LOCUS       NM_001360437            4190 bp    mRNA    linear   ROD 12-JUN-2024
DEFINITION  Mus musculus DNA cross-link repair 1A (Dclre1a), transcript variant
            2, mRNA.
ACCESSION   NM_001360437 XM_006527216
VERSION     NM_001360437.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4190)
  AUTHORS   Yan,Y., Akhter,S., Zhang,X. and Legerski,R.
  TITLE     The multifunctional SNM1 gene family: not just nucleases
  JOURNAL   Future Oncol 6 (6), 1015-1029 (2010)
   PUBMED   20528238
  REMARK    Review article
REFERENCE   2  (bases 1 to 4190)
  AUTHORS   Akhter,S. and Legerski,R.J.
  TITLE     SNM1A acts downstream of ATM to promote the G1 cell cycle
            checkpoint
  JOURNAL   Biochem Biophys Res Commun 377 (1), 236-241 (2008)
   PUBMED   18848520
REFERENCE   3  (bases 1 to 4190)
  AUTHORS   Hemphill,A.W., Bruun,D., Thrun,L., Akkari,Y., Torimaru,Y.,
            Hejna,K., Jakobs,P.M., Hejna,J., Jones,S., Olson,S.B. and
            Moses,R.E.
  TITLE     Mammalian SNM1 is required for genome stability
  JOURNAL   Mol Genet Metab 94 (1), 38-45 (2008)
   PUBMED   18180189
REFERENCE   4  (bases 1 to 4190)
  AUTHORS   Ahkter,S., Richie,C.T., Zhang,N., Behringer,R.R., Zhu,C. and
            Legerski,R.J.
  TITLE     Snm1-deficient mice exhibit accelerated tumorigenesis and
            susceptibility to infection
  JOURNAL   Mol Cell Biol 25 (22), 10071-10078 (2005)
   PUBMED   16260620
  REMARK    GeneRIF: Snm1 is a tumor suppressor in mice that in addition has a
            role in immunity
REFERENCE   5  (bases 1 to 4190)
  AUTHORS   Bonatto,D., Revers,L.F., Brendel,M. and Henriques,J.A.
  TITLE     The eukaryotic Pso2/Snm1/Artemis proteins and their function as
            genomic and cellular caretakers
  JOURNAL   Braz J Med Biol Res 38 (3), 321-334 (2005)
   PUBMED   15761611
  REMARK    Review article
REFERENCE   6  (bases 1 to 4190)
  AUTHORS   Akhter,S., Richie,C.T., Deng,J.M., Brey,E., Zhang,X., Patrick,C.
            Jr., Behringer,R.R. and Legerski,R.J.
  TITLE     Deficiency in SNM1 abolishes an early mitotic checkpoint induced by
            spindle stress
  JOURNAL   Mol Cell Biol 24 (23), 10448-10455 (2004)
   PUBMED   15542852
  REMARK    GeneRIF: Snm1 and 53BP1 are components of a mitotic stress
            checkpoint that negatively targets the APC prior to chromosome
            condensation
REFERENCE   7  (bases 1 to 4190)
  AUTHORS   Dronkert,M.L., de Wit,J., Boeve,M., Vasconcelos,M.L., van Steeg,H.,
            Tan,T.L., Hoeijmakers,J.H. and Kanaar,R.
  TITLE     Disruption of mouse SNM1 causes increased sensitivity to the DNA
            interstrand cross-linking agent mitomycin C
  JOURNAL   Mol Cell Biol 20 (13), 4553-4561 (2000)
   PUBMED   10848582
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC166746.7.
