LOCUS       NM_138942               2282 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus dopamine beta hydroxylase (Dbh), mRNA.
ACCESSION   NM_138942
VERSION     NM_138942.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2282)
  AUTHORS   Wang,T., Liu,L., Fang,J., Jin,H., Natarajan,S., Sheppard,H., Lu,M.,
            Turner,G., Confer,T., Johnson,M., Steinberg,J., Ha,L., Yadak,N.,
            Jain,R., Picketts,D.J., Ma,X., Murphy,A., Davidoff,A.M.,
            Glazer,E.S., Easton,J., Chen,X., Wang,R. and Yang,J.
  TITLE     Conditional Activation of c-MYC in Distinct Catecholaminergic Cells
            Drives Development of Neuroblastoma or Somatostatinoma
  JOURNAL   Cancer Res 85 (3), 424-441 (2025)
   PUBMED   39531507
REFERENCE   2  (bases 1 to 2282)
  AUTHORS   Pagiazitis,J.G., Delestree,N., Sowoidnich,L., Sivakumar,N.,
            Simon,C.M., Chatzisotiriou,A., Albani,M. and Mentis,G.Z.
  TITLE     Catecholaminergic dysfunction drives postural and locomotor
            deficits in a mouse model of spinal muscular atrophy
  JOURNAL   Cell Rep 44 (1), 115147 (2025)
   PUBMED   39752251
REFERENCE   3  (bases 1 to 2282)
  AUTHORS   Chen,H., Liu,C., Cui,S., Xia,Y., Zhang,K., Cheng,H., Peng,J.,
            Yu,X., Li,L., Yu,H., Zhang,J., Zheng,J.S. and Zhang,B.
  TITLE     Intermittent fasting triggers interorgan communication to suppress
            hair follicle regeneration
  JOURNAL   Cell 188 (1), 157-174 (2025)
   PUBMED   39674178
REFERENCE   4  (bases 1 to 2282)
  AUTHORS   Chang,Y., Lusk,S., Chang,A., Ward,C.S. and Ray,R.S.
  TITLE     Vglut2-based glutamatergic signaling in central noradrenergic
            neurons is dispensable for normal breathing and chemosensory
            reflexes
  JOURNAL   Elife 12, 88673 (2024)
   PUBMED   39287624
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2282)
  AUTHORS   Zhang,D., Turecek,J., Choi,S., Delisle,M., Pamplona,C.L.,
            Meltzer,S. and Ginty,D.D.
  TITLE     C-LTMRs mediate wet dog shakes via the spinoparabrachial pathway
  JOURNAL   bioRxiv (2024)
   PUBMED   38915692
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2282)
  AUTHORS   Shi,Y., Alin,K. and Goff,S.P.
  TITLE     Abl-interactor-1, a novel SH3 protein binding to the
            carboxy-terminal portion of the Abl protein, suppresses v-abl
            transforming activity
  JOURNAL   Genes Dev 9 (21), 2583-2597 (1995)
   PUBMED   7590237
REFERENCE   7  (bases 1 to 2282)
  AUTHORS   Compagnone,N.A., Bulfone,A., Rubenstein,J.L. and Mellon,S.H.
  TITLE     Steroidogenic enzyme P450c17 is expressed in the embryonic central
            nervous system
  JOURNAL   Endocrinology 136 (11), 5212-5223 (1995)
   PUBMED   7588260
REFERENCE   8  (bases 1 to 2282)
  AUTHORS   Narisawa,S., Hasegawa,H., Watanabe,K. and Millan,J.L.
  TITLE     Stage-specific expression of alkaline phosphatase during neural
            development in the mouse
  JOURNAL   Dev Dyn 201 (3), 227-235 (1994)
   PUBMED   7533563
REFERENCE   9  (bases 1 to 2282)
  AUTHORS   Nakano,T., Kobayashi,K., Saito,S., Fujita,K. and Nagatsu,T.
  TITLE     Mouse dopamine beta-hydroxylase: primary structure deduced from the
            cDNA sequence and exon/intron organization of the gene
  JOURNAL   Biochem Biophys Res Commun 189 (1), 590-599 (1992)
   PUBMED   1280432
REFERENCE   10 (bases 1 to 2282)
  AUTHORS   Pilz,A., Moseley,H., Peters,J. and Abbott,C.
