LOCUS       NM_028759               3306 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus DDB1 and CUL4 associated factor 6 (Dcaf6), mRNA.
ACCESSION   NM_028759 XM_917541 XM_976438
VERSION     NM_028759.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3306)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3306)
  AUTHORS   Tsai,L.K., Chen,I.H., Chao,C.C., Hsueh,H.W., Chen,H.H., Huang,Y.H.,
            Weng,R.W., Lai,T.Y., Tsai,Y.C., Tsao,Y.P. and Chen,S.L.
  TITLE     Autoantibody of NRIP, a novel AChR-interacting protein, plays a
            detrimental role in myasthenia gravis
  JOURNAL   J Cachexia Sarcopenia Muscle 12 (3), 665-676 (2021)
   PUBMED   33773096
  REMARK    GeneRIF: Autoantibody of NRIP, a novel AChR-interacting protein,
            plays a detrimental role in myasthenia gravis.
REFERENCE   3  (bases 1 to 3306)
  AUTHORS   Yang,K.C., Chuang,K.W., Yen,W.S., Lin,S.Y., Chen,H.H., Chang,S.W.,
            Lin,Y.S., Wu,W.L., Tsao,Y.P., Chen,W.P. and Chen,S.L.
  TITLE     Deficiency of nuclear receptor interaction protein leads to
            cardiomyopathy by disrupting sarcomere structure and mitochondrial
            respiration
  JOURNAL   J Mol Cell Cardiol 137, 9-24 (2019)
   PUBMED   31629737
REFERENCE   4  (bases 1 to 3306)
  AUTHORS   Chen,H.H., Tsai,L.K., Liao,K.Y., Wu,T.C., Huang,Y.H., Huang,Y.C.,
            Chang,S.W., Wang,P.Y., Tsao,Y.P. and Chen,S.L.
  TITLE     Muscle-restricted nuclear receptor interaction protein knockout
            causes motor neuron degeneration through down-regulation of
            myogenin at the neuromuscular junction
  JOURNAL   J Cachexia Sarcopenia Muscle 9 (4), 771-785 (2018)
   PUBMED   29608040
  REMARK    GeneRIF: we demonstrated that deprivation of NRIP decreases
            myogenin expression at NMJ, possibly leading to abnormal NMJ
            formation, denervation of acetylcholine receptor, and subsequent
            loss of spinal motor neuron.
REFERENCE   5  (bases 1 to 3306)
  AUTHORS   Chen,H.H., Chen,W.P., Yan,W.L., Huang,Y.C., Chang,S.W., Fu,W.M.,
            Su,M.J., Yu,I.S., Tsai,T.C., Yan,Y.T., Tsao,Y.P. and Chen,S.L.
  TITLE     NRIP is newly identified as a Z-disc protein, activating calmodulin
            signaling for skeletal muscle contraction and regeneration
  JOURNAL   J Cell Sci 128 (22), 4196-4209 (2015)
   PUBMED   26430214
REFERENCE   6  (bases 1 to 3306)
  AUTHORS   Tsai,T.C., Lee,Y.L., Hsiao,W.C., Tsao,Y.P. and Chen,S.L.
  TITLE     NRIP, a novel nuclear receptor interaction protein, enhances the
            transcriptional activity of nuclear receptors
  JOURNAL   J Biol Chem 280 (20), 20000-20009 (2005)
   PUBMED   15784617
REFERENCE   7  (bases 1 to 3306)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC162789.4 and AC116374.10.
