LOCUS       NM_001162943           10651 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus dachsous cadherin related 1 (Dchs1), mRNA.
ACCESSION   NM_001162943 XM_194371 XM_982545
VERSION     NM_001162943.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 10651)
  AUTHORS   Miyasaka,Y., Kobayashi,T., Gotoh,N., Kuga,M., Kobayashi,M.,
            Horio,F., Hashimoto,K., Kawabe,T. and Ohno,T.
  TITLE     Neonatal lethality of mouse A/J-7SM consomic strain is caused by an
            insertion mutation in the Dchs1 gene
  JOURNAL   Mamm Genome 34 (1), 32-43 (2023)
   PUBMED   36434174
  REMARK    GeneRIF: Neonatal lethality of mouse A/J-7[SM] consomic strain is
            caused by an insertion mutation in the Dchs1 gene.
REFERENCE   2  (bases 1 to 10651)
  AUTHORS   Sai,X., Ikawa,Y., Nishimura,H., Mizuno,K., Kajikawa,E., Katoh,T.A.,
            Kimura,T., Shiratori,H., Takaoka,K., Hamada,H. and Minegishi,K.
  TITLE     Planar cell polarity-dependent asymmetric organization of
            microtubules for polarized positioning of the basal body in node
            cells
  JOURNAL   Development 149 (9) (2022)
   PUBMED   35420656
REFERENCE   3  (bases 1 to 10651)
  AUTHORS   Moore,K.S., Moore,R., Fulmer,D.B., Guo,L., Gensemer,C.,
            Stairley,R., Glover,J., Beck,T.C., Morningstar,J.E., Biggs,R.,
            Muhkerjee,R., Awgulewitsch,A. and Norris,R.A.
  TITLE     DCHS1, Lix1L, and the Septin Cytoskeleton: Molecular and
            Developmental Etiology of Mitral Valve Prolapse
  JOURNAL   J Cardiovasc Dev Dis 9 (2), 62 (2022)
   PUBMED   35200715
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 10651)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 10651)
  AUTHORS   Lodge,E.J., Xekouki,P., Silva,T.S., Kochi,C., Longui,C.A.,
            Faucz,F.R., Santambrogio,A., Mills,J.L., Pankratz,N., Lane,J.,
            Sosnowska,D., Hodgson,T., Patist,A.L., Francis-West,P.,
            Helmbacher,F., Stratakis,C. and Andoniadou,C.L.
  TITLE     Requirement of FAT and DCHS protocadherins during
            hypothalamic-pituitary development
  JOURNAL   JCI Insight 5 (23), 134310 (2020)
   PUBMED   33108146
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 10651)
  AUTHORS   Cappello,S., Gray,M.J., Badouel,C., Lange,S., Einsiedler,M.,
            Srour,M., Chitayat,D., Hamdan,F.F., Jenkins,Z.A., Morgan,T.,
            Preitner,N., Uster,T., Thomas,J., Shannon,P., Morrison,V., Di
            Donato,N., Van Maldergem,L., Neuhann,T., Newbury-Ecob,R.,
            Swinkells,M., Terhal,P., Wilson,L.C., Zwijnenburg,P.J.,
            Sutherland-Smith,A.J., Black,M.A., Markie,D., Michaud,J.L.,
            Simpson,M.A., Mansour,S., McNeill,H., Gotz,M. and Robertson,S.P.
  TITLE     Mutations in genes encoding the cadherin receptor-ligand pair DCHS1
            and FAT4 disrupt cerebral cortical development
  JOURNAL   Nat Genet 45 (11), 1300-1308 (2013)
   PUBMED   24056717
REFERENCE   7  (bases 1 to 10651)
  AUTHORS   Mao,Y., Mulvaney,J., Zakaria,S., Yu,T., Morgan,K.M., Allen,S.,
            Basson,M.A., Francis-West,P. and Irvine,K.D.
  TITLE     Characterization of a Dchs1 mutant mouse reveals requirements for
            Dchs1-Fat4 signaling during mammalian development
  JOURNAL   Development 138 (5), 947-957 (2011)
   PUBMED   21303848
  REMARK    GeneRIF: Dchs1 and Fat4 function as a ligand-receptor pair during
            murine development, and novel requirements for Dchs1-Fat4 signaling
            in multiple organs are identified
REFERENCE   8  (bases 1 to 10651)
  AUTHORS   Ishiuchi,T., Misaki,K., Yonemura,S., Takeichi,M. and Tanoue,T.
  TITLE     Mammalian Fat and Dachsous cadherins regulate apical membrane
            organization in the embryonic cerebral cortex
  JOURNAL   J Cell Biol 185 (6), 959-967 (2009)
   PUBMED   19506035
  REMARK    GeneRIF: Results highlight the importance of the
            Fat4-Dachsous1-Pals1 complex in organizing the apical membrane
            architecture of neural progenitor cells.
REFERENCE   9  (bases 1 to 10651)
  AUTHORS   Rock,R., Schrauth,S. and Gessler,M.
