LOCUS       NM_010021               2942 bp    mRNA    linear   ROD 17-SEP-2024
DEFINITION  Mus musculus deleted in azoospermia-like (Dazl), transcript variant
            1, mRNA.
ACCESSION   NM_010021
VERSION     NM_010021.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2942)
  AUTHORS   Suzuki,A., Uranishi,K., Nishimoto,M., Mizuno,Y., Mizuno,S.,
            Takahashi,S., Eisenman,R.N. and Okuda,A.
  TITLE     MAX controls meiotic entry in sexually undifferentiated germ cells
  JOURNAL   Sci Rep 14 (1), 5236 (2024)
   PUBMED   38433229
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2942)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2942)
  AUTHORS   Yao,X., Wang,C., Yu,W., Sun,L., Lv,Z., Xie,X., Tian,S., Yan,L.,
            Li,L. and Liu,J.
  TITLE     BCAS2 regulates oocyte meiotic prophase I by participating in mRNA
            alternative splicing
  JOURNAL   FASEB J 38 (1), e23361 (2024)
   PUBMED   38085152
REFERENCE   4  (bases 1 to 2942)
  AUTHORS   Ding,Y., He,Z., Sha,Y., Kee,K. and Li,L.
  TITLE     Eif4enif1 haploinsufficiency disrupts oocyte mitochondrial dynamics
            and leads to subfertility
  JOURNAL   Development 150 (23) (2023)
   PUBMED   38088064
REFERENCE   5  (bases 1 to 2942)
  AUTHORS   Xu,X., Tan,X., Lin,Q., Schmidt,B., Engel,W. and Pantakani,D.V.
  TITLE     Mouse Dazl and its novel splice variant functions in translational
            repression of target mRNAs in embryonic stem cells
  JOURNAL   Biochim Biophys Acta 1829 (5), 425-435 (2013)
   PUBMED   23298641
  REMARK    GeneRIF: alternative splicing of exon8 of mDazl leads to the
            generation of the novel splice variant, Dazl-Delta8.
REFERENCE   6  (bases 1 to 2942)
  AUTHORS   Ruggiu,M., Speed,R., Taggart,M., McKay,S.J., Kilanowski,F.,
            Saunders,P., Dorin,J. and Cooke,H.J.
  TITLE     The mouse Dazla gene encodes a cytoplasmic protein essential for
            gametogenesis
  JOURNAL   Nature 389 (6646), 73-77 (1997)
   PUBMED   9288969
REFERENCE   7  (bases 1 to 2942)
  AUTHORS   Maiwald,R., Luche,R.M. and Epstein,C.J.
  TITLE     Isolation of a mouse homolog of the human DAZ (Deleted in
            Azoospermia) gene
  JOURNAL   Mamm Genome 7 (8), 628 (1996)
   PUBMED   8679003
REFERENCE   8  (bases 1 to 2942)
  AUTHORS   Reijo,R., Seligman,J., Dinulos,M.B., Jaffe,T., Brown,L.G.,
            Disteche,C.M. and Page,D.C.
  TITLE     Mouse autosomal homolog of DAZ, a candidate male sterility gene in
            humans, is expressed in male germ cells before and after puberty
  JOURNAL   Genomics 35 (2), 346-352 (1996)
   PUBMED   8661148
REFERENCE   9  (bases 1 to 2942)
  AUTHORS   Mizuki,N., Sarapata,D.E., Garcia-Sanz,J.A. and Kasahara,M.
  TITLE     The mouse male germ cell-specific gene Tpx-1: molecular structure,
            mode of expression in spermatogenesis, and sequence similarity to
            two non-mammalian genes
  JOURNAL   Mamm Genome 3 (5), 274-280 (1992)
   PUBMED   1638086
REFERENCE   10 (bases 1 to 2942)
  AUTHORS   Kasahara,M., Seboun,E., Fellous,M. and Nadeau,J.H.
  TITLE     Genetic mapping of a male germ cell-expressed gene Tpx-2 to mouse
            chromosome 17
  JOURNAL   Immunogenetics 34 (2), 132-135 (1991)
   PUBMED   1869307
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL592112.7.
            
            On Nov 10, 2022 this sequence version replaced NM_010021.5.
