LOCUS       NM_028523               6487 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus discoidin, CUB and LCCL domain containing 2 (Dcbld2),
            transcript variant 1, mRNA.
ACCESSION   NM_028523 XM_358854
VERSION     NM_028523.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6487)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 6487)
  AUTHORS   Wang,J., Zhang,H., Chen,L., Fu,K., Yan,Y. and Liu,Z.
  TITLE     CircDCBLD2 alleviates liver fibrosis by regulating ferroptosis via
            facilitating STUB1-mediated PARK7 ubiquitination degradation
  JOURNAL   J Gastroenterol 59 (3), 229-249 (2024)
   PUBMED   38310161
  REMARK    GeneRIF: CircDCBLD2 alleviates liver fibrosis by regulating
            ferroptosis via facilitating STUB1-mediated PARK7 ubiquitination
            degradation.
REFERENCE   3  (bases 1 to 6487)
  AUTHORS   Wang,S., Liu,X., Meng,Z., Feng,Q., Lin,Y., Niu,H., Yu,C., Zong,Y.,
            Guo,L., Yang,W., Ma,Y., Zhang,W., Li,C., Yang,Y., Wang,W., Gao,X.,
            Hu,Y., Liu,C. and Nie,L.
  TITLE     DCBLD2 regulates vascular hyperplasia by modulating the platelet
            derived growth factor receptor-beta endocytosis through Caveolin-1
            in vascular smooth muscle cells
  JOURNAL   FASEB J 36 (9), e22488 (2022)
   PUBMED   35929441
  REMARK    GeneRIF: DCBLD2 regulates vascular hyperplasia by modulating the
            platelet derived growth factor receptor-beta endocytosis through
            Caveolin-1 in vascular smooth muscle cells.
            Erratum:[FASEB J. 2023 Sep;37(9):e23150. doi:
            10.1096/fj.202301586.. PMID: 37594909]
REFERENCE   4  (bases 1 to 6487)
  AUTHORS   Hung,C.H., Lee,T.L., Huang,A.Y., Yang,K.C., Shyu,Y.C., Wen,S.C.,
            Lu,M.J., Yuan,S. and Shen,C.J.
  TITLE     A Positive Regulatory Feedback Loop between EKLF/KLF1 and TAL1/SCL
            Sustaining the Erythropoiesis
  JOURNAL   Int J Mol Sci 22 (15), 8024 (2021)
   PUBMED   34360789
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6487)
  AUTHORS   Coppo,R., Orso,F., Virga,F., Dalmasso,A., Baruffaldi,D., Nie,L.,
            Clapero,F., Dettori,D., Quirico,L., Grassi,E., Defilippi,P.,
            Provero,P., Valdembri,D., Serini,G., Sadeghi,M.M., Mazzone,M. and
            Taverna,D.
  TITLE     ESDN inhibits melanoma progression by blocking E-selectin
            expression in endothelial cells via STAT3
  JOURNAL   Cancer Lett 510, 13-23 (2021)
   PUBMED   33862151
REFERENCE   6  (bases 1 to 6487)
  AUTHORS   Li,X., Jung,J.J., Nie,L., Razavian,M., Zhang,J., Samuel,V. and
            Sadeghi,M.M.
  TITLE     The neuropilin-like protein ESDN regulates insulin signaling and
            sensitivity
  JOURNAL   Am J Physiol Heart Circ Physiol 310 (9), H1184-H1193 (2016)
   PUBMED   26921437
  REMARK    GeneRIF: ESDN regulates insulin signaling and subsequently a wide
            array of insulin effects in cultured cells and in vivo through
            modulation of IR interaction with APS and Grb10.
REFERENCE   7  (bases 1 to 6487)
  AUTHORS   Nie,L., Guo,X., Esmailzadeh,L., Zhang,J., Asadi,A., Collinge,M.,
            Li,X., Kim,J.D., Woolls,M., Jin,S.W., Dubrac,A., Eichmann,A.,
            Simons,M., Bender,J.R. and Sadeghi,M.M.
  TITLE     Transmembrane protein ESDN promotes endothelial VEGF signaling and
            regulates angiogenesis
  JOURNAL   J Clin Invest 123 (12), 5082-5097 (2013)
   PUBMED   24177422
  REMARK    GeneRIF: Deletion of Esdn in the mouse interfered with adult and
            developmental angiogenesis.