  TITLE     Expression of mouse dchs1, fjx1, and fat-j suggests conservation of
            the planar cell polarity pathway identified in Drosophila
  JOURNAL   Dev Dyn 234 (3), 747-755 (2005)
   PUBMED   16059920
  REMARK    GeneRIF: data are compatible with conservation and
            sub-functionalization of dachsous 1, Fj, and Fat signaling in
            higher vertebrates
REFERENCE   10 (bases 1 to 10651)
  AUTHORS   Lee,N.V., Rodriguez-Manzaneque,J.C., Thai,S.N., Twal,W.O.,
            Luque,A., Lyons,K.M., Argraves,W.S. and Iruela-Arispe,M.L.
  TITLE     Fibulin-1 acts as a cofactor for the matrix metalloprotease
            ADAMTS-1
  JOURNAL   J Biol Chem 280 (41), 34796-34804 (2005)
   PUBMED   16061471
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121823.3.
            
            On or before Jul 2, 2009 this sequence version replaced
            XM_982545.1, XM_194371.8.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN01164137,
                              SAMN01164138 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-192               AC121823.3         79018-79209
            193-2085            AC121823.3         93243-95135
            2086-2274           AC121823.3         100280-100468
            2275-2506           AC121823.3         100561-100792
            2507-2743           AC121823.3         100935-101171
            2744-3769           AC121823.3         101399-102424
            3770-3963           AC121823.3         102622-102815
            3964-4060           AC121823.3         103034-103130
            4061-4218           AC121823.3         103233-103390
            4219-5080           AC121823.3         103573-104434
            5081-5320           AC121823.3         104526-104765
            5321-5446           AC121823.3         104888-105013
            5447-5656           AC121823.3         105545-105754
            5657-6535           AC121823.3         107295-108173
            6536-6649           AC121823.3         108292-108405
            6650-6861           AC121823.3         108527-108738
            6862-7016           AC121823.3         108827-108981
            7017-7147           AC121823.3         109172-109302
            7148-7431           AC121823.3         109386-109669
            7432-7570           AC121823.3         110018-110156
            7571-10651          AC121823.3         110499-113579
FEATURES             Location/Qualifiers
     source          1..10651
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 55.98 cM"
     gene            1..10651
                     /gene="Dchs1"
                     /gene_synonym="3110041P15Rik; C130033F22Rik; CDH25; FIB1;
                     Gm165; PCDH16"
                     /note="dachsous cadherin related 1"
                     /db_xref="GeneID:233651"
                     /db_xref="MGI:MGI:2685011"
     exon            1..192
                     /gene="Dchs1"
                     /gene_synonym="3110041P15Rik; C130033F22Rik; CDH25; FIB1;
                     Gm165; PCDH16"
                     /inference="alignment:Splign:2.1.0"
     exon            193..2085
                     /gene="Dchs1"
                     /gene_synonym="3110041P15Rik; C130033F22Rik; CDH25; FIB1;
                     Gm165; PCDH16"
                     /inference="alignment:Splign:2.1.0"
     CDS             307..10182
                     /gene="Dchs1"
                     /gene_synonym="3110041P15Rik; C130033F22Rik; CDH25; FIB1;
                     Gm165; PCDH16"
                     /note="protein Dchs1; protein dachsous homolog 1;
                     protocadherin-16; dachsous 1"
                     /codon_start=1
                     /product="protocadherin-16 precursor"
                     /protein_id="NP_001156415.1"
                     /db_xref="CCDS:CCDS52351.1"
