LOCUS       NP_083035                876 aa            linear   ROD 30-APR-2024
DEFINITION  DDB1- and CUL4-associated factor 6 [Mus musculus].
ACCESSION   NP_083035 XP_922634 XP_981532
VERSION     NP_083035.1
DBSOURCE    REFSEQ: accession NM_028759.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 876)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 876)
  AUTHORS   Tsai,L.K., Chen,I.H., Chao,C.C., Hsueh,H.W., Chen,H.H., Huang,Y.H.,
            Weng,R.W., Lai,T.Y., Tsai,Y.C., Tsao,Y.P. and Chen,S.L.
  TITLE     Autoantibody of NRIP, a novel AChR-interacting protein, plays a
            detrimental role in myasthenia gravis
  JOURNAL   J Cachexia Sarcopenia Muscle 12 (3), 665-676 (2021)
   PUBMED   33773096
  REMARK    GeneRIF: Autoantibody of NRIP, a novel AChR-interacting protein,
            plays a detrimental role in myasthenia gravis.
REFERENCE   3  (residues 1 to 876)
  AUTHORS   Yang,K.C., Chuang,K.W., Yen,W.S., Lin,S.Y., Chen,H.H., Chang,S.W.,
            Lin,Y.S., Wu,W.L., Tsao,Y.P., Chen,W.P. and Chen,S.L.
  TITLE     Deficiency of nuclear receptor interaction protein leads to
            cardiomyopathy by disrupting sarcomere structure and mitochondrial
            respiration
  JOURNAL   J Mol Cell Cardiol 137, 9-24 (2019)
   PUBMED   31629737
REFERENCE   4  (residues 1 to 876)
  AUTHORS   Chen,H.H., Tsai,L.K., Liao,K.Y., Wu,T.C., Huang,Y.H., Huang,Y.C.,
            Chang,S.W., Wang,P.Y., Tsao,Y.P. and Chen,S.L.
  TITLE     Muscle-restricted nuclear receptor interaction protein knockout
            causes motor neuron degeneration through down-regulation of
            myogenin at the neuromuscular junction
  JOURNAL   J Cachexia Sarcopenia Muscle 9 (4), 771-785 (2018)
   PUBMED   29608040
  REMARK    GeneRIF: we demonstrated that deprivation of NRIP decreases
            myogenin expression at NMJ, possibly leading to abnormal NMJ
            formation, denervation of acetylcholine receptor, and subsequent
            loss of spinal motor neuron.
REFERENCE   5  (residues 1 to 876)
  AUTHORS   Chen,H.H., Chen,W.P., Yan,W.L., Huang,Y.C., Chang,S.W., Fu,W.M.,
            Su,M.J., Yu,I.S., Tsai,T.C., Yan,Y.T., Tsao,Y.P. and Chen,S.L.
  TITLE     NRIP is newly identified as a Z-disc protein, activating calmodulin
            signaling for skeletal muscle contraction and regeneration
  JOURNAL   J Cell Sci 128 (22), 4196-4209 (2015)
   PUBMED   26430214
REFERENCE   6  (residues 1 to 876)
  AUTHORS   Tsai,T.C., Lee,Y.L., Hsiao,W.C., Tsao,Y.P. and Chen,S.L.
  TITLE     NRIP, a novel nuclear receptor interaction protein, enhances the
            transcriptional activity of nuclear receptors
  JOURNAL   J Biol Chem 280 (20), 20000-20009 (2005)
   PUBMED   15784617
REFERENCE   7  (residues 1 to 876)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC162789.4 and AC116374.10.
