LOCUS       NM_027490               8643 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus decapping mRNA 2 (Dcp2), mRNA.
ACCESSION   NM_027490 XM_140308 XM_975674
VERSION     NM_027490.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8643)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 8643)
  AUTHORS   Perez,R.C., Yang,X., Familari,M., Martinez,G., Lovicu,F.J.,
            Hime,G.R. and de Iongh,R.U.
  TITLE     TOB1 and TOB2 mark distinct RNA processing granules in
            differentiating lens fiber cells
  JOURNAL   J Mol Histol 55 (1), 121-138 (2024)
   PUBMED   38165569
REFERENCE   3  (bases 1 to 8643)
  AUTHORS   Yang,J., Liu,X., Zhao,Y., Dong,W., Xue,Y., Ruan,X., Wang,P.,
            Liu,L., E,T., Song,J., Cui,Z. and Liu,Y.
  TITLE     Mechanism of Dcp2/RNCR3/Dkc1/Snora62 axis regulating neuronal
            apoptosis in chronic cerebral ischemia
  JOURNAL   Cell Biol Toxicol 39 (6), 2881-2898 (2023)
   PUBMED   37097350
  REMARK    GeneRIF: Mechanism of Dcp2/RNCR3/Dkc1/Snora62 axis regulating
            neuronal apoptosis in chronic cerebral ischemia.
REFERENCE   4  (bases 1 to 8643)
  AUTHORS   Kim,J., Muraoka,M., Okada,H., Toyoda,A., Ajima,R. and Saga,Y.
  TITLE     The RNA helicase DDX6 controls early mouse embryogenesis by
            repressing aberrant inhibition of BMP signaling through
            miRNA-mediated gene silencing
  JOURNAL   PLoS Genet 18 (10), e1009967 (2022)
   PUBMED   36197846
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8643)
  AUTHORS   Ibayashi,M., Aizawa,R. and Tsukamoto,S.
  TITLE     mRNA decapping factor Dcp1a is essential for embryonic growth in
            mice
  JOURNAL   Biochem Biophys Res Commun 555, 128-133 (2021)
   PUBMED   33813271
REFERENCE   6  (bases 1 to 8643)
  AUTHORS   Ma,J., Flemr,M., Strnad,H., Svoboda,P. and Schultz,R.M.
  TITLE     Maternally recruited DCP1A and DCP2 contribute to messenger RNA
            degradation during oocyte maturation and genome activation in mouse
  JOURNAL   Biol Reprod 88 (1), 11 (2013)
   PUBMED   23136299
  REMARK    GeneRIF: The results showed that DCP1A and DCP2 are critical in the
            transition from mRNA stability to instability during meiotic
            maturation and that mRNA degradation must be successful to execute
            the oocyte-to-zygote transition.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 8643)
  AUTHORS   Li,Y., Dai,J., Song,M., Fitzgerald-Bocarsly,P. and Kiledjian,M.
  TITLE     Dcp2 decapping protein modulates mRNA stability of the critical
            interferon regulatory factor (IRF) IRF-7
  JOURNAL   Mol Cell Biol 32 (6), 1164-1172 (2012)
   PUBMED   22252322
  REMARK    GeneRIF: In this study the increase in Irf-7 mRNA within the
            background of reduced Dcp2 levels was attributed to a stabilization
            of the Irf-7 mRNA, suggesting that Dcp2 normally modulates Irf-7
            mRNA stability.
REFERENCE   8  (bases 1 to 8643)
  AUTHORS   Song,M.G., Li,Y. and Kiledjian,M.
  TITLE     Multiple mRNA decapping enzymes in mammalian cells
  JOURNAL   Mol Cell 40 (3), 423-432 (2010)
   PUBMED   21070968
  REMARK    GeneRIF: Like Dcp2, Nudt16 also regulates the stability of a subset
            of mRNAs including a member of the motin family of proteins
            involved in angiogenesis.
REFERENCE   9  (bases 1 to 8643)
  AUTHORS   Suzuki,A., Igarashi,K., Aisaki,K., Kanno,J. and Saga,Y.
