LOCUS       NM_133865               4309 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus DNA cross-link repair 1B (Dclre1b), transcript variant
            1, mRNA.
ACCESSION   NM_133865
VERSION     NM_133865.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4309)
  AUTHORS   Wu,P., Takai,H. and de Lange,T.
  TITLE     Telomeric 3' overhangs derive from resection by Exo1 and Apollo and
            fill-in by POT1b-associated CST
  JOURNAL   Cell 150 (1), 39-52 (2012)
   PUBMED   22748632
  REMARK    GeneRIF: Study documents the combinatorial action of Apollo, POT1b,
            CST, and the 5' exonuclease Exo1 in postreplicative telomere end
            processing in mouse cells, clarifying the mechanism by which the
            telomeric 3' overhang is generated and modulated.
REFERENCE   2  (bases 1 to 4309)
  AUTHORS   Akhter,S., Lam,Y.C., Chang,S. and Legerski,R.J.
  TITLE     The telomeric protein SNM1B/Apollo is required for normal cell
            proliferation and embryonic development
  JOURNAL   Aging Cell 9 (6), 1047-1056 (2010)
   PUBMED   20854421
  REMARK    GeneRIF: The telomeric protein SNM1B/Apollo is required for normal
            cell proliferation and embryonic development
REFERENCE   3  (bases 1 to 4309)
  AUTHORS   Wu,P., van Overbeek,M., Rooney,S. and de Lange,T.
  TITLE     Apollo contributes to G overhang maintenance and protects
            leading-end telomeres
  JOURNAL   Mol Cell 39 (4), 606-617 (2010)
   PUBMED   20619712
  REMARK    GeneRIF: TRF2-bound Apollo functions at replicating telomeres,
            promoting the maintenance of the telomeric overhang, repressing S
            phase-specific ATM signaling, and protecting leading-end telomeres
            from fusion.
REFERENCE   4  (bases 1 to 4309)
  AUTHORS   Lam,Y.C., Akhter,S., Gu,P., Ye,J., Poulet,A., Giraud-Panis,M.J.,
            Bailey,S.M., Gilson,E., Legerski,R.J. and Chang,S.
  TITLE     SNMIB/Apollo protects leading-strand telomeres against
            NHEJ-mediated repair
  JOURNAL   EMBO J 29 (13), 2230-2241 (2010)
   PUBMED   20551906
  REMARK    GeneRIF: Apollo null mouse embryo fibroblasts exhibit an increased
            incidence of G2 chromatid-type fusions involving telomeres created
            by leading-strand DNA synthesis, reflective of a failure to protect
            these telomeres after DNA replication.
REFERENCE   5  (bases 1 to 4309)
  AUTHORS   Akhter,S. and Legerski,R.J.
  TITLE     SNM1A acts downstream of ATM to promote the G1 cell cycle
            checkpoint
  JOURNAL   Biochem Biophys Res Commun 377 (1), 236-241 (2008)
   PUBMED   18848520
REFERENCE   6  (bases 1 to 4309)
  AUTHORS   McKee,A.E., Minet,E., Stern,C., Riahi,S., Stiles,C.D. and
            Silver,P.A.
  TITLE     A genome-wide in situ hybridization map of RNA-binding proteins
            reveals anatomically restricted expression in the developing mouse
            brain
  JOURNAL   BMC Dev Biol 5, 14 (2005)
   PUBMED   16033648
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 4309)
  AUTHORS   VanBuren,V., Piao,Y., Dudekula,D.B., Qian,Y., Carter,M.G.,
            Martin,P.R., Stagg,C.A., Bassey,U.C., Aiba,K., Hamatani,T.,
            Kargul,G.J., Luo,A.G., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Assembly, verification, and initial annotation of the NIA mouse
            7.4K cDNA clone set
  JOURNAL   Genome Res 12 (12), 1999-2003 (2002)
   PUBMED   12466305
REFERENCE   8  (bases 1 to 4309)
  AUTHORS   Dronkert,M.L., de Wit,J., Boeve,M., Vasconcelos,M.L., van Steeg,H.,
            Tan,T.L., Hoeijmakers,J.H. and Kanaar,R.