                     /db_xref="GeneID:233651"
                     /db_xref="MGI:MGI:2685011"
                     /translation="MQKELSVALSCPGMKSLRTLLPLLVLLGATVPGSWGQAGSLDLQ
                     IDEEQPAGTLIGDISAGLPPGTAPPPMYFISAQEGSGVGTDLAIDEHSGVVRTARVLD
                     RERRDRYRFTAVTPDGATVEVTVRVADINDHAPAFPQARAALQIPEHTALGTRYPLEP
                     ARDADAGRLGTQGYALSGDGAGETFRLETRPGPGGAPVPELVIAGELDRENRSHYMLQ
                     LEAYDGGSPPRRAQALLDVTLLDINDHAPAFNQSRYHAVVSESLAPGSPVLQVFASDA
                     DAGANGAVTYEINRRQSEGDGPFSIDAHTGFLRLERPLDFEQRRVHELVVQARDGGAH
                     PELGSAFVTVHVRDANDNQPSMTVIFLSADGSPRVSEAAPPGQLVARISVSDPDDGDF
                     AHVNVSLEGGEGHFALSTQDSVIYLVCVARRLDREERDVYNLRVTATDSGSPPLRAEA
                     AFVLHVTDVNDNAPAFDRQLYRPEPLPEVALPGSFVVRVTARDPDQGTNGQITYSLAP
                     GTHTHWFSIDPTSGIITTAATLDYELEPQPQLIVVATDGGLPPLVSSATVSVALQDVN
                     DNEPQFQRTFYNASLPEGTQPGTCFLQVTATDADSGPFGLLSYSLGAGLGASGSPPFR
                     IDAHSGDVCTTRTLDRDQGPSSFDFTVTAIDGGGLKSMVYVKVFVADENDNPPQFYPR
                     EYAASLSAQSTPGTAVLRVHAHDPDQGPHGRLSYHILAGNSPPLFALDAHSGLLTVAW
                     PLGRRANSVVQLEIGAQDGGGLQAEPIARVNISIVPGTPTPPIFEQLQYVFSVPEDVA
                     PGTSVGIIQAHNPPGRLGPVTLTLSGGDPRGLFSLDSPSGLLKTLRPLDRELLGPVLE
                     LEVRAGSGTPPVFAVARIRVLLDDVNDNSPAFPAPEDTVLLPQNTAPGTPIYTLRALD
                     PDSGANSRITFNLLAGGDGLFTVDPTTGHVRLMGPLGPPGGPAHELEVEARDGGSPPR
                     TSHFRLRVVIQDLGIHGLAPRFDSPTYRVDLPSGTTTGTQILQVQAQAPDGSPVTYHL
                     AADGASSPFGLESQSGWLWVRTALDRESQELYTLKVMAVSGSKAELGQQTGTATVRVI
                     ILNQNDHSPRLSEEPTFLAVAENQPPGTSVGRVFATDRDSGPNGRLTYSLQQLSEDSK
                     AFRIHPQTGEVTTLQTLDREQQSSFQLLVQVQDGGSPPRSATGTVHVAVLDLNDNSPT
                     FLQASGAAGGGLPIQVPDRVPPGTLVTTLQAKDPDEGENGTILYTLTGPGSELFSLHP
                     HTGELHTAASLVRAERPHYVLTLSAHDQGSPPRSASLQLLVQVLPSTRVVESPDLIEA
                     DSAATVPVVLTVTAAEGLRPGSLLGSVAPQEPASVGVLTYTLVGGADPEGTFALDSAS
                     GRLYLARPLDFEAGPAWRALTVRAEGPGGAGARLLRVQVRVQDENEHAPTFARDPLAL
                     ALPENPDPGATLYTFRASDADGPGPNSEVRYRLLRQEPPVPALRLDARTGALSAPRGL
                     DRETTPALLLLVEATDRPANASRRRAARVSARVFVTDENDNAPVFASPSRVRLPEDQP
                     PGPAALHVVARDPDLGEAARVSYRLAAGGDGHFRLHATTGALSVVRPLDREQRAEHVL
                     TVVALDHGSPPRSSTQLLTVSVVDVNDEAPAFPQQEYNVILRENSPPGTSLLTLKATD
                     PDLGANGQVTYGGVSGESFSLDPNTGVLTTLRALDREEQEEIYLTVYARDRGLPPLLT
                     HITVRVTVEDENDHTPTFGNTHLSLEVPEGQDPQTLTTLRASDPDGGLNGQLQYRILD
                     GDSSGAFALDLTSGEFGTMRPLDREVEPAFQLQIEARDGGQPALSATLLVTVTVLDAN
                     DHAPVFPVPSYSVEVPEDAPVGTLLLQLQAHDPDDGDNGRVMYYLGAGTAGAFLLEPT
                     SGELSTATALDREHCASYAFSVTAVDGAAAGPLSTTVPITITVRDVNDHAPAFPTSPL
                     RLRLPRPGPSLNKPTLALATLRAEDRDAGANASILYRLAGTPPPGTTVDSYTGEIRVA
                     RSPVALGPQDRVLFIVATDLGRPARSATGVVVVGIQGEPERGPRFPRTSSEAVLRENA
                     PPGTPVISPKAVHSGGSNGPITYSILSGNERGIFSIQPSTGAITVRSAEGLDFETSPR
                     LRLVLQAESGGAFAFSVLTLTLQDANDNAPRFLRPHYVAFLPESRPLEGPLLQVEADD
                     LDQGSGGQISYSLAASQPARGLFHVDPATGTITTTAILDREIWAETRLVLMATDRGSP
                     ALVGSATLTVMVIDTNDNRPTIPQPWELRVSEDALLGSEIAQVTGNDVDSGPVLWYVL
                     SPSGPQDPFSIGRYGGRVSLTGPLDFEQCDHYHLQLLAHDGPHEGHANLTVLVEDVND
                     NVPTFSQSLYQVMMLEHTPPGSAILSVSATDRDSGANGHISYHLASPAEGFRVDPNNG
                     TLFTTVGAMALGHEGPGVVDVVLEARDHGAPGRTAQATVHVQLKDQNDHAPSFTLPHY
                     RVAVSEDLPPGSTLLTLEATDADGSRTHATVDYSIISGNRGRVFQLEPRLAEVGDGVG
                     PGPQALGCLVLLEPLDFESLTQYNLTVAAADRGQPPRSSAVPVTVTVLDVNDNPPVFT
                     RASYRVTVPEDMPVGAELLHVEASDADPGPHGLVHFTLSSGDPLGLFELDENSGALRL
                     SRPLDCETQAQHQLVVQAADPAGTHFSLVPVTVEVQDVNDHGPAFPLSLLSTSLAENQ
