LOCUS       NM_031403               2103 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus debranching RNA lariats 1 (Dbr1), transcript variant
            1, mRNA.
ACCESSION   NM_031403
VERSION     NM_031403.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2103)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2103)
  AUTHORS   Zheng,S., Vuong,B.Q., Vaidyanathan,B., Lin,J.Y., Huang,F.T. and
            Chaudhuri,J.
  TITLE     Non-coding RNA Generated following Lariat Debranching Mediates
            Targeting of AID to DNA
  JOURNAL   Cell 161 (4), 762-773 (2015)
   PUBMED   25957684
REFERENCE   3  (bases 1 to 2103)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   4  (bases 1 to 2103)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   5  (bases 1 to 2103)
  AUTHORS   Kim,H.C., Kim,G.M., Yang,J.M. and Ki,J.W.
  TITLE     Cloning, expression, and complementation test of the RNA lariat
            debranching enzyme cDNA from mouse
  JOURNAL   Mol Cells 11 (2), 198-203 (2001)
   PUBMED   11355701
REFERENCE   6  (bases 1 to 2103)
  AUTHORS   Kim,J.W., Kim,H.C., Kim,G.M., Yang,J.M., Boeke,J.D. and Nam,K.
  TITLE     Human RNA lariat debranching enzyme cDNA complements the phenotypes
            of Saccharomyces cerevisiae dbr1 and Schizosaccharomyces pombe dbr1
            mutants
  JOURNAL   Nucleic Acids Res 28 (18), 3666-3673 (2000)
   PUBMED   10982890
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK050090.1.
            
            On Apr 6, 2007 this sequence version replaced NM_031403.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK050090.1, SRR1660817.238253.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2103              AK050090.1         2-2104
FEATURES             Location/Qualifiers
     source          1..2103
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 51.86 cM"
     gene            1..2103
                     /gene="Dbr1"
                     /note="debranching RNA lariats 1"
                     /db_xref="GeneID:83703"
                     /db_xref="MGI:MGI:1931520"
     exon            1..327
                     /gene="Dbr1"
                     /inference="alignment:Splign:2.1.0"
     CDS             131..1783
                     /gene="Dbr1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     lariat debranching enzyme; debranching enzyme homolog 1"
                     /codon_start=1
                     /product="lariat debranching enzyme isoform 1"
                     /protein_id="NP_113580.2"
                     /db_xref="CCDS:CCDS23435.1"
                     /db_xref="GeneID:83703"
                     /db_xref="MGI:MGI:1931520"
                     /translation="MRVAVAGCCHGELDKIYETLALAERRGSGPVDLLLCCGDFQAVR
                     NEADLRCMAVPPKYRHMQTFYRYYSGEKKAPVLTIFIGGNHEASNHLQELPYGGWVAP
                     NIYYLGLAGVVKYRGVRIGGISGIFKSHDYRKGHFECPPYNSSTIRSIYHVRNIEVYK
                     LKQLKQPVHIFLSHDWPRNIYHYGNKKQLLKTKSFFRQEVENSTLGSPAASELLEHLQ
                     PAYWFSAHLHVKFAALMQHQATDKDQAGKETKFLALDKCLPHRDFLQVLEIEHDPSAP
                     EYLEYDVEWLTVLRATDDLINVTGGLWNMPEDNGLHTRWDYSATEETMKEVMEKLNHD
                     PKVPCNFTMTAACYDPSKPQTQVKLVHRINPQTTEFCAQLGITDINVMIQKAREEEHH
                     QCGEYEQQGDPGTEESEEDRSEYNTDTSALSSINPDEIMLDEEEEEEEEEEEAVSAHS
                     DMNTPSVEPASDQASDLSTSFSDIRNLPSSMFVSSDDASRSPASGEGKCGETVESGDE
                     KDLAKFPLKRLSDEHEPEQRKKIKRRNQAIYAAVDDGDASAE"
     exon            328..452
                     /gene="Dbr1"
                     /inference="alignment:Splign:2.1.0"
     exon            453..533