REFERENCE   8  (bases 1 to 6487)
  AUTHORS   Boyle,M.P., Bernard,A., Thompson,C.L., Ng,L., Boe,A., Mortrud,M.,
            Hawrylycz,M.J., Jones,A.R., Hevner,R.F. and Lein,E.S.
  TITLE     Cell-type-specific consequences of Reelin deficiency in the mouse
            neocortex, hippocampus, and amygdala
  JOURNAL   J Comp Neurol 519 (11), 2061-2089 (2011)
   PUBMED   21491433
REFERENCE   9  (bases 1 to 6487)
  AUTHORS   Yoshida,Y., Han,B., Mendelsohn,M. and Jessell,T.M.
  TITLE     PlexinA1 signaling directs the segregation of proprioceptive
            sensory axons in the developing spinal cord
  JOURNAL   Neuron 52 (5), 775-788 (2006)
   PUBMED   17145500
REFERENCE   10 (bases 1 to 6487)
  AUTHORS   Kobuke,K., Furukawa,Y., Sugai,M., Tanigaki,K., Ohashi,N.,
            Matsumori,A., Sasayama,S., Honjo,T. and Tashiro,K.
  TITLE     ESDN, a novel neuropilin-like membrane protein cloned from vascular
            cells with the longest secretory signal sequence among eukaryotes,
            is up-regulated after vascular injury
  JOURNAL   J Biol Chem 276 (36), 34105-34114 (2001)
   PUBMED   11447234
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC066097.1, AK051889.1, AK043915.1, AK052189.1 and CAAA01184608.1.
            
            On Jan 7, 2006 this sequence version replaced NM_028523.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF387548.1, SRR11927936.1269836.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-722               BC066097.1         1-722
            723-4843            AK051889.1         1-4121
            4844-6457           AK043915.1         635-2248
            6458-6477           AK052189.1         810-829
            6478-6487           CAAA01184608.1     20268-20277         c
FEATURES             Location/Qualifiers
     source          1..6487
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 34.52 cM"
     gene            1..6487
                     /gene="Dcbld2"
                     /gene_synonym="1700055P21Rik; CLCP1; Esdn"
                     /note="discoidin, CUB and LCCL domain containing 2"
                     /db_xref="GeneID:73379"
                     /db_xref="MGI:MGI:1920629"
     exon            1..417
                     /gene="Dcbld2"
                     /gene_synonym="1700055P21Rik; CLCP1; Esdn"
                     /inference="alignment:Splign:2.1.0"
     CDS             222..2531
                     /gene="Dcbld2"
                     /gene_synonym="1700055P21Rik; CLCP1; Esdn"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; discoidin, CUB and LCCL domain-containing
                     protein 2; endothelial and smooth muscle cell-derived
                     neuropilin-like protein"
                     /codon_start=1
                     /product="discoidin, CUB and LCCL domain-containing
                     protein 2 isoform 1 precursor"
                     /protein_id="NP_082799.2"
                     /db_xref="CCDS:CCDS28229.1"
                     /db_xref="GeneID:73379"
                     /db_xref="MGI:MGI:1920629"
                     /translation="MASRAPLRAARSPQGPGGPAAPAATGRAALPSAGCCPLPPGRNS
                     SSRPRLLLLLLLLLQDAGGQQGDGCGHTVLGPESGTLTSINYPHTYPNSTVCEWEIRV
                     RTGERIRIKFGDFDIEDSDYCHLNYLKIFNGIGVSRTEIGKYCGLGLQMNQSIESKGS