                     PPGTLVTTLHAIDGDAGTFGRLRYSLLEAVPGPEGREAFSLNSSTGELRARVPFDYEH
                     TGSFRLLVGAADAGNLSASVTVSVLITGEDEYDPVFLAPSFHFQVPEGAQRGHSLGHV
                     QATDEDGGADGLVLYSLATSSPYFGINQTTGALYLRVDSRAPGSGTTTSGGGGRTRRE
                     APRELRLEVVARGPLPGSRSATVPVTVDITHTALGLAPDLNLLLVGAVAASLGVVVVL
                     ALAALVLGLVRARSRKAEAAPGPMSQTAPIASSSLQKLGREPPSPPPSEHLYHQTLPS
                     YGGPGAGGPYPRGGSLDPSHSSGRGSAEAAEDDEIRMINEFPRVASVASSLAARGPDS
                     GIQQDADGLSDTSCEPPAPDTWYKGRKAGLLLPGAGATLYREEGPPATATAFLGGCGL
                     SPAPAGDYGFPADGKPCVAGALTAIVAGEEELRGSYNWDYLLSWCPQFQPLASVFTEI
                     ARLKDEARPCPPAPRIDPPPLITAVAHPGAKSVPPKPASTAVARAIFPPASHRSPISH
                     EGSLSSAAMSPSFSPSLSPLAARSPVVSPFGVAQGPSASALSTESGLEPPDDTELRI"
     exon            2086..2274
                     /gene="Dchs1"
                     /gene_synonym="3110041P15Rik; C130033F22Rik; CDH25; FIB1;
                     Gm165; PCDH16"
                     /inference="alignment:Splign:2.1.0"
     exon            2275..2506
                     /gene="Dchs1"
                     /gene_synonym="3110041P15Rik; C130033F22Rik; CDH25; FIB1;
                     Gm165; PCDH16"
                     /inference="alignment:Splign:2.1.0"
     exon            2507..2743
                     /gene="Dchs1"
                     /gene_synonym="3110041P15Rik; C130033F22Rik; CDH25; FIB1;
                     Gm165; PCDH16"
                     /inference="alignment:Splign:2.1.0"
     exon            2744..3769
                     /gene="Dchs1"
                     /gene_synonym="3110041P15Rik; C130033F22Rik; CDH25; FIB1;
                     Gm165; PCDH16"
                     /inference="alignment:Splign:2.1.0"
     exon            3770..3963
                     /gene="Dchs1"
                     /gene_synonym="3110041P15Rik; C130033F22Rik; CDH25; FIB1;
                     Gm165; PCDH16"
                     /inference="alignment:Splign:2.1.0"
     exon            3964..4060
                     /gene="Dchs1"
                     /gene_synonym="3110041P15Rik; C130033F22Rik; CDH25; FIB1;
                     Gm165; PCDH16"
                     /inference="alignment:Splign:2.1.0"
     exon            4061..4218
                     /gene="Dchs1"
                     /gene_synonym="3110041P15Rik; C130033F22Rik; CDH25; FIB1;
                     Gm165; PCDH16"
                     /inference="alignment:Splign:2.1.0"
     exon            4219..5080
                     /gene="Dchs1"
                     /gene_synonym="3110041P15Rik; C130033F22Rik; CDH25; FIB1;
                     Gm165; PCDH16"
                     /inference="alignment:Splign:2.1.0"
     exon            5081..5320
                     /gene="Dchs1"
                     /gene_synonym="3110041P15Rik; C130033F22Rik; CDH25; FIB1;
                     Gm165; PCDH16"
                     /inference="alignment:Splign:2.1.0"
     exon            5321..5446
                     /gene="Dchs1"
                     /gene_synonym="3110041P15Rik; C130033F22Rik; CDH25; FIB1;
                     Gm165; PCDH16"
                     /inference="alignment:Splign:2.1.0"
     exon            5447..5656
                     /gene="Dchs1"
                     /gene_synonym="3110041P15Rik; C130033F22Rik; CDH25; FIB1;
                     Gm165; PCDH16"
                     /inference="alignment:Splign:2.1.0"
     exon            5657..6535
                     /gene="Dchs1"
                     /gene_synonym="3110041P15Rik; C130033F22Rik; CDH25; FIB1;
                     Gm165; PCDH16"
                     /inference="alignment:Splign:2.1.0"
     exon            6536..6649
                     /gene="Dchs1"
                     /gene_synonym="3110041P15Rik; C130033F22Rik; CDH25; FIB1;
                     Gm165; PCDH16"
                     /inference="alignment:Splign:2.1.0"
