LOCUS       NM_001195730            1280 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus doublecortin domain containing 2b (Dcdc2b), mRNA.
ACCESSION   NM_001195730 XM_001472099 XM_910613 XM_990619
VERSION     NM_001195730.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1280)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1280)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1280)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. PMID: 29144450]
REFERENCE   4  (bases 1 to 1280)
  AUTHORS   Dijkmans,T.F., van Hooijdonk,L.W., Fitzsimons,C.P. and
            Vreugdenhil,E.
  TITLE     The doublecortin gene family and disorders of neuronal structure
  JOURNAL   Cent Nerv Syst Agents Med Chem 10 (1), 32-46 (2010)
   PUBMED   20236041
  REMARK    Review article
REFERENCE   5  (bases 1 to 1280)
  AUTHORS   Reiner,O., Coquelle,F.M., Peter,B., Levy,T., Kaplan,A., Sapir,T.,
            Orr,I., Barkai,N., Eichele,G. and Bergmann,S.
  TITLE     The evolving doublecortin (DCX) superfamily
  JOURNAL   BMC Genomics 7, 188 (2006)
   PUBMED   16869982
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1280)
  AUTHORS   Coquelle,F.M., Levy,T., Bergmann,S., Wolf,S.G., Bar-El,D.,
            Sapir,T., Brody,Y., Orr,I., Barkai,N., Eichele,G. and Reiner,O.
  TITLE     Common and divergent roles for members of the mouse DCX superfamily
  JOURNAL   Cell Cycle 5 (9), 976-983 (2006)
   PUBMED   16628014
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL671759.10.
            
            On Jun 18, 2019 this sequence version replaced NM_001195730.1.
            
            Summary: This gene encodes a member of the doublecortin family. The
            protein encoded by this gene contains two doublecortin domains. The
            doublecortin domain has been demonstrated to bind tubulin and
            enhance microtubule polymerization. [provided by RefSeq, Oct 2011].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMN00849374, SAMN00849381
                              [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-266               AL671759.10        43984-44249         c
            267-443             AL671759.10        40886-41062         c
            444-590             AL671759.10        40308-40454         c
            591-630             AL671759.10        40193-40232         c
            631-757             AL671759.10        39592-39718         c
            758-861             AL671759.10        39059-39162         c
            862-1280            AL671759.10        37907-38325         c
FEATURES             Location/Qualifiers
     source          1..1280
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 63.26 cM"
     gene            1..1280
                     /gene="Dcdc2b"
                     /gene_synonym="Gm12964; Gm1366"
                     /note="doublecortin domain containing 2b"
                     /db_xref="GeneID:100504491"
                     /db_xref="MGI:MGI:2686212"
     exon            1..266
                     /gene="Dcdc2b"
                     /gene_synonym="Gm12964; Gm1366"
                     /inference="alignment:Splign:2.1.0"
     CDS             16..879
                     /gene="Dcdc2b"
                     /gene_synonym="Gm12964; Gm1366"
                     /codon_start=1
                     /product="doublecortin domain-containing protein 2B"
                     /protein_id="NP_001182659.1"
                     /db_xref="CCDS:CCDS57299.1"
                     /db_xref="GeneID:100504491"
                     /db_xref="MGI:MGI:2686212"
                     /translation="MAAKRILVYRNGDAFFPGHQLVVTQRRYPTMEALLYEVTSAVQA
                     PLAVRVLYTLSDGHPVTNLADLQNGGQYVAAGFERFHKIQSLGDPSPYLAVLCLSVFR
                     NGDLLSPPFSLKLSQTAIQDWDTVLKLLSEKVTLQSGAVHKLCTLEGLPLSTGTALVN
                     GHYYVAVGEEEFKALPYMELLVPSPSLSRGCWCPPGLKYKAHRKRVQGYKASAAQPFP
                     KEPGETGPSTFYARPQQPWSKLPALSSPSGVTGVYGAPYPRKETAGAQEVNEDENTRT
                     EEPVDQPAKAL"
     exon            267..443
                     /gene="Dcdc2b"
                     /gene_synonym="Gm12964; Gm1366"
                     /inference="alignment:Splign:2.1.0"
     exon            444..590
                     /gene="Dcdc2b"
                     /gene_synonym="Gm12964; Gm1366"
                     /inference="alignment:Splign:2.1.0"
     exon            591..630
                     /gene="Dcdc2b"
                     /gene_synonym="Gm12964; Gm1366"
                     /inference="alignment:Splign:2.1.0"
     exon            631..757
                     /gene="Dcdc2b"
                     /gene_synonym="Gm12964; Gm1366"
                     /inference="alignment:Splign:2.1.0"
     exon            758..861
                     /gene="Dcdc2b"
                     /gene_synonym="Gm12964; Gm1366"
                     /inference="alignment:Splign:2.1.0"
     exon            862..1280
                     /gene="Dcdc2b"
                     /gene_synonym="Gm12964; Gm1366"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagtgaggat atacaatggc agccaagagg atattggtgt atcgaaatgg ggatgccttc
       61 ttcccaggcc accagctggt ggtgacccaa cgccgctacc ccaccatgga ggctttgctt
      121 tatgaggtga catcagctgt gcaagccccg ctggctgtac gtgtcctcta cacacttagt
      181 gatggccacc ctgttaccaa cttggctgac ctacagaacg gaggacagta tgtggctgct
      241 ggctttgaac gattccacaa gatccagagt ctcggggatc cttcccctta cttggctgtt
      301 ctctgtctca gtgtgttcag gaacggggac ctgctaagtc ccccctttag tctaaagctg
      361 tcccagactg ccatccagga ctgggacacg gtgttgaagc tgctcagtga gaaggttacg
      421 ttacagagtg gggctgtaca caaactctgc accctcgagg ggcttccact gtccacaggg
      481 actgctctgg tgaacggcca ttactacgtg gctgttggag aagaagaatt caaggccctg
      541 ccctatatgg agctgctggt gcccagcccc tctctgtcca ggggctgctg gtgtcctcca
      601 ggcctgaagt acaaagccca caggaagagg gtccagggct acaaggcctc agcagcccag
      661 ccttttccaa aggagccagg ggaaactggg ccatccactt tctatgccag gccccagcag
      721 ccctggagca agctccctgc tctctcatct ccatcaggag ttacgggagt gtatggggct
      781 ccatacccga ggaaggagac ggctggggct caggaagtga atgaggatga gaacacacgc
      841 acagaggagc ctgtggatca gccagccaaa gcactgtaat ggagctgtgg aggcttctgg
      901 ccattcctgg ttgagactgc agccagccct ttccatgtaa tggaggcgct gtgtgaggat
      961 gctgacagtc tacagcaggt aacggaggct gagtaacagc tgcctgaggt ggcagcagga
     1021 agacaaagat ggcagctgag ggtggctgta cagtctccag tgctaaatcc ttttaatgct
     1081 tttcttcttt ttggttttcc aagacagggt ttctctgtgt agccctggct gtcctggaac
     1141 ttgctttgta gaccaggctg acctcaaact cacagagatc cacctgcctc tgcctcctga
     1201 gtgattaatg gagtatacca ccatgcctgg ctccagtgct aaatctcaac cgtggaaccc
     1261 actaaaggtt acaaaacctt
//
