LOCUS       NM_198606               1511 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus DDB1 and CUL4 associated factor 13 (Dcaf13),
            transcript variant 1, mRNA.
ACCESSION   NM_198606 XM_128092
VERSION     NM_198606.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1511)
  AUTHORS   Zhou,L., Wang,S., Hu,W., Liu,X., Xu,L., Tong,B., Zhang,T., Xue,Z.,
            Guo,Y., Zhao,J., Lu,L., Fan,H., Qian,W., Chen,J., Chen,W. and
            Wang,L.
  TITLE     T cell proliferation requires ribosomal maturation in nucleolar
            condensates dependent on DCAF13
  JOURNAL   J Cell Biol 222 (10) (2023)
   PUBMED   37615668
REFERENCE   2  (bases 1 to 1511)
  AUTHORS   Yan,X., Rong,M., Zhou,Q. and Zhang,C.
  TITLE     DCAF13 is essential for the pathogenesis of preeclampsia through
            its involvement in endometrial decidualization
  JOURNAL   Mol Cell Endocrinol 556, 111741 (2022)
   PUBMED   35932979
REFERENCE   3  (bases 1 to 1511)
  AUTHORS   Shan,B.Q., Wang,X.M., Zheng,L., Han,Y., Gao,J., Lv,M.D., Zhang,Y.,
            Liu,Y.X., Zhang,H., Chen,H.S., Ao,L., Zhang,Y.L., Lu,X., Wu,Z.J.,
            Xu,Y., Che,X., Heger,M., Cheng,S.Q., Pan,W.W. and Zhang,X.
  TITLE     DCAF13 promotes breast cancer cell proliferation by ubiquitin
            inhibiting PERP expression
  JOURNAL   Cancer Sci 113 (5), 1587-1600 (2022)
   PUBMED   35178836
REFERENCE   4  (bases 1 to 1511)
  AUTHORS   Zhang,J., Zhang,Y.L., Zhao,L.W., Pi,S.B., Zhang,S.Y., Tong,C. and
            Fan,H.Y.
  TITLE     The CRL4-DCAF13 ubiquitin E3 ligase supports oocyte meiotic
            resumption by targeting PTEN degradation
  JOURNAL   Cell Mol Life Sci 77 (11), 2181-2197 (2020)
   PUBMED   31492966
  REMARK    GeneRIF: The DCAF13-dependent PTEN degradation mechanism fits in as
            a missing link between CRL4 ubiquitin E3 ligase and PI3K pathway,
            both of which are crucial for translational activation during
            oocyte germinal vesicle -metaphase of meiosis II transition.
REFERENCE   5  (bases 1 to 1511)
  AUTHORS   Zhang,J., Zhang,Y.L., Zhao,L.W., Guo,J.X., Yu,J.L., Ji,S.Y.,
            Cao,L.R., Zhang,S.Y., Shen,L., Ou,X.H. and Fan,H.Y.
  TITLE     Mammalian nucleolar protein DCAF13 is essential for ovarian
            follicle maintenance and oocyte growth by mediating rRNA processing
  JOURNAL   Cell Death Differ 26 (7), 1251-1266 (2019)
   PUBMED   30283081
REFERENCE   6  (bases 1 to 1511)
  AUTHORS   Liu,Y., Zhao,L.W., Shen,J.L., Fan,H.Y. and Jin,Y.
  TITLE     Maternal DCAF13 Regulates Chromatin Tightness to Contribute to
            Embryonic Development
  JOURNAL   Sci Rep 9 (1), 6278 (2019)
   PUBMED   31000741
  REMARK    GeneRIF: Maternal DCAF13 Regulates Chromatin Tightness to
            Contribute to Embryonic Development.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1511)
  AUTHORS   Zhang,Y.L., Zhao,L.W., Zhang,J., Le,R., Ji,S.Y., Chen,C., Gao,Y.,
            Li,D., Gao,S. and Fan,H.Y.
