LOCUS       NM_001177371            3044 bp    mRNA    linear   ROD 27-NOV-2023
DEFINITION  Mus musculus drebrin 1 (Dbn1), transcript variant 1, mRNA.
ACCESSION   NM_001177371
VERSION     NM_001177371.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3044)
  AUTHORS   Dorskind JM, Sudarsanam S, Hand RA, Ziak J, Amoah-Dankwah M,
            Guzman-Clavel L, Soto-Vargas JL and Kolodkin AL.
  TITLE     Drebrin Regulates Collateral Axon Branching in Cortical Layer
            II/III Somatosensory Neurons
  JOURNAL   J Neurosci 43 (46), 7745-7765 (2023)
   PUBMED   37798130
  REMARK    GeneRIF: Drebrin Regulates Collateral Axon Branching in Cortical
            Layer II/III Somatosensory Neurons.
REFERENCE   2  (bases 1 to 3044)
  AUTHORS   Wu JH, Zhang L, Nepliouev I, Brian L, Huang T, Snow KP, Schickling
            BM, Hauser ER, Miller FJ, Freedman NJ and Stiber JA.
  TITLE     Drebrin attenuates atherosclerosis by limiting smooth muscle cell
            transdifferentiation
  JOURNAL   Cardiovasc Res 118 (3), 772-784 (2022)
   PUBMED   33914863
REFERENCE   3  (bases 1 to 3044)
  AUTHORS   Karnam S, Maddala R, Stiber JA and Rao PV.
  TITLE     Drebrin, an actin-binding protein, is required for lens
            morphogenesis and growth
  JOURNAL   Dev Dyn 250 (11), 1600-1617 (2021)
   PUBMED   33896079
REFERENCE   4  (bases 1 to 3044)
  AUTHORS   Klemz A, Kreis P, Eickholt BJ and Gerevich Z.
  TITLE     The actin binding protein drebrin helps to protect against the
            development of seizure-like events in the entorhinal cortex
  JOURNAL   Sci Rep 11 (1), 8662 (2021)
   PUBMED   33883605
  REMARK    GeneRIF: The actin binding protein drebrin helps to protect against
            the development of seizure-like events in the entorhinal cortex.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3044)
  AUTHORS   Schiweck J, Murk K, Ledderose J, Munster-Wandowski A, Ornaghi M,
            Vida I and Eickholt BJ.
  TITLE     Drebrin controls scar formation and astrocyte reactivity upon
            traumatic brain injury by regulating membrane trafficking
  JOURNAL   Nat Commun 12 (1), 1490 (2021)
   PUBMED   33674568
  REMARK    GeneRIF: Drebrin controls scar formation and astrocyte reactivity
            upon traumatic brain injury by regulating membrane trafficking.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3044)
  AUTHORS   Butkevich E, Hulsmann S, Wenzel D, Shirao T, Duden R and Majoul I.
  TITLE     Drebrin is a novel connexin-43 binding partner that links gap
            junctions to the submembrane cytoskeleton
  JOURNAL   Curr Biol 14 (8), 650-658 (2004)
   PUBMED   15084279
REFERENCE   7  (bases 1 to 3044)
  AUTHORS   Peitsch WK, Hofmann I, Endlich N, Pratzel S, Kuhn C, Spring H,
            Grone HJ, Kriz W and Franke WW.
  TITLE     Cell biological and biochemical characterization of drebrin
            complexes in mesangial cells and podocytes of renal glomeruli
  JOURNAL   J Am Soc Nephrol 14 (6), 1452-1463 (2003)
   PUBMED   12761245
  REMARK    GeneRIF: Drebrin is involved in regulation of actin dynamics also
            outside the nervous system. Drebrin is one of the actin-binding
            proteins regulating the actomyosin system and the dynamics of
            mesangial cells and foot processes in podocytes.
