMP in the process of fusion.
REFERENCE   5  (bases 1 to 1999)
  AUTHORS   Arioka,M., Takahashi-Yanaga,F., Tatsumoto,N. and Sasaguri,T.
  TITLE     Inorganic phosphate-induced impairment of osteoclast cell-cell
            fusion by the inhibition of AP-1-mediated DC-STAMP expression
  JOURNAL   Biochem Biophys Res Commun 493 (1), 9-13 (2017)
   PUBMED   28939042
  REMARK    GeneRIF: These results suggested that hyperphosphatemia in the
            patients with CKD suppresses bone resorption by inhibiting
            osteoclastogenesis, and this impairs the regulation of bone
            metabolism.
REFERENCE   6  (bases 1 to 1999)
  AUTHORS   Lee,S.H., Rho,J., Jeong,D., Sul,J.Y., Kim,T., Kim,N., Kang,J.S.,
            Miyamoto,T., Suda,T., Lee,S.K., Pignolo,R.J., Koczon-Jaremko,B.,
            Lorenzo,J. and Choi,Y.
  TITLE     v-ATPase V0 subunit d2-deficient mice exhibit impaired osteoclast
            fusion and increased bone formation
  JOURNAL   Nat Med 12 (12), 1403-1409 (2006)
   PUBMED   17128270
REFERENCE   7  (bases 1 to 1999)
  AUTHORS   Yagi,M., Miyamoto,T., Toyama,Y. and Suda,T.
  TITLE     Role of DC-STAMP in cellular fusion of osteoclasts and macrophage
            giant cells
  JOURNAL   J Bone Miner Metab 24 (5), 355-358 (2006)
   PUBMED   16937266
  REMARK    Review article
REFERENCE   8  (bases 1 to 1999)
  AUTHORS   Yagi,M., Miyamoto,T., Sawatani,Y., Iwamoto,K., Hosogane,N.,
            Fujita,N., Morita,K., Ninomiya,K., Suzuki,T., Miyamoto,K., Oike,Y.,
            Takeya,M., Toyama,Y. and Suda,T.
  TITLE     DC-STAMP is essential for cell-cell fusion in osteoclasts and
            foreign body giant cells
  JOURNAL   J Exp Med 202 (3), 345-351 (2005)
   PUBMED   16061724
REFERENCE   9  (bases 1 to 1999)
  AUTHORS   Eleveld-Trancikova,D., Triantis,V., Moulin,V., Looman,M.W.,
            Wijers,M., Fransen,J.A., Lemckert,A.A., Havenga,M.J., Figdor,C.G.,
            Janssen,R.A. and Adema,G.J.
  TITLE     The dendritic cell-derived protein DC-STAMP is highly conserved and
            localizes to the endoplasmic reticulum
  JOURNAL   J Leukoc Biol 77 (3), 337-343 (2005)
   PUBMED   15601667
REFERENCE   10 (bases 1 to 1999)
  AUTHORS   Kukita,T., Wada,N., Kukita,A., Kakimoto,T., Sandra,F., Toh,K.,
            Nagata,K., Iijima,T., Horiuchi,M., Matsusaki,H., Hieshima,K.,
            Yoshie,O. and Nomiyama,H.
  TITLE     RANKL-induced DC-STAMP is essential for osteoclastogenesis
  JOURNAL   J Exp Med 200 (7), 941-946 (2004)
   PUBMED   15452179
  REMARK    GeneRIF: DC-STAMP has an essential role in osteoclastogenesis.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC158776.5 and AY517483.1.