  TITLE     DCAF13 promotes pluripotency by negatively regulating SUV39H1
            stability during early embryonic development
  JOURNAL   EMBO J 37 (18) (2018)
   PUBMED   30111536
  REMARK    GeneRIF: CRL4-DCAF13-mediated SUV39H1 degradation is an essential
            step for progressive genome reprogramming during preimplantation
            embryonic development.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC164883.5 and AC101886.16.
            
            On Jan 12, 2023 this sequence version replaced NM_198606.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC060375.1, SRR5189673.96597.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-147               AC164883.5         230455-230601
            148-347             AC164883.5         236261-236460
            348-455             AC164883.5         236895-237002
            456-545             AC164883.5         240763-240852
            546-701             AC164883.5         241879-242034
            702-779             AC164883.5         245440-245517
            780-862             AC164883.5         247766-247848
            863-1027            AC164883.5         255634-255798
            1028-1163           AC101886.16        29029-29164
            1164-1327           AC101886.16        30497-30660
            1328-1511           AC101886.16        32079-32262
FEATURES             Location/Qualifiers
     source          1..1511
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 15.42 cM"
     gene            1..1511
                     /gene="Dcaf13"
                     /gene_synonym="Gm83; Wdsof1"
                     /note="DDB1 and CUL4 associated factor 13"
                     /db_xref="GeneID:223499"
                     /db_xref="MGI:MGI:2684929"
     exon            1..147
                     /gene="Dcaf13"
                     /gene_synonym="Gm83; Wdsof1"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..1415
                     /gene="Dcaf13"
                     /gene_synonym="Gm83; Wdsof1"
                     /note="isoform 1 is encoded by transcript variant 1; WD
                     repeats and SOF domain containing 1; WD repeat and SOF
                     domain-containing protein 1"
                     /codon_start=1
                     /product="DDB1- and CUL4-associated factor 13 isoform 1"
                     /protein_id="NP_941008.2"
                     /db_xref="CCDS:CCDS37066.1"
                     /db_xref="GeneID:223499"
                     /db_xref="MGI:MGI:2684929"
                     /translation="MKVKMLSRNPDNYVRETKLDIQRVPRNYDPTLHPFEVPREYVRA
                     LNATKLERVFAKPFLASLDGHRDGVNCLAKHPKSLASVLSGACDGEVKIWNLTKRKCI
                     RTIQAHEGFVRGMCTRFCGTSFFTVGDDKTVKQWKMDGPGYGEEEEPLYTVLGKTVYT
                     GIDHHWKDPVFATCGQQVDIWDEQRTSPVCSMNWGFDSISSVKFNPVETFLLGSCASD
                     RNIVLYDMRQATPLKKVILEMRTNTICWNPMEAFNFTAANEDYNLYTFDMRALDTPVM
                     VHMDHVSAVLDVDYSPTGKEFVSASFDKSIRIFPVDKSRSREVYHTKRMQHVMCVKWT
                     SDSKYIMCGSDEMNIRLWKANASEKLGVLTSREKAANDYNQKLKEKFQYHPHVKRIAR
                     HRHLPKSIYSQIQEQRVMKEARRRKEMNRRKHSKPGSVPIVSERKKHVVAVVK"
     exon            148..347
                     /gene="Dcaf13"
                     /gene_synonym="Gm83; Wdsof1"
                     /inference="alignment:Splign:2.1.0"
     exon            348..455
                     /gene="Dcaf13"
                     /gene_synonym="Gm83; Wdsof1"
                     /inference="alignment:Splign:2.1.0"
     exon            456..545
                     /gene="Dcaf13"
