LOCUS       NM_029974               2342 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus DC-STAMP domain containing 1 (Dcst1), mRNA.
ACCESSION   NM_029974 XM_130969 XM_912521 XM_988954
VERSION     NM_029974.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2342)
  AUTHORS   Noda,T., Blaha,A., Fujihara,Y., Gert,K.R., Emori,C., Deneke,V.E.,
            Oura,S., Panser,K., Lu,Y., Berent,S., Kodani,M., Cabrera-Quio,L.E.,
            Pauli,A. and Ikawa,M.
  TITLE     Sperm membrane proteins DCST1 and DCST2 are required for sperm-egg
            interaction in mice and fish
  JOURNAL   Commun Biol 5 (1), 332 (2022)
   PUBMED   35393517
  REMARK    GeneRIF: Sperm membrane proteins DCST1 and DCST2 are required for
            sperm-egg interaction in mice and fish.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2342)
  AUTHORS   Inoue,N., Hagihara,Y. and Wada,I.
  TITLE     Evolutionarily conserved sperm factors, DCST1 and DCST2, are
            required for gamete fusion
  JOURNAL   Elife 10, e66313 (2021)
   PUBMED   33871360
  REMARK    Publication Status: Online-Only
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK030269.1.
            
            On May 7, 2015 this sequence version replaced NM_029974.1.
            
            Summary: This gene encodes a transmembrane protein. A similar gene
            in human has been associated with dendritic cells. [provided by
            RefSeq, May 2015].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK030269.1, BC125478.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2342              AK030269.1         2-2343
FEATURES             Location/Qualifiers
     source          1..2342
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 39.08 cM"
     gene            1..2342
                     /gene="Dcst1"
                     /gene_synonym="A330106H01Rik"
                     /note="DC-STAMP domain containing 1"
                     /db_xref="GeneID:77772"
                     /db_xref="MGI:MGI:1925022"
     exon            1..244
                     /gene="Dcst1"
                     /gene_synonym="A330106H01Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             100..2298
                     /gene="Dcst1"
                     /gene_synonym="A330106H01Rik"
                     /EC_number="2.3.2.27"
                     /note="DC-STAMP domain-containing protein 1; RING-type E3
                     ubiquitin transferase"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase DCST1"
                     /protein_id="NP_084250.1"
                     /db_xref="CCDS:CCDS38490.1"
                     /db_xref="GeneID:77772"
                     /db_xref="MGI:MGI:1925022"
                     /translation="MAFLSSTLHSLGIFEKISRIKEVLKNRLLDLTKRRDQAREQQRK
                     RPHTIIQGLLLWSLPVSWIRFLWRQPGEFPVTAFLLGAGTGGLLAIGLFQLLVNPMNI
                     YEEQKVVALYCLASLGAIGWGTSPHIRCASLLLVPKMLGKEGRLFVMGYALAAIYSGP
                     AANLRSNINEVIASLGCTVELQINNTRSAWRVSTAPLRAVFKGMVGSKDSLNKEIQNV
                     STSFEEMDEQVKSDAGYSSEDWDKNRESTEMFGTSRVRPYLSTQMVYELRTRLRCIHV
                     VNKAILSCYRWFDKKHKNCMRRIHLPLFNNMICVPMKFKFLCNIAKVIEIWCYKRIPV
                     EGNFGQTYDSVNQSIHGLSGEFSANINLKEEKQSSMVGLNTTNWEHMGTEVRDYVRQQ
                     ETYLQWAMGLLHVLLSCTFLLVFHSAFSYMDHYNWDIRFDNIYISTYFCQIDARRKKL
                     GKQSLLPLRKAERKTVIFPFKATIQAWEMRYVIRELLETLPIVLLLLVLCAIDWALYS
                     VFDTIRQHSFVQYSFRSSHKLEIKVEGDSILAKLLRKTIGALNTSSSTDVETNNMPCL
                     PQPISLNARDYFKASLPTLLLVCLCLAQAFGYRLRRVIAAFYFPKREKKRALFFYNEF
                     LKKRSAFTKLRRAAIVRRANQQKAPPHYLVEALYRRCPLLHRFMRQRCVVCQAMETPD
                     SYVCPTPDCKALYCRSCWDDMQRLCPVCTPREELSSSAHSDSNDDAVYGD"
     exon            245..370
                     /gene="Dcst1"
                     /gene_synonym="A330106H01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            371..445
                     /gene="Dcst1"
                     /gene_synonym="A330106H01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            446..574
                     /gene="Dcst1"
                     /gene_synonym="A330106H01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            575..714
                     /gene="Dcst1"
                     /gene_synonym="A330106H01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            715..922
                     /gene="Dcst1"
                     /gene_synonym="A330106H01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            923..1066
                     /gene="Dcst1"
                     /gene_synonym="A330106H01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1188
