LOCUS       NM_007832               3057 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus deoxycytidine kinase (Dck), mRNA.
ACCESSION   NM_007832 XM_977104
VERSION     NM_007832.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3057)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3057)
  AUTHORS   Cui,W., Dai,X., Marcho,C., Han,Z., Zhang,K., Tremblay,K.D. and
            Mager,J.
  TITLE     Towards Functional Annotation of the Preimplantation Transcriptome:
            An RNAi Screen in Mammalian Embryos
  JOURNAL   Sci Rep 6, 37396 (2016)
   PUBMED   27869233
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3057)
  AUTHORS   Bunimovich,Y.L., Nair-Gill,E., Riedinger,M., McCracken,M.N.,
            Cheng,D., McLaughlin,J., Radu,C.G. and Witte,O.N.
  TITLE     Deoxycytidine kinase augments ATM-Mediated DNA repair and
            contributes to radiation resistance
  JOURNAL   PLoS One 9 (8), e104125 (2014)
   PUBMED   25101980
  REMARK    GeneRIF: Mutation of a single serine 74 residue has profound
            effects on murine T and B lymphocyte development, suggesting that
            post-translational regulation of dCK has a role in maintaining
            genomic stability during hematopoiesis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3057)
  AUTHORS   Weng,T., Karmouty-Quintana,H., Garcia-Morales,L.J., Molina,J.G.,
            Pedroza,M., Bunge,R.R., Bruckner,B.A., Loebe,M., Seethamraju,H. and
            Blackburn,M.R.
  TITLE     Hypoxia-induced deoxycytidine kinase expression contributes to
            apoptosis in chronic lung disease
  JOURNAL   FASEB J 27 (5), 2013-2026 (2013)
   PUBMED   23392349
  REMARK    GeneRIF: activating the dAdo-DCK-dATP pathway directly results in
            increased apoptosis in the lungs of mice with air-space enlargement
            and suggests a novel therapeutic target for the treatment of COPD
REFERENCE   5  (bases 1 to 3057)
  AUTHORS   Austin,W.R., Armijo,A.L., Campbell,D.O., Singh,A.S., Hsieh,T.,
            Nathanson,D., Herschman,H.R., Phelps,M.E., Witte,O.N., Czernin,J.
            and Radu,C.G.
  TITLE     Nucleoside salvage pathway kinases regulate hematopoiesis by
            linking nucleotide metabolism with replication stress
  JOURNAL   J Exp Med 209 (12), 2215-2228 (2012)
   PUBMED   23148236
REFERENCE   6  (bases 1 to 3057)
  AUTHORS   Saada,A., Shaag,A., Mandel,H., Nevo,Y., Eriksson,S. and Elpeleg,O.
  TITLE     Mutant mitochondrial thymidine kinase in mitochondrial DNA
            depletion myopathy
  JOURNAL   Nat Genet 29 (3), 342-344 (2001)
   PUBMED   11687801
REFERENCE   7  (bases 1 to 3057)
  AUTHORS   Johansson,M., Norda,A. and Karlsson,A.
  TITLE     Conserved gene structure and transcription factor sites in the
            human and mouse deoxycytidine kinase genes
  JOURNAL   FEBS Lett 487 (2), 209-212 (2000)
   PUBMED   11150511
REFERENCE   8  (bases 1 to 3057)
  AUTHORS   Chan,T.S. and Nelson,J.A.
  TITLE     Specific selection of deoxycytidine kinase mutants with tritiated
            deoxyadenosine
  JOURNAL   Biochem Genet 33 (9-10), 327-340 (1995)
   PUBMED   8748457
REFERENCE   9  (bases 1 to 3057)
  AUTHORS   Karlsson,A., Johansson,M. and Eriksson,S.
  TITLE     2 cloning and expression of mouse deoxycytidine kinase. Pure
            recombinant mouse and human enzymes show differences in substrate
            specificity
  JOURNAL   J Biol Chem 269 (39), 24374-24378 (1994)
   PUBMED   7929097
REFERENCE   10 (bases 1 to 3057)
  AUTHORS   Datta,N.S., Shewach,D.S., Hurley,M.C., Mitchell,B.S. and Fox,I.H.
