LOCUS       NM_027946               5765 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus DDB1 and CUL4 associated factor 7 (Dcaf7), mRNA.
ACCESSION   NM_027946 XM_181295
VERSION     NM_027946.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5765)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5765)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5765)
  AUTHORS   Yu,D., Cattoglio,C., Xue,Y. and Zhou,Q.
  TITLE     A complex between DYRK1A and DCAF7 phosphorylates the C-terminal
            domain of RNA polymerase II to promote myogenesis
  JOURNAL   Nucleic Acids Res 47 (9), 4462-4475 (2019)
   PUBMED   30864669
  REMARK    GeneRIF: We show that active DYRK1A exists in a complex with the
            WD40-repeat protein DCAF7 that stabilizes and tethers DYRK1A to Pol
            II, so that DYRK1A-DCAF7 can co-migrate with and phosphorylate Pol
            II along the myogenic gene loci. Thus, DCAF7 modulates the kinase
            signaling output of DYRK1A on Pol II to stimulate myogenic
            transcription after active P-TEFb function is shut off.
REFERENCE   4  (bases 1 to 5765)
  AUTHORS   Zhang,Y.L., Zhao,L.W., Zhang,J., Le,R., Ji,S.Y., Chen,C., Gao,Y.,
            Li,D., Gao,S. and Fan,H.Y.
  TITLE     DCAF13 promotes pluripotency by negatively regulating SUV39H1
            stability during early embryonic development
  JOURNAL   EMBO J 37 (18) (2018)
   PUBMED   30111536
REFERENCE   5  (bases 1 to 5765)
  AUTHORS   Xiang,J., Yang,S., Xin,N., Gaertig,M.A., Reeves,R.H., Li,S. and
            Li,X.J.
  TITLE     DYRK1A regulates Hap1-Dcaf7/WDR68 binding with implication for
            delayed growth in Down syndrome
  JOURNAL   Proc Natl Acad Sci U S A 114 (7), E1224-E1233 (2017)
   PUBMED   28137862
  REMARK    GeneRIF: Depleting Huntingtin-associated protein 1 (Hap1) promoted
            the dual-specificity tyrosine phosphorylation-regulated kinase 1A
            (DYRK1A)-DDB1 and CUL4 associated factor 7 (Dcaf7) interaction and
            increased the DYRK1A protein level.
REFERENCE   6  (bases 1 to 5765)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   7  (bases 1 to 5765)
  AUTHORS   Stoller,J.Z., Huang,L., Tan,C.C., Huang,F., Zhou,D.D., Yang,J.,
            Gelb,B.D. and Epstein,J.A.
  TITLE     Ash2l interacts with Tbx1 and is required during early
            embryogenesis
  JOURNAL   Exp Biol Med (Maywood) 235 (5), 569-576 (2010)
   PUBMED   20463296
REFERENCE   8  (bases 1 to 5765)
  AUTHORS   Morita,K., Lo Celso,C., Spencer-Dene,B., Zouboulis,C.C. and
            Watt,F.M.
  TITLE     HAN11 binds mDia1 and controls GLI1 transcriptional activity
  JOURNAL   J Dermatol Sci 44 (1), 11-20 (2006)
   PUBMED   16887337
REFERENCE   9  (bases 1 to 5765)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB646282.1, AK047435.1 and BC048165.1.