  TITLE     Comparative mapping of mouse chromosome 2 and human chromosome 9q:
            the genes for gelsolin and dopamine beta-hydroxylase map to mouse
            chromosome 2
  JOURNAL   Genomics 12 (4), 715-719 (1992)
   PUBMED   1315305
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK132245.1 and BB109310.1.
            
            On Jul 28, 2006 this sequence version replaced NM_138942.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK132245.1, S50200.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849379
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2274              AK132245.1         2-2275
            2275-2282           BB109310.1         177-184
FEATURES             Location/Qualifiers
     source          1..2282
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 19.29 cM"
     gene            1..2282
                     /gene="Dbh"
                     /note="dopamine beta hydroxylase"
                     /db_xref="GeneID:13166"
                     /db_xref="MGI:MGI:94864"
     exon            1..360
                     /gene="Dbh"
                     /inference="alignment:Splign:2.1.0"
     CDS             10..1878
                     /gene="Dbh"
                     /EC_number="1.14.17.1"
                     /note="dopamine beta-monooxygenase"
                     /codon_start=1
                     /product="dopamine beta-hydroxylase"
                     /protein_id="NP_620392.2"
                     /db_xref="CCDS:CCDS38088.1"
                     /db_xref="GeneID:13166"
                     /db_xref="MGI:MGI:94864"
                     /translation="MQAHLSHQPCWSSLPSPSVREAASMYGTAVAIFLVILVAALRGS
                     EPPESPFPYHIPLDPEGILELSWNVSYVQEIIHFQLQVQGLRAGVLFGMSDRGEMENA
                     DLIMLWTDGDRAYFADAWSDRKGQIHLDSQQDYQLLQAQRTRDGLSLLFKRPFVTCDP
                     KDYVIEDDTVHLVYGILEEPFQSLEAINTSGLHTGLQRVQLLKSEVPTPSMPEDVQTM
                     DIRAPDILIPDNETTYWCYITELPPRFPRHHIIMYEAIVTEGNEALVHHMEVFQCAAE
                     SEDFPQFNGPCDSKMKPDRLNYCRHVLAAWALGAKAFYYPKEAGVPFGGPGSSPFLRL
                     EVHYHNPRKIQGRQDSSGIRLHYTATLRRYDAGIMELGLVYTPLMAIPPQETAFVLTG
                     YCTDKCTQMALQDSGIHIFASQLHTHLTGRKVVTVLARDGQERKVVNRDNHYSPHFQE
                     IRMLKKVVTVYPGDVLITSCTYNTENKTLATVGGFGILEEMCVNYVHYYPQTELELCK
                     SAVDDGFLQKYFHMVNRFSSEEVCTCPQASVPQQFSSVPWNSFNRDMLKALYDYAPIS
                     MHCNKTSAVRFPGEWNLQPLPKITSTLEEPTPRCPIRQTQSPANPTVPITTEADAE"
     exon            361..507
                     /gene="Dbh"
                     /inference="alignment:Splign:2.1.0"
     exon            508..765
                     /gene="Dbh"
                     /inference="alignment:Splign:2.1.0"
     exon            766..942
                     /gene="Dbh"
                     /inference="alignment:Splign:2.1.0"
     exon            943..1045
                     /gene="Dbh"
                     /inference="alignment:Splign:2.1.0"
     exon            1046..1212
                     /gene="Dbh"
                     /inference="alignment:Splign:2.1.0"
     exon            1213..1356
                     /gene="Dbh"
                     /inference="alignment:Splign:2.1.0"
     exon            1357..1395
                     /gene="Dbh"
                     /inference="alignment:Splign:2.1.0"
     exon            1396..1455
                     /gene="Dbh"
