LOCUS       NP_598495                549 aa            linear   ROD 27-APR-2025
DEFINITION  DDB1- and CUL4-associated factor 11 [Mus musculus].
ACCESSION   NP_598495
VERSION     NP_598495.1
DBSOURCE    REFSEQ: accession NM_133734.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 549)
  AUTHORS   Duangjan,C., Arpawong,T.E., Spatola,B.N. and Curran,S.P.
  TITLE     Hepatic WDR23 proteostasis mediates insulin homeostasis by
            regulating insulin-degrading enzyme capacity
  JOURNAL   Geroscience 46 (5), 4461-4478 (2024)
   PUBMED   38767782
REFERENCE   2  (residues 1 to 549)
  AUTHORS   Liu,J., Duangjan,C., Irwin,R.W. and Curran,S.P.
  TITLE     WDR23 mediates NRF2 proteostasis and cytoprotective capacity in the
            hippocampus
  JOURNAL   Mech Ageing Dev 218, 111914 (2024)
   PUBMED   38301772
  REMARK    GeneRIF: WDR23 mediates NRF2 proteostasis and cytoprotective
            capacity in the hippocampus.
REFERENCE   3  (residues 1 to 549)
  AUTHORS   Duangjan,C., Irwin,R.W. and Curran,S.P.
  TITLE     Loss of WDR23 proteostasis impacts mitochondrial homeostasis in the
            mouse brain
  JOURNAL   Cell Signal 116, 111061 (2024)
   PUBMED   38242270
  REMARK    GeneRIF: Loss of WDR23 proteostasis impacts mitochondrial
            homeostasis in the mouse brain.
REFERENCE   4  (residues 1 to 549)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (residues 1 to 549)
  AUTHORS   Wang,K., Liu,Y., Yu,Z., Gu,B., Hu,J., Huang,L., Ge,X., Xu,L.,
            Zhang,M., Zhao,J., Hu,M., Le,R., Wu,Q., Ye,S., Gao,S., Zhang,X.,
            Xu,R.M. and Li,G.
  TITLE     Phosphorylation at Ser68 facilitates DCAF11-mediated ubiquitination
            and degradation of CENP-A during the cell cycle
  JOURNAL   Cell Rep 37 (6), 109987 (2021)
   PUBMED   34758320
REFERENCE   6  (residues 1 to 549)
  AUTHORS   Zhang,Y.L., Zhao,L.W., Zhang,J., Le,R., Ji,S.Y., Chen,C., Gao,Y.,
            Li,D., Gao,S. and Fan,H.Y.
  TITLE     DCAF13 promotes pluripotency by negatively regulating SUV39H1
            stability during early embryonic development
  JOURNAL   EMBO J 37 (18) (2018)
   PUBMED   30111536
REFERENCE   7  (residues 1 to 549)
  AUTHORS   Kannan,M., Bayam,E., Wagner,C., Rinaldi,B., Kretz,P.F., Tilly,P.,
            Roos,M., McGillewie,L., Bar,S., Minocha,S., Chevalier,C., Po,C.,
            Chelly,J., Mandel,J.L., Borgatti,R., Piton,A., Kinnear,C., Loos,B.,
            Adams,D.J., Herault,Y., Collins,S.C., Friant,S., Godin,J.D. and
            Yalcin,B.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     WD40-repeat 47, a microtubule-associated protein, is essential for
            brain development and autophagy
  JOURNAL   Proc Natl Acad Sci U S A 114 (44), E9308-E9317 (2017)
   PUBMED   29078390
REFERENCE   8  (residues 1 to 549)
  AUTHORS   Evsikov,A.V., Graber,J.H., Brockman,J.M., Hampl,A., Holbrook,A.E.,
            Singh,P., Eppig,J.J., Solter,D. and Knowles,B.B.
