LOCUS       NM_146114               3759 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Mus musculus DNA cross-link repair 1C (Dclre1c), transcript variant
            1, mRNA.
ACCESSION   NM_146114
VERSION     NM_146114.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3759)
  AUTHORS   Collins,P.L., Purman,C., Porter,S.I., Nganga,V., Saini,A.,
            Hayer,K.E., Gurewitz,G.L., Sleckman,B.P., Bednarski,J.J.,
            Bassing,C.H. and Oltz,E.M.
  TITLE     DNA double-strand breaks induce H2Ax phosphorylation domains in a
            contact-dependent manner
  JOURNAL   Nat Commun 11 (1), 3158 (2020)
   PUBMED   32572033
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3759)
  AUTHORS   Liu,X., Wang,X.S., Lee,B.J., Wu-Baer,F.K., Lin,X., Shao,Z.,
            Estes,V.M., Gautier,J., Baer,R. and Zha,S.
  TITLE     CtIP is essential for early B cell proliferation and development in
            mice
  JOURNAL   J Exp Med 216 (7), 1648-1663 (2019)
   PUBMED   31097467
REFERENCE   3  (bases 1 to 3759)
  AUTHORS   Spehalski,E., Capper,K.M., Smith,C.J., Morgan,M.J., Dinkelmann,M.,
            Buis,J., Sekiguchi,J.M. and Ferguson,D.O.
  TITLE     MRE11 Promotes Tumorigenesis by Facilitating Resistance to
            Oncogene-Induced Replication Stress
  JOURNAL   Cancer Res 77 (19), 5327-5338 (2017)
   PUBMED   28819025
REFERENCE   4  (bases 1 to 3759)
  AUTHORS   Jiang,W., Crowe,J.L., Liu,X., Nakajima,S., Wang,Y., Li,C.,
            Lee,B.J., Dubois,R.L., Liu,C., Yu,X., Lan,L. and Zha,S.
  TITLE     Differential phosphorylation of DNA-PKcs regulates the interplay
            between end-processing and end-ligation during nonhomologous
            end-joining
  JOURNAL   Mol Cell 58 (1), 172-185 (2015)
   PUBMED   25818648
  REMARK    GeneRIF: ATM phosphorylates DNA-PKcs to recruit Artemis and promote
            end-processing.
REFERENCE   5  (bases 1 to 3759)
  AUTHORS   Desai,A. and Gerson,S.
  TITLE     Exo1 independent DNA mismatch repair involves multiple compensatory
            nucleases
  JOURNAL   DNA Repair (Amst) 21, 55-64 (2014)
   PUBMED   25037770
REFERENCE   6  (bases 1 to 3759)
  AUTHORS   Yan,Y., Akhter,S., Zhang,X. and Legerski,R.
  TITLE     The multifunctional SNM1 gene family: not just nucleases
  JOURNAL   Future Oncol 6 (6), 1015-1029 (2010)
   PUBMED   20528238
  REMARK    Review article
REFERENCE   7  (bases 1 to 3759)
  AUTHORS   Mills,K.D., Ferguson,D.O. and Alt,F.W.
  TITLE     The role of DNA breaks in genomic instability and tumorigenesis
  JOURNAL   Immunol Rev 194, 77-95 (2003)
   PUBMED   12846809
  REMARK    Review article
REFERENCE   8  (bases 1 to 3759)
  AUTHORS   Rooney,S., Alt,F.W., Lombard,D., Whitlow,S., Eckersdorff,M.,
            Fleming,J., Fugmann,S., Ferguson,D.O., Schatz,D.G. and Sekiguchi,J.
  TITLE     Defective DNA repair and increased genomic instability in
            Artemis-deficient murine cells
  JOURNAL   J Exp Med 197 (5), 553-565 (2003)
   PUBMED   12615897
  REMARK    GeneRIF: Data show that Artemis appears to be required for a subset
            of nonhomologous DNA end joining reactions that require end
            processing [Artemis].
REFERENCE   9  (bases 1 to 3759)
  AUTHORS   Rooney,S., Sekiguchi,J., Zhu,C., Cheng,H.L., Manis,J., Whitlow,S.,
            DeVido,J., Foy,D., Chaudhuri,J., Lombard,D. and Alt,F.W.
  TITLE     Leaky Scid phenotype associated with defective V(D)J coding end
            processing in Artemis-deficient mice
  JOURNAL   Mol Cell 10 (6), 1379-1390 (2002)
   PUBMED   12504013
  REMARK    GeneRIF: deficient mice have a phenotype similar to that of
            DNA-PKcs-deficient mice-including severe combined immunodeficiency
            associated with defects in opening and joining V(D)J coding hairpin
            ends and increased cellular ionizing radiation sensitivity
            (artemis)
REFERENCE   10 (bases 1 to 3759)
  AUTHORS   Callebaut,I., Moshous,D., Mornon,J.P. and de Villartay,J.P.
