LOCUS       NM_133188               2051 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus DAZ associated protein 1 (Dazap1), transcript variant
            1, mRNA.
ACCESSION   NM_133188 XM_986609
VERSION     NM_133188.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2051)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2051)
  AUTHORS   Chen,H.Y., Yu,Y.H. and Yen,P.H.
  TITLE     DAZAP1 regulates the splicing of Crem, Crisp2 and Pot1a transcripts
  JOURNAL   Nucleic Acids Res 41 (21), 9858-9869 (2013)
   PUBMED   23965306
  REMARK    GeneRIF: Identification of Crem, Crisp2 and Pot1a as the natural
            substrates of DAZAP1 and show that DAZAP1 promotes the inclusion of
            specific exons in these genes.
REFERENCE   3  (bases 1 to 2051)
  AUTHORS   Zheng,S., Damoiseaux,R., Chen,L. and Black,D.L.
  TITLE     A broadly applicable high-throughput screening strategy identifies
            new regulators of Dlg4 (Psd-95) alternative splicing
  JOURNAL   Genome Res 23 (6), 998-1007 (2013)
   PUBMED   23636947
REFERENCE   4  (bases 1 to 2051)
  AUTHORS   Yang,C.K. and Yen,P.
  TITLE     Differential translation of Dazap1 transcripts during
            spermatogenesis
  JOURNAL   PLoS One 8 (4), e60873 (2013)
   PUBMED   23658607
  REMARK    GeneRIF: The translation of the two Dazap1 transcripts is
            differentially regulated during spermatogenesis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2051)
  AUTHORS   Hsu,L.C., Chen,H.Y., Lin,Y.W., Chu,W.C., Lin,M.J., Yan,Y.T. and
            Yen,P.H.
  TITLE     DAZAP1, an hnRNP protein, is required for normal growth and
            spermatogenesis in mice
  JOURNAL   RNA 14 (9), 1814-1822 (2008)
   PUBMED   18669443
  REMARK    GeneRIF: DAZAP1 is not only essential for spermatogenesis, but also
            required for the normal growth and development of mice.
REFERENCE   6  (bases 1 to 2051)
  AUTHORS   Moore,F.L., Jaruzelska,J., Dorfman,D.M. and Reijo-Pera,R.A.
  TITLE     Identification of a novel gene, DZIP (DAZ-interacting protein),
            that encodes a protein that interacts with DAZ (deleted in
            azoospermia) and is expressed in embryonic stem cells and germ
            cells
  JOURNAL   Genomics 83 (5), 834-843 (2004)
   PUBMED   15081113
REFERENCE   7  (bases 1 to 2051)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   8  (bases 1 to 2051)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 2051)
  AUTHORS   Vera,Y., Dai,T., Hikim,A.P., Lue,Y., Salido,E.C., Swerdloff,R.S.
            and Yen,P.H.
  TITLE     Deleted in azoospermia associated protein 1 shuttles between
            nucleus and cytoplasm during normal germ cell maturation
  JOURNAL   J Androl 23 (5), 622-628 (2002)
   PUBMED   12185095
REFERENCE   10 (bases 1 to 2051)
  AUTHORS   Dai,T., Vera,Y., Salido,E.C. and Yen,P.H.
  TITLE     Characterization of the mouse Dazap1 gene encoding an RNA-binding
            protein that interacts with infertility factors DAZ and DAZL
  JOURNAL   BMC Genomics 2, 6 (2001)
   PUBMED   11604102
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC140229.3.
            
            On Mar 17, 2020 this sequence version replaced NM_133188.2.