  TITLE     NANOS2 interacts with the CCR4-NOT deadenylation complex and leads
            to suppression of specific RNAs
  JOURNAL   Proc Natl Acad Sci U S A 107 (8), 3594-3599 (2010)
   PUBMED   20133598
REFERENCE   10 (bases 1 to 8643)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK153105.1, AK153310.1 and AC147551.5.
            
            On or before Jun 8, 2008 this sequence version replaced
            XM_975674.1, XM_140308.6.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK152160.1, AK153264.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-626               AK153105.1         3-628
            627-2168            AK153310.1         600-2141
            2169-8643           AC147551.5         176038-182512       c
FEATURES             Location/Qualifiers
     source          1..8643
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 23.74 cM"
     gene            1..8643
                     /gene="Dcp2"
                     /gene_synonym="2410015D23Rik; 5730537H01Rik"
                     /note="decapping mRNA 2"
                     /db_xref="GeneID:70640"
                     /db_xref="MGI:MGI:1917890"
     exon            1..187
                     /gene="Dcp2"
                     /gene_synonym="2410015D23Rik; 5730537H01Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             135..1403
                     /gene="Dcp2"
                     /gene_synonym="2410015D23Rik; 5730537H01Rik"
                     /EC_number="3.6.1.62"
                     /note="mRNA-decapping enzyme 2; DCP2 decapping enzyme
                     homolog"
                     /codon_start=1
                     /product="m7GpppN-mRNA hydrolase"
                     /protein_id="NP_081766.1"
                     /db_xref="CCDS:CCDS50275.1"
                     /db_xref="GeneID:70640"
                     /db_xref="MGI:MGI:1917890"
                     /translation="MEPKRLEIPGSVLDDLCSRFILHIPSEERDNAIRVCFQIELAHW
                     FYLDFYMQNTPGLPQCGIRDFAKAVFSHCPFLLPQGEDVEKILDEWKEYKMGVPTYGA
                     IILDETLENVLLVQGYLAKSGWGFPKGKVNKEEAPHDCAAREVFEETGFDIKDYICKD
                     DYIELRINDQLARLYIIPGVPKDTKFNPKTRREIRNIEWFSIEKLPCHRNDMTPKSKL
                     GLAPNKFFMAIPFIRPLRDWLSRRFGDSSDSDNGFSSAGSTPARPTVEKLSRTKFRHS
                     QQLFPEGSPSDQWVKHRQPLQQKSHSNHGEVSDLLKAKNQNMRGNGRKQYQDSPNQKK
                     RANGVHGQPAKQQNPLVKCEKKLHPRKLQDNFETDATCDLPCSGEEPSVEHAEGHSVA
                     CNGHCKFPFSSRAFLSFKFDQNAIMKILDL"
     exon            188..339
                     /gene="Dcp2"
                     /gene_synonym="2410015D23Rik; 5730537H01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            340..467
                     /gene="Dcp2"
                     /gene_synonym="2410015D23Rik; 5730537H01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            468..566
                     /gene="Dcp2"
                     /gene_synonym="2410015D23Rik; 5730537H01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            567..719
                     /gene="Dcp2"