            
            On Jul 16, 2005 this sequence version replaced NM_027946.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC048165.1, SRR1660821.87541.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-660               BB646282.1         2-661
            661-1790            AK047435.1         663-1792
            1791-5765           BC048165.1         1704-5678
FEATURES             Location/Qualifiers
     source          1..5765
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 68.89 cM"
     gene            1..5765
                     /gene="Dcaf7"
                     /gene_synonym="1700012F10Rik; 2610037L01Rik; HAN11; Wdr68"
                     /note="DDB1 and CUL4 associated factor 7"
                     /db_xref="GeneID:71833"
                     /db_xref="MGI:MGI:1919083"
     exon            1..390
                     /gene="Dcaf7"
                     /gene_synonym="1700012F10Rik; 2610037L01Rik; HAN11; Wdr68"
                     /inference="alignment:Splign:2.1.0"
     CDS             253..1281
                     /gene="Dcaf7"
                     /gene_synonym="1700012F10Rik; 2610037L01Rik; HAN11; Wdr68"
                     /note="WD repeat domain 68; WD repeat-containing protein
                     68; WD repeat-containing protein An11 homolog; WD-repeat
                     protein"
                     /codon_start=1
                     /product="DDB1- and CUL4-associated factor 7"
                     /protein_id="NP_082222.1"
                     /db_xref="CCDS:CCDS25546.1"
                     /db_xref="GeneID:71833"
                     /db_xref="MGI:MGI:1919083"
                     /translation="MSLHGKRKEIYKYEAPWTVYAMNWSVRPDKRFRLALGSFVEEYN
                     NKVQLVGLDEESSEFICRNTFDHPYPTTKLMWIPDTKGVYPDLLATSGDYLRVWRVGE
                     TETRLECLLNNNKNSDFCAPLTSFDWNEVDPYLLGTSSIDTTCTIWGLETGQVLGRVN
                     LVSGHVKTQLIAHDKEVYDIAFSRAGGGRDMFASVGADGSVRMFDLRHLEHSTIIYED
                     PQHHPLLRLCWNKQDPNYLATMAMDGMEVVILDVRVPCTPVARLNNHRACVNGIAWAP
                     HSSCHICTAADDHQALIWDIQQMPRAIEDPILAYTAEGEINNVQWASTQPDWIAICYN
                     NCLEILRV"
     exon            391..549
                     /gene="Dcaf7"
                     /gene_synonym="1700012F10Rik; 2610037L01Rik; HAN11; Wdr68"
                     /inference="alignment:Splign:2.1.0"
     exon            550..661
                     /gene="Dcaf7"
                     /gene_synonym="1700012F10Rik; 2610037L01Rik; HAN11; Wdr68"
                     /inference="alignment:Splign:2.1.0"
     exon            662..780
                     /gene="Dcaf7"
                     /gene_synonym="1700012F10Rik; 2610037L01Rik; HAN11; Wdr68"
                     /inference="alignment:Splign:2.1.0"
     exon            781..990
                     /gene="Dcaf7"
                     /gene_synonym="1700012F10Rik; 2610037L01Rik; HAN11; Wdr68"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1108
                     /gene="Dcaf7"
                     /gene_synonym="1700012F10Rik; 2610037L01Rik; HAN11; Wdr68"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..5750
                     /gene="Dcaf7"
                     /gene_synonym="1700012F10Rik; 2610037L01Rik; HAN11; Wdr68"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1534..1539
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dcaf7"
                     /gene_synonym="1700012F10Rik; 2610037L01Rik; HAN11; Wdr68"
                     /note="hexamer: ATTAAA"
     polyA_site      1551
                     /gene="Dcaf7"
                     /gene_synonym="1700012F10Rik; 2610037L01Rik; HAN11; Wdr68"
     regulatory      5722..5727
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dcaf7"
                     /gene_synonym="1700012F10Rik; 2610037L01Rik; HAN11; Wdr68"
