LOCUS       NM_027030               1194 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus decapping enzyme, scavenger (Dcps), mRNA.
ACCESSION   NM_027030
VERSION     NM_027030.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1194)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1194)
  AUTHORS   Mei,Z.Z., Sun,H., Ou,X., Li,L., Cai,J., Hu,S., Wang,J., Luo,H.,
            Liu,J. and Jiang,Y.
  TITLE     The natural antisense transcript NATTD regulates the transcription
            of decapping scavenger (DcpS) enzyme
  JOURNAL   Int J Biochem Cell Biol 110, 103-110 (2019)
   PUBMED   30858142
  REMARK    GeneRIF: NATTD as a regulator of DcpS transcription through
            epigenetic mechanisms
REFERENCE   3  (bases 1 to 1194)
  AUTHORS   Sundberg,J.P., Dadras,S.S., Silva,K.A., Kennedy,V.E., Garland,G.,
            Murray,S.A., Sundberg,B.A., Schofield,P.N. and Pratt,C.H.
  TITLE     Systematic screening for skin, hair, and nail abnormalities in a
            large-scale knockout mouse program
  JOURNAL   PLoS One 12 (7), e0180682 (2017)
   PUBMED   28700664
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1194)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   5  (bases 1 to 1194)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (bases 1 to 1194)
  AUTHORS   Van Meerbeke,J.P., Gibbs,R.M., Plasterer,H.L., Miao,W., Feng,Z.,
            Lin,M.Y., Rucki,A.A., Wee,C.D., Xia,B., Sharma,S., Jacques,V.,
            Li,D.K., Pellizzoni,L., Rusche,J.R., Ko,C.P. and Sumner,C.J.
  TITLE     The DcpS inhibitor RG3039 improves motor function in SMA mice
  JOURNAL   Hum Mol Genet 22 (20), 4074-4083 (2013)
   PUBMED   23727836
REFERENCE   7  (bases 1 to 1194)
  AUTHORS   Han,G.W., Schwarzenbacher,R., McMullan,D., Abdubek,P., Ambing,E.,
            Axelrod,H., Biorac,T., Canaves,J.M., Chiu,H.J., Dai,X.,
            Deacon,A.M., DiDonato,M., Elsliger,M.A., Godzik,A., Grittini,C.,
            Grzechnik,S.K., Hale,J., Hampton,E., Haugen,J., Hornsby,M.,
            Jaroszewski,L., Klock,H.E., Koesema,E., Kreusch,A., Kuhn,P.,
            Lesley,S.A., McPhillips,T.M., Miller,M.D., Moy,K., Nigoghossian,E.,
            Paulsen,J., Quijano,K., Reyes,R., Spraggon,G., Stevens,R.C., van
            den Bedem,H., Velasquez,J., Vincent,J., White,A., Wolf,G., Xu,Q.,
            Hodgson,K.O., Wooley,J. and Wilson,I.A.
  TITLE     Crystal structure of an Apo mRNA decapping enzyme (DcpS) from Mouse
            at 1.83 A resolution
  JOURNAL   Proteins 60 (4), 797-802 (2005)
   PUBMED   16001405
  REMARK    GeneRIF: Amino acid sequence and xray crystallograpy structure
            given
REFERENCE   8  (bases 1 to 1194)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK005584.1.
