LOCUS       NM_026797               3706 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus dysbindin domain containing 2 (Dbndd2), transcript
            variant 2, mRNA.
ACCESSION   NM_026797
VERSION     NM_026797.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3706)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3706)
  AUTHORS   Armfield,B.A., Seifert,A.W., Zheng,Z., Merton,E.M., Rock,J.R.,
            Lopez,M.C., Baker,H.V. and Cohn,M.J.
  TITLE     Molecular Characterization of the Genital Organizer: Gene
            Expression Profile of the Mouse Urethral Plate Epithelium
  JOURNAL   J Urol 196 (4), 1295-1302 (2016)
   PUBMED   27173853
REFERENCE   3  (bases 1 to 3706)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   4  (bases 1 to 3706)
  AUTHORS   Jia,J.M., Hu,Z., Nordman,J. and Li,Z.
  TITLE     The schizophrenia susceptibility gene dysbindin regulates dendritic
            spine dynamics
  JOURNAL   J Neurosci 34 (41), 13725-13736 (2014)
   PUBMED   25297099
  REMARK    GeneRIF: These findings reveal the essential roles of dysbindin and
            CaMKIIalpha in the stabilization of dendritic protrusions
REFERENCE   5  (bases 1 to 3706)
  AUTHORS   Kirchhof,P., Kahr,P.C., Kaese,S., Piccini,I., Vokshi,I.,
            Scheld,H.H., Rotering,H., Fortmueller,L., Laakmann,S., Verheule,S.,
            Schotten,U., Fabritz,L. and Brown,N.A.
  TITLE     PITX2c is expressed in the adult left atrium, and reducing Pitx2c
            expression promotes atrial fibrillation inducibility and complex
            changes in gene expression
  JOURNAL   Circ Cardiovasc Genet 4 (2), 123-133 (2011)
   PUBMED   21282332
REFERENCE   6  (bases 1 to 3706)
  AUTHORS   Pratscher,B., Friedrich,C., Goger,W., Allen,M., Fink,D.,
            Thallinger,C., Wolschek,M., Frei,K., Schofer,C., Pehamberger,H.,
            Wacheck,V., Sorensen,P.H., Muller,M., Jansen,B. and Lucas,T.
  TITLE     Characterization of NKIP: a novel, Na+/K+-ATPase interacting
            protein mediates neural differentiation and apoptosis
  JOURNAL   Exp Cell Res 314 (3), 463-477 (2008)
   PUBMED   18096156
  REMARK    GeneRIF: Thus, we have identified NKIP as an important novel
            protein that interacts to the NKA complex, influencing cellular ion
            balance, induction of apoptosis and neuronal differentiation.(NKIP
            PROTEIN, MOUSE)
REFERENCE   7  (bases 1 to 3706)
  AUTHORS   Pazzaglia,S., Pariset,L., Rebessi,S., Saran,A., Coppola,M.,
            Covelli,V., Moody,J., Bouffler,S., Cox,R. and Silver,A.
  TITLE     Somatic cell hybrids for high-density mapping of chromosome 2
            breakpoints in radiation-induced myeloid leukemia cell lines from
            inbred mice
  JOURNAL   Mol Carcinog 27 (3), 219-228 (2000)
   PUBMED   10708484
REFERENCE   8  (bases 1 to 3706)
  AUTHORS   Brady,K.P., Rowe,L.B., Her,H., Stevens,T.J., Eppig,J.,
            Sussman,D.J., Sikela,J. and Beier,D.R.
  TITLE     Genetic mapping of 262 loci derived from expressed sequences in a
            murine interspecific cross using single-strand conformational
            polymorphism analysis
  JOURNAL   Genome Res 7 (11), 1085-1093 (1997)
   PUBMED   9371744
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CX241653.1 and AL591478.19.