            
            On or before Jul 18, 2009 this sequence version replaced
            XP_922634.3, XP_981532.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK004618.1, ERR3363657.101880.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..876
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 72.67 cM"
     Protein         1..876
                     /product="DDB1- and CUL4-associated factor 6"
                     /note="IQ motif and WD repeats 1; IQ motif and WD
                     repeat-containing protein 1; NRIP; nuclear receptor
                     interaction protein"
                     /calculated_mol_wt=97457
     Region          43..>292
                     /region_name="WD40"
                     /note="WD40 domain, found in a number of eukaryotic
                     proteins that cover a wide variety of functions including
                     adaptor/regulatory modules in signal transduction,
                     pre-mRNA processing and cytoskeleton assembly; typically
                     contains a GH dipeptide 11-24 residues from...; cl29593"
                     /db_xref="CDD:475233"
     Region          49..88
                     /region_name="WD 1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9DC22.1)"
     Region          55..92
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          92..133
                     /region_name="WD 2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9DC22.1)"
     Region          97..138
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          139..179
                     /region_name="WD 3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9DC22.1)"
     Region          148..181
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          188..233
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          189..229
                     /region_name="WD 4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9DC22.1)"
     Region          251..290
                     /region_name="WD 5"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9DC22.1)"
     Region          256..282
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          288..340
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9DC22.1)"
     Site            336
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9DC22.1)"
     Region          355..391
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9DC22.1)"
     Region          408..485
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9DC22.1)"
     Region          498..645
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9DC22.1)"
     Region          658..691
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9DC22.1)"
     Site            665
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q58WW2; propagated from
                     UniProtKB/Swiss-Prot (Q9DC22.1)"
     Site            670
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9DC22.1)"
     Site            673
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9DC22.1)"
     Region          734..772
                     /region_name="WD 6"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9DC22.1)"
     Region          <746..805
                     /region_name="WD40"
                     /note="WD40 domain, found in a number of eukaryotic
                     proteins that cover a wide variety of functions including
                     adaptor/regulatory modules in signal transduction,
                     pre-mRNA processing and cytoskeleton assembly; typically
                     contains a GH dipeptide 11-24 residues from...; cl29593"
                     /db_xref="CDD:475233"
     Region          775..814
                     /region_name="WD 7"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9DC22.1)"
     Site            863
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9DC22.1)"
     Site            866
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9DC22.1)"
     CDS             1..876
                     /gene="Dcaf6"
                     /gene_synonym="1200006M05Rik; Iqwd1; PC326"
                     /coded_by="NM_028759.1:237..2867"
                     /db_xref="CCDS:CCDS48424.1"
                     /db_xref="GeneID:74106"
                     /db_xref="MGI:MGI:1921356"
ORIGIN      
        1 marsgscphl lwdvrkrslg ledpsrlrsr ylgrrefiqr lkleatlnvh dgcvnticwn
       61 dtgeyilsgs ddtklvisnp ysrkvlttir sghranifsa kflpctddkq ivscsgdgvi
      121 fytnieqdae tnrqcqftch ygttyeimtv pndpytflsc gedgtvrwfd triktsctke
      181 dckddilinc rraatsvaic ppvpyylavg csdssvriyd rrmlgtratg nyagrgttgm
      241 varfipshls nkscrvtslc ysedgqeilv syssdyiylf dpkddtarel ktpsaeerre
      301 elrqppvkrl rlrgdwsdtg prarpesere rdgeqspnvs lmqrmsdmls rwfeeaseva
      361 qsnrgrgrpr prggtnqpdv stlptvpssp nlevcetamd vdmpaallqp stsstdpvqa
      421 qaataaiesp rsssllscpd seprqsveas ghhahhqsdn snerlspkpg tgepvlslhy
      481 stegtttsti klnftdewss tasssrgngs hcksegqeec lvppssvqpp egdsetrape
      541 elsekgtlpe nltqnqidta qldnfpaepl dsnsgeknnp sqdspcglpe egtlsetdre
      601 tceqastesa trhastkpel psqteaieqa stesatrhts anpelpsqte aiaplahedp
      661 sardsalqdt ddsdddpvli pgaryrtgpg drrsavariq effrrrkerk emeeldtlni
      721 rrplvkmvyk ghrnsrtmik eanfwganfv msgsdcghif iwdrhtaehl mlleadnhvv
      781 nclqphpfdp ilassgidyd ikiwsplees rifnrklade vitrnelmle etrntitvpa
      841 sfmlrmlasl nhiradrleg drsegsgqen enedee
//