     exon            6650..6861
                     /gene="Dchs1"
                     /gene_synonym="3110041P15Rik; C130033F22Rik; CDH25; FIB1;
                     Gm165; PCDH16"
                     /inference="alignment:Splign:2.1.0"
     exon            6862..7016
                     /gene="Dchs1"
                     /gene_synonym="3110041P15Rik; C130033F22Rik; CDH25; FIB1;
                     Gm165; PCDH16"
                     /inference="alignment:Splign:2.1.0"
     exon            7017..7147
                     /gene="Dchs1"
                     /gene_synonym="3110041P15Rik; C130033F22Rik; CDH25; FIB1;
                     Gm165; PCDH16"
                     /inference="alignment:Splign:2.1.0"
     exon            7148..7431
                     /gene="Dchs1"
                     /gene_synonym="3110041P15Rik; C130033F22Rik; CDH25; FIB1;
                     Gm165; PCDH16"
                     /inference="alignment:Splign:2.1.0"
     exon            7432..7570
                     /gene="Dchs1"
                     /gene_synonym="3110041P15Rik; C130033F22Rik; CDH25; FIB1;
                     Gm165; PCDH16"
                     /inference="alignment:Splign:2.1.0"
     exon            7571..10651
                     /gene="Dchs1"
                     /gene_synonym="3110041P15Rik; C130033F22Rik; CDH25; FIB1;
                     Gm165; PCDH16"
                     /inference="alignment:Splign:2.1.0"
     regulatory      10629..10634
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dchs1"
                     /gene_synonym="3110041P15Rik; C130033F22Rik; CDH25; FIB1;
                     Gm165; PCDH16"
                     /note="hexamer: AATAAA"
     polyA_site      10650
                     /gene="Dchs1"
                     /gene_synonym="3110041P15Rik; C130033F22Rik; CDH25; FIB1;
                     Gm165; PCDH16"
                     /note="major polyA site"
ORIGIN      
        1 agacggacgg accgaccgac ggtcgagcga gcgcagacag acggcggccc gcgccgaggg
       61 cactgtgagc ccgagccagt caaagcggac gatgcgcggc cccaggcccc gcactggcgg
      121 gcgctgcccc gggggctgac cgcggccgga ctgcgcccca acactgggcg agggagcccg
      181 caccgcatcg aggtcaggga gcctgaactg cagctaaagc ccaagttgga tccgatccaa
      241 accctgaaat caagctgggc taagagtctg gtgtggagct ggagcttcag ctggactggc
      301 cctgccatgc agaaggagct gagtgtcgca ctttcctgcc ctggcatgaa gagcctcagg
      361 actctattac cattgctggt gctgttaggg gctacagtgc caggaagctg gggtcaggct
      421 gggagcctgg acctacagat cgacgaggaa caaccagcag gcacgctgat tggagacatc
      481 agtgcagggc ttccaccagg cacagcgcct cctcccatgt acttcatctc tgcccaggaa
      541 ggcagtggcg taggcacaga ccttgctatt gatgagcaca gtggagtggt ccgtacagct
      601 cgggtcctag accgtgagcg gagagaccgt taccgcttca ctgcagtcac tcctgatggg
      661 gccaccgtgg aagttacagt gagagtagct gatatcaatg accacgcacc agctttccct
      721 caggctcggg cagccctgca gatacctgag catacagctc ttggtacacg ttacccactg
      781 gagcctgctc gtgatgcaga tgccggccgc ctaggaaccc aagggtatgc gctatctggt
      841 gatggggctg gagagacctt tcggctggag acacgtcctg gtcctggtgg agctccagta
      901 cctgagctgg tgattgccgg agaactggac cgggagaacc gctcacacta catgttgcag
      961 ctcgaagcct acgatggtgg ctcacctccg cggagagcac aggccctgct agatgtgaca
     1021 cttctggaca tcaatgacca tgccccagct ttcaatcaaa gccgatacca tgctgtggta
     1081 tctgagagtc tggcccctgg aagtcctgtt ttgcaggtgt ttgcatctga tgctgatgct
     1141 ggtgccaacg gagctgtgac ttatgagatc aacaggagac agagtgaagg tgatggaccc
     1201 ttctccattg atgcacacac agggtttctg aggctggagc gcccactgga ctttgaacaa
     1261 aggcgagttc atgaactggt ggtacaggca cgggatggtg gggctcaccc agagctgggt
     1321 tcagcttttg tgacagtgca tgtgcgagat gcaaatgaca atcagccgtc catgactgtc
     1381 atcttcctga gtgctgatgg ctccccccga gtgtctgagg ctgccccacc tggacagctt
     1441 gttgctcgaa tctctgtgtc agatccagat gatggtgact tcgcccacgt caatgtgtcc