                     /gene_synonym="2410015D23Rik; 5730537H01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            720..832
                     /gene="Dcp2"
                     /gene_synonym="2410015D23Rik; 5730537H01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            833..940
                     /gene="Dcp2"
                     /gene_synonym="2410015D23Rik; 5730537H01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            941..1076
                     /gene="Dcp2"
                     /gene_synonym="2410015D23Rik; 5730537H01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1187
                     /gene="Dcp2"
                     /gene_synonym="2410015D23Rik; 5730537H01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..1239
                     /gene="Dcp2"
                     /gene_synonym="2410015D23Rik; 5730537H01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1240..8643
                     /gene="Dcp2"
                     /gene_synonym="2410015D23Rik; 5730537H01Rik"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1627
                     /gene="Dcp2"
                     /gene_synonym="2410015D23Rik; 5730537H01Rik"
                     /note="major polyA site"
     regulatory      8619..8624
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dcp2"
                     /gene_synonym="2410015D23Rik; 5730537H01Rik"
                     /note="hexamer: AATAAA"
     polyA_site      8643
                     /gene="Dcp2"
                     /gene_synonym="2410015D23Rik; 5730537H01Rik"
                     /note="major polyA site"
ORIGIN      
        1 ccgcccctcg cctcggcccg gcctcggggt ccgggcggag ggtttcactg tccgcggggc
       61 ccgcgcctct gtgcttctcc acggtgccgg ctgcgcggag ccgggatgcg ctgcgcctgc
      121 tgcgggtcct cattatggag cccaaacgcc tggagattcc cggcagcgtc ctggatgatc
      181 tctgcagccg atttattttg catattccca gtgaagaaag agacaatgcg atccgagtgt
      241 gcttccagat tgaacttgcc cattggtttt acttggattt ctacatgcag aacacaccag
      301 gattacctca gtgcgggata agagactttg ccaaagctgt tttcagtcac tgtccatttc
      361 tgctgccaca aggtgaagat gtggaaaaga ttttggatga atggaaggaa tataaaatgg
      421 gagtcccgac ttacggtgca attattctcg atgagacact ggagaatgta ctgctggttc
      481 aggggtacct ggcaaagtca ggctggggat tcccaaaagg aaaagtaaat aaagaagagg
      541 cgcctcatga ctgtgcggcg agagaggtct tcgaggaaac tggttttgat ataaaagact
      601 atatttgtaa ggatgattac attgaactgc gaatcaatga ccagcttgct cgcttgtaca
      661 tcattccagg agtcccaaaa gacacaaaat ttaaccccaa aaccagaaga gaaattagga
      721 atattgagtg gttctccatt gagaaattgc cctgtcatag aaatgacatg actcccaagt
      781 ccaagcttgg cttggcacct aataagtttt ttatggccat tccctttatc agaccactaa
      841 gggactggct gtctcgaaga tttggagatt cctcggacag tgacaatggg ttttcctcag
      901 ctggtagcac accagctaga cccaccgtgg agaaattgag tcgaacaaaa ttccgccaca
      961 gccagcagct gtttcctgaa ggttccccga gtgaccagtg ggttaagcac cggcagccac
     1021 tgcagcagaa gtcacacagt aaccacgggg aggtgtcgga ccttctcaaa gcaaagaatc
     1081 aaaatatgag agggaatggc agaaaacagt atcaagactc acctaatcaa aagaagagag
     1141 cgaacggagt ccatggtcag ccggcaaagc agcagaatcc cttggtgaaa tgtgaaaaga
     1201 agctgcatcc acggaaactt caggacaact tcgagacaga tgccacatgt gacctgcctt