REFERENCE   8  (bases 1 to 3044)
  AUTHORS   Jin M, Tanaka S, Sekino Y, Ren Y, Yamazaki H, Kawai-Hirai R, Kojima
            N and Shirao T.
  TITLE     A novel, brain-specific mouse drebrin: cDNA cloning, chromosomal
            mapping, genomic structure, expression, and functional
            characterization
  JOURNAL   Genomics 79 (5), 686-692 (2002)
   PUBMED   11991718
REFERENCE   9  (bases 1 to 3044)
  AUTHORS   Kessels MM, Engqvist-Goldstein AE and Drubin DG.
  TITLE     Association of mouse actin-binding protein 1 (mAbp1/SH3P7), an Src
            kinase target, with dynamic regions of the cortical actin
            cytoskeleton in response to Rac1 activation
  JOURNAL   Mol Biol Cell 11 (1), 393-412 (2000)
   PUBMED   10637315
REFERENCE   10 (bases 1 to 3044)
  AUTHORS   Keon BH, Jedrzejewski PT, Paul DL and Goodenough DA.
  TITLE     Isoform specific expression of the neuronal F-actin binding
            protein, drebrin, in specialized cells of stomach and kidney
            epithelia
  JOURNAL   J Cell Sci 113 Pt 2, 325-336 (2000)
   PUBMED   10633083
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT009762.8.
            
            [WARNING] On Dec 26, 2023 this sequence was replaced by
            NM_001177371.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF187147.1, SRR7345562.3439506.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-214               CT009762.8         44714-44927
            215-270             CT009762.8         49348-49403
            271-383             CT009762.8         49986-50098
            384-458             CT009762.8         50303-50377
            459-605             CT009762.8         50493-50639
            606-683             CT009762.8         50800-50877
            684-835             CT009762.8         51100-51251
            836-899             CT009762.8         51378-51441
            900-959             CT009762.8         54954-55013
            960-1089            CT009762.8         55110-55239
            1090-1227           CT009762.8         56017-56154
            1228-1398           CT009762.8         56474-56644
            1399-2075           CT009762.8         57254-57930
            2076-2178           CT009762.8         58232-58334
            2179-3044           CT009762.8         58497-59362
FEATURES             Location/Qualifiers
     source          1..3044
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 30.06 cM"
     gene            1..3044
                     /gene="Dbn1"
                     /note="drebrin 1"
                     /db_xref="GeneID:56320"
                     /db_xref="MGI:MGI:1931838"
     exon            1..214
                     /gene="Dbn1"
                     /inference="alignment:Splign:2.1.0"
     CDS             129..2249
                     /gene="Dbn1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     drebrin E2; developmentally-regulated brain protein;
                     drebrin A"
                     /codon_start=1
                     /product="drebrin isoform 1"
                     /protein_id="NP_001170842.1"
                     /db_xref="CCDS:CCDS49274.1"
                     /db_xref="GeneID:56320"
                     /db_xref="MGI:MGI:1931838"