                     /note="hexamer: AATAAA"
     polyA_site      5750
                     /gene="Dcaf7"
                     /gene_synonym="1700012F10Rik; 2610037L01Rik; HAN11; Wdr68"
                     /note="major polyA site"
ORIGIN      
        1 ggcttccgtt ccgagagggc gggccggcat cccaaacgga aggtggtagc gctgcccgag
       61 ctggtttgaa actggtggtc gggcccggcc gagtgtgagt gtgtgtagcc gaggacccgc
      121 tggagggcta ggccgttctt gaccgccccg gccccgcctc ccctcggacc cgcggaccca
      181 agcccgggtc cccgcctgtc ttgtgcccca gcccgctgcc tctctggccg gctctgcggc
      241 ccagccgcca ccatgtccct gcacggcaaa cggaaggaga tctacaaata tgaagcgccc
      301 tggactgtgt acgccatgaa ctggagcgtg cggccggaca agcgctttcg cctggcgctg
      361 ggcagcttcg tggaagagta caacaacaag gttcagcttg ttggtttaga tgaggagagt
      421 tcagagttta tttgccgaaa cacctttgac cacccgtacc ctaccacaaa gctcatgtgg
      481 attcctgaca caaagggcgt ctatccagac ctcctggcaa caagtggtga ctatctccgt
      541 gtgtggaggg ttggtgaaac agagaccagg ctggagtgct tgctaaacaa caacaagaac
      601 tcagacttct gtgctcccct gacctccttt gactggaacg aggtggatcc ttatcttcta
      661 ggtacctcaa gcattgacac aacgtgcacc atctggggac tagagaccgg gcaagtgctg
      721 ggacgagtga atctcgtgtc tggccatgtg aagacccagc taattgccca tgacaaagag
      781 gtctatgaca tcgccttcag ccgcgctgga gggggcaggg acatgtttgc ctctgtgggc
      841 gctgatgggt ctgtgagaat gtttgacctc cgccatctgg aacatagcac catcatttat
      901 gaagacccac agcaccaccc cctgcttcgc ctctgctgga acaagcagga ccctaactac
      961 ctggccacca tggccatgga cgggatggag gtggtgattc tggatgttcg agttccctgc
     1021 acaccggttg ctaggctaaa caaccaccga gcatgtgtca atggcattgc ctgggcccca
     1081 cactcgtcct gccacatctg tactgcagcg gatgaccatc aggccctcat ctgggacatc
     1141 cagcagatgc ctcgggccat cgaggaccct atcttggcct acacagctga gggagagatc
     1201 aacaatgtgc agtgggcctc cactcagcct gactggatcg ctatctgcta caacaactgc
     1261 ctggagatac tccgcgtgta gtgttggtgg cacctcacgt atccggcagg ggcttgtgtg
     1321 cttcagcctc tgcccccttc cctcccatgt aagaagaaca tgttcccagt ggccagtatg
     1381 tctactgctg ctttacaccc actgtgttca gaagctgctg tagaagtcca ggccagttac
     1441 cccgctgtct gtgttggact gtgctgtgtg gcgccactgc agcccagggc tgggttttaa
     1501 attttcactc ctttcctctt ctttgcttct tcaattaaac gtttctgtat atttgtttgt
     1561 cagctgttgt gttcataaac agtacaagca ctggctctgt ctgtgtccat ttgcccatgt
     1621 ctgtctgtct gctgctgagg cagtcatcca tctcgtgtcc ccatctgtgt cgtgctagca
     1681 cttaagtggg aacaaaggcc aacttgagat tgtctttcct cctggcacca gtgtctttta
     1741 acaaacctca actttgtatg ttttttatct atcaggctag tttttttatg aaaagaattt
     1801 aacctttctg gtttcttgat ttcacagatt tccctctttg taccttcctc tcttccctca
     1861 gtgcctgcag tgggtactgg accctagacc ccacgagcag tttgctttcc tgagtcactg
     1921 cctgtggggc acagccctga cccctgaccg ggagttgaca actgcgctgg tgctctgaag
     1981 tctactgact caccaaccgt tctcagcctg ggtctcctga aggccctcgg aggcccagga
     2041 gatgcaggag gcttctgttc accctcaagt ccctttctct ggcttcacta gttgagtacc
     2101 ctgtggggct gagataagca gttgactagg ggtcatgcgg aaggagaatc atgttcagga
     2161 aagctgaact tatattgtgt ttccagtacc tggtttcaga atctattttt ccagtttcga
     2221 acttgaatga taggcaagag agatctctca gctaagcttc tgtgtttctg tttgctgagt
     2281 ctcctctacc tggtgggaca ctggcccatc tttggattga gtactctgaa taagagactt
     2341 cctgggagct accgtctgtg cttgaccctg aacaagatct ttagactgtg acagacaggc
     2401 agttctcata aatgatgagc aaatcagcca aggtagactc agggccagcc agctaagact
     2461 ctccacgcct gtggcacctg ccctctcttc agttaaggtt atgagcagta ttggactttg
     2521 taggctgcag ttggccatgc tgacttacag gcctcgcgtg tctgtttccg ttaggtgtat
     2581 gggttccaca gaggggactt gtatgtggtt ctgactttag atgagtcccc ggcagtttgg
     2641 aacatggtct aggagagggt ggctgtttat aatctgctga gctgcttgca ggtttcttag
     2701 acgctctggg acaaggagag cagcaggcct gatggctgat ggctggttgg ccactcatgc