            
            On or before Jul 18, 2009 this sequence version replaced
            XM_917541.3, XM_976438.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK004618.1, ERR3363657.101880.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-333               AC162789.4         137266-137598       c
            334-395             AC162789.4         106389-106450       c
            396-488             AC116374.10        175969-176061       c
            489-674             AC116374.10        174523-174708       c
            675-788             AC116374.10        171778-171891       c
            789-924             AC116374.10        163131-163266       c
            925-1139            AC116374.10        151321-151535       c
            1140-1233           AC116374.10        143806-143899       c
            1234-1353           AC116374.10        142081-142200       c
            1354-1611           AC116374.10        140325-140582       c
            1612-1729           AC116374.10        109096-109213       c
            1730-1845           AC116374.10        103628-103743       c
            1846-1914           AC116374.10        103139-103207       c
            1915-2311           AC116374.10        102551-102947       c
            2312-2450           AC116374.10        91552-91690         c
            2451-2607           AC116374.10        89855-90011         c
            2608-2696           AC116374.10        88412-88500         c
            2697-2802           AC116374.10        84956-85061         c
            2803-3306           AC116374.10        81167-81670         c
FEATURES             Location/Qualifiers
     source          1..3306
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 72.67 cM"
     gene            1..3306
                     /gene="Dcaf6"
                     /gene_synonym="1200006M05Rik; Iqwd1; PC326"
                     /note="DDB1 and CUL4 associated factor 6"
                     /db_xref="GeneID:74106"
                     /db_xref="MGI:MGI:1921356"
     exon            1..333
                     /gene="Dcaf6"
                     /gene_synonym="1200006M05Rik; Iqwd1; PC326"
                     /inference="alignment:Splign:2.1.0"
     CDS             237..2867
                     /gene="Dcaf6"
                     /gene_synonym="1200006M05Rik; Iqwd1; PC326"
                     /note="IQ motif and WD repeats 1; IQ motif and WD
                     repeat-containing protein 1; NRIP; nuclear receptor
                     interaction protein"
                     /codon_start=1
                     /product="DDB1- and CUL4-associated factor 6"
                     /protein_id="NP_083035.1"
                     /db_xref="CCDS:CCDS48424.1"
                     /db_xref="GeneID:74106"
                     /db_xref="MGI:MGI:1921356"
                     /translation="MARSGSCPHLLWDVRKRSLGLEDPSRLRSRYLGRREFIQRLKLE
                     ATLNVHDGCVNTICWNDTGEYILSGSDDTKLVISNPYSRKVLTTIRSGHRANIFSAKF
                     LPCTDDKQIVSCSGDGVIFYTNIEQDAETNRQCQFTCHYGTTYEIMTVPNDPYTFLSC
                     GEDGTVRWFDTRIKTSCTKEDCKDDILINCRRAATSVAICPPVPYYLAVGCSDSSVRI
                     YDRRMLGTRATGNYAGRGTTGMVARFIPSHLSNKSCRVTSLCYSEDGQEILVSYSSDY
                     IYLFDPKDDTARELKTPSAEERREELRQPPVKRLRLRGDWSDTGPRARPESERERDGE
                     QSPNVSLMQRMSDMLSRWFEEASEVAQSNRGRGRPRPRGGTNQPDVSTLPTVPSSPNL
                     EVCETAMDVDMPAALLQPSTSSTDPVQAQAATAAIESPRSSSLLSCPDSEPRQSVEAS
                     GHHAHHQSDNSNERLSPKPGTGEPVLSLHYSTEGTTTSTIKLNFTDEWSSTASSSRGN
                     GSHCKSEGQEECLVPPSSVQPPEGDSETRAPEELSEKGTLPENLTQNQIDTAQLDNFP
                     AEPLDSNSGEKNNPSQDSPCGLPEEGTLSETDRETCEQASTESATRHASTKPELPSQT
                     EAIEQASTESATRHTSANPELPSQTEAIAPLAHEDPSARDSALQDTDDSDDDPVLIPG
                     ARYRTGPGDRRSAVARIQEFFRRRKERKEMEELDTLNIRRPLVKMVYKGHRNSRTMIK
                     EANFWGANFVMSGSDCGHIFIWDRHTAEHLMLLEADNHVVNCLQPHPFDPILASSGID
                     YDIKIWSPLEESRIFNRKLADEVITRNELMLEETRNTITVPASFMLRMLASLNHIRAD
                     RLEGDRSEGSGQENENEDEE"
     exon            334..395
                     /gene="Dcaf6"