     1261 gttctggtga agagccgtcg gtagaacatg ctgagggaca ttctgtggca tgcaacggac
     1321 attgcaagtt cccattttca tccagagcct ttctgagttt caagtttgac caaaatgcta
     1381 taatgaaaat cttggacctt tgagccagca agagtattgc agaagtccct cgatctgaga
     1441 cctgttgcgt gtgagtggct gtctcctcaa gccttacctt tctcaggtat ctgaaagaag
     1501 tgcagggagg ccatgtttct aaagagatgt tctgtacaga cgagaaacta gaaagaaaca
     1561 caagtttgca ctgtaaatgc atttagaact ttttatatgg atttaccatt tcagtgtttg
     1621 gaaccaagtt ttagttgcct gtgttttttt ttgtctctcc cttatttttg tgtgactgtg
     1681 ttttgtttta tattctcatc aagagttgtt ttgattgcat catcagcaag tagccatgtc
     1741 aataggagtg tttcacctcc ccatcttagt gattgcaaaa agcttgctta ttgaaaactt
     1801 aaaggaactt aaaaccccag ttaccaatgt actgggcatc agagctgaac cgtgaggtga
     1861 ggatgcaggc gtttactcat ctctgcctct aaccactgag agtctaacct tccaactgga
     1921 gctgcacagt gaacctcgag cacttcatca ggaccacatc cacagcctgg agagagatgg
     1981 agtcagtggg gagctgatgc tgtggatatt gagctctgat gtttgctgtc aaaaacctgt
     2041 gagtgctgga gcagagagca tggaagcaat agctgacagt tactccaggt catgccttga
     2101 ctctcctgcc tccgtccgtt cagtattgtg tcgtgattat gcctgtgtga aacgtctatg
     2161 cgtattctag ttgtgagtct gtgtggaaaa cttcattctt agttctatat tgcatctcaa
     2221 cgttgatctg tgtaagctgg tattatgtta ggttccagtt tgcagtaata ctagactgac
     2281 atgcttttca ttaatatctt gaagcccctg agttacaacg tgagaaagaa ggggatctgc
     2341 agtttaccag taagtccagc atgtcactag gggaccgacc cttgaagtaa tgtacttaga
     2401 tcacacgtag gaatgtattt tgtattttgc tccttcagaa ttcttaaacc aaacacgggt
     2461 gacagtgccc actttgcaga gatcgcctgt tgttgaggac aatcaccaga gctttaagga
     2521 ggcaatatga tgttggctgc ccctgacctc gctgagaatc tcttctgggg tggactgtgc
     2581 tgttagagtg catgtgtaca cgtgcgtctg tcgtgtgcgg ttttaacaag tggtatccac
     2641 aaagtatatc tctgcttata aatagtacta tagaaatctc tatgctgtat atgtagccta
     2701 tttaactggg ggttctgcct aaccccatgg gacttaaaag gaagggctat tattgtaagg
     2761 aattcacttg gtattactac tttgctttag cttttaaatg actgatttta aagaagaaat
     2821 tatatttatt catgaaagtg tcactcggtg ctaagcagga gacttcacag tgatacagta
     2881 tgtttggaat cttctatgcg actactttgt gaatccttct gtgacctttg ctttttaatg
     2941 cattatatga ttgtgtttgg aagcccttac tgttcttgtc agaaatacag ctgctttgct
     3001 tgggtcttct tgagccatat ttataattgg tcccagcatt ccagatttct gttaaatggt
     3061 taagggagtg aaaactgaag cttgcctggc agtgagccac tgtcactccc tgactgtcac
     3121 caagaaacca ttgtgtgtgt gtgtgtgtga gagagagaga gagagagaga gagagagaga
     3181 gagagagaga tattcttctt aagtgagcac ttcagtcagt ccctggtgcc tgtagaggtt
     3241 ggattctcag ctctccatac tagagcaaaa tcaactagct agcacaaggt ccatggccct
     3301 taaagtggtt gactgtaaga accaaccagt gatgtgctgc ttcatttaat gcactgtgga
     3361 acaaagcaag ggcatggttg gggtgcattt acaataactt taggctttag gtctctcaac
     3421 aggctgaaat gttgagagag taaggtttgt atgtgtgatg tgactcaact atgcagaaaa
     3481 tgttaagttg gtgttcttgt taatgtaagt ccagcgtaca cacttcttca ctgtacagtt
     3541 tagctgggag accatattta gcacaggacg ggatttcttc tctgagctat gttagcgttt
     3601 cttcatagga tctagtgatg aggactctga atatgcagta atgtgcttct gtgtagtgcc
     3661 gcatttagag acagactcta gagggaacag tagatacgtc ggccttatta ttatttgtgt