  TITLE     Disruption of mouse SNM1 causes increased sensitivity to the DNA
            interstrand cross-linking agent mitomycin C
  JOURNAL   Mol Cell Biol 20 (13), 4553-4561 (2000)
   PUBMED   10848582
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CA548899.1, AK049115.1, AK084347.1 and BC067017.1.
            
            On Jul 13, 2005 this sequence version replaced NM_133865.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK137495.1, AK134324.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 CA548899.1         1-6
            7-783               AK049115.1         2-778
            784-2261            AK084347.1         613-2090
            2262-4309           BC067017.1         2005-4052
FEATURES             Location/Qualifiers
     source          1..4309
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 45.52 cM"
     gene            1..4309
                     /gene="Dclre1b"
                     /gene_synonym="Apollo; mSNM1B; SNMIB"
                     /note="DNA cross-link repair 1B"
                     /db_xref="GeneID:140917"
                     /db_xref="MGI:MGI:2156057"
     exon            1..488
                     /gene="Dclre1b"
                     /gene_synonym="Apollo; mSNM1B; SNMIB"
                     /inference="alignment:Splign:2.1.0"
     CDS             300..1925
                     /gene="Dclre1b"
                     /gene_synonym="Apollo; mSNM1B; SNMIB"
                     /EC_number="3.5.2.6"
                     /note="isoform a is encoded by transcript variant 1; DNA
                     cross-link repair 1B protein; 5' exonuclease Apollo; SNM1
                     homolog B; DNA cross-link repair 1B, PSO2 homolog;
                     beta-lactamase MBLAC2"
                     /codon_start=1
                     /product="5' exonuclease Apollo isoform a"
                     /protein_id="NP_598626.2"
                     /db_xref="CCDS:CCDS17694.1"
                     /db_xref="GeneID:140917"
                     /db_xref="MGI:MGI:2156057"
                     /translation="MNGVVIPQTPIAVDFWSLRRAGSARLFFLTHMHCDHTVGLSSTW
                     ARPLYCSPITACLLHRRLQVSKHWIRALEVGESHVLPLDEIGQETMTVTLIDANHCPG
                     SVMFLFEGYFGTILYTGDFRYTPSMLKEPALILGKQIHTLYLDNTNCNPALVLPSRQE
                     ATQQIVQLIRQFPQHNIKIGLYSLGKESLLEQLALEFRTWVVLSPQRLELVQLLGLAD
                     VFTVEEEAGRIHAVDHTEICHSAMLQWNQSHPTIAIFPTSRKVRSPHPSIYTVPYSDH
                     SSYSELRAFVAALRPCQVVPIVHQKPCGEFFQDSLSPRLAMPLIPHSVQQYMSSSSRK
                     TNVLWQLERRLKRPRTQGVVFESPEEKANQVKVDRDSKKHKKENLSPWAGHLERLCPH
                     PLQARKQLFPDFCRKERDEPVLFCDSNKMATVLTAPLEFSVQLQPIDEFLFPETREKI
                     GLESPLLSRGDSGSPARGNQSDCVGCGSPPAHISRAVPLTPESRGLALKYLLTPVHFL
                     QAGFSSRNFDKQVEKHQRVQRSSPAVLSPVDVG"
     exon            489..654
                     /gene="Dclre1b"
                     /gene_synonym="Apollo; mSNM1B; SNMIB"
                     /inference="alignment:Splign:2.1.0"
     exon            655..837
                     /gene="Dclre1b"
                     /gene_synonym="Apollo; mSNM1B; SNMIB"
                     /inference="alignment:Splign:2.1.0"