            
            On Apr 8, 2021 this sequence version replaced NM_001360437.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660813.86804.1,
                                           SRR1660811.122403.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164143 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on conservation,
                                                expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-152               AC166746.7         127311-127462       c
            153-1219            AC166746.7         125974-127040       c
            1220-2851           AC166746.7         123352-124983       c
            2852-2985           AC166746.7         121970-122103       c
            2986-3104           AC166746.7         120842-120960       c
            3105-3245           AC166746.7         119519-119659       c
            3246-3391           AC166746.7         117634-117779       c
            3392-3546           AC166746.7         116465-116619       c
            3547-3688           AC166746.7         110554-110695       c
            3689-4190           AC166746.7         108498-108999       c
FEATURES             Location/Qualifiers
     source          1..4190
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 51.89 cM"
     gene            1..4190
                     /gene="Dclre1a"
                     /gene_synonym="2810043H12Rik; mKIAA0086; Pso2; Smn1a;
                     Snm1"
                     /note="DNA cross-link repair 1A"
                     /db_xref="GeneID:55947"
                     /db_xref="MGI:MGI:1930042"
     exon            1..152
                     /gene="Dclre1a"
                     /gene_synonym="2810043H12Rik; mKIAA0086; Pso2; Smn1a;
                     Snm1"
                     /inference="alignment:Splign:2.1.0"
     exon            153..1219
                     /gene="Dclre1a"
                     /gene_synonym="2810043H12Rik; mKIAA0086; Pso2; Smn1a;
                     Snm1"
                     /inference="alignment:Splign:2.1.0"
     CDS             760..3849
                     /gene="Dclre1a"
                     /gene_synonym="2810043H12Rik; mKIAA0086; Pso2; Smn1a;
                     Snm1"
                     /EC_number="3.5.2.6"
                     /note="isoform 1 is encoded by transcript variant 2; DNA
                     cross-link repair 1A protein; SNM1 homolog A; DNA
                     cross-link repair 1A, PSO2 homolog; beta-lactamase MBLAC2"
                     /codon_start=1
                     /product="DNA cross-link repair 1A protein isoform 1"
                     /protein_id="NP_001347366.2"
                     /db_xref="CCDS:CCDS29917.2"
                     /db_xref="GeneID:55947"
                     /db_xref="MGI:MGI:1930042"
                     /translation="MLEDTFWEEEIWEYKSKRKPKPVHPNNCSENISESVEKSTDGKH
                     QSKGNEKRTSENPGKTKDHKVCLAETDSQISAGSSQSSSCRDESQQSQNKETTPKKQH
                     RTRRGKQVTPKVRPVYDGYCPSCQMPFSSLLGQTPQWHVFECLDSPPISDTECPEGLL
                     CTSTIPSHYKKYTHILLAQSRDSKEPLGSPSDALAGLFAAAAPGSPCNLEERRSMTLK
                     TENLRKVSDHSLLMMQYLETSQPSAEINRKNVSSPCSQTSPVPQCAEFVKRDQLVGGG
                     SPLAEVALNSQSKSGSMGLPLPENDTDSCEISYSPLHSDEETYDIDQELDDSQQELFF
                     TQSSKDSSLEEDGSAIFENLHGPSPKEAEGIRPTAKSLVAQARCSAPSEGSTLSDSFL
                     LLFYTSNRLSQEDLPHTDAAFHLLSPALAVGGAASNYQTSKAKLDEPEKFLSLASSHQ
                     QQKIETSAVGNQTSLPLLTRARSKPLEKEGGKCLPLHPTQSQTRGSPRKGLGAPGANC
                     ACRNAQKRSSMPLDKPLGTSPSSPKCSPSQPSKKVMKQMDIGVFFGLPPKRQETSLRE
                     SASEGPNVSPVVSPNQKRPRLCKRKAQSSLSDLEFDAKNLNESQHSVGLSGEKRQHRR
                     KRHKTSNSPREGPCQRRSGHLMNNPELGPVILSKGKAFVRRTRGRTQRGNMNISESSG