                     /gene_synonym="1200006M05Rik; Iqwd1; PC326"
                     /inference="alignment:Splign:2.1.0"
     exon            396..488
                     /gene="Dcaf6"
                     /gene_synonym="1200006M05Rik; Iqwd1; PC326"
                     /inference="alignment:Splign:2.1.0"
     exon            489..674
                     /gene="Dcaf6"
                     /gene_synonym="1200006M05Rik; Iqwd1; PC326"
                     /inference="alignment:Splign:2.1.0"
     exon            675..788
                     /gene="Dcaf6"
                     /gene_synonym="1200006M05Rik; Iqwd1; PC326"
                     /inference="alignment:Splign:2.1.0"
     exon            789..924
                     /gene="Dcaf6"
                     /gene_synonym="1200006M05Rik; Iqwd1; PC326"
                     /inference="alignment:Splign:2.1.0"
     exon            925..1139
                     /gene="Dcaf6"
                     /gene_synonym="1200006M05Rik; Iqwd1; PC326"
                     /inference="alignment:Splign:2.1.0"
     exon            1140..1233
                     /gene="Dcaf6"
                     /gene_synonym="1200006M05Rik; Iqwd1; PC326"
                     /inference="alignment:Splign:2.1.0"
     exon            1234..1353
                     /gene="Dcaf6"
                     /gene_synonym="1200006M05Rik; Iqwd1; PC326"
                     /inference="alignment:Splign:2.1.0"
     exon            1354..1611
                     /gene="Dcaf6"
                     /gene_synonym="1200006M05Rik; Iqwd1; PC326"
                     /inference="alignment:Splign:2.1.0"
     exon            1612..1729
                     /gene="Dcaf6"
                     /gene_synonym="1200006M05Rik; Iqwd1; PC326"
                     /inference="alignment:Splign:2.1.0"
     exon            1730..1845
                     /gene="Dcaf6"
                     /gene_synonym="1200006M05Rik; Iqwd1; PC326"
                     /inference="alignment:Splign:2.1.0"
     exon            1846..1914
                     /gene="Dcaf6"
                     /gene_synonym="1200006M05Rik; Iqwd1; PC326"
                     /inference="alignment:Splign:2.1.0"
     exon            1915..2311
                     /gene="Dcaf6"
                     /gene_synonym="1200006M05Rik; Iqwd1; PC326"
                     /inference="alignment:Splign:2.1.0"
     exon            2312..2450
                     /gene="Dcaf6"
                     /gene_synonym="1200006M05Rik; Iqwd1; PC326"
                     /inference="alignment:Splign:2.1.0"
     exon            2451..2607
                     /gene="Dcaf6"
                     /gene_synonym="1200006M05Rik; Iqwd1; PC326"
                     /inference="alignment:Splign:2.1.0"
     exon            2608..2696
                     /gene="Dcaf6"
                     /gene_synonym="1200006M05Rik; Iqwd1; PC326"
                     /inference="alignment:Splign:2.1.0"
     exon            2697..2802
                     /gene="Dcaf6"
                     /gene_synonym="1200006M05Rik; Iqwd1; PC326"
                     /inference="alignment:Splign:2.1.0"
     exon            2803..3306
                     /gene="Dcaf6"
                     /gene_synonym="1200006M05Rik; Iqwd1; PC326"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3230..3235
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dcaf6"
                     /gene_synonym="1200006M05Rik; Iqwd1; PC326"
                     /note="hexamer: AATAAA"
     polyA_site      3250
                     /gene="Dcaf6"
                     /gene_synonym="1200006M05Rik; Iqwd1; PC326"
                     /note="major polyA site"
     regulatory      3273..3278
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dcaf6"
                     /gene_synonym="1200006M05Rik; Iqwd1; PC326"
                     /note="hexamer: ATTAAA"
     polyA_site      3306
                     /gene="Dcaf6"
                     /gene_synonym="1200006M05Rik; Iqwd1; PC326"
                     /note="major polyA site"
ORIGIN      
        1 atgttctggg tagtctgagg agagtatgag gcgagccgtg gcccgggtac ctctccgctc
