LOCUS       NM_001373956            2222 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus doublecortin domain containing 2C (Dcdc2c), transcript
            variant 1, mRNA.
ACCESSION   NM_001373956 XM_006515184
VERSION     NM_001373956.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2222)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2222)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2222)
  AUTHORS   Harrow,J.L., Steward,C.A., Frankish,A., Gilbert,J.G.,
            Gonzalez,J.M., Loveland,J.E., Mudge,J., Sheppard,D., Thomas,M.,
            Trevanion,S. and Wilming,L.G.
  TITLE     The Vertebrate Genome Annotation browser 10 years on
  JOURNAL   Nucleic Acids Res 42 (Database issue), D771-D779 (2014)
   PUBMED   24316575
REFERENCE   4  (bases 1 to 2222)
  AUTHORS   Dijkmans,T.F., van Hooijdonk,L.W., Fitzsimons,C.P. and
            Vreugdenhil,E.
  TITLE     The doublecortin gene family and disorders of neuronal structure
  JOURNAL   Cent Nerv Syst Agents Med Chem 10 (1), 32-46 (2010)
   PUBMED   20236041
  REMARK    Review article
REFERENCE   5  (bases 1 to 2222)
  AUTHORS   Reiner,O., Coquelle,F.M., Peter,B., Levy,T., Kaplan,A., Sapir,T.,
            Orr,I., Barkai,N., Eichele,G. and Bergmann,S.
  TITLE     The evolving doublecortin (DCX) superfamily
  JOURNAL   BMC Genomics 7, 188 (2006)
   PUBMED   16869982
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC165283.2 and AC159197.3.
            
            On Sep 5, 2019 this sequence version replaced XM_006515184.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189685.174500.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-383               AC165283.2         88990-89372         c
            384-435             AC165283.2         84184-84235         c
            436-512             AC165283.2         78445-78521         c
            513-641             AC165283.2         72425-72553         c
            642-779             AC165283.2         67323-67460         c
            780-822             AC165283.2         65592-65634         c
            823-946             AC165283.2         63665-63788         c
            947-1047            AC165283.2         61648-61748         c
            1048-1116           AC165283.2         53620-53688         c
            1117-1158           AC165283.2         47939-47980         c
            1159-1206           AC159197.3         176069-176116       c
            1207-2222           AC159197.3         171759-172774       c
FEATURES             Location/Qualifiers
     source          1..2222
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 10.94 cM"
     gene            1..2222
                     /gene="Dcdc2c"
                     /gene_synonym="1110015M06Rik"
                     /note="doublecortin domain containing 2C"
                     /db_xref="GeneID:68511"
                     /db_xref="MGI:MGI:1915761"
     exon            1..383
                     /gene="Dcdc2c"
                     /gene_synonym="1110015M06Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             97..1230
                     /gene="Dcdc2c"
                     /gene_synonym="1110015M06Rik"
                     /note="isoform 1 is encoded by transcript variant 1;
                     putative doublecortin domain-containing protein
                     ENSP00000382097 homolog; doublecortin domain-containing
                     protein 2C"
                     /codon_start=1
                     /product="doublecortin domain-containing protein 2C
                     isoform 1"
                     /protein_id="NP_001360885.1"
                     /db_xref="GeneID:68511"
                     /db_xref="MGI:MGI:1915761"
                     /translation="MGTRGPYALVDTTPAKTILVYRNGDQFYVGRKFVFSRRRVANFE
                     ALLEQLTEQVEVPFGVRRLYTPTRGHPVLGLDALQTGGKYVAAGRERFKKLDYIHIVP
                     RKPSKMRKLKEIKPVVHCDIKVPSRWQIQSRTSRYINVFTNGRLFIPPIKVIIPKFSL
                     SDWNSVLAMIGEKVFPLGGVRKLFTMDGHLLDDSKNLQDNYFYVAAGLETFKSIPYWK
                     SSWVPSEVQQRFGGNDKYTQTKKRVESKVKEPLQNDSVPPRSQDSVYYAKEKKQMDTE
                     LLVQSGAEGDVYKAQTPAKEAQEALEVKEDPEVKVEVPVDQAPAEIVKEIDEIGDSSP
                     GLKSGMEKEVERLYEDIDRKQLSRTSARIKRWFQRLKKNNMTF"
     exon            384..435
                     /gene="Dcdc2c"
                     /gene_synonym="1110015M06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            436..512
                     /gene="Dcdc2c"
