LOCUS       NM_133734               2515 bp    mRNA    linear   ROD 04-OCT-2024
DEFINITION  Mus musculus DDB1 and CUL4 associated factor 11 (Dcaf11),
            transcript variant 2, mRNA.
ACCESSION   NM_133734
VERSION     NM_133734.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2515)
  AUTHORS   Duangjan,C., Arpawong,T.E., Spatola,B.N. and Curran,S.P.
  TITLE     Hepatic WDR23 proteostasis mediates insulin homeostasis by
            regulating insulin-degrading enzyme capacity
  JOURNAL   Geroscience 46 (5), 4461-4478 (2024)
   PUBMED   38767782
REFERENCE   2  (bases 1 to 2515)
  AUTHORS   Liu,J., Duangjan,C., Irwin,R.W. and Curran,S.P.
  TITLE     WDR23 mediates NRF2 proteostasis and cytoprotective capacity in the
            hippocampus
  JOURNAL   Mech Ageing Dev 218, 111914 (2024)
   PUBMED   38301772
  REMARK    GeneRIF: WDR23 mediates NRF2 proteostasis and cytoprotective
            capacity in the hippocampus.
REFERENCE   3  (bases 1 to 2515)
  AUTHORS   Duangjan,C., Irwin,R.W. and Curran,S.P.
  TITLE     Loss of WDR23 proteostasis impacts mitochondrial homeostasis in the
            mouse brain
  JOURNAL   Cell Signal 116, 111061 (2024)
   PUBMED   38242270
  REMARK    GeneRIF: Loss of WDR23 proteostasis impacts mitochondrial
            homeostasis in the mouse brain.
REFERENCE   4  (bases 1 to 2515)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 2515)
  AUTHORS   Wang,K., Liu,Y., Yu,Z., Gu,B., Hu,J., Huang,L., Ge,X., Xu,L.,
            Zhang,M., Zhao,J., Hu,M., Le,R., Wu,Q., Ye,S., Gao,S., Zhang,X.,
            Xu,R.M. and Li,G.
  TITLE     Phosphorylation at Ser68 facilitates DCAF11-mediated ubiquitination
            and degradation of CENP-A during the cell cycle
  JOURNAL   Cell Rep 37 (6), 109987 (2021)
   PUBMED   34758320
REFERENCE   6  (bases 1 to 2515)
  AUTHORS   Zhang,Y.L., Zhao,L.W., Zhang,J., Le,R., Ji,S.Y., Chen,C., Gao,Y.,
            Li,D., Gao,S. and Fan,H.Y.
  TITLE     DCAF13 promotes pluripotency by negatively regulating SUV39H1
            stability during early embryonic development
  JOURNAL   EMBO J 37 (18) (2018)
   PUBMED   30111536
REFERENCE   7  (bases 1 to 2515)
  AUTHORS   Kannan,M., Bayam,E., Wagner,C., Rinaldi,B., Kretz,P.F., Tilly,P.,
            Roos,M., McGillewie,L., Bar,S., Minocha,S., Chevalier,C., Po,C.,
            Chelly,J., Mandel,J.L., Borgatti,R., Piton,A., Kinnear,C., Loos,B.,
            Adams,D.J., Herault,Y., Collins,S.C., Friant,S., Godin,J.D. and
            Yalcin,B.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     WD40-repeat 47, a microtubule-associated protein, is essential for
            brain development and autophagy
  JOURNAL   Proc Natl Acad Sci U S A 114 (44), E9308-E9317 (2017)
   PUBMED   29078390
REFERENCE   8  (bases 1 to 2515)
  AUTHORS   Evsikov,A.V., Graber,J.H., Brockman,J.M., Hampl,A., Holbrook,A.E.,
            Singh,P., Eppig,J.J., Solter,D. and Knowles,B.B.
  TITLE     Cracking the egg: molecular dynamics and evolutionary aspects of
            the transition from the fully grown oocyte to embryo
  JOURNAL   Genes Dev 20 (19), 2713-2727 (2006)
   PUBMED   17015433
REFERENCE   9  (bases 1 to 2515)
  AUTHORS   Welch,C.L., Xia,Y.R., Shechter,I., Farese,R., Mehrabian,M.,
            Mehdizadeh,S., Warden,C.H. and Lusis,A.J.
  TITLE     Genetic regulation of cholesterol homeostasis: chromosomal
            organization of candidate genes
  JOURNAL   J Lipid Res 37 (7), 1406-1421 (1996)
   PUBMED   8827514
  REMARK    Erratum:[J Lipid Res 1996 Oct;37(10):2269]
REFERENCE   10 (bases 1 to 2515)
  AUTHORS   Warden,C.H., Mehrabian,M., He,K.Y., Yoon,M.Y., Diep,A., Xia,Y.R.,
            Wen,P.Z., Svenson,K.L., Sparkes,R.S. and Lusis,A.J.