            
            Summary: This gene encodes a member of the depleted in
            azoospermia-like (DAZL) protein family. Members of this family
            contain an RNA recognition motif, interact with poly A binding
            proteins, and may be involved in the initiation of translation. The
            encoded protein is expressed in the cytoplasm of pluripotent stem
            cells, and in both male and female germ cells, where it is
            essential for gametogenesis. Disruption of this gene is associated
            with infertility. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Apr 2013].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK014854.1, AK033183.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-193               AL592112.7         58870-59062
            194-340             AL592112.7         63231-63377
            341-432             AL592112.7         63764-63855
            433-484             AL592112.7         64307-64358
            485-548             AL592112.7         64651-64714
            549-688             AL592112.7         64802-64941
            689-760             AL592112.7         66147-66218
            761-811             AL592112.7         67423-67473
            812-925             AL592112.7         68118-68231
            926-1024            AL592112.7         69243-69341
            1025-2942           AL592112.7         71158-73075
FEATURES             Location/Qualifiers
     source          1..2942
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 25.86 cM"
     gene            1..2942
                     /gene="Dazl"
                     /gene_synonym="Daz-like; Dazh; Dazl1; Dazla; Tpx-2; Tpx2"
                     /note="deleted in azoospermia-like"
                     /db_xref="GeneID:13164"
                     /db_xref="MGI:MGI:1342328"
     exon            1..193
                     /gene="Dazl"
                     /gene_synonym="Daz-like; Dazh; Dazl1; Dazla; Tpx-2; Tpx2"
                     /inference="alignment:Splign:2.1.0"
     CDS             191..1087
                     /gene="Dazl"
                     /gene_synonym="Daz-like; Dazh; Dazl1; Dazla; Tpx-2; Tpx2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     DAZ-like autosomal; deleted in azoospermia-like 1"
                     /codon_start=1
                     /product="deleted in azoospermia-like isoform 1"
                     /protein_id="NP_034151.3"
                     /db_xref="CCDS:CCDS37649.1"
                     /db_xref="GeneID:13164"
                     /db_xref="MGI:MGI:1342328"
                     /translation="MSATTSEAPNSAVSREASTQSSSATTSQGYVLPEGKIMPNTVFV
                     GGIDVRMDETEIRSFFARYGSVKEVKIITDRTGVSKGYGFVSFYNDVDVQKIVESQIN
                     FHGKKLKLGPAIRKQNLCTYHVQPRPLIFNPPPPPQFQSVWSSPNAETYMQPPTMMNP
                     ITQYVQAYPPYPSSPVQVITGYQLPVYNYQMPPQWPAGEQRSYVIPPAYTTVNYHCSE
                     VDPGADILPNECSVHDAAPASGNGPQKKSVDRSIQTVVSCLFNPENRLRNSLVTQDDY
                     FKDKRVHHFRRSRAVLKSDHLC"
     exon            194..340
                     /gene="Dazl"
                     /gene_synonym="Daz-like; Dazh; Dazl1; Dazla; Tpx-2; Tpx2"
                     /inference="alignment:Splign:2.1.0"
     exon            341..432
                     /gene="Dazl"
                     /gene_synonym="Daz-like; Dazh; Dazl1; Dazla; Tpx-2; Tpx2"
                     /inference="alignment:Splign:2.1.0"
     exon            433..484
                     /gene="Dazl"
                     /gene_synonym="Daz-like; Dazh; Dazl1; Dazla; Tpx-2; Tpx2"
                     /inference="alignment:Splign:2.1.0"
     exon            485..548
                     /gene="Dazl"
                     /gene_synonym="Daz-like; Dazh; Dazl1; Dazla; Tpx-2; Tpx2"
                     /inference="alignment:Splign:2.1.0"
     exon            549..688
                     /gene="Dazl"
                     /gene_synonym="Daz-like; Dazh; Dazl1; Dazla; Tpx-2; Tpx2"
                     /inference="alignment:Splign:2.1.0"
     exon            689..760
                     /gene="Dazl"
                     /gene_synonym="Daz-like; Dazh; Dazl1; Dazla; Tpx-2; Tpx2"
                     /inference="alignment:Splign:2.1.0"
     exon            761..811
                     /gene="Dazl"
                     /gene_synonym="Daz-like; Dazh; Dazl1; Dazla; Tpx-2; Tpx2"
                     /inference="alignment:Splign:2.1.0"
     exon            812..925
                     /gene="Dazl"
                     /gene_synonym="Daz-like; Dazh; Dazl1; Dazla; Tpx-2; Tpx2"