     exon            838..4288
                     /gene="Dclre1b"
                     /gene_synonym="Apollo; mSNM1B; SNMIB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2116..2121
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dclre1b"
                     /gene_synonym="Apollo; mSNM1B; SNMIB"
                     /note="hexamer: ATTAAA"
     polyA_site      2144
                     /gene="Dclre1b"
                     /gene_synonym="Apollo; mSNM1B; SNMIB"
     regulatory      4269..4274
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dclre1b"
                     /gene_synonym="Apollo; mSNM1B; SNMIB"
                     /note="hexamer: AATAAA"
     polyA_site      4288
                     /gene="Dclre1b"
                     /gene_synonym="Apollo; mSNM1B; SNMIB"
                     /note="major polyA site"
ORIGIN      
        1 ctccccgccg ccgcgcgagc tttgacaatg tggggactgg gcccgagctc cagcgcgcgg
       61 ttgtgagtga tgctctcccg acttcttccg cgttgggcgc tttcatcctg atcgtcccga
      121 gcgcggccac cttctttttt ctcactctgt ctactaattc cgtttctggg atggttttcc
      181 tttagggctt ctggacttgt tccagagtcc acttgtcatt gggacgctgt cgtggaaacc
      241 tcactcagga gtgcggttcc cgcgaagacc ccactgggtg acacctcaac tctgccacca
      301 tgaacggggt cgtaatcccc caaacgccca ttgctgtgga cttttggagc ctgcgccgtg
      361 ccggttcggc gcggctcttc ttcttaaccc acatgcactg tgaccacacg gtgggtttgt
      421 ctagcacttg ggcccggccc ctctactgct ctcccatcac tgcttgcctc ttgcatcgtc
      481 gcctgcaggt gtctaagcac tggatccggg ccctggaggt tggcgagagt catgtattac
      541 ctctagatga aattgggcaa gaaaccatga ctgtaacgct catagatgcc aatcactgcc
      601 ctggttctgt catgtttctc tttgaaggat actttggaac aattctatac acaggtgatt
      661 ttcgatatac accatccatg ctgaaggaac ctgctctgat actggggaaa cagattcata
      721 ctttgtatct agacaacact aattgcaatc cagccctggt tcttccttcc cgacaagagg
      781 ctactcagca gattgtccag ctaatccgac agttcccaca acacaacata aaaattggac
      841 tctatagtct aggaaaagaa tcactgctgg agcaactagc ccttgagttt cggacctggg
      901 tggtattaag tcctcaacgc ctggagttgg tacagttgct gggcctggca gacgtgttca
      961 cagttgagga agaagccggg cgcatccatg ctgtggacca tacggagatc tgccactctg
     1021 ccatgcttca gtggaaccag agtcacccta ccattgctat tttccccaca agccggaaag
     1081 tgcgcagccc tcaccccagc atctacaccg tcccgtactc tgaccattca tcttactccg
     1141 agctccgtgc ttttgtggca gcgctgaggc cttgtcaggt ggtgcccatc gtccatcaaa
     1201 agccttgtgg agagttcttt caggacagct tgagtcctag gctcgctatg cctctgattc
     1261 cacactctgt gcagcagtac atgagttcct cctctaggaa aacaaatgtg ctttggcagt
     1321 tagaaaggag gctcaagagg ccaagaactc agggtgttgt gtttgaatcc cctgaggaga
     1381 aagctaatca ggttaaagtt gacagagact caaagaagca caaaaaggaa aacctctctc
     1441 cctgggctgg gcaccttgag aggctttgcc cccatcctct gcaggccagg aagcagttgt
     1501 tcccagactt ctgcaggaaa gaacgtgatg agccagtcct cttttgtgac tccaacaaga
     1561 tggcgactgt gttgactgcc ccactggaat tctcagtgca attacaacct atagatgagt
     1621 ttctctttcc agaaaccagg gagaaaattg gcttagagtc cccattgctg tcaaggggag
     1681 acagtggctc accagcgaga gggaaccaaa gtgactgcgt aggctgtggt tctcccccgg
     1741 ctcacattag cagagctgtt cctctaactc ctgagtccag gggcctggcg ctaaaatacc