                     EVTVLFMSGTHAAGRGFLASYSVIDKEDLITCLDTVSNFLEPEFSKYCPAGCLLPFAE
                     ISGTIPHGYRDSSPLCMAGIHAGVVSNVLGGQISIVISKGTPYYESSLANNVTSTVGY
                     LSASLFTFKTSGCYGTLGMESGVIADPQITASSALEWTDHMGQENSWTAEKARLRKPG
                     PPWAAFATDEHQWLQIDLNKEKKITGIVTTGSTMIEHSYYVSAYRVLYSDDGQRWTVY
                     REPGVDQDKIFQGNKDYHKDVRNNFLPPIIARFIRVNPVQWQQKIAMKVELLGCQFTL
                     KGRLPKLTPPPRNGNNLRNTTARPKLGKGRAPKFTQVLQPRSRNELPVQPAETTTTPD
                     IKNTTVTPSVTKDVALAAVLVPVLVMALTTLILILVCAWHWRNRKKKTEGAYDLPHWD
                     RAGWWKGMKQLLPAKSVDHEETPVRYSTSEVSHLSAREVTTVLQADSAEYAQPLVGGI
                     VGTLHQRSTFKPEEGKEAGYADLDPYNSPMQEVYHAYAEPLPVTGPEYATPIVMDMSG
                     HPTASVGLPSTSTFKTAGTQPHALVGTYNTLLSRTDSCSSGQAQYDTPKGGKSAATPE
                     ELVYQVPQSTQELSGAGRDEKFDAFKEIL"
     exon            418..645
                     /gene="Dcbld2"
                     /gene_synonym="1700055P21Rik; CLCP1; Esdn"
                     /inference="alignment:Splign:2.1.0"
     exon            646..783
                     /gene="Dcbld2"
                     /gene_synonym="1700055P21Rik; CLCP1; Esdn"
                     /inference="alignment:Splign:2.1.0"
     exon            784..835
                     /gene="Dcbld2"
                     /gene_synonym="1700055P21Rik; CLCP1; Esdn"
                     /inference="alignment:Splign:2.1.0"
     exon            836..908
                     /gene="Dcbld2"
                     /gene_synonym="1700055P21Rik; CLCP1; Esdn"
                     /inference="alignment:Splign:2.1.0"
     exon            909..1042
                     /gene="Dcbld2"
                     /gene_synonym="1700055P21Rik; CLCP1; Esdn"
                     /inference="alignment:Splign:2.1.0"
     exon            1043..1083
                     /gene="Dcbld2"
                     /gene_synonym="1700055P21Rik; CLCP1; Esdn"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..1299
                     /gene="Dcbld2"
                     /gene_synonym="1700055P21Rik; CLCP1; Esdn"
                     /inference="alignment:Splign:2.1.0"
     exon            1300..1424
                     /gene="Dcbld2"
                     /gene_synonym="1700055P21Rik; CLCP1; Esdn"
                     /inference="alignment:Splign:2.1.0"
     exon            1425..1575
                     /gene="Dcbld2"
                     /gene_synonym="1700055P21Rik; CLCP1; Esdn"
                     /inference="alignment:Splign:2.1.0"
     exon            1576..1656
                     /gene="Dcbld2"
                     /gene_synonym="1700055P21Rik; CLCP1; Esdn"
                     /inference="alignment:Splign:2.1.0"
     exon            1657..1782
                     /gene="Dcbld2"
                     /gene_synonym="1700055P21Rik; CLCP1; Esdn"
                     /inference="alignment:Splign:2.1.0"
     exon            1783..1876
                     /gene="Dcbld2"
                     /gene_synonym="1700055P21Rik; CLCP1; Esdn"
                     /inference="alignment:Splign:2.1.0"
     exon            1877..1926
                     /gene="Dcbld2"
                     /gene_synonym="1700055P21Rik; CLCP1; Esdn"
                     /inference="alignment:Splign:2.1.0"
     exon            1927..2064
                     /gene="Dcbld2"