                     /gene="Dcst1"
                     /gene_synonym="A330106H01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1189..1349
                     /gene="Dcst1"
                     /gene_synonym="A330106H01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1350..1449
                     /gene="Dcst1"
                     /gene_synonym="A330106H01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1450..1545
                     /gene="Dcst1"
                     /gene_synonym="A330106H01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1546..1672
                     /gene="Dcst1"
                     /gene_synonym="A330106H01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1673..1789
                     /gene="Dcst1"
                     /gene_synonym="A330106H01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1790..1932
                     /gene="Dcst1"
                     /gene_synonym="A330106H01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1933..2046
                     /gene="Dcst1"
                     /gene_synonym="A330106H01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2047..2342
                     /gene="Dcst1"
                     /gene_synonym="A330106H01Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2324..2329
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dcst1"
                     /gene_synonym="A330106H01Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2342
                     /gene="Dcst1"
                     /gene_synonym="A330106H01Rik"
                     /note="major polyA site"
ORIGIN      
        1 agaacccact acccagttgt tctgagggct cccggagctg aggagttgaa ggacacaggc
       61 cagtcgtggg ctgtatgtga agcaaaagac aggggcggca tggcgttcct ctcatcaaca
      121 cttcacagcc tagggatctt tgaaaagatt tccaggataa aagaggttct caagaatagg
      181 ctgctggacc ttacaaagcg tcgggaccaa gcacgggagc aacaaaggaa acggccccac
      241 accatcatac aggggctgct cctctggagt cttccagttt cctggatccg gttcctgtgg
      301 cgacagccag gggagtttcc agtaactgct ttcctgctag gagcaggcac tggtgggctc
      361 ctggccatag gtctctttca gctcttggtg aatcccatga acatttatga ggagcagaag
      421 gtggtggcgt tatactgctt ggcaagcttg ggggccatcg gctggggcac ctcccctcac
      481 atccgctgtg ccagtctcct gttggtaccc aagatgctgg gcaaagaagg cagactcttt
      541 gtcatgggat atgctttggc tgctatctac agtgggccgg cggccaatct aaggtccaac
      601 atcaacgagg tgatagcatc cctgggctgc actgtggagc tgcagatcaa caacacccga
      661 tccgcctggc gagtctccac agcccctctg cgggcagtgt tcaagggcat ggtgggcagc
      721 aaagattcat tgaataaaga gattcagaac gtctctacct cctttgaaga gatggatgaa
      781 caggtgaaga gtgatgctgg ctactcatct gaggactggg acaagaacag agaaagcaca
      841 gagatgttcg gaacctcccg cgtccgaccc tacctgtcca cacagatggt gtatgagctg
      901 aggaccaggc tacgctgcat ccatgtagta aataaggcca tactcagctg ctaccgctgg
      961 tttgataaaa agcataaaaa ctgcatgcga cgcatccacc tcccactctt caacaacatg
     1021 atctgtgtgc caatgaagtt caagttcctc tgtaacattg ccaaggtgat agagatctgg
     1081 tgttacaaac gcatccccgt ggaaggcaac tttgggcaaa cctatgactc ggtcaaccag
     1141 tctatccatg gactgtctgg agaattttca gccaatatta accttaagga agagaagcag
     1201 tcttcaatgg tgggtctcaa caccacgaac tgggagcaca tgggcaccga ggtgcgggac
     1261 tatgttcgcc agcaggagac ctatctgcag tgggctatgg ggctgctgca cgtgcttctg
     1321 tcctgcacgt tcctgctggt cttccattca gccttctcct acatggacca ctacaactgg
     1381 gacatccgct ttgacaacat ctacatcagc acctacttct gtcagattga tgcacgcagg
     1441 aagaagctgg gcaaacagag tctgttgcca ctccgcaagg cagaaaggaa aacggttatc
     1501 ttccctttca aagctactat ccaggcctgg gaaatgcgct atgtgataag agagctccta
     1561 gagactctgc ctattgtgct gctgctcctg gtgctgtgcg cgatcgactg ggcactctac
     1621 tctgtctttg acaccatccg ccagcactct ttcgtgcagt attcctttcg aagcagtcac
     1681 aagctggaga taaaagtcga gggagattcc atactcgcca agcttcttcg taaaaccatc
     1741 ggcgctctga acacctcctc gagtacagat gtggaaacaa acaacatgcc ctgcctgccc
     1801 caacccatta gcctgaatgc cagggattac ttcaaggcct cactgccaac cctcctgctt
     1861 gtgtgtctct gcctagctca ggcctttggc taccgactcc ggagagtcat cgcagccttc
     1921 tatttcccca agcgagagaa gaagcgggct ctgttcttct acaatgagtt cctgaagaag
     1981 agatcagctt tcactaaact gaggagggcc gccattgttc ggagggcaaa tcagcagaag
     2041 gctccacccc actacctggt ggaggctctg tatcgccggt gccctctcct gcaccgcttc
     2101 atgcgtcagc gctgtgtggt gtgccaggca atggagacgc cggattccta cgtgtgcccc
     2161 acaccagact gcaaggccct gtactgccgg tcgtgctggg acgacatgca acggctctgc
     2221 ccggtgtgca cgccccgcga agagctctcg tcatccgccc acagcgacag caacgacgac
     2281 gctgtgtatg gcgattgaag ggatgctgcc cgccttcttg cttaataaag tgtgatgcac
     2341 gc
//