            
            On Sep 22, 2006 this sequence version replaced NM_026797.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CX241653.1, AK013571.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-596               CX241653.1         1-596
            597-3706            AL591478.19        43285-46394
FEATURES             Location/Qualifiers
     source          1..3706
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 85.17 cM"
     gene            1..3706
                     /gene="Dbndd2"
                     /gene_synonym="1110017A21Rik; 2900022J10Rik; D2Bwg0891e;
                     Nkip; R74724"
                     /note="dysbindin domain containing 2"
                     /db_xref="GeneID:52840"
                     /db_xref="MGI:MGI:106562"
     exon            1..233
                     /gene="Dbndd2"
                     /gene_synonym="1110017A21Rik; 2900022J10Rik; D2Bwg0891e;
                     Nkip; R74724"
                     /inference="alignment:Splign:2.1.0"
     exon            234..380
                     /gene="Dbndd2"
                     /gene_synonym="1110017A21Rik; 2900022J10Rik; D2Bwg0891e;
                     Nkip; R74724"
                     /inference="alignment:Splign:2.1.0"
     CDS             242..718
                     /gene="Dbndd2"
                     /gene_synonym="1110017A21Rik; 2900022J10Rik; D2Bwg0891e;
                     Nkip; R74724"
                     /note="SCF apoptosis response protein 1; dysbindin
                     (dystrobrevin binding protein 1) domain containing 2;
                     likely orthologue of H. sapiens chromosome 20 open reading
                     frame 35"
                     /codon_start=1
                     /product="dysbindin domain-containing protein 2"
                     /protein_id="NP_081073.1"
                     /db_xref="CCDS:CCDS38322.1"
                     /db_xref="GeneID:52840"
                     /db_xref="MGI:MGI:106562"
                     /translation="MDPNPRAALERQQLRLRERQKFFEDILQPETEFVFPLSHLHLES
                     QRPPIGSISSMEVNVDTLEQVEFIDLADQDGADVFLPCEESSPAPQMSGVDDHPEELS
                     LLVPTSDRTTSRTSSLSSDSSNLRSPNPSDGGGDTPLAQSDEEDGDDGGAEPGPCS"
     exon            381..518
                     /gene="Dbndd2"
                     /gene_synonym="1110017A21Rik; 2900022J10Rik; D2Bwg0891e;
                     Nkip; R74724"
                     /inference="alignment:Splign:2.1.0"
     exon            519..3706
                     /gene="Dbndd2"
                     /gene_synonym="1110017A21Rik; 2900022J10Rik; D2Bwg0891e;
                     Nkip; R74724"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1128..1133
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dbndd2"
                     /gene_synonym="1110017A21Rik; 2900022J10Rik; D2Bwg0891e;
                     Nkip; R74724"
                     /note="hexamer: AATAAA"
     polyA_site      1146
                     /gene="Dbndd2"
                     /gene_synonym="1110017A21Rik; 2900022J10Rik; D2Bwg0891e;
                     Nkip; R74724"
                     /note="major polyA site"
     regulatory      3683..3688
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dbndd2"
                     /gene_synonym="1110017A21Rik; 2900022J10Rik; D2Bwg0891e;
                     Nkip; R74724"
                     /note="hexamer: AATAAA"
     polyA_site      3702
                     /gene="Dbndd2"
                     /gene_synonym="1110017A21Rik; 2900022J10Rik; D2Bwg0891e;
                     Nkip; R74724"
ORIGIN      
        1 cgcaagtccg ggtcccggcg tttagaggag ctgtcctccg ccgccagccc cgagtgcccg
       61 ccccgccccc acttccgcct cccgcctctt cctcgttccc ggctcccagg gccgccggtc
      121 cccagggaac cccgcaggct tagccccacc cggccggcgc tgctcgctcc cacgcccccg
      181 ccgccgcttg tcgggagcgc acccagggag ccagcggggc gcgggcgctg caggggctga
      241 catggaccca aatccgagag cagccctgga gcgccaacag ctgcggctcc gggagaggca
      301 gaagttcttt gaggacattt tacagccaga gacagagttt gtcttccccc tgtcccatct
      361 gcacctggag tcacaaagac cccccatagg tagcatctcg tctatggaag tgaatgtgga