  TITLE     Cracking the egg: molecular dynamics and evolutionary aspects of
            the transition from the fully grown oocyte to embryo
  JOURNAL   Genes Dev 20 (19), 2713-2727 (2006)
   PUBMED   17015433
REFERENCE   9  (residues 1 to 549)
  AUTHORS   Welch,C.L., Xia,Y.R., Shechter,I., Farese,R., Mehrabian,M.,
            Mehdizadeh,S., Warden,C.H. and Lusis,A.J.
  TITLE     Genetic regulation of cholesterol homeostasis: chromosomal
            organization of candidate genes
  JOURNAL   J Lipid Res 37 (7), 1406-1421 (1996)
   PUBMED   8827514
  REMARK    Erratum:[J Lipid Res 1996 Oct;37(10):2269]
REFERENCE   10 (residues 1 to 549)
  AUTHORS   Warden,C.H., Mehrabian,M., He,K.Y., Yoon,M.Y., Diep,A., Xia,Y.R.,
            Wen,P.Z., Svenson,K.L., Sparkes,R.S. and Lusis,A.J.
  TITLE     Linkage mapping of 40 randomly isolated liver cDNA clones in the
            mouse
  JOURNAL   Genomics 18 (2), 295-307 (1993)
   PUBMED   8288233
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB845333.1 and AK033540.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR,
            compared to variant 1. Variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK033540.1, AK170657.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..549
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 28.19 cM"
     Protein         1..549
                     /product="DDB1- and CUL4-associated factor 11"
                     /note="WD repeat domain 23; WD repeat-containing protein
                     23"
                     /calculated_mol_wt=61861
     Region          1..40
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91VU6.1)"
     Site            73
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17242355,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q91VU6.1)"
     Site            75
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q91VU6.1)"
     Region          170..210
                     /region_name="WD 1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91VU6.1)"
     Region          177..214
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          <180..511
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          216..258
                     /region_name="WD 2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91VU6.1)"
     Region          221..263
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          263..302
                     /region_name="WD 3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91VU6.1)"
     Region          269..305
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          305..345
                     /region_name="WD 4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91VU6.1)"
     Region          310..352
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          353..392
                     /region_name="WD 5"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91VU6.1)"
     Region          359..391
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          435..480
                     /region_name="WD 6"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91VU6.1)"
     Region          444..470
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          481..520
                     /region_name="WD 7"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91VU6.1)"
     Region          486..510
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..549
                     /gene="Dcaf11"
                     /gene_synonym="0710008A13Rik; D14Ucla1; Dacf11; GLO14;
                     Wdr23"
                     /coded_by="NM_133734.3:172..1821"
                     /db_xref="CCDS:CCDS27115.1"
                     /db_xref="GeneID:28199"
                     /db_xref="MGI:MGI:90168"
ORIGIN      
        1 mgsrnsssag sgslepsegl srrgtglrrs eeeeeededv dlaqvlayll rrgqvrlvqg
       61 rgaanlqliq alsdseeehd sawdgrlgdr ynppvdatpd treleyneik tqvglatgrl
      121 glrrtalqqs fpqmlhqrer glchrgsfsl geqsrvmshf lpndlsftdt ysqkafcgiy
      181 skdgqifmsa cqdqtirlyd crygrfhkfk sikardvgws vldvaftpdg nhflysswsd
      241 yihicniyge gdthtaldlr pderrfavfs iavssdgrev lggandgcly vfdreqnrrt
      301 lqiesheddv navafadiss qilfsggdda ickvwdrrtm reddpkpvga laghqdgitf
      361 idskgdaryl isnskdqtik lwdirrfssr egmeasrlaa tqqnwdyrwq qvpkiawkkl
      421 klpgdsslmt yrghgvlhtl ircrfspahs tgqqfiysgc stgkvvvydl lsghivkklt
      481 nhkacvrdvs whpfeekivs sswdgnlrlw qyrqaeyfqd dmpesdmnrv cssgptpvpc
      541 psvafsspq
//