     2761 tgccattgct ggagaagtca atgtcgactc attcttctgg gaacatggac tgtctggcag
     2821 agtctttgct tgcttccaca actgatgtag ttgtatgcca aaagtcttag atttagattc
     2881 actatattag gaccttgtcc caaaggaaag gccttttcag tcagggtatt tctccttggc
     2941 cttcctaatc tgtcattctg attttgggtc tctggggttc ctgcactaac ctgtggcttg
     3001 tcctggatca gtttgtggtt ccctctgctc ttagtggcgt ttgccagcca ggtacagact
     3061 cctcaaaggt agcagacttg ctgatggttg ctgctgtagg agccctcagt ttcttcctgg
     3121 gctgagtcta cagtagtagg ctgagtcagg gcgtcgcagg gcctgtaggg agcacctgtg
     3181 ctggggagca cctgtgctgg ggagcacctg tgctgggtgg actttagctt ggggtgaatg
     3241 ataggattgt caactagaac ttgaaaacaa agttttaaaa ggttagcagc agttttagaa
     3301 tacatttgtg tgaggtctct atgtgctttg gaaaccaacc acgtgatgac tttttccttg
     3361 ctctgtggac acttgtcaac tttcttcagt cttccttttc tgctctccaa ctagattagg
     3421 taagactctt gctatctctg cctccaagta cgtgtgtacc cacagttgca gggttgctgg
     3481 catttgaagt ctctctctta tcatatgcac aggtggcccc tgtagctgag gaagaggttt
     3541 ctgtgggcgt gagatgcagg aagtccataa gtctgctctc ttccctgaag cacagctctg
     3601 ttaaagtttc aaagccagtc tcttaatatt tgctagttct tagcctgacg gtgaggtggg
     3661 tcagtatctc cagatctgtc ctctaggctc caggctctgg tggggctgca gtgctatttt
     3721 gacgtggttt tggcaagcta cagctagagg ctctggcctg tggtttctgt gtctgctgta
     3781 ggggaggctg catgatcggt cagactagca gagagctgag ctggtgagtg ggtctgaggc
     3841 ttttgtgggc ttgcgctgtc cccactggag attgatccct ttcctgacct ccgaggctgg
     3901 gcttgaggag gagagtgaca tgagacaagt cggtggggac ttcctatcaa aatcagcatt
     3961 aggtcagata actggagaca gcccaggaag aacgggaaaa aggcagaatc ctatagtatt
     4021 ttgatgattg ttacaactaa gatttgatat ttagggtaga gtagaaggaa atactagaga
     4081 acacagagag tctgagggga gaaacattca gatggttctg tctcatagct atgcagcgga
     4141 cctgtgcctc agcctaggtt ggcttctgca ccattaatga agcctctgtg tcgctgggtg
     4201 ccaggaggta ctgtgggcgg agagcccttc tggcagcagc gtgatgtctg gtggttaaat
     4261 tctaggtttt gggtatcccg tgacagtgca tgatgacact gtttgagaca ggttctttct
     4321 ttgtagacca ggctatcctt gaactgagtg ctgggagcac aggatgagcc actgccccag
     4381 catccgtgct tcttccctag cgcaggcctc aggctaggcc agtgacctgc cactgaacca
     4441 caccctctag cccctgccgt ttctttcctt tgtccctttc tcattacctc gctactgtag
     4501 aatgttctcc ctgatgctct gggcccttga ttcctaggcc gtaagaaaat gtaggactcc
     4561 ggggtttacc aaacatggtc ggcagttcat aagtgcaccc tactttcccc attgtgaaat
     4621 agggcaggtc ctttgattgc ctggctcagg ctagagtacc attgcaatag aggcctcaga
     4681 acgagtgttt tctttagagc ctgccctgag ggtgaggaag gccggcctat tcagcatgtg
     4741 ggttttctga gaggagagct ggtctgagca gttactgtga accctgagcc aggtttccca
     4801 gagttgtcct ctcctcctgt gaggcagcag ctgagtgtct cacgtctcca atcttgttca
     4861 cctcgagcca tctacattct ctctttctcc catactgtca ttgctgctaa tgttcagagt
     4921 caagcatgtg gcattacgga atgagcaggt cttcttgggc tgctatctga atgtcccttt
     4981 ttaaatgtgg aaacgtgcag atgctttctc cgagatgctt agactgatgt gtcagccaga
     5041 agaagcttag actccaaagg atcgatgctg acatctgtgc aacagctggg aagtgtacaa
     5101 gtgaagccga actgtgctat ccaccattgg aaagaaacgt tctcaccttg ggctgactgt
     5161 gatgtacagt gtgttatggg aattgttggg ctgaagcttt cgtcaaatct gagtcccttg
     5221 ctttgatccc gtgtatgtta tgacccctct gtcagtgact ttcccctgag tgtgaattat
     5281 agcatgattg tataaacctc tatgtagaaa atggagattt catgttctac aaatgttaag
     5341 ctctaactga cccacttctg tgcgcatgtg tatgacctga ctttcttata tatttaaact
     5401 ttccttctgt tctaaagctt ttgtggcatt ccttgttcag gtggagagga agctgtccct
     5461 ttgcagacct gtactgtaac catttctcct ttataaatat tattttcaca gggctgattg
     5521 tatacagggc ttataataaa aatttaacac tgtgttgtca acgagctgcg gtttctccac
     5581 tggaggtgac ttcaaaagca cctgagggtg gagtgtccct tctgtgacct tacttcctag
     5641 tacgtgaagt ctaatctcag ttttgtcctg tttcagcctc ctgtataaga agtatcatat
     5701 tttctgccca tcatactttg taataaaact tgaacatgta tagattgaaa aaaaaaaaaa
     5761 aaaaa
//