  TITLE     Metallo-beta-lactamase fold within nucleic acids processing
            enzymes: the beta-CASP family
  JOURNAL   Nucleic Acids Res 30 (16), 3592-3601 (2002)
   PUBMED   12177301
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL732620.14, BY729142.1,
            AK052490.1, AA254140.1, BE850534.1, AA940383.1 and BX516565.1.
            
            On Nov 1, 2007 this sequence version replaced NM_146114.2.
            
            Summary: This gene encodes a member of the SNM1 family of nucleases
            and is involved in V(D)J recombination and DNA repair. This protein
            has single-strand-specific 5'-3' exonuclease activity; it also
            exhibits endonuclease activity on 5' and 3' overhangs and hairpins.
            The protein also functions in the regulation of the cell cycle in
            response to DNA damage. Homozygous knockout mice for this gene
            exhibit severe combined immunodeficiency with sensitivity to
            ionizing radiation. Mutations in this gene in humans can cause
            Athabascan-type severe combined immunodeficiency (SCIDA) and Omenn
            syndrome. Alternative splicing results in multiple transcript
            variants encoding different isoforms. [provided by RefSeq, Nov
            2014].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF387731.1, AK052490.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            multifunctional gene product(s) :: PMID: 20528238
            RefSeq Select criteria          :: based on conservation,
                                               expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                AL732620.14        134933-134950
            19-62               BY729142.1         2-45
            63-1656             AK052490.1         2-1595
            1657-2172           AK052490.1         1604-2119
            2173-3098           AL732620.14        164579-165504
            3099-3297           AA254140.1         1-199
            3298-3351           BE850534.1         83-136
            3352-3695           AA940383.1         39-382
            3696-3759           BX516565.1         129-192
FEATURES             Location/Qualifiers
     source          1..3759
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 1.93 cM"
     gene            1..3759
                     /gene="Dclre1c"
                     /gene_synonym="9930121L06Rik; Art; Snm1l"
                     /note="DNA cross-link repair 1C"
                     /db_xref="GeneID:227525"
                     /db_xref="MGI:MGI:2441769"
     exon            1..196
                     /gene="Dclre1c"
                     /gene_synonym="9930121L06Rik; Art; Snm1l"
                     /inference="alignment:Splign:2.1.0"
     CDS             88..2205
                     /gene="Dclre1c"
                     /gene_synonym="9930121L06Rik; Art; Snm1l"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein artemis; SNM1-like protein; DNA cross-link repair
                     1C protein; DNA cross-link repair 1A, PSO2 homolog; DNA
                     cross-link repair 1C, PSO2 homolog"
                     /codon_start=1
                     /product="protein artemis isoform 1"
                     /protein_id="NP_666226.2"
                     /db_xref="CCDS:CCDS15650.1"
                     /db_xref="GeneID:227525"
                     /db_xref="MGI:MGI:2441769"
                     /translation="MSSFQGQMAEYPTISIDRFDRENLKARAYFLSHCHKDHMKGLRA
                     PSLKRRLECSLKVFLYCSPVTKELLLTSPKYRFWENRIITIEIETPTQISLVDEASGE
                     KEEVVVTLLPAGHCPGSVMFLFQGSNGTVLYTGDFRLAKGEASRMELLHSGGRVKDIQ
                     SVYLDTTFCDPRFYQIPSREQCLRGILELVRSWVTRSPHHVVWLNCKAAYGYEYLFTN
                     LSEELGVQVHVDKLDMFKNMPDILHHLTTDRNTQIHACRHPKAEECFQWNKLPCGITS