     1501 ctggaaggtg gagagggcca ctttgctctg agcacccaag acagtgtcat ctatctggtg
     1561 tgtgtggctc gaaggctgga tcgggaggag agagatgtct ataacttgcg agtcacagcc
     1621 acggactcag gctcaccccc acttagggcc gaagctgctt ttgtgctaca tgtcactgat
     1681 gtcaatgaca acgcacctgc ttttgaccgc cagctctacc gacctgagcc tctgcctgaa
     1741 gttgcattgc ctggcagctt cgtggtacgg gtgactgccc gggatcctga ccaaggcacc
     1801 aatggtcaga tcacctacag cctggctcct ggcactcaca ctcactggtt ctccattgat
     1861 cccacttcag gcatcatcac cacagctgcc acactggact atgaactaga gcctcagcca
     1921 cagcttattg tggtggccac agatgggggc ctgcctcctt tagtctcctc ggccacagtt
     1981 agtgtggcct tacaagacgt gaatgacaat gagccccagt tccagaggac tttctacaat
     2041 gcctcgctgc ctgaaggtac ccagcctgga acctgtttcc tgcaggtaac agccacagat
     2101 gctgacagtg gcccatttgg cctcctctcc tattccttgg gtgctgggct tggagcttct
     2161 ggatcccccc cattccgcat tgatgcccac agtggtgatg tgtgtaccac ccggaccctg
     2221 gaccgtgatc agggaccttc aagctttgac ttcacggtga cagctatcga tgggggaggc
     2281 ctcaagtcca tggtgtacgt gaaggtattt gtggcagatg agaatgacaa cccacctcag
     2341 ttttatccac gggagtatgc tgccagtctg agtgctcaga gtacaccagg cacagctgtg
     2401 ctgagggtgc atgcccatga ccctgaccag ggaccccatg ggcgactttc ctaccatatc
     2461 ctggctggca acagtccccc actctttgca ttggatgcac actcagggct gttgacagta
     2521 gcctggccct taggcagacg ggctaattct gtggtgcagc tggagatcgg ggctcaggat
     2581 ggaggtggtc tacaagcaga acccattgcc cgagtcaaca tcagcattgt gcctgggacc
     2641 cccacaccac ctatatttga gcaactacag tatgtttttt cagtgccaga agatgtggca
     2701 cccggcacca gtgtgggcat aatccaggca cacaacccac caggtcgctt agggcctgtg
     2761 accctcaccc tatcaggtgg ggacccccga gggctcttct ccctagattc accctcaggg
     2821 ctattaaaaa cacttcgccc tctggaccgg gagctcctgg gacctgtcct agagctagaa
     2881 gttcgagcag gcagtggaac cccaccagtg tttgctgtgg ctcggatccg cgtgctgctg
     2941 gatgatgtga atgataattc tcctgccttc cctgcacctg aagacactgt actgttgcca
     3001 caaaacactg ctccagggac tcccatctat acactgcgcg ctctagaccc tgactcagga
     3061 gctaacagta gaatcacctt taatctactt gctgggggtg atggattgtt cactgtggat
     3121 cccaccacag gccacgtccg gctcatggga cctctggggc ctccaggggg accagcccat
     3181 gagttggagg tggaggcccg ggatggaggc tccccaccac gcaccagcca tttccgactt
     3241 cgtgtggtga tacaggattt gggaatccat gggctggctc cacgatttga tagccctacc
     3301 taccgtgtgg acttaccctc gggcactacc accggaactc agatcttgca agtgcaggcc
     3361 caggcaccag atgggagccc tgtcacttac catcttgcag cagatggtgc cagtagcccc
     3421 tttggcctgg agtcacagag tgggtggctg tgggtacgga cagcactaga ccgtgagtcc
     3481 caggagttat acacattgaa ggtgatggct gtatccggtt ccaaagctga attggggcaa
     3541 cagacaggca cagccacagt gagggtcatt atcctcaacc aaaatgacca cagtccccgc
     3601 ttgtctgaag agcccacctt tctggctgta gcagagaatc aacccccagg gaccagtgta
     3661 ggccgagtct ttgccactga cagagactca ggtcctaatg gacgtctgac ctacagcctt
     3721 caacagcttt cagaagacag caaggccttc cgcatccacc cccagactgg agaagtgact
     3781 acactccaaa ccctggaccg agagcagcag agcagtttcc agctcctggt gcaagtgcag
     3841 gatgggggta gtccacctcg cagtgccaca ggcactgtgc atgtcgctgt gctcgatctt
     3901 aatgacaaca gtcccacctt cctgcaggct tcaggggctg ctggtggggg cctccctata
     3961 caggtaccag atcgagtgcc tccaggaaca ctggtgacaa ctctacaggc caaagatcca
     4021 gatgaggggg agaatggaac catcctatac accctaactg gtcctggctc tgagctcttc
     4081 tctctgcatc ctcacaccgg ggagctgcac acagcagcat ccctggttag agctgagcgg
     4141 cctcactatg tactaactct aagtgctcac gaccagggca gcccccctcg aagtgccagc
     4201 ctccaactgc tcgtgcaggt acttccctcg actcgggtgg tggagtcacc agatctcata
     4261 gaagctgact cagcggcaac agtgcctgta gtacttacgg tgacagcagc tgagggcctt
     4321 cgacctggat ccctgttggg ttcggtggcc ccgcaggagc cagctagtgt gggcgtactc
     4381 acctatactc tggttggtgg cgcggacccc gagggcacct tcgcgctgga ctcagcctcc
     4441 ggtcgcctgt acttggcgcg tcccttggac ttcgaggctg ggccagcctg gcgcgcgctc
     4501 accgtgcgcg ccgaggggcc gggaggcgca ggcgcgcggc tgttgagagt gcaggtgcgt