  TITLE     Human T-lymphoblast deoxycytidine kinase: purification and
            properties
  JOURNAL   Biochemistry 28 (1), 114-123 (1989)
   PUBMED   2539852
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BU052737.1 and BC060062.1.
            
            On Jan 30, 2007 this sequence version replaced NM_007832.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC060062.1, AK145353.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 BU052737.1         1-5
            6-23                BU052737.1         7-24
            24-3057             BC060062.1         10-3043
FEATURES             Location/Qualifiers
     source          1..3057
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 43.96 cM"
     gene            1..3057
                     /gene="Dck"
                     /note="deoxycytidine kinase"
                     /db_xref="GeneID:13178"
                     /db_xref="MGI:MGI:102726"
     exon            1..334
                     /gene="Dck"
                     /inference="alignment:Splign:2.1.0"
     CDS             244..1026
                     /gene="Dck"
                     /EC_number="2.7.1.74"
                     /EC_number="2.7.1.113"
                     /EC_number="2.7.1.76"
                     /note="deoxyadenosine kinase; deoxyguanosine kinase"
                     /codon_start=1
                     /product="deoxycytidine kinase"
                     /protein_id="NP_031858.1"
                     /db_xref="CCDS:CCDS19405.1"
                     /db_xref="GeneID:13178"
                     /db_xref="MGI:MGI:102726"
                     /translation="MATPPKRFCPSPSTSSEGTRIKKISIEGNIAAGKSTFVNILKQA
                     SEDWEVVPEPVARWCNVQSTQEEFEELTTSQKSGGNVLQMMYEKPERWSFTFQSYACL
                     SRIRAQLASLNGKLKDAEKPVLFFERSVYSDRYIFASNLYESDCMNETEWTIYQDWHD
                     WMNSQFGQSLELDGIIYLRATPEKCLNRIYLRGRNEEQGIPLEYLEKLHYKHESWLLH
                     RTLKTSFDYLQEVPVLTLDVNEDFKDKHESLVEKVKEFLSTL"
     exon            335..450
                     /gene="Dck"
                     /inference="alignment:Splign:2.1.0"
     exon            451..644
                     /gene="Dck"
                     /inference="alignment:Splign:2.1.0"
     exon            645..792
                     /gene="Dck"
                     /inference="alignment:Splign:2.1.0"
     exon            793..908
                     /gene="Dck"
                     /inference="alignment:Splign:2.1.0"
     exon            909..999
                     /gene="Dck"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..3057
                     /gene="Dck"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3033..3038
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dck"
                     /note="hexamer: AATAAA"
     regulatory      3037..3042
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dck"
                     /note="hexamer: AATGAA"
     polyA_site      3054
                     /gene="Dck"
     polyA_site      3057
                     /gene="Dck"
                     /note="major polyA site"
ORIGIN      
        1 gctcctggga cgcccggccc gcccggagga accacagaca tgcagatccc gcgagggcga
       61 ggcgtatagg gtgggagtcg gggccgtcag ggcgggttct ccacggtctg cccaatcgcc
      121 tgcgcctccg cgcgccaaag tcaaagtgcg ggtcccgccg gcgcgagatt gacgctgcaa
      181 cccggagccg cccgtgccgc cgtgtccctg caggttccgc acccgagccg tctggagcta
      241 ggcatggcca ccccacctaa gaggttctgc ccttctccct cgaccagctc cgaggggacc