                     /gene_synonym="1700055P21Rik; CLCP1; Esdn"
                     /inference="alignment:Splign:2.1.0"
     exon            2065..6487
                     /gene="Dcbld2"
                     /gene_synonym="1700055P21Rik; CLCP1; Esdn"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2775..2780
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dcbld2"
                     /gene_synonym="1700055P21Rik; CLCP1; Esdn"
                     /note="hexamer: AATACA"
     polyA_site      2814
                     /gene="Dcbld2"
                     /gene_synonym="1700055P21Rik; CLCP1; Esdn"
                     /note="major polyA site"
     regulatory      5787..5792
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dcbld2"
                     /gene_synonym="1700055P21Rik; CLCP1; Esdn"
                     /note="hexamer: AATAAA"
     polyA_site      5816
                     /gene="Dcbld2"
                     /gene_synonym="1700055P21Rik; CLCP1; Esdn"
     regulatory      5830..5835
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dcbld2"
                     /gene_synonym="1700055P21Rik; CLCP1; Esdn"
                     /note="hexamer: AATAAA"
     polyA_site      5852
                     /gene="Dcbld2"
                     /gene_synonym="1700055P21Rik; CLCP1; Esdn"
                     /note="major polyA site"
     regulatory      6462..6467
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dcbld2"
                     /gene_synonym="1700055P21Rik; CLCP1; Esdn"
                     /note="hexamer: AATAAA"
     polyA_site      6487
                     /gene="Dcbld2"
                     /gene_synonym="1700055P21Rik; CLCP1; Esdn"
ORIGIN      
        1 gcgggagcgc gttccagctc gggccccggt gctatcctcc gatccgccgc gctccggcct
       61 ggggtctcgg ggcgggaagc tcggtgaagc gggcgcgggg agcagggcgg aggggacgag
      121 gcgcgctgcg ctgccgcccg gtcctcaccg ggtgctgcgg gccccgggcg cgcggggctc
      181 cgcggcgcgc gcactatgcg ggcggattgc cggccgccgc gatggcgagc cgggcgccgc
      241 tgagagccgc gcgcagcccc cagggtcccg gaggcccggc cgcgcccgcc gccaccggcc
      301 gggccgcgct gcccagcgcc ggctgctgtc ccctccctcc tggccgcaac tcctcctcca
      361 ggcctcgact gctccttctg ctgctcctac tgctccagga cgctggaggc cagcaaggtg
      421 atggatgtgg acacactgta ctaggccctg agagtggaac ccttacatcc atcaactacc
      481 cacataccta tcctaacagc actgtgtgtg aatgggagat tcgagtcagg acgggagaaa
      541 ggattcgcat caaattcggt gactttgaca ttgaagattc tgattattgt caccttaatt
      601 acctgaaaat ctttaatgga attggagtca gcagaacgga aataggcaaa tactgtggtc
      661 tgggtttaca aatgaatcag tcaattgagt ccaaaggcag tgaagtcaca gtgctgttca
      721 tgagtggaac ccatgctgct gggcgaggat ttttggcttc atactcagtt atagataaag
      781 aagatttaat cacttgtttg gatactgtat ctaatttttt ggaaccagag ttcagtaagt
      841 actgcccagc tggctgtctt ttgccttttg ctgaaatatc tggaacaatt cctcatggat
      901 acagagattc ttcaccattg tgtatggctg gaatccatgc aggagtagtg tcaaacgtgc
      961 tgggtggcca aatcagcatt gtgattagca aagggacccc atattatgaa agctctttgg
     1021 ccaacaatgt cacttccacg gtgggatact tatctgcaag tctgtttaca tttaagacaa
     1081 gtggttgcta tgggactctg gggatggagt ctggtgtgat tgccgatccc cagataacag
     1141 catcgtctgc actggagtgg actgaccaca tggggcagga gaacagctgg acagcggaga
     1201 aggccaggct gagaaaaccc gggcctccct gggctgcttt tgccactgat gagcatcagt