      421 cacactggag caagtggagt ttattgatct tgcggatcag gatggagcag atgtgttctt
      481 gccttgtgag gagtcctcgc cagctcccca gatgtctgga gtggatgacc atccagagga
      541 gctgagcctg ctggtaccca cgtctgacag gaccacatcc cggacctcct ccttgtcctc
      601 tgactcctcc aacctgcgca gtccaaatcc aagtgatggg ggaggagaca ctcccttggc
      661 acagtctgat gaggaggacg gggatgacgg aggggcagag cctggaccct gcagctagca
      721 gtgggcctcg tacagactga ccagcccggc tgttctccat ggaaaggaga cctaggccca
      781 gcagagcctg gagaagacct gacactttcc ttacttcagc accaaaggga gggaaggatg
      841 gtggatggtg tgcctgagag ttagcctccc ctgctttacc gctaacgcta tcctgctgcc
      901 acgcccccac agtgcttttc ttctgaggta ggacttccaa gtgagacttg agaggtgagg
      961 tgggacaaga cgcagctgct ttcttagtcc cctcctgccc ccagatgatc ctgttgtctt
     1021 ccacagagtc tcctaagcca gtgtctctga ggggatgttc tgaggagttc cactttccag
     1081 ttatcctgcc tctataagtt cttttgggaa caggatatgg tataaataat aaataataat
     1141 ataccactca tttcacctca ttcttcatat tgcaaagata ccaaccccac tgtcattaac
     1201 taactagtgt catatctcca tcattcattc actccatttt gccaagagat acttgggaat
     1261 ttcatctccg caaggcattg ggaatagagt cctgagtaag atgaagtact ttcctgtttt
     1321 cacagagtta ctgtctggtg aagaaaatca ggtaaataga gtacagtata gtacgtagca
     1381 tgatcgcgtc ctcctctgct ctcaggaaag agaatggcaa gatggtttct taggcagaga
     1441 tctaaaggac acaagtagcc aagcaaggcc gagggagaag gatcctgtgg ggagaagctg
     1501 ttgccttaga acactaagtg ggaaggctgg gctgggtgtg gggctcatcc ctgaaacctt
     1561 tgcacttcag aggtggaggc agggggacag ctttggcttc ctagcttatt tgagggcagc
     1621 ctgggtctca tgagactgtc tcaaaaataa aataagccaa aaaaaaaaaa aaagaagaag
     1681 aagaagaaga agaaggtagg aggaggagga ggaggaagag ggctaaagaa gctaaaatac
     1741 tcggtttggc taaattgttg gatttgaaaa tatacaggga gaggtaaact tgatgaaggt
     1801 cagattgtga aatgctttga agcctgtatt aggtttcagt gtgacagcta gtaaaagatc
     1861 atgacttaag agataaattt atttccacgt accaaagaag ccgaaaatct caggctcctt
     1921 ggggaaggtc cgtagtaact gagcaccagg ctgctttggg gtggttttcc ttagccatcc
     1981 agggcacgga tgcccattcc tgcccatgcc ttgtgtttag gatggctggc aaagcatcag
     2041 ccagcgtgac tttgaaaaag gcagaaaacg agatgaagtg gcgaatgggc aaaaagggca
     2101 cagcctgggg cctgttctca cctggaagga agctgtaaga aatggtgccc acttatattt
     2161 cattgcccag aattttataa cagaaaatgt agcattttag acattttata gatactgaca
     2221 cagcattttt tctaaaagag tagattttag cttttggaaa gacaataacc ctttcaaatc
     2281 actgaatttg atgccactgc atcggattcc agcaccacct aacatctttg agaagcaccc
     2341 agtctagagg atgctggggc atcccttttt atcaggcact ctactgtctt gactggtcag
     2401 ggtttttttt tttttcctaa ggagaaagag gatagtagtc atttagcagt ttacgtgttc
     2461 ggaggccatg ttacagggtt tggacttttc tggacataat gaaagattac aaatggttgt
     2521 gttaatccca gagatgcgag gggaaagacc accagcccaa accatcacga ccacattaat
     2581 taaagcaagc tttttctgcg tgtacccagg ctgtctccct aaaggcaggc ttcaagagat
     2641 caacgttgga aatggggaag atacggtttt tatagctcag gggtaggtca tttccaaatg
     2701 gggtatttgg caggcaaaac agggttacag aagcagaaaa aggtggtctt aacaaggtag
     2761 tcatgtcaac aggcagtcct tacaaccttc agaaacaaag gtagggttcc aaaacggtgg
     2821 tcactttttg aaacaagcat ggttgctgtt ccctgggaca ggccacacag aaccatttat
     2881 agtgaaggtt atagggggtg cacagcaggt ttaatccttg agactcaggt ttaatcacaa
     2941 acaggaatga gtgagcctag ctggtcttca ctgtcaaatg accttcaggc ctaagatgga
     3001 ggcaggcagg ctgcttcatc ggttggactt ttgtttaaaa ggtaattctg actgcagttt
     3061 agagaatata ctggagaagg caggctctag atgaacaaag aatacagtaa catatagaag
     3121 tcataacagg tccagtagac tgaagtgatc ttcctactca ggctcaagca gggtataaac
     3181 aaattggcat tatttcgtcc cataagtact gcatgttggt atttaacaag tgtgaaacac
     3241 aaatacagta tctgatactt ctgtcactga gctcagtgtc gtggagccca aatgtaaatt
     3301 tgcagctatg actcgtgctg caaaacagcc agcctattca gagaggtcac gggagtcagt
     3361 ctcccttgag gaagtgacat tggagctgag acctgaataa caagtaggaa gaaagaagct
     3421 aggggaagag agaatggctg gaaggcccct tgaggctgat tacagggatc aagtgccccg
     3481 agaccagaag attgcattta tcaaaatagg agataagagt tggggcagag tggcaggatg
     3541 taggaaggtg gagggtttag aagacttcag agataaacat ggacaccttt ttattgggtg
     3601 agtttggaag gaaggggact aaggtacagt attgtttcta cctcatgccg cagggtgatt
     3661 gtggggtgtg ggttgaaatt gtaataaatt tgtttagatg gattga
//