                     /gene_synonym="Gm83; Wdsof1"
                     /inference="alignment:Splign:2.1.0"
     exon            546..701
                     /gene="Dcaf13"
                     /gene_synonym="Gm83; Wdsof1"
                     /inference="alignment:Splign:2.1.0"
     exon            702..779
                     /gene="Dcaf13"
                     /gene_synonym="Gm83; Wdsof1"
                     /inference="alignment:Splign:2.1.0"
     exon            780..862
                     /gene="Dcaf13"
                     /gene_synonym="Gm83; Wdsof1"
                     /inference="alignment:Splign:2.1.0"
     exon            863..1027
                     /gene="Dcaf13"
                     /gene_synonym="Gm83; Wdsof1"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..1163
                     /gene="Dcaf13"
                     /gene_synonym="Gm83; Wdsof1"
                     /inference="alignment:Splign:2.1.0"
     exon            1164..1327
                     /gene="Dcaf13"
                     /gene_synonym="Gm83; Wdsof1"
                     /inference="alignment:Splign:2.1.0"
     exon            1328..1511
                     /gene="Dcaf13"
                     /gene_synonym="Gm83; Wdsof1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1480..1485
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dcaf13"
                     /gene_synonym="Gm83; Wdsof1"
                     /note="hexamer: AATAAA"
     polyA_site      1511
                     /gene="Dcaf13"
                     /gene_synonym="Gm83; Wdsof1"
                     /note="major polyA site"
ORIGIN      
        1 agtgtgtctg cgtgctggcc ccggtaagtc gagcccggtt taaaggctcg tggagtccga
       61 cacccagagc cgccaagatg aaggtgaaaa tgctgagccg aaaccctgac aactatgtcc
      121 gcgaaaccaa gctggacata caaagagtcc caagaaacta tgatcccact ttacatcctt
      181 ttgaagtccc acgagaatat gtgagagctt taaatgctac caagttggaa cgagtgtttg
      241 caaagccgtt ccttgcttcc ctggatggtc accgtgatgg agtcaattgc ctggcaaagc
      301 atccaaagag cctggcttct gtcctttctg gggcatgtga tggagaggtt aaaatttgga
      361 atctgactaa acgaaaatgt atccgaacaa tacaagcaca tgaaggtttt gtgcggggaa
      421 tgtgcactcg cttttgtggc acttcttttt ttactgttgg agatgacaaa actgtgaagc
      481 agtggaaaat ggatggacca ggctatggag aggaggagga gccgttgtac acagtattag
      541 gaaagacagt atatactggc attgatcatc actggaaaga cccagtcttt gccacttgtg
      601 gacagcaagt agacatttgg gatgaacaaa gaaccagccc tgtgtgctca atgaactggg
      661 gatttgacag cataagtagt gttaaattta accctgttga gacatttctc ttgggaagtt
      721 gtgcttctga taggaatata gtactgtatg atatgcggca agctactcct ttgaaaaagg
      781 ttatcctgga aatgaggaca aatacaatct gttggaaccc tatggaagct ttcaatttta
      841 ctgcagcaaa tgaagactat aacttgtata cttttgatat gcgcgcactg gacactcctg
      901 ttatggtgca catggatcac gtgtctgcag tacttgatgt ggactactct cccactggga
      961 aggaatttgt gtctgccagc tttgataagt ctattagaat ctttcctgtg gacaagagcc
     1021 gaagcaggga agtgtatcat acgaaacgaa tgcaacatgt gatgtgtgtg aaatggactt
     1081 ctgacagcaa gtacattatg tgtgggtctg acgaaatgaa catccgactg tggaaagcta
     1141 atgcgtctga aaaactgggt gtgcttacat cacgagaaaa agcagcaaat gattataacc
     1201 agaagttaaa ggaaaaattt caataccatc cacatgtaaa acggattgct cgccaccgac
     1261 atctcccgaa atctatctac agccagattc aggagcagcg cgtgatgaag gaagctcggc
     1321 gccgaaagga aatgaatcgt cgtaaacata gcaagcctgg atctgtgccg attgtgtcag
     1381 agaggaagaa acacgtagtg gcggttgtga aataatgttt tgtcttccta ccaagtttga
     1441 tatataatta tttgctactt ttgatttggg aactctgtaa ataaaagtcc tgagtctggt
     1501 ttaatagtaa a
//
