LOCUS       NM_007830                587 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus diazepam binding inhibitor (Dbi), transcript variant
            2, mRNA.
ACCESSION   NM_007830
VERSION     NM_007830.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 587)
  AUTHORS   Montegut,L., Liu,P., Zhao,L., Perez-Lanzon,M., Chen,H., Mao,M.,
            Zhang,S., Derosa,L., Naour,J.L., Lambertucci,F., Mingoia,S.,
            Nogueira-Recalde,U., Mena-Osuna,R., Herranz-Montoya,I., Djouder,N.,
            Baulande,S., Pan,H., Joseph,A., Messaoudene,M., Routy,B.,
            Fidelle,M., Ben Ahmed,T., Caron,O., Busson,P., Boulate,D.,
            Deschasaux-Tanguy,M., Arnault,N., Pol,J.G., Piaggio,E., Touvier,M.,
            Zitvogel,L., Delaloge,S., Martins,I. and Kroemer,G.
  TITLE     Acyl-coenzyme a binding protein (ACBP) - a risk factor for cancer
            diagnosis and an inhibitor of immunosurveillance
  JOURNAL   Mol Cancer 23 (1), 187 (2024)
   PUBMED   39242519
  REMARK    GeneRIF: Acyl-coenzyme a binding protein (ACBP) - a risk factor for
            cancer diagnosis and an inhibitor of immunosurveillance.
            Erratum:[Mol Cancer. 2024 Oct 17;23(1):231. doi:
            10.1186/s12943-024-02152-2. PMID: 39420364]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 587)
  AUTHORS   Schott,M., Leon-Perinan,D., Splendiani,E., Strenger,L., Licha,J.R.,
            Pentimalli,T.M., Schallenberg,S., Alles,J., Samut Tagliaferro,S.,
            Boltengagen,A., Ehrig,S., Abbiati,S., Dommerich,S., Pagani,M.,
            Ferretti,E., Macino,G., Karaiskos,N. and Rajewsky,N.
  TITLE     Open-ST: High-resolution spatial transcriptomics in 3D
  JOURNAL   Cell 187 (15), 3953-3972 (2024)
   PUBMED   38917789
REFERENCE   3  (bases 1 to 587)
  AUTHORS   Bouyakdan,K., Manceau,R., Robb,J.L., Rodaros,D., Fulton,S. and
            Alquier,T.
  TITLE     Role of astroglial ACBP in energy metabolism flexibility and
            feeding responses to metabolic challenges in male mice
  JOURNAL   J Neuroendocrinol 34 (12), e13218 (2022)
   PUBMED   36471907
  REMARK    GeneRIF: Role of astroglial ACBP in energy metabolism flexibility
            and feeding responses to metabolic challenges in male mice.
REFERENCE   4  (bases 1 to 587)
  AUTHORS   Doherty,R., MacLeod,B.L., Nelson,M.M., Ibrahim,M.M.H., Borges,B.C.,
            Jaradat,N.W., Finneran,M.C., Giger,R.J. and Corfas,G.
  TITLE     Identification of in vivo roles of ErbB4-JMa and its direct nuclear
            signaling using a novel isoform-specific knock out mouse
  JOURNAL   Sci Rep 12 (1), 17267 (2022)
   PUBMED   36241655
  REMARK    Erratum:[Sci Rep. 2022 Dec 1;12(1):20748. doi:
            10.1038/s41598-022-25021-8. PMID: 36456684]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 587)
  AUTHORS   Motino,O., Lambertucci,F., Anagnostopoulos,G., Li,S., Nah,J.,
            Castoldi,F., Senovilla,L., Montegut,L., Chen,H., Durand,S.,
            Bourgin,M., Aprahamian,F., Nirmalathasan,N., Alvarez-Valadez,K.,
            Sauvat,A., Carbonnier,V., Djavaheri-Mergny,M., Pietrocola,F.,
            Sadoshima,J., Maiuri,M.C., Martins,I. and Kroemer,G.
  TITLE     ACBP/DBI protein neutralization confers autophagy-dependent organ
            protection through inhibition of cell loss, inflammation, and
            fibrosis
  JOURNAL   Proc Natl Acad Sci U S A 119 (41), e2207344119 (2022)
   PUBMED   36191214
  REMARK    GeneRIF: ACBP/DBI protein neutralization confers
            autophagy-dependent organ protection through inhibition of cell
            loss, inflammation, and fibrosis.
REFERENCE   6  (bases 1 to 587)
  AUTHORS   Kragelund,B.B., Knudsen,J. and Poulsen,F.M.
  TITLE     Acyl-coenzyme A binding protein (ACBP)
  JOURNAL   Biochim Biophys Acta 1441 (2-3), 150-161 (1999)
   PUBMED   10570243
  REMARK    Review article
REFERENCE   7  (bases 1 to 587)
  AUTHORS   Takenaka,M., Imai,E., Kaneko,T., Ito,T., Moriyama,T., Yamauchi,A.,
            Hori,M., Kawamoto,S. and Okubo,K.