                     /gene="Dbr1"
                     /inference="alignment:Splign:2.1.0"
     exon            534..619
                     /gene="Dbr1"
                     /inference="alignment:Splign:2.1.0"
     exon            620..844
                     /gene="Dbr1"
                     /inference="alignment:Splign:2.1.0"
     exon            845..925
                     /gene="Dbr1"
                     /inference="alignment:Splign:2.1.0"
     exon            926..1071
                     /gene="Dbr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..2103
                     /gene="Dbr1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1946..1951
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dbr1"
                     /note="hexamer: ATTAAA"
     polyA_site      1968
                     /gene="Dbr1"
                     /note="major polyA site"
ORIGIN      
        1 gaaactcagc cgcggctcgg ttggtgttgg cgggagccgg gtgggccggc tgcctggtgt
       61 tctttgctgt gcgacccggg ctgcaggtgc tccggggtgt tgctgttgag ttccgcggcc
      121 caacgtcacg atgagggtgg ccgtggccgg ctgctgccac ggcgagctgg acaagatcta
      181 cgagactctg gcgctggcgg agcggcgcgg ctcgggaccc gtggatctcc ttctgtgctg
      241 cggcgacttc caggcggtgc gcaacgaggc cgacctgcgc tgcatggccg tgccgcccaa
      301 gtaccgtcac atgcagacct tctacagata ttactctgga gagaaaaagg ccccggttct
      361 caccatcttc attggaggaa accatgaagc ctcaaaccat ttgcaagagt taccctatgg
      421 tggctgggta gcgccgaata tttattattt aggcttggct ggtgttgtca aataccgagg
      481 agtaaggatt ggtggcatct ctggcatatt taaatctcat gattatagaa aaggtcattt
      541 tgagtgcccc ccttataatt catctaccat aaggagtata tatcatgtga gaaatataga
      601 ggtctacaaa ttaaaacagt taaagcagcc tgtacatata ttcttgtctc atgattggcc
      661 aagaaatata tatcattatg gcaataagaa gcagcttctt aagaccaaat cttttttccg
      721 ccaagaagtg gaaaacagca ccctggggag ccccgctgcc tcggagctgc tggagcacct
      781 acagcctgcg tactggttct ccgcgcacct gcatgtcaag ttcgcagccc tgatgcagca
      841 tcaggccaca gataaagacc aagcaggcaa agaaaccaag tttttagcct tggacaagtg
      901 cttgccacac agagacttcc ttcaggtgtt agagatagaa catgacccca gtgctcctga
      961 gtacttagag tatgacgttg aatggcttac tgttctcagg gccactgatg acctgattaa
     1021 tgtgactggg ggcctgtgga atatgcctga agacaacggt ctgcacacaa ggtgggatta
     1081 tagtgcaacg gaagaaacta tgaaggaagt aatggaaaaa ttgaaccatg accctaaagt
     1141 cccctgtaac ttcaccatga cagctgcttg ttatgatccc agtaagcccc agacacaagt
     1201 gaagctggtt cacaggatca atccacagac gactgagttc tgtgcccagc ttggcatcac
     1261 agacatcaat gtcatgattc agaaggccag agaggaagag caccatcagt gtggtgaata
     1321 tgagcagcag ggtgacccgg ggactgagga gtctgaagag gaccggagtg agtacaacac
     1381 agacacgtcg gccctctcct ccattaatcc agatgaaatc atgctggatg aagaggagga
     1441 ggaggaggag gaggaggagg aggctgtaag cgctcacagt gacatgaaca caccttctgt
     1501 ggaacctgct tctgaccagg cttctgacct ctctacaagc ttttctgaca tcaggaactt
     1561 accaagttcc atgtttgtgt cctctgacga tgcatcccgt tctccagcaa gtggagaggg
     1621 gaaatgtggt gaaacggtgg agtctgggga tgaaaaagac ttggctaagt ttcctctgaa
     1681 gcggctgagt gatgaacacg aacctgaaca aaggaagaaa ataaagagga ggaaccaagc
     1741 catctacgct gcagtggatg atggggatgc tagtgccgag tgagacagag gctggactgt
     1801 gataaatgta ggggtgggat ttccagaccc tgtttttagg gcagaatttc tgatttatta
     1861 ctggactttg taataatgaa atgatggaat tttggttata agctctgtat ttagatgtat
     1921 gtttatatga ttcagatata gacttattaa atttcatatg agatttgatt gatgaccatt
     1981 tttaagacat tcacttccat agttttcagc acttagtaca catgaatttt gagaaacact
     2041 gttctctaag atgggactat aaagattttg taaatacatt aaatgccact taattgctga
     2101 aat
//