                     /inference="alignment:Splign:2.1.0"
     exon            1456..1583
                     /gene="Dbh"
                     /inference="alignment:Splign:2.1.0"
     exon            1584..1743
                     /gene="Dbh"
                     /inference="alignment:Splign:2.1.0"
     exon            1744..2282
                     /gene="Dbh"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2278
                     /gene="Dbh"
                     /note="major polyA site"
ORIGIN      
        1 atccctgcca tgcaagctca tctcagccac cagccttgtt ggagcagcct cccaagcccc
       61 agtgtccgtg aggcggcttc catgtacggc actgctgtgg ccatcttcct ggtcatcctg
      121 gtggctgcac tgcggggctc ggagcctcca gagagcccct tcccctacca catccccctg
      181 gaccccgaag ggattttaga gctctcatgg aacgtcagct atgtccagga gatcatccac
      241 ttccagctcc aggtgcaagg gctgagggct ggggtcctgt ttggaatgtc agatcgagga
      301 gagatggaga acgcagatct catcatgctc tggactgatg gggacagggc ctactttgcg
      361 gatgcctgga gtgaccggaa agggcagatc catctggatt cccagcaaga ctaccagctg
      421 ctccaggcac agaggactcg agatggcctg tccctgctct tcaagaggcc ctttgtcacc
      481 tgtgacccca aggattatgt cattgaggat gacactgtcc atctagtgta tgggatcttg
      541 gaagagccat ttcagtcgct ggaggccatc aacacctcag gcctgcatac agggctgcag
      601 cgggtgcagc ttctgaagtc tgaggtcccc actccatcca tgcctgagga tgtacaaacc
      661 atggatatcc gggctcctga catcctcatc cccgacaatg agaccacgta ctggtgctat
      721 atcactgagc tacccccacg cttcccccga caccacatca tcatgtatga ggccattgtc
      781 actgagggca atgaggccct ggtgcaccac atggaggtct tccaatgtgc agctgagtct
      841 gaggacttcc cccagttcaa cggaccctgt gactccaaaa tgaagcctga ccgactcaac
      901 tactgccggc acgtgctggc agcatgggcc ctgggtgcca aggcatttta ctacccaaaa
      961 gaagctggtg ttccctttgg gggcccgggg tcctccccgt ttctccgact ggaagttcat
     1021 taccacaacc cacggaagat acaaggccgg caggactcct ctggcatccg cctacactac
     1081 acagctactc tccgacgcta tgatgcgggc atcatggagc tcggactggt gtatacaccc
     1141 ttgatggcca tcccccctca ggagactgcc tttgtgttga ccggctactg cacagacaag
     1201 tgcacccaga tggcactgca ggactccgga atccacatct ttgcctctca gcttcataca
     1261 cacctgacgg gcaggaaggt ggttactgtg ctcgccaggg atggccaaga gaggaaggtg
     1321 gtgaacaggg acaaccacta cagcccccac ttccaggaga tcagaatgct gaagaaggtt
     1381 gtgacagtct acccggggga cgtactcatc acttcatgca catacaacac agaaaacaag
     1441 acgctggcca cagtgggggg gtttggaatc ttggaggaga tgtgtgtcaa ctatgtgcac
     1501 tactaccccc agacagagct ggaactctgc aagagtgccg tggacgacgg cttcctacag
     1561 aaatacttcc acatggtaaa caggttcagc agtgaggagg tctgcacctg ccctcaggcc
     1621 tcagtccccc agcagttctc ctccgtgccc tggaactctt tcaatcggga tatgctcaag
     1681 gctctgtatg actacgcccc tatctccatg cattgcaaca agacttctgc tgtccgcttc
     1741 ccgggtgagt ggaatctgca gcctttgcct aagatcacct ccacgctgga agaacccacc
     1801 ccacgctgcc ccatccgaca gactcagagc cccgctaacc ccactgtgcc catcacaaca
     1861 gaggcagatg ctgaatagac ccaccttgtg agaagctatt cttcagaccc tcctcctcct
     1921 gtccacctgg gctcacacca gctctgtgta gccctccctt cctgtgtgaa gactcacttc
     1981 catagactag tgctggccat ccagggagaa ggagcatgtc accttggaga cacttgcatg
     2041 actgcacccc atgaggtcca actgaacgga gaagccctgg acattatcta cacactgctg
     2101 actccacata gggacagctc gctgtggtag tccagattca acaccacctt gcctccagaa
     2161 cagccttgcc aggctgggtg cagactcccc aagccccaca gtcccgaccc tgttggtcct
     2221 ctggtggtga cttgtgttag tgtatgccgt gacaacactg cttaaatatt cctttgcaga
     2281 gt
//