                     /inference="alignment:Splign:2.1.0"
     exon            926..1024
                     /gene="Dazl"
                     /gene_synonym="Daz-like; Dazh; Dazl1; Dazla; Tpx-2; Tpx2"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..2942
                     /gene="Dazl"
                     /gene_synonym="Daz-like; Dazh; Dazl1; Dazla; Tpx-2; Tpx2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2919..2924
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dazl"
                     /gene_synonym="Daz-like; Dazh; Dazl1; Dazla; Tpx-2; Tpx2"
                     /note="hexamer: AATAAA"
     polyA_site      2942
                     /gene="Dazl"
                     /gene_synonym="Daz-like; Dazh; Dazl1; Dazla; Tpx-2; Tpx2"
                     /note="major polyA site"
ORIGIN      
        1 agtgactcgg cgaccctcag cacgctcgct tcgggactcc gctgtctccg tggccgtggg
       61 ctctctttcc accaccgcct cggctttttt ttgcccgttg gccggctagg cagccacctc
      121 acgtagctgc cccgtcgcgt ggcttctgct ccaccttcga ggttttacca cccgaactct
      181 ggccgccatc atgtctgcca caacttctga ggctccaaat tcagctgtct ccagggaggc
      241 cagcactcag tcttcatcag caaccacaag tcaaggatat gttttgccag aaggcaaaat
      301 catgccaaac accgtttttg ttggaggaat tgatgttagg atggatgaaa ccgaaatcag
      361 gagtttcttt gccagatatg gctcagtaaa agaagtgaag ataatcactg atcgaactgg
      421 tgtgtcgaag ggctatggat ttgtctcatt ttataatgac gtggatgtgc agaagatagt
      481 agaatcacag ataaatttcc atggtaaaaa gctgaaactg ggccctgcaa tcaggaaaca
      541 aaatttatgt acttatcatg tgcagccacg tcctttgatt tttaatcctc ctcctccacc
      601 acagttccag agtgtttgga gtagtccaaa tgctgagact tacatgcagc ctccaaccat
      661 gatgaatcct atcactcagt atgttcaggc atatcctcct tatccaagtt caccagttca
      721 ggtcatcact ggatatcagc tgcctgttta taactaccag atgccaccgc agtggcctgc
      781 tggagagcag aggagttatg ttatacctcc ggcttataca actgttaact accactgcag
      841 tgaagttgat ccaggagctg atattttgcc caatgaatgt tcagttcatg atgctgctcc
      901 agcttctgga aatggcccgc aaaagaagtc tgtggaccga agcatacaga cagtggtctc
      961 ttgtctgttt aaccctgaga acagactgag aaactctctt gttactcaag atgactactt
     1021 caaggataaa agagtacatc acttcagaag aagtcgggca gtgcttaaat ctgatcatct
     1081 ctgctaactc atctcagggg gttgttggtt ttgaatatta aaagaaactg aaaagttttc
     1141 aatactatag aaaatttgac aaatcactca gactttctat aaaagttata ttagattgca
     1201 tagttttatg ttaaacttgt tagatgttta tatagaaact ggttttgtgt tcatcatata
     1261 gttgaaagaa aagataattg caagtaaaaa aaaaagataa aaaataattt tcaaataatt
     1321 gaaaaatagt tgaaaggaat aacttttaag atttaccgta aggactttta gttgaaattg
     1381 gcattttaag agttcaaaaa caagtactaa ttttcaagaa aagaatttta taaacctatt
     1441 ttgaaaggtc aggattttga tagtttgact ataagaattt cacttctcaa caggtacctg
     1501 aacagtacaa tattaacgat attgtacttt atatttatta tttgtctaaa catttgccac
     1561 aaaagcagaa tttttagaac tgcattttta atcaatggaa ctcaatatat agttagcttt
     1621 attgaagtct tccttatcta aacccaggaa aacagattct caacagtcca atcagtgggt
     1681 cttaacattt atacaaaata ttttaccctt tatctagaat ccacacatat acatatatcc
     1741 tatttatttg gttgggatgg taattaggat atctaaaatt ctaggtataa ttttgtttaa
     1801 agaatccaag acaaactaaa tttcactagg tgtataagct attcttagtg agttaatact
     1861 cttttttttt ttttcttaaa atgctaaact caatggctgt cttaaaattg tgcaaaatac
     1921 tggtattaaa gagtgctgaa aattttttat gtcacttaaa agttaatcag agtatctgaa
     1981 aaattgtttt tataaaaaca ttcaaaatat tagttgttac agagtaaata catttttagt
     2041 tttgttagtc tattgtattt ccctttgtaa agtaaaatat gtccaaaaca gtcaaagtag
     2101 gcaatttgac atttctaaac cacaaaatgt gtttcataaa tgtatcccaa gaatgtgcta
     2161 aagtgaatct gtttttagac tagatggaca tgagatcatt ggacattatg cattgtgaca
     2221 gcagagaacc tttgtaccca cagtcttttg cagtcttaat cctattctgt caggattgct
     2281 ccctggtata aagtagacaa gtaacagtta acaagcagct caggggctaa gccttaggaa
     2341 tatagcactg gaacagcacc ttgctaccta aaacaattgg ctgaacatca atctgacctg
     2401 ccagggacat gagttttaaa atgccttgtt gatctatctt gtattagtcc tttccttcaa
     2461 acatggattc cacttactct tacttagtgg aactaatggg tcatatcaca actgtcccta
     2521 atgatcttta actcttaatc ttattctgca tctaaagtca aaattctttt atgtcaccaa
     2581 gtcagtatat accagaaaac taagaagtgt cctgaaattt aattcttttt agattttgtc
     2641 cccttacttc agtgtatttg tagtgtatgt ccttacatgt accattctgt gactaaatat
     2701 ccaacttact atgaatgata acctaaattc tgaggcacaa atgtaattgt tgctgtatga
     2761 ctttaaagaa aagtaaggga ataaactttt gtctgctgtt ttgttggagt caagtattta
     2821 agagaaggga gaaagagaca agtactgagc ctttcaaaat ggaagattaa ttttaaactt
     2881 aaaagtatgt tcctattacc tatttccttg tatacacgaa taaaaccttt ttttcaaaag
     2941 ca
//