                     QNKTALHTISIKPSTMWFGERTRKTNVIVRTGESSYRACFSFHSSFSEIKDFLSYICP
                     VNVYPNVIPVGLTVDKVMDVLKPLCRSPQSVEPKYKPLGKLKRARTIHLDSEEDDDLF
                     DDPLPTPLRHKVPYQLTLQPELFSMKALPLDQPELRQSPGGCKAESVWSPSLANFIDC
                     EESNSDSGEELETPPPSLQGGLGPSTLVQQNADPDVDIPQWEVFFKRRDEITGECLEH
                     LPSSIETGGSQSPKLCSDSPKLCSDSPKLCSDSDGDSTHISSQNSSQSTHITDQGSQG
                     WDSQCDTVLLSSQEKSGGDSTSLNKGAYKPKLKESISASQIEQDALCPQDTHCDLKSR
                     AEVNGAPCLVELDTLSGRKSPPEKTLLSSTRADSQSSSDFEIPSTPEAELPTPEHLQC
                     LYRKLATGQSIVVEKRKCSLLDS"
     exon            197..248
                     /gene="Dclre1c"
                     /gene_synonym="9930121L06Rik; Art; Snm1l"
                     /inference="alignment:Splign:2.1.0"
     exon            249..333
                     /gene="Dclre1c"
                     /gene_synonym="9930121L06Rik; Art; Snm1l"
                     /inference="alignment:Splign:2.1.0"
     exon            334..393
                     /gene="Dclre1c"
                     /gene_synonym="9930121L06Rik; Art; Snm1l"
                     /inference="alignment:Splign:2.1.0"
     exon            394..449
                     /gene="Dclre1c"
                     /gene_synonym="9930121L06Rik; Art; Snm1l"
                     /inference="alignment:Splign:2.1.0"
     exon            450..551
                     /gene="Dclre1c"
                     /gene_synonym="9930121L06Rik; Art; Snm1l"
                     /inference="alignment:Splign:2.1.0"
     exon            552..624
                     /gene="Dclre1c"
                     /gene_synonym="9930121L06Rik; Art; Snm1l"
                     /inference="alignment:Splign:2.1.0"
     exon            625..765
                     /gene="Dclre1c"
                     /gene_synonym="9930121L06Rik; Art; Snm1l"
                     /inference="alignment:Splign:2.1.0"
     exon            766..867
                     /gene="Dclre1c"
                     /gene_synonym="9930121L06Rik; Art; Snm1l"
                     /inference="alignment:Splign:2.1.0"
     exon            868..1004
                     /gene="Dclre1c"
                     /gene_synonym="9930121L06Rik; Art; Snm1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1059
                     /gene="Dclre1c"
                     /gene_synonym="9930121L06Rik; Art; Snm1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1148
                     /gene="Dclre1c"
                     /gene_synonym="9930121L06Rik; Art; Snm1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..1243
                     /gene="Dclre1c"
                     /gene_synonym="9930121L06Rik; Art; Snm1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1244..3750
                     /gene="Dclre1c"
                     /gene_synonym="9930121L06Rik; Art; Snm1l"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggtgcgcagg ttcccggaag tggcgcccag ggtcagtgtg tgcttctgtt tccgaggtgg
       61 gctttgggtc tagtgttccc gggtgcgatg agctccttcc agggacagat ggcggagtat
      121 ccaaccatct ccattgaccg cttcgacagg gagaacctga aagcccgtgc ctacttcctt
      181 tcgcactgtc acaaggatca catgaaagga ttaagggctc cttccttgaa aagaaggctg
      241 gaatgcagct tgaaggtctt cctgtactgt tctccagtca ctaaggagct gttgttaact
      301 agcccaaagt acagattctg ggaaaacaga attataacaa ttgaaattga aactcctacg
      361 cagatatctt tagttgatga ggcttcgggt gagaaggaag aggttgttgt gactctctta
      421 ccagctggtc actgcccagg atcagttatg tttttatttc agggcagtaa tggaactgtc
      481 ttatacacag gagacttcag actggcaaaa ggagaagctt ccagaatgga gcttctgcac
      541 tctggaggca gagtaaaaga catccaaagt gtgtatttag acacgacttt ctgtgaccca
      601 aggttttatc agatcccaag tcgtgagcag tgtttgaggg gcattttgga gctggttcgg
      661 agctgggtca ctaggagtcc gcaccacgtc gtgtggctga actgtaaagc agcttatggc