                     AGEVRRTCPFYKRIPGTGFTVDAFQYGEIEGCTAYFLTHFHSDHYAGLSKDFTRPVYC
                     SEITGNLLKKKLRVQEQYIRQLPMDTECVVDSVKVVLLDANHCPGATMILFQLPNGAV
                     ILHTGDFRADPSMERSRLAGRKVHTLFLDTTYCSPEYTFPSQQEVIQFAINTAFEAVT
                     LNPRALVVCGTYCIGKEKVFLAIADVLGSKVGMSQEKYKTLQCLNIPEVSSLITTDMC
                     DSLVHLLPMMQINFKGLQSHLKKCGGKYDQILAFRPTGWTHSNNITSTADIIPQTRGN
                     ISIYGIPYSEHSSYLEMKRFVQWLKPQKIIPTVNVGSFRSRNTMEKYFKEWRLEAGY"
     exon            1220..2851
                     /gene="Dclre1a"
                     /gene_synonym="2810043H12Rik; mKIAA0086; Pso2; Smn1a;
                     Snm1"
                     /inference="alignment:Splign:2.1.0"
     exon            2852..2985
                     /gene="Dclre1a"
                     /gene_synonym="2810043H12Rik; mKIAA0086; Pso2; Smn1a;
                     Snm1"
                     /inference="alignment:Splign:2.1.0"
     exon            2986..3104
                     /gene="Dclre1a"
                     /gene_synonym="2810043H12Rik; mKIAA0086; Pso2; Smn1a;
                     Snm1"
                     /inference="alignment:Splign:2.1.0"
     exon            3105..3245
                     /gene="Dclre1a"
                     /gene_synonym="2810043H12Rik; mKIAA0086; Pso2; Smn1a;
                     Snm1"
                     /inference="alignment:Splign:2.1.0"
     exon            3246..3391
                     /gene="Dclre1a"
                     /gene_synonym="2810043H12Rik; mKIAA0086; Pso2; Smn1a;
                     Snm1"
                     /inference="alignment:Splign:2.1.0"
     exon            3392..3546
                     /gene="Dclre1a"
                     /gene_synonym="2810043H12Rik; mKIAA0086; Pso2; Smn1a;
                     Snm1"
                     /inference="alignment:Splign:2.1.0"
     exon            3547..3688
                     /gene="Dclre1a"
                     /gene_synonym="2810043H12Rik; mKIAA0086; Pso2; Smn1a;
                     Snm1"
                     /inference="alignment:Splign:2.1.0"
     exon            3689..4190
                     /gene="Dclre1a"
                     /gene_synonym="2810043H12Rik; mKIAA0086; Pso2; Smn1a;
                     Snm1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgtaggcag tgaggccggt ggttttgtgt tgacaacaac aaaagtgtcc tgtgactctg
       61 ggtgtgctga aagtgcgggc gcgaatggaa tgtcccgcga gctggcgcag agaggaggca
      121 gctgcagcgg ggtccccctg ctgccaggcc agggtttgat cctaggatgg aggaagaaat
      181 ggactgaccc aggaagctga aactggttgg acccatgagt cacgaataag ggcagctgtc
      241 ggttgtaacc aacacctctt tgattatggt ctagtctatg gactagtctc acactaagta
      301 gactagggac tgtgactgga cttgtaaatg gacacttgtc cacatgaacg agagccagaa
      361 tagctttcta accattatat ggagactgtt ttcagttaaa gtcattgagc ctggtactta
      421 ccgtcagtgc ttgacattca agacattctt gattcttatt tttataaatc aagttctgag
      481 aagttaaaaa aaaacctgaa tgaaatagtg tcacaatgta aagaaaaccg tatagatgtt
      541 accctgtagt gagttctctt aattttatta tggtataaaa tggaacagca ggtgttcaca
      601 ggtactaagt gggttgtgtg ccaatatcac caaagctttc agttccaacc aagttagttg
      661 gcttttggct actttttttt tcctattaaa aacttgttac aagaaatgga ctctgaattc
      721 accaaagact ggtgctgtac tcacaaaaat catttggcca tgttagaaga cacgttttgg
      781 gaagaagaaa tctgggaata taaatctaaa agaaagccca aacccgtaca tccaaataat
      841 tgttctgaaa atatttcaga atctgttgaa aaatcaacag atggaaaaca ccagtcaaaa
      901 ggaaatgaaa aaaggacttc agaaaatcca ggcaagacga aggaccacaa agtgtgcctt
      961 gcagaaacag acagtcagat ttctgcaggt tccagtcaga gttcgagctg tagagatgag
     1021 agtcagcagt ctcaaaacaa agagacaaca ccgaaaaagc aacatagaac tcgcagaggg
     1081 aagcaagtga ccccgaaggt gcgccctgtt tatgatggat actgcccaag ctgccagatg
     1141 cccttctcct cattgctggg tcagacgccc cagtggcatg tgtttgagtg tttggattct