     1801 ttctcactcc agtgcatttc ctccaagcag gcttctcttc caggaacttc gacaagcaag
     1861 tggaaaaaca ccagagagta cagcgtagca gtcctgcagt tctgagcccg gtggatgttg
     1921 gctagtgaca ggaggtggct tgctgtcttc ctttaaaaga accctggggc tcaccccagc
     1981 agctcttctg aagcttttca tgaagtccta gtgcctatga gacccgtagc tttatagtac
     2041 actatattgt ttattttaat tttattatat ttaagaaaca gatttcatta taaactattc
     2101 agtgttcata agcacattaa aagttctaag aagttccata gcaatttaat ttgttccact
     2161 tggtttaacc cagtttttct caaaccttta tcaacatgca gttcgttttg ttttttgttt
     2221 tgttttgttt gagtggaaaa aatagagtct gaatcaaaaa gaaccagtat attgttatta
     2281 aatttgtcct gtccccatcc tcaagtccca gataaaagat gtcggttatt tgttttcaga
     2341 ttgtaattca tggtgctgga ggataaagta ggagtcctgt tctaaccctg actgtcactg
     2401 acttgctgtg acatgaccct aaccaaggaa cttcctgtct ttgcctctcg gagcgaacag
     2461 gaaaccatga agaggcactg aaacagtgtt aggaaaataa caccttcctt cttcatgaag
     2521 gggtttcgta actgtcatga gacatccatc tggaacatag ccatttggag gttaggcacc
     2581 acgcaccaag ggggtacacg gaataagctg aacattaagg gttagagtat gtcagagcta
     2641 ctggatgctt ggagacacta ctttgttaaa gctacaggga tcaaatgtgc tgccagatat
     2701 tctccaattg ttcacatagc tgggattttc cccccacccc cacaagtttg aattagggag
     2761 ccagagcaca gagcttgttt gttttagtat ccaggggaga gaccaaggag ccagctggct
     2821 ggaacgggtc agagtgtgca gttctaccct gtcctgctca taacctgaca aaatgccaaa
     2881 ccaataagca agacagctga tagcacagcc atgaggaaat gcggtctggg agggtgcagg
     2941 cgaggaacgg cctgggcctg gaaccttgag ccatagcagt aaagaaagcc atctcttacc
     3001 cttggggagg agggaggagc tttgctactt taggagggag aagtgaagtt tagtgagcaa
     3061 aataagactt tgctcttgga cacgctgtac tcagttctgt ttttgtcagt gaccttacaa
     3121 acctctaagg gcttcatagg aactgcagca ggtgaggcat gtggttcaac aggaaacctg
     3181 gacattggct ggctggaatc cagggcacat ggcaaattgt ttaaatagag gagccttact
     3241 cagctgtaat gtgggggctg ggatgcctac ctctcatgat tgctatacag attattggta
     3301 aaattcccta gttcattgcc tggcacatga ttggttttcg tagctaaagg tgtagctttg
     3361 gtaggatgtg tgtttagcaa gctgaagtct tgggttctat cctgagttgt gtcccccccc
     3421 ccccaaaaaa aagcctttga tcttctctat gagaatacaa agtaaaatgt cttccatgta
     3481 gactagttaa tgggcatttt ttttctagtc tttctgagga tataaatgtt agatttatac
     3541 attttcagaa ttaggataat ttacatgtgt gtgttacatg tgtgtgtaca cacaaagggt
     3601 gctgaacaga tggcccagtg gttaagagct cttaatgtgc tcttgaagaa aacctaggtt
     3661 tggtttccag caccaacatc aaattgatca taactcaagt tcctcaggtc tgatgccttc
     3721 tgacctctga acaactgcac acaactcata cagtctcaca caatacacat aaataaaaat
     3781 aattttaagt aatgttttta aaagatgtat ttgtttattt tatgtattca tatacactgt
     3841 cactgtcttc tgagacacca gaagagggca tcagatccta ttccaggtgg ttgtgaccca
     3901 ccatgtggtt gctgggattt gaactcagga cctctggatg agcagtcagt gctcttaacc
     3961 actgagcact ccagccctta aataatgttt taaagggcca gtgagatggc ttagtgggta
     4021 aaagcacttg ccacataaac tggtgagctg gattcaatcc ctagagccca cataaaaatg
     4081 gaaaaggaga tctgagtgca taaggttgtc ctttggctgc catgcttgcc tataaacagt
     4141 actaaaaagg ggtgggtaag aataatactg tatatgattt tagattctgc attttactta
     4201 attccttaat tggaactcaa aatgccatta tcaaaaaatg cttacccaaa aggatgtaac
     4261 tacatgttaa taaatcattc tcattcaaaa aaaaaaaaaa aaaaaaaaa
//