       61 ccggggagaa ggcgcggccg tggctgccgc cctctgagtc gcggcgccgg cgaggccccg
      121 gggcgcgcgc atggtgctgg tgccgctcgg gtgttgatcg gcctgtcccc tccctctctt
      181 cccctcccca ccccccgcgg tggtctcccc tttcccaccc cagcccctgc ggagccatgg
      241 ctcggagtgg ctcctgcccg cacctgttgt gggacgtgag gaaaaggtcc cttgggctgg
      301 aggacccgtc ccggctgagg agccgctacc tgggaagaag agaatttatc caaagattaa
      361 aacttgaagc aactttaaat gtgcatgatg gctgtgttaa tacaatctgt tggaatgaca
      421 ctggagaata tattttatct ggctctgatg acactaaact tgtaattagt aatccataca
      481 gcagaaaggt tttgacaacc atccgttcag ggcatcgagc aaatatattt agtgcaaagt
      541 ttttgccgtg cacagatgat aagcagattg tgtcttgctc tggagatgga gtcatatttt
      601 atactaacat tgagcaagat gcagaaacta acagacagtg ccaatttacg tgccattatg
      661 gaactactta tgagattatg actgtaccaa acgaccctta cacctttctg tcctgtggtg
      721 aagatggaac tgttaggtgg tttgacacac gcatcaaaac cagttgcaca aaagaagact
      781 gtaaagatga tattttaatc aactgtaggc gtgctgccac atctgtggct atttgtcccc
      841 cagtaccata ttaccttgct gtgggttgtt ctgacagctc agtacggatt tatgatcggc
      901 gaatgctggg cacaagagct acagggaatt atgcaggccg aggaactact ggaatggttg
      961 ctcgatttat accttctcat cttagtaaca aatcatgcag agtgacatca ctgtgttaca
     1021 gtgaagatgg tcaagagatt cttgtcagtt attcttcaga ctacatctat ctttttgacc
     1081 ccaaagatga tactgcacga gaacttaaaa ctccttctgc agaggagagg cgagaagagt
     1141 tacgacagcc tccagttaag cgcttgagac ttcgtggtga ttggtcagat actggtccca
     1201 gagcacggcc agaaagtgaa cgagaacgag atggagagca aagtcccaat gtgtcactga
     1261 tgcagagaat gtctgatatg ttatcaaggt ggtttgaaga agcaagtgaa gttgcacaaa
     1321 gcaacagagg aagaggaaga cctcggccca gaggtggaac aaatcagcca gatgtttcaa
     1381 ctcttcctac ggttccatca agtcctaatt tggaagtgtg tgaaactgca atggatgtag
     1441 acatgccagc tgcacttctt cagccttcta catcctctac agatccagtt caggctcagg
     1501 cagccacagc cgccatagaa agccctcgtt ccagctcgtt gctgtcttgc ccagacagtg
     1561 aaccgaggca gtctgttgag gcgtctggac accatgcaca tcatcagtca gataacagta
     1621 atgagaggct gagccccaaa ccagggacag gtgaacccgt tttaagtttg cactacagca
     1681 cagaaggaac aactacaagc acaataaaac tgaactttac agatgaatgg agcagtacag
     1741 cctcaagttc cagaggaaat gggagccatt gcaaatctga gggtcaggaa gaatgcttgg
     1801 tccctccgag ctctgtgcag ccaccggaag gagacagtga aacaagagct cctgaagaac
     1861 tatcagagaa aggaacactt ccagaaaacc tcactcaaaa ccagatagat acagcacaac
     1921 ttgataactt cccagctgag ccattggatt ctaactcagg agagaagaat aacccaagtc
     1981 aggacagccc ttgtgggctt ccagaagaag gcactttgtc tgaaacagac agggagactt
     2041 gtgagcaggc cagcactgag agtgctacca ggcatgctag caccaagcct gaactcccat
     2101 cccagacaga agccattgag caggccagca ctgagagtgc taccaggcat accagtgcca
     2161 atcctgaact cccatcccag acagaagcca tagcaccttt agctcatgaa gacccatctg
     2221 ccagggactc tgctctccag gacacagatg acagcgatga tgatccggtc ttgatccctg
     2281 gtgcaagata ccgaacagga cctggtgata gacgctccgc tgttgcccgc attcaggagt
     2341 tcttcaggag gagaaaagaa aggaaagaaa tggaagagct ggatactttg aacattagga
     2401 ggccactagt aaagatggtt tataagggcc accgcaactc ccggacaatg ataaaagaag
     2461 ccaatttctg gggtgctaac tttgtaatga gcggttccga ttgtggccat atcttcatct
     2521 gggaccggca cactgctgag catttgatgc ttctggaagc tgataatcat gtggtcaact
     2581 gcctgcagcc ccatccgttt gacccaattc tagcctcatc tggcatagat tatgacataa
     2641 agatctggtc gccactagaa gagtcaagaa tttttaatcg aaaacttgct gatgaagtta
     2701 taactcggaa tgaactcatg ctggaagaga ctcggaacac catcaccgtc ccagcctctt
     2761 tcatgttgag gatgttggcg tcactgaatc atatccgagc tgaccgtctg gagggtgaca
     2821 gatcagaagg ttcaggtcag gagaatgaaa atgaggatga agaataaaga actccttggc
     2881 aagcacttag atgttctgag atttgtatac gacatttatt atattttttt tctttacaga
     2941 actttagtgc aatttaaggc tatgggtttt tttttttttt tttttttttt ggagttcttc
     3001 cctattttgg ggataaccaa acattggttt ggaatgagtg tgtgcatgag ttgggagagt
     3061 gtgtaaaaca aagtaagcaa aatgtttttt gaaacctttt gccgtgtatg gagtccaaaa
     3121 aaaaaaaaaa aaaaaaaaaa aaagcaaagt gcaatacttc ctgaccctcc gctgtgggag
     3181 cttggatcaa tgctgaagtc attttcattg tagtgaaaat gttggttcaa ataaatttct
     3241 acacttgcca tttgcatgtt tgttgctttc taattaaaga tgttggttgc tttaagatat
     3301 cctaaa
//