  TITLE     Isolation of genes identified in mouse renal proximal tubule by
            comparing different gene expression profiles
  JOURNAL   Kidney Int 53 (3), 562-572 (1998)
   PUBMED   9507200
REFERENCE   8  (bases 1 to 587)
  AUTHORS   Katsura,M., Ohkuma,S., Jun,X., Tsujimura,A. and Kuriyama,K.
  TITLE     Ethanol stimulates diazepam binding inhibitor (DBI) mRNA expression
            in primary cultured neurons
  JOURNAL   Brain Res Mol Brain Res 34 (2), 355-359 (1995)
   PUBMED   8750843
REFERENCE   9  (bases 1 to 587)
  AUTHORS   Kambouris,M., Triarhou,L.C., Dlouhy,S.R., Sangameswaran,L., Luo,F.,
            Ghetti,B. and Hodes,M.E.
  TITLE     Novel cDNA clones obtained by antibody screening of a mouse
            cerebellar cDNA expression library
  JOURNAL   Brain Res Mol Brain Res 25 (3-4), 183-191 (1994)
   PUBMED   7808216
REFERENCE   10 (bases 1 to 587)
  AUTHORS   Owens,G.P., Sinha,A.K., Sikela,J.M. and Hahn,W.E.
  TITLE     Sequence and expression of the murine diazepam binding inhibitor
  JOURNAL   Brain Res Mol Brain Res 6 (2-3), 101-108 (1989)
   PUBMED   2615592
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ183794.1, AK020692.1 and AV001592.1.
            
            On Mar 17, 2010 this sequence version replaced NM_007830.3.
            
            Transcript Variant: This variant (2) has an alternate 5' exon, as
            compared to variant 1. The resulting isoform (2) is shorter and has
            a different N-terminus, as compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AV001592.1, AV574848.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-31                CJ183794.1         2-32
            32-575              AK020692.1         2-545
            576-587             AV001592.1         470-481
FEATURES             Location/Qualifiers
     source          1..587
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 52.65 cM"
     gene            1..587
                     /gene="Dbi"
                     /gene_synonym="ACBD1; Acbp; endozepine; EP"
                     /note="diazepam binding inhibitor"
                     /db_xref="GeneID:13167"
                     /db_xref="MGI:MGI:94865"
     exon            1..152
                     /gene="Dbi"
                     /gene_synonym="ACBD1; Acbp; endozepine; EP"
                     /inference="alignment:Splign:2.1.0"
     CDS             144..407
                     /gene="Dbi"
                     /gene_synonym="ACBD1; Acbp; endozepine; EP"
                     /EC_number="3.4.17.3"
                     /note="isoform 2 is encoded by transcript variant 2;
                     acyl-CoA-binding protein; diazepam binding inhibitor,
                     splice form 1b"
                     /codon_start=1
                     /product="acyl-CoA-binding protein isoform 2"
                     /protein_id="NP_031856.1"
                     /db_xref="CCDS:CCDS15230.1"
                     /db_xref="GeneID:13167"
                     /db_xref="MGI:MGI:94865"
                     /translation="MSQAEFDKAAEEVKRLKTQPTDEEMLFIYSHFKQATVGDVNTDR
                     PGLLDLKGKAKWDSWNKLKGTSKESAMKTYVEKVDELKKKYGI"
     exon            153..270
                     /gene="Dbi"
                     /gene_synonym="ACBD1; Acbp; endozepine; EP"
                     /inference="alignment:Splign:2.1.0"
     exon            271..333
                     /gene="Dbi"
                     /gene_synonym="ACBD1; Acbp; endozepine; EP"
                     /inference="alignment:Splign:2.1.0"
     exon            334..587
                     /gene="Dbi"
                     /gene_synonym="ACBD1; Acbp; endozepine; EP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      554..559
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dbi"
                     /gene_synonym="ACBD1; Acbp; endozepine; EP"
                     /note="hexamer: ATTAAA"
     polyA_site      577
                     /gene="Dbi"
                     /gene_synonym="ACBD1; Acbp; endozepine; EP"
                     /note="major polyA site"
ORIGIN      
        1 gattggctgc tgccgctcgc ccgagctcag ttggaacgcc ggggttgtgc ttttaaaggc
       61 gctagctggt gcgctctgtg acttgattgc tgctgcttct gagcttgctc ccgcgctttc
      121 ggcatccgta tcacctcacc agtatgtctc aggctgaatt tgacaaagcc gctgaggagg
      181 tgaagcgcct caagactcag ccaactgatg aagagatgct gttcatctac agtcacttca
      241 aacaagctac tgtgggcgat gtaaatacag atcggccggg gctcttggac ctcaagggca
      301 aagccaagtg ggactcgtgg aacaagctga aagggacttc caaggaaagt gccatgaaga
      361 cctatgtgga aaaggtagac gagctaaaga agaaatacgg aatataaatc accagatttg
      421 gtggccagcc acacgtgtga cctgtgagga cataatgcct tggttttttc taatgtagat
      481 gatatggctg tgatacatta gggccagcgt taacctctgc tcctcctccc tctgtagttt
      541 ttacctacaa tcaattaaaa gtacatttgt tactctgtgc ctgggtt
//