     3721 ttgagaggtg agactttaaa atcgctttta aacatcctta ggatccaact gcatgtgttc
     3781 cgaggtgcag tgcactgtga atctttttaa gtctaagttt gtaggtgctt ttatgtgtaa
     3841 cttaagtggt tggaagaatg tttaataact ttgtcctcaa ccattgtact caaagagaca
     3901 aaggatacag tttacatact ttctgtaaga ttttgttaag aaatagtgaa tgaatgactc
     3961 taggatttca aacagagatt ccatcctgag acatgagcac ttggaggggc tggaaaaccc
     4021 aatagatcgg atagcttgga aaacttggtg agccatgttg aaagagctaa ctagatttct
     4081 gtaccaatat gtgaaagata gttgcccaga actgtcagag ggattgtggt cactgcttgc
     4141 tgctttgacc tttgaatatc attattttta tattaaatac taattagtaa ttagctatat
     4201 agcagattaa tattatgctg taagacttgg ctaggctttt tttgggaggc tttaataatt
     4261 tacatgtaat gtcaataaaa atacaaatct aagagaatgg ccacaggaat cagattcctt
     4321 tataaaatac tgtgttttct aaaaatgtca aggactggca cctgtgtgca ttaaaaaaca
     4381 tttcattacc aaattcctta ccagtcctgt ttctctagca ttagttcaac agtaaggaga
     4441 gagtgggacc tcgaaatgat aactggctgg acaggtttta ttcccataat gcctcttggc
     4501 ctttgctgtg tctatgcgtg ccatgttgga gattttaatg acagctgttg tgtccatgtt
     4561 ctctgaggca gtattttctt tgtattatta ttcatggttg tattcattaa tacttcttct
     4621 gtttttgagt tgggttattg tgtattatta ttattgagaa aagaggttca aacgtgttat
     4681 aactagaatt gaccatcagc aaaggacacc actcccaggt ctaatggtat tcttcacctt
     4741 tgtgtatgta gtgttactcc ttagagctca gtacagctgg tgtcctaaca cttcagaata
     4801 catttgtata gtttcttaaa agcctagaaa tgggcttata gaaggcctct ccacaccttc
     4861 ctatcaatat atgtaggatt gtcactcctg aagcctaggt cagaaggcag gttgagatca
     4921 gcagaatgag atttgtcata agggttttgc tgttttaagt gtgttgtggg aaaggatctt
     4981 gaaaagaaca gatagcagtt gctgggagga gtgaggaaga aactactacg catttggcac
     5041 ttgagtgctt cctggaagga tgctcagggg agaaatgtgg tcaccccctg cccaagcaga
     5101 attgagcatg cagttctttc caggcatttt ctattccttg gtgaagtatt gttttctaag
     5161 tatgatcgcc aagcagtcca tggttgctaa tggaattttt ttcgctctaa ggaccagtgt
     5221 tcgagtcctt tctgtgttga ttctgtcaag ctctaggctg agtttgggtt ttgtttgttt
     5281 gtttggtttg tcattacttt aatttgtttt taatgtgtat gtatgttttg cctgtatatt
     5341 tgtttgtata ccacatgtgt gcctgtggtg cccagggagg tcagaaaaag tgtgtcggat
     5401 aacccgcccc cctccacccc ccggaactgg ggttcagagc aattggaaat ggaacccagg
     5461 ccctctgcca gagctctcac cctctctgtt gttgataaca aggtagccca gagtgttgca
     5521 cagtcatgtg caaatgctgg cagcactttc cttgtgacaa acagcatttg tcactgaagt
     5581 actctacagc cattgaataa tggagactca gcccaccctc ctgggtagaa ctggatgaaa
     5641 gggcatttct gtcaacgtag ttcatcagga aggttgtttg tttaggtttt ccctgtatac
     5701 atctttgtac ttcgtgttaa agctcagagg cttcattttg agacatgttc agagtggaat
     5761 atctaatttg aagccatcca taaagagatt acattaatct ggagtcttag tgtagcacag
     5821 gggttgggtc tgtgtctctg tcacagttta aaaggaattc acctcaagat gtgactagtt
     5881 gggcaggatt gactaagggc cctctgggaa aaggaacccc aggagtatca gtttcagggt
     5941 gtgacttggt cctcctagtg gacatcagct ctttggtgga aggtaagtgt gtcagctagg
     6001 gggcgggggt ggttttgttg atattgttac tagtttgtta agtgtccttt tctgagcatc
     6061 tgtttcagta tttctcaggc tttttgtttg tgctacgtct ctaatacatc tgacaccatg
     6121 agaatttgct gtaagtttaa ctcctgagcc tcaagtagat aaaagggctg tgttctctca