  TITLE     Linkage mapping of 40 randomly isolated liver cDNA clones in the
            mouse
  JOURNAL   Genomics 18 (2), 295-307 (1993)
   PUBMED   8288233
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB845333.1 and AK033540.1.
            
            On Nov 18, 2010 this sequence version replaced NM_133734.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR,
            compared to variant 1. Variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK033540.1, AK170657.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 BB845333.1         13-15
            4-2515              AK033540.1         2-2513
FEATURES             Location/Qualifiers
     source          1..2515
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 28.19 cM"
     gene            1..2515
                     /gene="Dcaf11"
                     /gene_synonym="0710008A13Rik; D14Ucla1; Dacf11; GLO14;
                     Wdr23"
                     /note="DDB1 and CUL4 associated factor 11"
                     /db_xref="GeneID:28199"
                     /db_xref="MGI:MGI:90168"
     exon            1..93
                     /gene="Dcaf11"
                     /gene_synonym="0710008A13Rik; D14Ucla1; Dacf11; GLO14;
                     Wdr23"
                     /inference="alignment:Splign:2.1.0"
     exon            94..326
                     /gene="Dcaf11"
                     /gene_synonym="0710008A13Rik; D14Ucla1; Dacf11; GLO14;
                     Wdr23"
                     /inference="alignment:Splign:2.1.0"
     exon            327..454
                     /gene="Dcaf11"
                     /gene_synonym="0710008A13Rik; D14Ucla1; Dacf11; GLO14;
                     Wdr23"
                     /inference="alignment:Splign:2.1.0"
     exon            455..582
                     /gene="Dcaf11"
                     /gene_synonym="0710008A13Rik; D14Ucla1; Dacf11; GLO14;
                     Wdr23"
                     /inference="alignment:Splign:2.1.0"
     exon            583..647
                     /gene="Dcaf11"
                     /gene_synonym="0710008A13Rik; D14Ucla1; Dacf11; GLO14;
                     Wdr23"
                     /inference="alignment:Splign:2.1.0"
     exon            648..748
                     /gene="Dcaf11"
                     /gene_synonym="0710008A13Rik; D14Ucla1; Dacf11; GLO14;
                     Wdr23"
                     /inference="alignment:Splign:2.1.0"
     exon            749..895
                     /gene="Dcaf11"
                     /gene_synonym="0710008A13Rik; D14Ucla1; Dacf11; GLO14;
                     Wdr23"
                     /inference="alignment:Splign:2.1.0"
     exon            896..950
                     /gene="Dcaf11"
                     /gene_synonym="0710008A13Rik; D14Ucla1; Dacf11; GLO14;
                     Wdr23"
                     /inference="alignment:Splign:2.1.0"
     exon            951..1019
                     /gene="Dcaf11"
                     /gene_synonym="0710008A13Rik; D14Ucla1; Dacf11; GLO14;
                     Wdr23"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..1077
                     /gene="Dcaf11"
                     /gene_synonym="0710008A13Rik; D14Ucla1; Dacf11; GLO14;
                     Wdr23"
                     /inference="alignment:Splign:2.1.0"
     exon            1078..1263
                     /gene="Dcaf11"
                     /gene_synonym="0710008A13Rik; D14Ucla1; Dacf11; GLO14;
                     Wdr23"
                     /inference="alignment:Splign:2.1.0"
     exon            1264..1417
                     /gene="Dcaf11"
                     /gene_synonym="0710008A13Rik; D14Ucla1; Dacf11; GLO14;
                     Wdr23"
                     /inference="alignment:Splign:2.1.0"
     exon            1418..1570
                     /gene="Dcaf11"
                     /gene_synonym="0710008A13Rik; D14Ucla1; Dacf11; GLO14;
                     Wdr23"
                     /inference="alignment:Splign:2.1.0"
     exon            1571..1677