                     /translation="MAGVSFSGHRLELLAAYEEVIREESAADWALYTYEDGSDDLKLA
                     ASGEGGLQELSGHFENQKVMYGFCSVKDSQAALPKYVLINWVGEDVPDARKCACASHV
                     AKVAEFFQGVDVIVNASSVEDIDAGAIGQRLSNGLARLSSPVLHRLRLREDENAEPVG
                     TTYQKTDAAVEMKRINREQFWEQAKKEEELRKEEERKKALDARLRFEQERMEQERQEQ
                     EERERRYREREQQIEEHRRKQQSLEAEEAKRRLKEQSIFGDQRDEEEESQMKKSESEV
                     EEAAAIIAQRPDNPREFFRQQERVASASGGSCDAPAPAPFNHRPGRPYCPFIKASDSG
                     PSSSSSSSSSPPRTPFPYITCHRTPNLSSSLPCSHLDSHRRMAPTPIPTRSPSDSSTA
                     STPIAEQIERALDEVTSSQPPPPPPPPPPTQEAQETTPSLDEELSKEAKVTAAPEVWA
                     GCAAEPPQAQEPPLLQSSPLEDSMCTESPEQAALAAPAEPAASVTSVADVHAADTIET
                     TTATTDTTIANNVTPAAASLIDLWPGNGEEASTLQAEPRVPTPPSGAEASLAEVPLLN
                     EAAQEPLPPVGEGCANLLNFDELPEPPATFCDPEEEVGETLAASQVLTMPSALEEVDQ
                     VLEQELEPEPHLLTNGETTQKEGTQASEGYFSQSQEEEFAQSEEPCAKVPPPVFYNKP
                     PEIDITCWDADPVPEEEEGFEGGD"
     exon            215..270
                     /gene="Dbn1"
                     /inference="alignment:Splign:2.1.0"
     exon            271..383
                     /gene="Dbn1"
                     /inference="alignment:Splign:2.1.0"
     exon            384..458
                     /gene="Dbn1"
                     /inference="alignment:Splign:2.1.0"
     exon            459..605
                     /gene="Dbn1"
                     /inference="alignment:Splign:2.1.0"
     exon            606..683
                     /gene="Dbn1"
                     /inference="alignment:Splign:2.1.0"
     exon            684..835
                     /gene="Dbn1"
                     /inference="alignment:Splign:2.1.0"
     exon            836..899
                     /gene="Dbn1"
                     /inference="alignment:Splign:2.1.0"
     exon            900..959
                     /gene="Dbn1"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1089
                     /gene="Dbn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1090..1227
                     /gene="Dbn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1228..1398
                     /gene="Dbn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1399..2075
                     /gene="Dbn1"
                     /inference="alignment:Splign:2.1.0"
     exon            2076..2178
                     /gene="Dbn1"
                     /inference="alignment:Splign:2.1.0"
     exon            2179..3044
                     /gene="Dbn1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggctcgctcg ctctcagcgc tgcagaggct ctgaggcggc ggcggcgact ccctcatccc
       61 ctccctccgg tgtcggtcgg tccgcctgtg cgtgcgtctg tccgttcggc ctcggtccgg
      121 cccgcagcat ggccggcgtc agcttcagcg gccaccgcct ggagctgctg gcggcgtacg
      181 aggaggtgat ccgggaggag agcgcagccg actgggctct gtacacatac gaggatggct
      241 cagatgacct caagcttgca gcgtcaggag aagggggctt gcaggagctt tccggccact
      301 tcgagaacca gaaagtgatg tatggtttct gcagcgtcaa ggactcccaa gctgccctgc
      361 caaaatatgt gctcatcaac tgggttggtg aggatgtgcc tgatgcccga aaatgtgctt
      421 gcgccagtca tgtggccaag gtggctgaat tcttccaggg tgttgatgtc attgtgaatg