     6181 agtcagtgtc tatagctgtg aaattggtgt gggagcacag aaaacacttt gaggttctcg
     6241 ttggtagctt tagagtggaa cgggcagcat ttcctaacac tcagttctta ggatagtgag
     6301 cttttaaagt agaaggtagg gtgctttcta attttaatta tttgatccaa atgtgtaaaa
     6361 cggtagctct agactggtga agcatttggg acacagttgg acattttaaa agccatttct
     6421 caagctttaa ggcatttagc acagcctttg cagtgctcag cagaggcgcg aatgcaagca
     6481 gaggcgcggc catgaggtcg gtgtccgacg ctggccgtgg ctggagagat gcagtaatac
     6541 ttgtggagtg tgagcggcag tggataggac acgtgacgtg cacggtgcct tgggagagca
     6601 tgggctggtc ctgcaggact ctgcatttca ctgtgactgt gcagcacatt ttaggctgtg
     6661 tttgaatgtc tcacaagtta ctgttaagtg tcaaatgcaa gaatccaaga aggagctgag
     6721 cctttcattt tacatgttgt ttgaaattag gacaagagac aattcacttc tgttgtgtaa
     6781 atagtaattt ttttttcagt tcagcaaata gggcaaaaca gtgaaaccat taacttctag
     6841 tttttgaaaa ctattttttt atatttactg ataagtttta aatcttatgg tagttgtaaa
     6901 aatgagtatt gacttactag acttatgtat aattcaaata atctgttggc ttcaatgaaa
     6961 ccgtaatgaa tcttcatgaa tgttcatgta tttagctatt ttaagtgata ttctcttaat
     7021 ttggatagtc ttaggtcagg ccagtagaga tgatgcccac ctgtaatccc agcacttggg
     7081 aggcagaggc aggagagtct ctgagtttga ggccagcctg gtctacagag tgagttccag
     7141 gacagccagg gctacataga gaaaccctgt ctggaggcag gggttggggg tggggttggg
     7201 ggggtgttgt gggtggaaaa tgggcggggg taagtttaac aaaattgaag catagtttgg
     7261 gtgcaaaagt gaataaaatt tggatatttt tatgcactgt gtctttggtt tgtagtagtt
     7321 tacactctgc tgtaaagacc tgatgttcct aaacagtgta gttttcaaac agtttaattc
     7381 taggtatgtc tgggaaagtt gtaaacatgc agagtcatag aagctacaaa aagctggtac
     7441 atgaattttg gtgaaattgc ttcattaatg atacaatatt cagtgaaaaa cctaggcttc
     7501 agaataagta gatttgtaaa ctgtttcttc attaattggt tttgtcttat ataaaatgat
     7561 ttaacataga atctctgcca gacttataac gacgctttat attttattgg gagaaagatg
     7621 taagcaaatc ctttacatga ttatgtctat gataatagga aagtatttgc tttactgtag
     7681 ttattagtca aacatttagg gaaaccaaag aggaaccccc aaaatagctc gttgggttta
     7741 ctgtagtgtg acaacatcct ttagtgctac atttatttag tgagcccctc ccccaagttt
     7801 ggtgtttatg aataattgga actgcttttc acctacatcg atgtaactca taaatttcta
     7861 gtgactcggg tctgtgaatt agtgatgctg gagcacccac cgcccttcca aagatgtggg
     7921 gtgacccgac acctgtgctg taacatctaa cagcttttca gtgtgatgca cactagttta
     7981 ggagctaaaa ccatactgta aagaatgcac tgacagtgat ggaaggccac ccacgctggc
     8041 tttctgtcga atactgtgag ctttgctcta actctgtctg taaggaatta cccataaact
     8101 gggctgcttg ggcacagtta ctgctctgcc tttggttctg ttctgtttaa agtcattgct
     8161 gttactggtt attactctgg accagaaagg ctaggaatgt ataggataaa catgagaagt
     8221 tgttcgcatt catagaaata taaaaggtag aatttattca gagatgaaag tggcctgtgg
     8281 gaatgtcacc tttatctcag gtcggcttgg ctcttaagct gcagtacagt ggtgggcagg
     8341 agataaaaat ccgacctgta acgtgcagtg gttcttaggc ttgagccaga accaggcaga
     8401 atgtccagca gagtgtccta ttgcccctcc ctctcaggca ggagagtcct cagctacgta
     8461 actatgttgt catctttcca tggagcagaa agtctgtgtt tcgacactcc tgatgtgcta
     8521 tgaaactgct tgctatctcc taggtttaga cttcttgaaa ctttttttcc tgttttcagt
     8581 agagaaactt ctgtttatgc tgtatgtgaa gacaaccaaa taaaaattga tgataaatga
     8641 gaa
//