            
            On Apr 6, 2007 this sequence version replaced NM_027030.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC016273.1, AK005584.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1194              AK005584.1         2-1195
FEATURES             Location/Qualifiers
     source          1..1194
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 19.71 cM"
     gene            1..1194
                     /gene="Dcps"
                     /gene_synonym="1700001E16Rik; DCS-1; HINT-5"
                     /note="decapping enzyme, scavenger"
                     /db_xref="GeneID:69305"
                     /db_xref="MGI:MGI:1916555"
     exon            1..217
                     /gene="Dcps"
                     /gene_synonym="1700001E16Rik; DCS-1; HINT-5"
                     /inference="alignment:Splign:2.1.0"
     CDS             20..1036
                     /gene="Dcps"
                     /gene_synonym="1700001E16Rik; DCS-1; HINT-5"
                     /EC_number="3.6.1.59"
                     /note="mRNA decapping enzyme; scavenger mRNA-decapping
                     enzyme DcpS; histidine triad protein member 5;
                     hint-related 7meGMP-directed hydrolase; decapping
                     scavenger enzyme; histidine triad nucleotide-binding
                     protein 5"
                     /codon_start=1
                     /product="m7GpppX diphosphatase"
                     /protein_id="NP_081306.1"
                     /db_xref="CCDS:CCDS22957.1"
                     /db_xref="GeneID:69305"
                     /db_xref="MGI:MGI:1916555"
                     /translation="MADTAPQLKRKREQEAEEAETPSTEEKEAGVGNGTSAPVRLPFS
                     GFRVQKVLRESARDKIIFLHGKVNEDSGDTHGEDAVVILEKTPFQVEHVAQLLTGSPE
                     LKLQFSNDIYSTYNLFPPRHLSDIKTTVVYPATEKHLQKYMRQDLRLIRETGDDYRTI
                     TLPYLESQSLSIQWVYNILDKKAEADRIVFENPDPSDGFVLIPDLKWNQQQLDDLYLI
                     AICHRRGIRSLRDLTPEHLPLLRNILREGQEAILKRYQVTGDRLRVYLHYLPSYYHLH
                     VHFTALGFEAPGSGVERAHLLAQVIENLECDPKHYQQRTLTFALRTDDPLLQLLQKAQ
                     QERN"
     exon            218..392
                     /gene="Dcps"
                     /gene_synonym="1700001E16Rik; DCS-1; HINT-5"
                     /inference="alignment:Splign:2.1.0"
     exon            393..538
                     /gene="Dcps"
                     /gene_synonym="1700001E16Rik; DCS-1; HINT-5"
                     /inference="alignment:Splign:2.1.0"
     exon            539..652
                     /gene="Dcps"
                     /gene_synonym="1700001E16Rik; DCS-1; HINT-5"
                     /inference="alignment:Splign:2.1.0"
     exon            653..763
                     /gene="Dcps"
                     /gene_synonym="1700001E16Rik; DCS-1; HINT-5"
                     /inference="alignment:Splign:2.1.0"
     exon            764..1194
                     /gene="Dcps"
                     /gene_synonym="1700001E16Rik; DCS-1; HINT-5"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1194
                     /gene="Dcps"
                     /gene_synonym="1700001E16Rik; DCS-1; HINT-5"
                     /note="putative"
ORIGIN      
        1 acggttcttc ccaggcagca tggcggatac agcgcctcaa ctcaagagaa agcgcgaaca
       61 ggaggcagag gaggcagaaa cccccagcac agaggagaag gaagcaggcg ttggcaatgg
      121 cacctctgcc cctgtccgct taccgttctc cggctttaga gtacaaaaag tgctcaggga
      181 gtctgcgcgg gacaaaatta ttttcctgca tgggaaggtg aatgaggact ctggggatac
      241 tcatggagaa gatgcggttg tgatcctgga gaagacacca tttcaggtag aacacgtggc
      301 gcagctccta acggggagcc ctgagctcaa gttgcagttc tccaatgata tctacagcac
      361 ctataacctg tttcctccaa ggcatctgag tgatataaaa acaactgtgg tgtaccctgc
      421 cacagagaaa cacctgcaaa aatacatgcg tcaggacctc cgcctgatcc gagagactgg
      481 agatgactac aggaccatca ccttacccta cctggaatcc cagagcctta gcatccagtg
      541 ggtgtataac attcttgaca agaaggctga agctgaccgg attgtttttg agaacccaga
      601 cccttctgat ggctttgtcc tcatcccaga cctcaagtgg aaccagcagc agcttgatga
      661 cctgtatttg atcgccatct gccatcgccg gggtatcaga tcacttcgag atctcactcc
      721 agagcatctg ccactactga ggaacattct ccgggaagga caagaagcca tcctgaagcg
      781 ctaccaggtg acaggagacc gtctgcgagt gtacctacac tacctgccct cttactatca
      841 cctgcacgtg catttcacag ctctgggctt cgaggctccg ggctcagggg tggagcgggc
      901 acacctgctg gctcaagtga tcgagaacct ggagtgtgac cccaagcact atcaacagcg
      961 cactcttact tttgccctca ggaccgatga ccccctgctt cagctcctgc agaaggccca
     1021 gcaagagagg aactagtggg tcgggcctgg ggtagtgtgg gctgggtttt tatctctaag
     1081 ggatttccct aaaatgcatt ttgtagtttc tcggcctttc agcaaaggtc aagtgtaaga
     1141 tgtttttttg tactggttta ttcctcacat gagaataaag aactttctga ttgg
//