            
            On Jan 23, 2014 this sequence version replaced NM_029422.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB109560.1, AY517483.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849385
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AC158776.5         84773-84774
            3-1842              AY517483.1         2-1841
            1843-1999           AC158776.5         99625-99781
FEATURES             Location/Qualifiers
     source          1..1999
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 15.51 cM"
     gene            1..1999
                     /gene="Dcstamp"
                     /gene_synonym="4833414I07Rik; DC-STAMP; FIND; mDC-STAMP;
                     Tm7sf4"
                     /note="dendrocyte expressed seven transmembrane protein"
                     /db_xref="GeneID:75766"
                     /db_xref="MGI:MGI:1923016"
     exon            1..38
                     /gene="Dcstamp"
                     /gene_synonym="4833414I07Rik; DC-STAMP; FIND; mDC-STAMP;
                     Tm7sf4"
                     /inference="alignment:Splign:2.1.0"
     exon            39..1080
                     /gene="Dcstamp"
                     /gene_synonym="4833414I07Rik; DC-STAMP; FIND; mDC-STAMP;
                     Tm7sf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1081..1389
                     /gene="Dcstamp"
                     /gene_synonym="4833414I07Rik; DC-STAMP; FIND; mDC-STAMP;
                     Tm7sf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1390..1999
                     /gene="Dcstamp"
                     /gene_synonym="4833414I07Rik; DC-STAMP; FIND; mDC-STAMP;
                     Tm7sf4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1977..1982
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dcstamp"
                     /gene_synonym="4833414I07Rik; DC-STAMP; FIND; mDC-STAMP;
                     Tm7sf4"
                     /note="hexamer: AATAAA"
     polyA_site      1996
                     /gene="Dcstamp"
                     /gene_synonym="4833414I07Rik; DC-STAMP; FIND; mDC-STAMP;
                     Tm7sf4"
                     /note="major polyA site"
ORIGIN      
        1 gtgtgctttg tgcttgtgga ggaacctaag cggaacttag acacagggag aatgaggctc
       61 tggaccttgg gcaccagtat tttcctgagg ctttggggga cttatgtgtt tccacgaagc
      121 cctagctggc tggacttcat ccagcatttg ggagtctgtt gctttgtggc cttcctttcg
      181 gtgagcctct tctctgcagc cttttactgg atcctgccac ccgttgccct gctctcttct
      241 gtctggatga tcacctgtgt tttcctatgc tgttccaagc gcgcacgatg cttcattctt
      301 ctggccgttc tgtcgtgtgg cctccgtgaa ggtaggaacg ctttgattgc ggctggcact
      361 ggggtagtga tctttggaca tgtggaaaat attttttata acttcagagg tctcctagac
      421 agcatgactt gcaacctaag ggcaaagagc ttttcagtac atttcccact tttaaaacgg
      481 tatactgaag ccatccagtg gatttacggc cttgccactc cgctgaatct atttgatgac
      541 cttgtttctt ggaaccagac tctggtggtc tctcttttta gtcccagcca tgccctggag
      601 gctcatatga atgacactag aggagaagtc ctgggagtcc tgcaccatat ggtggtcacg
      661 acagagctgt tgacttccgt gggccagaag ttgcttgccc ttgccgggct tctgctcatc
      721 ctagtcagca ctggcctctt cctgaagcga ttcctgggcc cttgtggctg gaagtatgag
      781 aatgtctaca tcaccaaaca atttgttcgg tttgatgaaa aggagaggca ccaacagcgg
      841 ccctgtgtcc tcccgctgaa taagaaggaa aggaagaaat atgtcatcgt cccatctttg
      901 cagctgactc ctaaggagaa gaaaaccctt gggctgttct tccttcctgt cctgacctat
      961 ctctacatgt gggtgctgtt tgccgctgtg gactatctgc tgtatcggct catctcctcc
     1021 atgaacaaac agttccaaag cttgccaggg ctggaagttc acttgaaact acgtggagag
     1081 aagcaaggaa cccaaggagt cgtccatgat tctgccttta atatatctat gtttgaaccg
     1141 agctgcattc ctaaaccacg tctcagtgtg tctgagactt gggttcctct cagtattatt
     1201 ctgttaacac taataatact aggattgttg tcttctatgc tgatgcagct taaaattctc
     1261 gtgtcagtct ccttctaccc caaagtggag agggagagaa ttgaatacct gcatgcgaag
     1321 ctccttgaga aacgatcaaa gcagccattg agagaggctg acgggaaacc gagcctgtac
     1381 tttaaaaaga ttcatttctg gtttccagtc ctgaaaatga ttaggaagaa gcagacaatc
     1441 cctgcaaatg aagatgatct atgagcaaca cagtccctct ttctgggcca actgctgctt
     1501 ctgtctactc aacaagaggg ggctatctga gaaggtctac agatgtttga gtttgcaagg
     1561 ctgcctttct ctttggtgat ccttcaagat acatgtcgat cataatgcca aatagcccct
     1621 aggtaaatag tttcagagtc tgtcttccaa acaaaacaca gtatctaaac tgtgtcatag
     1681 ttaaagctat ggtgatggct ggcatggaaa tgtcctccaa aggcttagat atttgaaaac
     1741 ttggtcccca gttagtgcat cttgggggag gcttataagg tgtcatgttg ctggacaaag
     1801 tgtgactcca gaggagtgtt ttgcagtttt aaaagtcatg tgctactcct gttcactcta
     1861 ctcagcctgt ggctggagat gtgggctctc agctgtccct gcctccatgt ctgtctgtaa
     1921 tagagttccc aactgtgata ttgatggagt cttacctctc tgaaacctta agcccaaata
     1981 aatccttcct tctatatgt
//