     1201 ccacctatct ctgacacaga atgtcccgag ggtttgctat gtacttccac aattccttcc
     1261 cattataaga aatacactca catcctgctc gctcaaagtc gagatagcaa ggagcctctg
     1321 ggcagcccct cggatgcatt ggctgggctg tttgctgcag cagcgccagg ttctccttgt
     1381 aaccttgagg aaagacgctc tatgactctg aaaactgaga acttaagaaa agtctcagat
     1441 cactctttgt tgatgatgca gtatctagaa acatctcagc cttcagctga aatcaacagg
     1501 aagaatgtct cttccccatg ttctcaaaca tcgccagttc cacagtgtgc agagttcgtc
     1561 aagagagacc agctggtggg aggtggatcg cctcttgctg aggttgcatt aaacagccaa
     1621 agcaagtcag ggagtatggg tttgccattg ccagaaaatg acactgacag ctgtgagatc
     1681 tcttattctc cgctgcacag tgatgaagag acttacgaca tagaccaaga gctggatgat
     1741 tcacagcagg aactattttt tacccaaagc tctaaagaca gcagcctaga agaagatggc
     1801 tctgccatat ttgaaaacct tcatggtccc tccccaaagg aagcagaggg gatccggccc
     1861 acagcgaaga gcctggttgc ccaggctagg tgtagtgcac cgagtgaagg cagtacacta
     1921 agtgactctt ttctgcttct cttctacacc tcgaacaggc tttcccaaga agacctacca
     1981 cacacagatg cggccttcca cttgctttca cctgccttgg cagtgggagg tgctgcttct
     2041 aattatcaga ccagtaaggc caagctcgac gagccagaaa aattcctctc acttgcatca
     2101 agtcatcagc aacagaaaat tgaaacatca gctgttggca atcagacttc tctgccgtta
     2161 cttacaagag ccaggtcaaa gccacttgaa aaggagggag gcaagtgtct gcctttgcat
     2221 ccaacccaaa gtcagaccag aggatcaccg cgcaagggct tgggtgctcc aggggctaac
     2281 tgtgcctgca ggaatgcaca gaagcgctct agcatgcctc ttgacaagcc cttgggcaca
     2341 tcgccttcca gtcccaagtg cagcccgagc caaccgtcta agaaagtaat gaagcaaatg
     2401 gatataggcg tgttttttgg actaccaccc aaaagacaag agacgtcact gagggaaagc
     2461 gcatcagaag ggcccaatgt cagtccagtt gtgagtccca accaaaagag gccccggttg
     2521 tgcaagagga aagcccagag ctctctgagt gacttagagt ttgatgcaaa gaatttaaat
     2581 gagagtcagc actctgtggg actgtctgga gagaagcggc aacatcgaag aaagagacat
     2641 aaaacgtcaa attcaccacg ggaaggacca tgccagagaa ggtcaggtca cctcatgaac
     2701 aacccagagt tgggaccagt catcctcagc aaaggcaaag ccttcgtgag acggactcgt
     2761 ggcaggacgc agagagggaa catgaacatt tcagagtcct ctggtgcagg ggaagtgaga
     2821 agaacatgtc cgttctataa gagaatcccc gggactggct tcactgtgga tgcttttcag
     2881 tacggtgaga tcgaaggctg caccgcctac ttcctcacac atttccattc tgatcattac
     2941 gccgggttgt ccaaggactt cacaaggcca gtctattgca gcgagataac aggcaatctg
     3001 ttgaagaaga agcttcgagt gcaagagcaa tacatccgtc agttgccgat ggacaccgag
     3061 tgtgtcgtgg acagcgtcaa ggtggttttg ctggatgcca atcactgtcc aggtgctacc
     3121 atgatccttt tccagcttcc caacggtgct gtcatactgc acaccggaga cttccgagcg
     3181 gaccccagca tggaacgctc tcgcctggcg ggccgcaaag tccacacact gttcctggat
     3241 accacatact gcagcccaga atataccttc ccgtcacagc aggaggttat ccagtttgcc
     3301 atcaacactg cctttgaggc tgtaactcta aacccacgtg cccttgttgt ctgtggcact
     3361 tactgcatcg gaaaggagaa agtcttccta gccattgccg atgttttagg ttcaaaggtg
     3421 ggcatgtccc aagaaaagta taaaactttg cagtgcctca atataccaga agtcagttcc
     3481 ctcataacca cagacatgtg cgactctttg gttcacctcc tcccaatgat gcaaattaat
     3541 tttaagggtt tgcagagcca tttgaagaag tgtggtggga aatacgatca gattttggcg
     3601 ttccgaccca caggatggac acactctaac aacataacta gcacagcgga tattattccc
     3661 cagacaagag gaaatatatc gatatatggg attccctaca gtgaacacag cagctactta
     3721 gaaatgaagc gttttgtcca gtggctgaag ccacagaaaa tcatccccac tgtcaatgtc
     3781 ggcagctttc ggtctaggaa cacgatggag aaatacttta aggagtggag actggaagcc
     3841 ggatactgat gctgtcacag acgtctgctg agttccgtac agcaggcggc gataatgaaa
     3901 tctaaattga tgtgaggtac gggccatgag aagaacagcc tcaggactgc gctcctccct
     3961 cgctttgaac agtgatacac ccaaggtgct gggtgccttc agacccccca gtgaccactg
     4021 agaggagctc ttcccagtcc ctttcactct gaatctcgtc cccatgggtt aacggtcatc
     4081 tgcggcaacc atggagacca gacaccaagc attatctatg tagtaatgaa acaaaccttt
     4141 tatatgatat gtattcttaa ataaaattta atatagaact taccagagca
//
