LOCUS       NP_081169                453 aa            linear   ROD 30-APR-2024
DEFINITION  DDB1- and CUL4-associated factor 12 [Mus musculus].
ACCESSION   NP_081169
VERSION     NP_081169.2
DBSOURCE    REFSEQ: accession NM_026893.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 453)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 453)
  AUTHORS   Lidak,T., Baloghova,N., Korinek,V., Sedlacek,R., Balounova,J.,
            Kasparek,P. and Cermak,L.
  TITLE     CRL4-DCAF12 Ubiquitin Ligase Controls MOV10 RNA Helicase during
            Spermatogenesis and T Cell Activation
  JOURNAL   Int J Mol Sci 22 (10), 5394 (2021)
   PUBMED   34065512
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 453)
  AUTHORS   Zhang,Y.L., Zhao,L.W., Zhang,J., Le,R., Ji,S.Y., Chen,C., Gao,Y.,
            Li,D., Gao,S. and Fan,H.Y.
  TITLE     DCAF13 promotes pluripotency by negatively regulating SUV39H1
            stability during early embryonic development
  JOURNAL   EMBO J 37 (18) (2018)
   PUBMED   30111536
REFERENCE   4  (residues 1 to 453)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY338453.1, AK031089.1, AK173289.1 and AA207929.1.
            
            On Jun 9, 2003 this sequence version replaced NP_081169.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660817.115576.1,
                                           SRR1660817.178719.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164142
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..453
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 21.32 cM"
     Protein         1..453
                     /product="DDB1- and CUL4-associated factor 12"
                     /note="WD repeat domain 40A; WD repeat-containing protein
                     40A"
                     /calculated_mol_wt=50328
     Region          1..38
                     /region_name="Required for nuclear location and
                     interaction with MOV10.
                     /evidence=ECO:0000250|UniProtKB:Q5T6F0"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BGZ3.1)"
     Region          1..34
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BGZ3.1)"
     Site            15
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q5T6F0; propagated from
                     UniProtKB/Swiss-Prot (Q8BGZ3.1)"
     Region          <101..283
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          138..178
                     /region_name="WD 1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BGZ3.1)"
     Region          144..180
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          182..220
                     /region_name="WD 2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BGZ3.1)"
     Region          187..233
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          250..289
                     /region_name="WD 3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BGZ3.1)"
     Region          255..292
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          300..336
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          338..375
                     /region_name="WD 4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BGZ3.1)"
     CDS             1..453
                     /gene="Dcaf12"
                     /gene_synonym="1500001L20Rik; 5830424K06Rik; Wdr40a"
                     /coded_by="NM_026893.3:337..1698"
                     /db_xref="CCDS:CCDS18059.1"
                     /db_xref="GeneID:68970"
                     /db_xref="MGI:MGI:1916220"
ORIGIN      
        1 markavsrkr kasaspgags daqgpqfgwd hslhkrkrlp pvkrslvyyl knrevrlqne
       61 tsysrllhgy aaqqlpsllk erefhlgtln kvfasqwlnh rqvvcgtkcn tlfvvdvqtg
      121 qitkipilkd repggvtqqg cgihaielnp srtllatggd npnslaiyrl ptldpvcvgd
      181 dghkdwifsi awindtmavs gsrdgsmglw evtddvltks darhnvspvp vyahithkal
      241 kdipkedtnp dnckvralaf nnknkelgav sldgyfhlwk aentlsklls tklpycrenv
      301 claygsewsv yavgsqahvs fldprqpsyn vksvcsrerg sgirsvsfye hiitvgtgqg
      361 sllfydiraq rfleerlsac ygskprlage nlklttgrgw lnhdetwrny fsdidffpna
      421 vythcydssg tklfvaggpl psglhgnyag lws
//