     1261 ggctgcagat agaccttaac aaggagaaga agataacagg tatcgtaacc actgggtcta
     1321 ccatgataga acacagttac tatgtgtctg cctacagagt cctgtacagt gacgatgggc
     1381 agagatggac tgtgtacaga gaacctggtg tggaccagga caagatattt caaggaaaca
     1441 aagattatca caaggatgtt cgtaataact ttttgccacc aattattgca cgtttcatta
     1501 gagtgaaccc tgtccagtgg caacagaaaa ttgccatgaa agtggaactg ctcggatgtc
     1561 agtttactct caaaggtcgc cttccaaagc ttactccacc tcctcggaac ggcaataacc
     1621 tcagaaatac tacagctcgt cccaaactag gtaaaggtcg tgcccctaaa tttactcaag
     1681 tgctccaacc tcgaagtagg aatgaacttc ctgtgcagcc ggcggagaca actaccactc
     1741 ctgatataaa aaacacgact gtaactccca gtgtaaccaa agatgtcgca ctggctgccg
     1801 ttctggtccc tgtgctggtc atggccctca ccacactcat cctcattcta gtgtgtgctt
     1861 ggcactggag aaacaggaag aagaaaactg aaggcgccta tgatttaccc cactgggatc
     1921 gggcaggttg gtggaaagga atgaagcagc ttctccctgc caagtcggtg gaccacgagg
     1981 agacgccagt gcgctacagc actagtgaag tcagtcacct gagtgccagg gaagtcacca
     2041 cagtgctgca ggccgactct gcagaatatg cacagcccct cgtgggagga attgttggca
     2101 cactccatca gagatccacc tttaaacctg aggaagggaa ggaagcaggc tatgcagacc
     2161 tcgatcctta caactctcca atgcaggaag tgtaccacgc ctatgctgaa ccactgcccg
     2221 taacggggcc tgagtacgca accccgatcg tcatggacat gtcagggcac cccacagcct
     2281 cagttggtct gccctccaca tccaccttca aaactgcagg gacccagcct cacgctttag
     2341 tgggaactta caacactctt ctctccagga ctgacagctg ttcctcaggc caggctcagt
     2401 atgacacccc aaaaggtggg aagtcagctg ctaccccaga ggaactggta taccaggtgc
     2461 cccagagcac ccaggagcta tcaggagcag gaagggatga gaagtttgat gcttttaaag
     2521 aaatcctttg acggtggtgc tgctttctga caaggcatcc atttaaagca catggctttt
     2581 ttcattctta gtggtagtga tgtagaatgt attacgtatc tgtcactgaa gtggttaggg
     2641 gaatgtggtg accgaggtac aagaaactac ttgccttgcc atcttgcttt aaaggggtta
     2701 ctgtgtgaca cagttactgc tcgcctgcta catgtcaagc gtcctgtttg ttactactgt
     2761 aaaacactat ttttaataca gaaacagagc tccctataat gcacttcaga gaaactgaaa
     2821 atcactgagt atttattacc aatgctgcag gtacattaat gaacttgagg tggttctgta
     2881 agccttgctg gcaataatgc atggtactgt tcttgaaata ccgaatggct tgaaattctc
     2941 cctttgtgaa agtgggtact atcacgcgtc ccttctcctt taatcctgta gtgccgtctg
     3001 cattcttttt tttttttttt ctcacatcca tcagtgataa gcattgctct agctgtggcc
     3061 acatacactt ctctgtattt ccctaggaag gtgcagagtt agaacagcct gccttgcggt
     3121 gagctggagg actgactcct tgtttgatga cacttttaac agtattgaca ccgcctcata
     3181 cagggcttgg tctcagctct gctcatccct gccacccttg gtggccttgc tccaacctgt
     3241 gttcataaac cctggcagct cctatccagc agcagtcacg ggaagccagc ccttcccatc
     3301 tttaagtata cttctccaca gggaactggg agagaagcaa cttacgatgt agaaaagcta
     3361 taaagggagt cctctgcgtc actaaagtaa tctgtaaatt actttaggga caaagttaag
     3421 ggggaactaa aatttaacct tctttgcttt ctttacacac aagcccaaaa atttgcaaaa
     3481 ttttttttaa atttcaatta aatttttaaa tttaatttta aaccattgta agaaaaagaa
     3541 agccaacatg agccaggtct gatggctcaa gccagcaatc ccaactgacc caagtggacc
     3601 cccaaggtca gtgctttata gtctacagag tgagttcagg attaacctag gccgctcatg
     3661 ggataagggg tggagctcag gctccggggt ttagtgctcc agtataacaa gttcaaggtc
     3721 ataggttcaa tcctctctac tacaaaaaga aaaacgggca acaggcgttc tccaggtctg
     3781 tgtgatttct gccttctgtc tggggagaca cttaagtggt cctttgtgtc agacctggtt
     3841 gacagagatg ctgtgcgatc ggaattgtgt ggaatccttc ccagcaactt acttgtcagt