     4561 gtgcaggacg agaacgagca cgcgccaact tttgcgcgcg accccctggc actggcgcta
     4621 cctgagaacc ccgaccccgg tgccacgcta tacactttcc gcgcatcaga cgccgatggc
     4681 ccaggtccca acagtgaggt gcgataccgc ctgctgaggc aggagccccc ggtgcccgcc
     4741 ctgcgcttgg acgcgcgcac cggggcgctc agcgctcctc gtggtctgga tcgagagacc
     4801 acacctgcgc tgttactgct cgtggaagcc accgaccggc cagccaatgc cagccgccgc
     4861 agggcagcgc gcgtttcagc gcgcgtcttt gtcacagatg aaaatgacaa cgccccggtc
     4921 ttcgcctccc catcacgggt gcgcctccca gaggatcagc cccctgggcc cgcagcactg
     4981 cacgtggtag ctcgggatcc agacctgggg gaggctgccc gcgtgtccta tcgccttgcg
     5041 gctggagggg acggccactt ccggctacac gcgaccactg gagcgctgtc cgtggtgcgg
     5101 cctttggacc gtgaacagcg agctgagcat gtactgacag tggtggcctt ggaccatggc
     5161 tcccctccac gttcatccac tcagctcctg actgtcagtg ttgttgacgt caacgacgag
     5221 gcaccggctt tccctcagca ggagtacaat gtcatccttc gtgagaacag tccccctggc
     5281 acttctctgc tcactctgaa ggcaactgac cctgaccttg gggccaatgg gcaagtgact
     5341 tatgggggtg tctctggcga gagcttctct ctggacccaa acactggagt tctcacgact
     5401 ctgagggctc tggaccggga ggagcaggag gagatctatt tgacagtata tgctcgggat
     5461 aggggcttgc cacccctgtt aacgcacatc acagtgagag tgactgtgga agatgaaaat
     5521 gaccatactc caacttttgg gaacacccac ctctccctgg aagtgcctga aggccaggac
     5581 ccccaaaccc taaccacact aagagcctct gatccagatg ggggactcaa tggacagcta
     5641 cagtaccgca tccttgatgg ggactcttca ggagcctttg cactagatct cacttctggg
     5701 gagtttggca ccatgaggcc actagaccgg gaggtagagc cagcattcca gctgcagata
     5761 gaggccagag atggaggcca gccagccctc agtgccacct tgcttgtgac agtgacagtg
     5821 ctggatgcca atgaccatgc accagtcttt cctgtgcctt cttattctgt ggaggtgcct
     5881 gaggatgcac ctgtagggac cctactgctg cagctacagg ctcatgaccc agatgatggg
     5941 gacaatggcc gtgtgatgta ctacctgggt gcaggtacag cgggggcctt cctgttggag
     6001 cctacctctg gggaactgag cacagctaca gccttggaca gagaacactg tgccagctat
     6061 gccttttctg tgaccgcagt ggatggtgca gctgctgggc ctctgagcac cacagtacca
     6121 atcaccatca cagtgcgtga cgtcaatgat catgcacccg ctttccccac gagtcctctc
     6181 cgcctccgcc taccccgccc aggtcctagc ctcaacaaac caaccctggc tctggccacg
     6241 cttcgagctg aagatcgaga tgctggtgcc aatgcctcca ttctataccg gctggcaggc
     6301 acaccaccac ctggcaccac tgtggactct tacactggtg aaattcgtgt ggctcgatcc
     6361 cccgtggctc ttggacccca ggatcgtgtc ctcttcattg tagctactga ccttggacgc
     6421 ccagctcgct ccgccactgg tgtggtcgtt gttggaatac agggagagcc tgagcgtgga
     6481 ccccgctttc ccagaactag tagtgaggct gtgctccgtg aaaatgcacc accagggact
     6541 ccagttatct ccccaaaggc tgtccattca ggaggttcaa atggaccaat tacttatagc
     6601 attctcagtg ggaatgagag agggatattc tccatccaac ctagcacagg agccatcaca
     6661 gttcgctcag cagagggtct tgactttgaa acaagcccac ggctgcggct ggtgctacag
     6721 gcagagagtg gaggagcctt tgctttctca gtgctgaccc tgacccttca agatgccaat
     6781 gacaacgctc cccgtttcct gcggcctcac tatgtggctt tcctgccaga gtcccgaccc
     6841 ttggaagggc ccctgctgca ggtggaagcc gatgacctgg accaaggctc tggaggacag
     6901 atttcctaca gtctggctgc atcccagcca gcacggggct tgttccatgt agacccagcc
     6961 acaggcacta tcactaccac agccatcctg gaccgggaaa tctgggcaga aacacggctg
     7021 gtactgatgg ccacagacag aggaagccca gcactggtgg gctcagctac cctgacagtg
     7081 atggtcatcg ataccaatga caatcgtccc accatccccc agccctggga gctccgagta
     7141 tcagaagatg cactgttggg ctcagagatc gcacaggtga ctgggaatga cgtggactct
     7201 ggaccagtgc tatggtatgt gctgagccca tcggggcctc aggatccctt cagtattggc
     7261 cggtatggag gacgtgtctc cctcacgggc cccctggact ttgagcagtg tgaccactac
     7321 cacctacagc tgctggcaca tgatgggcct catgagggcc atgccaacct cacagtgctt
     7381 gtggaagatg tcaatgacaa tgtacctacc ttctcacaaa gcctctacca ggtaatgatg
     7441 ttggagcaca cccctccggg cagcgccatt ctctccgtct ctgccaccga cagagactcg
     7501 ggtgccaatg gtcacatatc ttaccatctg gcttcccctg ctgagggctt ccgtgtcgac
     7561 cctaacaatg gaactctgtt cacaacagta ggagcaatgg ccttgggtca tgaggggcca