      481 ccagcagtgt ggaagacatc gatgctggtg ccattgggca gcggctctcc aatggactgg
      541 cacggctctc cagcccagta ttgcaccgcc tgcgccttcg ggaggatgaa aatgctgaac
      601 cggtgggtac cacctaccag aagacggatg cagcagtgga gatgaagcgg attaaccgtg
      661 agcagttttg ggagcaggcc aagaaggagg aagagctgcg gaaggaggag gagcggaaga
      721 aggctctgga cgccaggctc aggtttgaac aggaacggat ggagcaggag cggcaggagc
      781 aggaagaacg tgagcggcgc taccgggagc gggagcagca gattgaggag cacaggagga
      841 aacagcagag tctggaagct gaagaagcca agaggaggtt aaaggagcag tctatctttg
      901 gtgaccagcg ggatgaagag gaagagtccc agatgaagaa gtcggagtca gaggtggagg
      961 aggcggctgc catcattgcc cagcggcctg ataacccacg ggagttcttc agacagcagg
     1021 aacgagtggc atcggcctct ggtggcagct gtgacgcgcc tgcgcctgca cccttcaacc
     1081 accgaccagg tcgtccgtac tgccctttca taaaggcatc ggacagtggg ccttcctcct
     1141 cctcctcttc ctcctcttcc cctccacgga ctccctttcc ctatatcacc tgccaccgca
     1201 ccccaaacct ctcttcctcc ctcccatgca gccacctgga cagccaccgg aggatggcac
     1261 ccactcctat tcccacccgg agcccatctg attccagcac agcctctacc cccatcgctg
     1321 agcagatcga gagggccctg gatgaggtca catcctcgca gcctccacct ccacctccac
     1381 cacctccacc aactcaagag gcccaggaga ctaccccaag cctggatgaa gagctcagca
     1441 aggaggccaa agtaacagca gctcctgagg tctgggctgg ctgtgcggca gagccccctc
     1501 aggcacagga acctcccctg ttgcaaagca gccccctgga ggactcgatg tgcacagaat
     1561 ctccagagca ggctgccctg gctgcccctg cggagcctgc tgcctctgtc acctcagtag
     1621 ctgatgtcca tgcagctgac accattgaga ccaccactgc cactactgac accactattg
     1681 ccaacaacgt cacccctgcc gctgccagcc tcattgatct atggcctggc aacggggaag
     1741 aggcctcaac acttcaggct gaacccaggg tgcccacacc accctcaggt gctgaggcct
     1801 ccctggcaga ggtgcccctg ctgaatgagg ccgctcagga gccgctgccg ccggtaggcg
     1861 aaggctgtgc taaccttctt aattttgatg agctgccaga acctccagcc accttctgtg
     1921 acccagagga ggaagtagga gaaacgctgg ctgcctccca ggtcctaact atgccctcag
     1981 ctctagagga ggtagatcag gtgctggagc aggagctgga gccagaacct cacctgctga
     2041 ccaatggaga gaccactcaa aaggagggga cccaggccag cgaaggatac ttcagtcagt
     2101 cacaggagga agagttcgcc caatcagaag agccatgtgc aaaggttccg cctcctgtat
     2161 tttacaacaa gcctccagaa atcgacatca cctgctggga tgcagaccca gttcctgaag
     2221 aggaagaggg cttcgagggt ggtgattagt agcggcgact gccccctggc tgccctcgcc
     2281 aaggctgcct acctgcagtg gcctctggcc agccggcttg cagtgccagc attagcagca
     2341 gccccgcctg gctcccactc tggattccgg cactggccgg ggacctgtct gcttccttac
     2401 ccacagggcc tgacttttac agcttttctc ttttttttaa aagttgatag acttgtacaa
     2461 ttgactggtt ttcctcccgt tggtagttga aacaatgttg cagattccac ccccttcctg
     2521 cccagaccag attgtagctt agttctttct gctcagctga ccagggtgga ggcctcacct
     2581 tgtttgggac ctggtggggg tcgggggttc tggtgggaaa atgttccccc catcactttt
     2641 cctagtttta tgtttcttgg aaaaaaaatc actttgtatt ctctatccag ggcttcagat
     2701 attttgcacg aaatttaaaa catggcaata aatggctcgt gggctctggc tccctgggac
     2761 ccttcccctt ctctttaccc tcgctgcttg gtcagaagga attatcagac ccacctgggg
     2821 ccccttggct tcccgccctc tcctgccggg caggtcccag gctggaggtc ctaggcatga
     2881 ctcaagtcag ggcttattga tgggacccag tggtttgggt ggcccctccc caattctttc
     2941 ctctctgctt gggttctttt tcacattaac tttttttttt tttctaagca caaacttatg
     3001 taatgggtcg tgctcatgtc tgttaataaa gaaatccaga tccc
//