      301 cgcatcaaga agatctccat cgaggggaac atcgctgctg ggaagtcaac gtttgtgaat
      361 atcctaaagc aagcctctga ggattgggaa gtggttcccg agcctgtggc caggtggtgc
      421 aacgtgcaga gcactcaaga ggaatttgag gaattgacaa cgtctcagaa gagcggtgga
      481 aatgttcttc aaatgatgta tgagaaacct gaacggtggt ctttcacctt ccagtcatat
      541 gcctgtctca gccggatccg agcccagcta gcctctctca atggcaagct caaagatgca
      601 gagaaacctg tattattttt tgaaagatct gtgtatagtg acaggtacat tttcgcttct
      661 aatttgtacg aatctgactg catgaatgaa acagagtgga ccatatatca agactggcac
      721 gactggatga acagccagtt tggccaaagc cttgaattgg atggaataat ctatcttcga
      781 gctactcccg agaaatgctt aaacagaata tacctacggg gaagaaatga agaacaaggc
      841 attcctcttg aatatttaga gaaacttcac tataaacatg aaagctggct ccttcatcgg
      901 actctgaaaa ccagctttga ttatctgcaa gaggtgcccg tcctcacact ggatgttaat
      961 gaagacttta aagacaaaca cgaaagcctg gttgaaaagg tcaaagaatt tctgagtact
     1021 ttgtgattgt acaggagcca gcggcaatag aacgtttccg gatacttcct gcagttttgt
     1081 gtactgccat tgcttgatat tcatacaaaa gtctttacaa gtgtcaagtt tttaaaccag
     1141 ttttgtttta aggaaagccc ttttctttat gtatacatat atatatagtt tatttaatat
     1201 ttgcaatcat atgtaaaact tgtgtccctc ccggtcttcc ttccacagtt ttaaataaac
     1261 caggtgtgaa tctcttacag cagggagtct ggaggtagat ttttcttagc atcagggcag
     1321 tgagtggata aactgttcta acaggccagc cttctctgcc ttctcacttg tcatcctgag
     1381 tgggttaaca tgttttcatt gtgtctttgc ttcagaggtt gaccaatttc gtcccgggac
     1441 acttgaccat tccgtgtaga ggatgtgtgt cttctgtgag ttggtatact taggacaggc
     1501 tgagaagtgg ggagtccctg ggagagggat gctgaagtgt ttgcttggtt tccttcctgg
     1561 tccctttggt agtgttggag attgaagcca gggtctctcg agctggggaa cctctacaga
     1621 actgtcccca gcccttttgt tctaatcaag tgcctctcct gctctactta gtgttgataa
     1681 gaccatgtta gcgtcaccac agtaatgttt actactgtgt ccgtgctgtg tttgtagagg
     1741 aggaggctaa actcttccca gtttggtaat ggtataatta cttcataaat cttttcatct
     1801 ttaatctgtc tgggataaga actctgtatt tatgtgaaat tttggaccag aagaaatctt
     1861 taagaggtag ctaagaagtt tattacatga gtataaagct tcattaagat agctactgct
     1921 tttctcggac tactgcagtt aaaatgcttg tttatgtttc tttttttaag acagggtctc
     1981 tctacatacc cctagctgtc ctggaactca ccatgtaggc cattctggcc tggccttgaa
     2041 ctcacagaga tccacccacc tctgcctccc tccccactcc cactgctcag ataaggtgtg
     2101 cagcatcacg cctgactcgg aggtttttga aatcacttga agtgcaagta cagatttttc
     2161 catttttctt ttagtttcct aactaaattt cttttagttt tcatgtaaaa tgaggataga
     2221 acatgccaag gttttccatt tttccccatg ggccctgagt tgataatgag tggtctctct
     2281 ttagctttgt atgaggtgag acactgagaa gcctaggcgg gctgttcagc cccgcccagc
     2341 cccgcctcca tcacctggca gacactctcc cttttctgtc tgaagttaga aggcagtctg
     2401 ctgacttggg atttaagtca catttctgct gagagtgctg tggtcacact gtgcttcata
     2461 gtttgcttgc tttgtagaat gtttcttaac gtttttgtag ttaaatacaa attcctgata
     2521 aaacattttt tcattgcata tattgtatca tgggaatgtt acaattttgt tgaactagga
     2581 aataaaatta acaaatacca ggaggctcaa agcccccatt aataatgccc gtttctctag
     2641 acagctttca tatttagttg taaagtaagc ttatatataa ttaacaacgt tttgtttttt
     2701 aattattgtt ttttgtctgc tgttgttttt aaagttaaaa tgtatattgt ttttaccaag
     2761 tagttgacct ttctaattca tattaggaaa aatgtataat ttcttgaaac aaagaattac
     2821 atttgttttg aaactataat tattctttct aaaatattac cttttatttt tggtttctta
     2881 ttcaaagatg ataattgagt ggattagcac ggatctttga aaagatgatt gaatttcaag
     2941 tctgtaataa ccatagcttg ttttgtgata ttgttttttt gttgttgttg ttgtttgata
     3001 taaataaatt tacgaactta aatatatatg tcaataaatg aatttaaatt tcttgaa
//