     7621 ggagtggtgg atgtggtact ggaagcccga gaccatgggg ctccaggccg gacagcacag
     7681 gccacagtgc atgtgcagct gaaggaccag aatgaccatg ccccaagctt cacattgcca
     7741 cactaccgtg ttgctgtgtc tgaagatttg ccccctggtt ccaccctgct caccctggag
     7801 gccacagatg ctgatggaag ccgcacccat gctactgtgg actacagcat catcagtggc
     7861 aatcggggcc gagttttcca gctggaaccc cgtctggctg aggtcgggga cggtgttggg
     7921 ccaggtcccc aagcactggg ctgcctagtg ttgcttgaac ctctagactt tgaaagcctg
     7981 acacagtaca atttaactgt ggctgcagct gatcggggac agccaccccg cagttcagcc
     8041 gtgccagtga ctgtcactgt gctggatgtc aatgacaacc cacccgtctt tactcgagca
     8101 tcctaccgtg tgacagtacc tgaggacatg cctgttggag ctgagctatt gcatgtggag
     8161 gcctctgatg ctgaccctgg acctcatggt cttgtgcatt tcactcttag ttcaggtgac
     8221 cctttgggtc tctttgagct ggatgagaac tcgggtgcct tgaggctatc ccgccctctg
     8281 gactgtgaaa cccaggctca acaccagctt gtggtgcagg cagctgaccc tgctggaaca
     8341 cacttttctt tggtaccagt gacagttgag gtccaggatg tgaatgacca tggtccggcc
     8401 ttcccattga gtctgctcag tactagcctt gctgagaatc agcctccagg cactcttgtg
     8461 accacactac acgcgattga tggggatgct gggacttttg gtagactccg atatagcctg
     8521 ttggaggcag tgccagggcc tgagggtcgt gaggcatttt ccctgaacag ctcaacaggg
     8581 gaattgcggg cacgggtgcc ttttgactat gagcacacag gaagcttccg tctactagtg
     8641 ggtgctgccg atgctgggaa tctctcagcc tctgtcactg tgtcagtact gattactgga
     8701 gaagatgaat atgaccctgt attcttggct ccatctttcc atttccaagt gccagaaggt
     8761 gcccagcgag gccacagcct gggtcacgtg caggccacag atgaggatgg aggtgccgat
     8821 ggtctggtgc tctactcgct ggctacctct tccccctatt ttggtatcaa ccagacaaca
     8881 ggtgctttgt acttgcgagt ggacagtcgc gcaccaggaa gtggaacaac cacctctggg
     8941 ggtgggggcc ggacccgacg tgaagcacct cgggagttaa ggctggaggt agtagcaaga
     9001 gggcctctgc ctggatcccg gagtgccaca gtacctgtga ctgtggatat tacccacact
     9061 gctctaggcc tggcacctga cctcaacttg ctattggttg gggctgtggc agcctccttg
     9121 ggagttgtgg tggtgcttgc cctggcagct ctggtcctgg gccttgttcg ggcgcgaagc
     9181 cgcaaggctg aggcagcccc tggcccgatg tcacagacag cgccgatagc cagtagctct
     9241 ttacagaaac tgggtcggga accccccagt ccaccaccct ctgaacatct gtatcatcag
     9301 actcttccca gctacggtgg cccaggagct ggaggtccct accctcgtgg cggctccctg
     9361 gacccttcac attcaagtgg cagaggctca gcagaggctg cagaggatga cgagatccgc
     9421 atgatcaacg agtttccccg agtggccagt gtagcctcct ccctggctgc tcgaggccct
     9481 gactctggca tccagcagga tgcggatgga ttgagtgaca cgtcttgtga gcctcctgcc
     9541 cctgacacct ggtacaaggg cagaaaggca gggttgctgc tgccaggcgc aggagccact
     9601 ctgtaccgag aggaggggcc tccagccact gctacagcct tcctgggggg ctgtggcctg
     9661 agccctgcac ccgctgggga ctatggcttc ccagcagacg ggaagccgtg tgtagctgga
     9721 gcactgacgg ccattgtggc tggtgaggaa gagctccgtg gcagctataa ctgggactac
     9781 ctgttgagct ggtgccctca gttccagcct ctggccagtg tcttcacaga gattgctcgg
     9841 ctcaaggatg aagctcgtcc gtgtcctcca gctccccgta ttgacccacc acccctcatc
     9901 actgctgtgg cacacccagg agccaagtct gttcccccaa agcctgcaag cacagctgta
     9961 gcccgggcca tcttcccacc agcctctcac cgctccccta tcagccatga aggctccctc
    10021 tcctcagctg ccatgtcccc cagcttctca ccctcactgt ctcctttggc tgctcgctct
    10081 cccgttgtct caccattcgg ggtagcccag ggcccctcag cttcagcact cagtacagag
    10141 tctggcctgg agcctccgga tgacacagag ctgcgcatct agctgtggcc ctaactgggc
    10201 cccgacctgg gacacgtcca gtgtccccaa agcaggcccc attctcagcc tgccctgggc
    10261 agcctcggac catgactgac tatggggagg ccaccaccag tcccctgctc tccaccttaa
    10321 actcttatag ctgggacagg tcccacattt ctctgcagtt ccttcagcac taggaccaca
    10381 gagggcctgt tggtcatgac ctgtggccag atccagtgtg gagagaaata agaatgaggc
    10441 aacagccttg ggttctcttc agccaagact tcctgccctg caccagcgcc ctgcgatgga
    10501 gctgagactt tatttattgg gggttagggg gatggggagg tccctccaat ctgggcccag
    10561 ctcttttggg ttcttctgac atccctgccc ctgcccagaa caagtgccaa ttctcactct
    10621 ggagccttaa taaactgcag tttgtatcca g
//