                     /gene_synonym="1110015M06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            513..641
                     /gene="Dcdc2c"
                     /gene_synonym="1110015M06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            642..779
                     /gene="Dcdc2c"
                     /gene_synonym="1110015M06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            780..822
                     /gene="Dcdc2c"
                     /gene_synonym="1110015M06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            823..946
                     /gene="Dcdc2c"
                     /gene_synonym="1110015M06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1047
                     /gene="Dcdc2c"
                     /gene_synonym="1110015M06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..1116
                     /gene="Dcdc2c"
                     /gene_synonym="1110015M06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1117..1158
                     /gene="Dcdc2c"
                     /gene_synonym="1110015M06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1159..1206
                     /gene="Dcdc2c"
                     /gene_synonym="1110015M06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1207..2222
                     /gene="Dcdc2c"
                     /gene_synonym="1110015M06Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2200..2205
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dcdc2c"
                     /gene_synonym="1110015M06Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      2222
                     /gene="Dcdc2c"
                     /gene_synonym="1110015M06Rik"
                     /note="major polyA site"
ORIGIN      
        1 agtcccgcct gtggcccgca gcccgaggga gcccgtgggt gtgctgggcg cctccttgca
       61 cagttctgcg tgtcccgagg cgagcgagca gtggccatgg gcacgcgcgg gccctatgcg
      121 ctggtggaca ccacaccggc caagaccatc ttggtgtacc gcaacgggga ccagttctat
      181 gtgggccgca agttcgtgtt ctcccggcgc cgcgtagcca acttcgaggc tctgctggag
      241 cagctgaccg agcaggtgga ggtgcccttc ggtgtgcgga ggctctacac gcccacgcgc
      301 ggccacccgg tgctcggact ggacgcgctg cagaccggtg gcaagtacgt ggctgcaggc
      361 cgggagcgct tcaagaagct ggactatatt catatagttc ccagaaaacc ttcaaagatg
      421 agaaagttga aggaaatcaa gccggtggtc cattgtgata tcaaagtgcc ttctagatgg
      481 caaatacaga gcaggacatc ccgatacata aacgttttca caaatggaag attatttatc
      541 cctcctataa aagttattat acccaaattc agcctgtcag attggaatag cgtgctggcc
      601 atgattggag aaaaagtctt ccctctagga ggagttcgaa agttgtttac aatggatgga
      661 catcttttgg atgactcaaa gaatttgcaa gacaattatt tttatgttgc tgcaggactg
      721 gagactttta aatccattcc ttactggaag tcctcatggg tccccagtga ggtccagcag
      781 agatttggag gcaatgataa atacacgcaa acaaagaaaa gagtggagtc caaagtaaaa
      841 gaacctcttc aaaatgacag tgtaccacct agaagtcagg attctgttta ttatgccaaa
      901 gagaaaaagc agatggatac agaactttta gttcaaagtg gtgcagaagg tgatgtttat
      961 aaagcccaga ctccggctaa ggaggcccaa gaagccctgg aagtcaagga ggacccagag
     1021 gtgaaggtgg aggtgccagt cgatcaggca ccagctgaaa ttgtcaaaga aattgacgag
     1081 ataggcgata gcagccctgg cctgaagagt ggcatggaaa aggaagtgga aaggctttat
     1141 gaagatattg acagaaagca gctctcaaga acttctgcaa gaataaagag gtggttccaa
     1201 cgcctgaaaa aaaacaacat gacattttag aagaaaaatc cacacctgta ctgatagaaa
     1261 cccaagtaga agcagaagtt cagagagatc catcaatagg acaagaatca ctagaagagt
     1321 catcattaac tgaagaccaa agacatgagc aacaagaatc ctttgtaaag tcatttttgg
     1381 gagcaccatc cccagaacaa agacctgaga aaaaggaatc ccctacgcaa tcatccttgg
     1441 atccaatacc tctaaagcat caacttgagc agcaaaagat acctgtacag tcctccttgg
     1501 gaccaccatc tctagagcaa caacctgaac aacaagaggt acatatacag tcattcctgg
     1561 gactaccatt cctagagcag aaacttgaac aacaaacggt acctgtacag ttgtccttgg
     1621 gaccaccatc cccagagcaa caacttgaac aacatgaggt ttctgtaaag tcatccttgg
     1681 aaccaccatc cccagagcaa caacttgaac aagagtctcc tggacagtta ttcttgggac
     1741 caccatcccc agagcagcaa tggcaagaga tacctgtata ctcatctttc aaaccatcat
     1801 ctccagaaca acaatttgaa cgagagtcct ctaaagagtc atccttggga cagttcttag
     1861 aacaaccacc tgagcaatga gaatctctta aatagtcatc tttgggacca ccattccaag
     1921 aatatctacc caagcaacta gatcccaatg acagtcatcc ttgagataac aatcttagaa
     1981 acaggtgact ctgggacagc acatgaaaca aatactatgg tgacaaaaca tcagccatgc
     2041 tgtgaagaga aacaagtcag gaactggaca ggaccgtagg caaatgaaaa taaaattaga
     2101 caatttattt tcatattatg ctgaggtatg ccagtagggt attacaattg tcaacctcat
     2161 attttgatgg ccggacttaa agtttaaaag atgagtaaga ttaaatgcat gtggaaaccc
     2221 tt
//