      721 tacgagtatt tattcaccaa cctaagcgag gagctgggag ttcaggttca tgtggacaag
      781 ctggacatgt ttaaaaacat gcctgatatc ctgcaccatc tcacaacgga cagaaacacc
      841 cagatccacg cctgccgcca cccaaaggca gaagagtgtt ttcagtggaa taaactaccc
      901 tgtggtataa cttcccaaaa caaaactgca ctccacacaa tcagcatcaa gccatctacc
      961 atgtggtttg gagagaggac cagaaaaacc aacgtgatcg ttaggactgg agagagctca
     1021 tacagagctt gcttctcttt tcactcctcc ttcagtgaga ttaaagattt tttgagctac
     1081 atctgcccag tgaatgtgta tccaaatgtc atcccagttg gcctcactgt ggataaggtc
     1141 atggacgttt taaagcctct gtgccggtct ccccaaagtg ttgagccaaa gtacaaaccg
     1201 cttggaaaat tgaagagagc cagaacaatc catcttgact cggaggaaga cgatgatctc
     1261 tttgatgacc ctctaccgac acctttaagg cacaaagttc cgtaccagct aactcttcag
     1321 cctgagctgt tttcaatgaa ggcactgcca ctagaccagc ctgaactgag acaaagccca
     1381 ggaggctgca aagcagagag tgtgtggagc ccttctttgg ctaacttcat agactgtgaa
     1441 gaatccaaca gcgacagtgg agaagagcta gaaaccccac caccctcact gcagggaggt
     1501 ctgggcccct cgacactcgt ccagcaaaat gctgatccgg atgtggacat accacagtgg
     1561 gaagtcttct tcaaaagaag agatgaaatc acaggtgaat gtttggaaca cttaccttcc
     1621 tccatagaga cagggggatc tcagtcacca aagctctgca gtgactcacc aaagctctgc
     1681 agtgactcac caaagctctg cagtgactct gatggagact ccacccatat ctcttcccag
     1741 aattcatctc agtcaaccca tataacagat caaggaagtc aaggctggga cagccagtgt
     1801 gatactgttt tgttatcttc ccaagagaaa agtggtgggg atagtacctc tttaaacaag
     1861 ggtgcctaca aaccaaaact caaagagagt atttctgcct ctcaaataga acaggatgca
     1921 ctgtgtccac aagatactca ctgtgatttg aaaagcagag ctgaagtaaa tggagcccct
     1981 tgtcttgtag aactagacac cctgagtggc aggaagtctc cacctgagaa gacattgcta
     2041 agcagcacac gtgcagactc acagagctcc tctgactttg aaatcccctc aactcccgaa
     2101 gcggagcttc ctacgccaga gcatttgcag tgcttataca ggaaactggc aacaggtcaa
     2161 agtatagttg tcgaaaaaag aaaatgttca cttttagata gttaacaaat aaaactctac
     2221 acagagaaac cctgtctcga aaaaccaaaa caacaacaac aacaacagaa aaaaaaaccc
     2281 tctcattcta gcaaagatgt ccagcctttc gatgttgcaa tacaatgcta tacataaaag
     2341 tcctgggcaa tatccatagc tgtggatgta tgtggcctgg agggtagaca cacttgttag
     2401 atcaaccaca agaaatctgc agagtgacac atctatataa taagatcaac atgaaatatt
     2461 aaaggatgct caagtgacct aaaagaaaga gaaacaggct caaaaccagc attgcatgag
     2521 atggtagaac taaatctaaa catataatca cattaaatgc aaatgatata aaaagattta
     2581 tggtgagatg gctcagtggg taagagcacc cgactgctct tccgaaggtc cggagttcaa
     2641 atcccagcaa ccacatggtg gctcacaacc atccataacg agatctgact ccctcttctg
     2701 gagtgtctga agacagctac agtgtactta catataaata aacaaatctt aaaagaaaaa
     2761 aaaaaagatt tacaaaaaga cagagtacag gaaaaacact gcccaactat gtgctgtttt
     2821 tagaaaacac aactcaagtg atgtaaaagt tgaaggtaaa gggcagacca cataaataat
     2881 gttaaagcca gaatgataca gtaggagcag gcaccttccc caacataatg tctacctcac
     2941 caagaagatg taatggtaag gttcttgcct agattgtatg aaggcctagc tgcagtttcc
     3001 agtacagtac agtgccatgc cctccacaaa agagcaaata atacagatac aagccatgga
     3061 acacgctttc ctagagaacc agtgcacaca ggaaagcagt aagacgagaa ctgaccacca
     3121 gtaactggat ctgatagaca agagtatttt acttcatagc agaatacatc tcttcaaatg
     3181 tacaaggacc attcctccac caagatacac tgtatcttga atcactacaa gcagtctaga
     3241 aaaataaagg tgggctctat tttagtaaac tggtagcagg gggtaaacca ggaccttatt
     3301 aacctctatc acataaagac ctgggtgggg gggcagggct ggagcagttt agagcacttg
     3361 tcggttttgt gggttaccca gatttggttc cctacaccca tatggtggct cttaactgtc
     3421 tgtaacccca ttccagggga tccatgcaca catacataca tacaggcaaa agactcatat
     3481 ataaaaataa accttaaaag ctaccagcag gctaggcaag gctgtgttct acaagctgag
     3541 actagaggga cttgagttgg aggtcaggcc tgggcaatgt atgtagcaag agcttgtttc
     3601 agtacatgaa actgttccca atgcaatgat gtaaaggaaa atacttaaat atttaacata
     3661 catgctctgt gaattattaa agtgccttaa ggtacaatgc ttttgtattg atgtgtatgg
     3721 attaataaag ctttataagc attttcataa aaaaaaaaa
//