     3901 gcttgacaac cgggctgcac tcacgtcagg tcgggtaaat taaatgttac agcggattag
     3961 cactgaagca gcacatcgga tgaaaacaca aacttgatcc ctcgccacaa acctgtgtgt
     4021 aggtttagag tacactcggc cttcaggtcc ccagccgttt ctcagcttgt accatcctgg
     4081 ttgtagacct gccacacttg tctagatttg gatagccttg aacagtgtta actgtgcttc
     4141 cttccacaag tacatcagcg ttttaaaacg tcgctctgca ctggtggcag gctctctgcc
     4201 acctcctcag acagtttgca tcgctttcat tataaaccgc ctttcgtctt gcagagtctc
     4261 ggacacagtc tctctccttg ttgaaaaaaa tcagtgcaca ttttgtttca aagttcttat
     4321 gaagcaaaaa aaagcacaga tgctgtacta aaacatgtaa gaatgtgtag agcacaagat
     4381 gcagttgtcc tctttcaggt gggaacaaag caaaccttta gctgtttcat tttcgttcac
     4441 gcttagtggg cagagggtag ccttttcttt gagtcaccta accattggaa gctttaagag
     4501 accctttgaa gatgaagttg ttttcccaaa gaagcctact attctaactg tgtgtcccag
     4561 aactgtttca gaacagagtg aggccatggt tgttgatgcg ttacacattg tgagacttga
     4621 ctcctatggc cactgctctc cttgcactct accaatggtt ttcataacat acctagttat
     4681 tgttatatgg ttttctcttg cagataaaga gctgagcctg attcaaatga tttttttttt
     4741 ctggttttgt acttttcctt ttaatttttt gtattataga ttacatgtct ggtaaatctt
     4801 tggaagacaa tcaagtaaaa tgtgaaagta accattgctg accaaacccc ttggttattt
     4861 tgttttgctt taattctttg cttgagatat tcaatactta agtcactgtg gcttagtggg
     4921 tttctctttt cctgatagta caattgatta gagacagcag tgtggcaagg gcagccttag
     4981 gagatttcag aaaagttaca ctaacttggc tgtcacttga tccttggaac cagcacagat
     5041 attatgaatt ctgctttgca tttattttaa atgctgttta tagatcgtag tagttcctgt
     5101 tgagagtaac aggactagtc cagttattta attcatgttt cactatttgc actttccact
     5161 gaacagtggg ttgatttgct gttcacacac agaatttatc cagtagttac agctatcatg
     5221 tgttctgtgt atgctcctcc tccacctgcc cccagggatg aagcagtaaa agtgcttgta
     5281 gccatttcca tgccttggct ccacgttgtc acccagagag cagtaaaggg agtaggaaag
     5341 caagatagaa aaaagacaga caagaccact agaacgaacc cagaaattat gggggggtgg
     5401 gaggttccaa atcctctacg gagcagaact aacggggctc cgctgtatgg aaaggagttg
     5461 ttaattctac cttttgggtt gaacttgaaa gtccttgaac tgcaaaaact ctaggaagtt
     5521 ggatggttgt agggtatcta ggttaactgt ggcaccaatc tcaattagac cattttgtgt
     5581 gtagtttctc tcgtttcctg tgtttggcac tgggaatggt gaaaataaaa cttactcaag
     5641 tacagaagaa gtggaagtgg ctgagtgtca gtgatattcc cccagaatgt atttttctta
     5701 cctcggcatg tactgtagtc acttgatatt tgtatatgtt gctagaattt aggctgttga
     5761 aaatagtgag attctaatgt gtttttaata aattatatgt gtgtgtcttg ctcagatttt
     5821 tttggattaa ataaaacaac cttgacatca tagtccagaa aatgccaaat ttctcaaagt
     5881 tgacaacagt cacattttat gaccagtatt atagtgggta tagatagcat cattggtccc
     5941 cctgccactg tccctgccgg caactccaca accctcaagc ctaccttatg gaagtgaatc
     6001 tgggcagccc agctctgtgt ggctatagag taaaggggca caccccatca gcatggagag
     6061 ccagccagtg ccagcgtccc catcagttag gtgctggaca ctgccagcat gagctaccct
     6121 cactgtcaga cccctcctat ttacagtttg tcagtatttc atttattctt tttctgacat
     6181 ttcactcttt ttattttaca cacaaactct ttagggagga ggcaaattga ttgccattat
     6241 caccagcgtt tccaataata acacttcctg tttgctctcc tcccattcta ccccctttgg
     6301 ttgtgtctac taacagttga aaggtggaac ttgcctcgca ggccaccatt tgtttgtgtt
     6361 tcttcagatt tttctctcat gtgcctgaaa tgaccactga atgtttcact gaaggtgaaa
     6421 tttagtcatg tgaaatagga catttttttc cctatacaaa taataaaaaa aaaagctcaa
     6481 ctcttaa
//