                     /gene="Dcaf11"
                     /gene_synonym="0710008A13Rik; D14Ucla1; Dacf11; GLO14;
                     Wdr23"
                     /inference="alignment:Splign:2.1.0"
     exon            1678..2515
                     /gene="Dcaf11"
                     /gene_synonym="0710008A13Rik; D14Ucla1; Dacf11; GLO14;
                     Wdr23"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2492..2497
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dcaf11"
                     /gene_synonym="0710008A13Rik; D14Ucla1; Dacf11; GLO14;
                     Wdr23"
                     /note="hexamer: AATAAA"
     polyA_site      2514
                     /gene="Dcaf11"
                     /gene_synonym="0710008A13Rik; D14Ucla1; Dacf11; GLO14;
                     Wdr23"
                     /note="major polyA site"
ORIGIN      
        1 accggaaagg ctccggggac ggccgcggca cttagggagc gtatgcaaag accaagaaag
       61 gaagccaggg gtcgtcagac aagacccccg ctgcaggctt tgctttcacc aaacccaagt
      121 tggagacagg agcagcccct gcgcaagaca taaggatgct gtaaccagaa gatgggatca
      181 cggaacagca gcagcgccgg atccgggtcc ttagaaccct ctgagggctt gtcccgaaga
      241 gggactggcc tgcgtcgtag tgaggaagag gaagaagagg atgaagatgt ggatctggcc
      301 caggtactgg cctatctcct ccgcagaggc caagtgagac tggtgcaagg aagaggtgca
      361 gcaaatttac agctcatcca ggccctctcg gactcagagg aagagcatga cagtgcctgg
      421 gatggtcgcc ttggagatcg atataaccca cccgtggatg cgacccccga cacccgggag
      481 ctggaataca atgagatcaa gacacaggtg ggattggcca cggggcggct gggacttcgg
      541 aggactgcgc tgcagcagag ttttccgcag atgttacacc agagagaacg gggcctctgc
      601 caccggggaa gcttctccct tggagaacag tctcgagtga tgtctcactt cttgcccaat
      661 gatctaagct tcactgatac ctactctcag aaggctttct gcggcatcta cagcaaagat
      721 ggtcaaatct tcatgtctgc ttgccaagat cagacgatcc gactgtacga ctgtcgctat
      781 ggccgattcc acaaattcaa aagcatcaag gctcgggatg taggctggag tgtcctggac
      841 gtggccttca cccctgatgg aaaccacttc ctgtactcca gctggtctga ctacattcat
      901 atctgcaaca tctatgggga aggagacaca catactgccc tggatttaag gccagatgag
      961 cgtcgctttg ctgtcttctc catcgcagtc tcctcagatg gacgagaagt actaggagga
     1021 gccaatgatg gctgcctata tgtctttgac cgagaacaaa accggcgtac tcttcagatc
     1081 gagtctcatg aggacgatgt gaatgcagtg gcctttgctg acataagctc ccaaatcctg
     1141 ttctctgggg gagacgatgc catctgcaaa gtgtgggatc gacgaaccat gagggaggat
     1201 gatcccaagc ctgtgggtgc actggccggg caccaggatg gcatcacctt tattgacagt
     1261 aagggtgatg cccggtacct catctccaac tccaaagatc agaccattaa gctttgggat
     1321 atcaggcgct tttccagccg agaaggcatg gaagcatcac gactggctgc cacacagcaa
     1381 aactgggact atcgctggca gcaggtgccc aagatcgcct ggaagaagtt gaagctccca
     1441 ggtgacagct ccttgatgac ctacagaggc catggagtgc ttcacactct gatccgatgc
     1501 cgattctccc cagcccacag caccggccag cagttcatct acagtggctg ctctactggc
     1561 aaagtggttg tatatgacct cttgagcggc cacattgtta agaagctgac caatcacaag
     1621 gcctgtgtgc gtgatgtcag ttggcatccc tttgaagaaa agattgtcag cagttcgtgg
     1681 gatgggaacc tacgtctgtg gcagtaccgc caagctgagt acttccagga tgacatgcca
     1741 gagtctgaca tgaacagagt ctgttccagt ggccctactc cagtgccctg cccatctgtg
     1801 gccttttcct cacctcagta gatctgacct ccagttctgt gtagggtgaa ttctcagcat
     1861 attctctgcc tcctcctccc tttccccttc tggggagtac gtggaggaac tgctcacact
     1921 gggtgagaaa cagaaaccca gggtctgggc ccaggctgag cctggactga ccacccccaa
     1981 actgggccaa gtggtttcct cgtgcattca tacccagtct gcttggattt cgatctctag
     2041 ccagagtgtg gcagggcatc cattatctgg ggtgccgctt ctggctacaa gagtcttgag
     2101 tgtgtttaat catgttctga tgttagatat tggctcatag tgtagacact tgaggtctga
     2161 atggacccat tagcagtacc ctttgcccag gtcttcacac tgagagttag attggtggcc
     2221 atcagggcca agtataccga gacctttctt tctgaggtct tcgagggtgg acaggatggg
     2281 tagggaggtg tttgcctcag caacctcctg gggtgagaac tatgtctgct ctcatacttg
     2341 gactttgaag tgaaaagact ggtctgagag gtatgggtct cagatacggc ccaactcgcc
     2401 attggatcct atcattgctg gtggccagca gcttcaacaa aagaggataa aacaggactt
     2461 ctttcacctt ctcactggct gtggctctcc caataaactg tctgtgggaa actgg
//