            
            Transcript Variant: This variant (1) encodes isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK152345.1, AK152314.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-165               AC140229.3         115167-115331
            166-206             AC140229.3         124160-124200
            207-373             AC140229.3         124601-124767
            374-439             AC140229.3         124957-125022
            440-547             AC140229.3         127728-127835
            548-596             AC140229.3         128386-128434
            597-679             AC140229.3         131082-131164
            680-833             AC140229.3         133177-133330
            834-863             AC140229.3         134383-134412
            864-1004            AC140229.3         134562-134702
            1005-1181           AC140229.3         135403-135579
            1182-2051           AC140229.3         137692-138561
FEATURES             Location/Qualifiers
     source          1..2051
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 39.72 cM"
     gene            1..2051
                     /gene="Dazap1"
                     /gene_synonym="2410042M16Rik; mPrrp"
                     /note="DAZ associated protein 1"
                     /db_xref="GeneID:70248"
                     /db_xref="MGI:MGI:1917498"
     exon            1..165
                     /gene="Dazap1"
                     /gene_synonym="2410042M16Rik; mPrrp"
                     /inference="alignment:Splign:2.1.0"
     CDS             137..1354
                     /gene="Dazap1"
                     /gene_synonym="2410042M16Rik; mPrrp"
                     /note="isoform a is encoded by transcript variant 1;
                     deleted in azoospermia-associated protein 1"
                     /codon_start=1
                     /product="DAZ-associated protein 1 isoform a"
                     /protein_id="NP_573451.2"
                     /db_xref="CCDS:CCDS35977.1"
                     /db_xref="GeneID:70248"
                     /db_xref="MGI:MGI:1917498"
                     /translation="MNSAGADEIGKLFVGGLDWSTTQETLRSYFSQYGEVVDCVIMKD
                     KTTNQSRGFGFVKFKDPNCVGTVLASRPHTLDGRNIDPKPCTPRGMQPERTRPKEGWK
                     GPRSDSSKSNKIFVGGIPHNCGETELREYFKKFGVVTEVVMIYDAEKQRPRGFGFITF
                     EDEQSVDQAVNMHFHDIMGKKVEVKRAEPRDSKNQAPGQPGASQWGSRVAPSAANGWA
                     GQPPPTWQQGYGPQGMWVPAGQAIGGYGPPPAGRGAPPPPPPFTSYIVSTPPGGFPPP
                     QGFPQGYGAPPQFSFGYGPPPPPPDQFAPPGVPPPPATPGAAPLAFPPPPSQAAPDMS
                     KPPTAQPDFPYGQYGYGQDLSGFGQGFSDPSQQPPSYGGPSVPGSGGPPAGGSGFGRG
                     QNHNVQGFHPYRR"
     exon            166..206
                     /gene="Dazap1"
                     /gene_synonym="2410042M16Rik; mPrrp"
                     /inference="alignment:Splign:2.1.0"
     exon            207..373
                     /gene="Dazap1"
                     /gene_synonym="2410042M16Rik; mPrrp"
                     /inference="alignment:Splign:2.1.0"
     exon            374..439
                     /gene="Dazap1"
                     /gene_synonym="2410042M16Rik; mPrrp"
                     /inference="alignment:Splign:2.1.0"
     exon            440..547
                     /gene="Dazap1"
                     /gene_synonym="2410042M16Rik; mPrrp"
                     /inference="alignment:Splign:2.1.0"
     exon            548..596
                     /gene="Dazap1"
                     /gene_synonym="2410042M16Rik; mPrrp"
                     /inference="alignment:Splign:2.1.0"
     exon            597..679
                     /gene="Dazap1"
                     /gene_synonym="2410042M16Rik; mPrrp"
                     /inference="alignment:Splign:2.1.0"
     exon            680..833
                     /gene="Dazap1"
                     /gene_synonym="2410042M16Rik; mPrrp"
                     /inference="alignment:Splign:2.1.0"
     exon            834..863
                     /gene="Dazap1"
                     /gene_synonym="2410042M16Rik; mPrrp"
                     /inference="alignment:Splign:2.1.0"
     exon            864..1004
                     /gene="Dazap1"
                     /gene_synonym="2410042M16Rik; mPrrp"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1181
                     /gene="Dazap1"
                     /gene_synonym="2410042M16Rik; mPrrp"
                     /inference="alignment:Splign:2.1.0"
     exon            1182..2051
                     /gene="Dazap1"
                     /gene_synonym="2410042M16Rik; mPrrp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2026..2031
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dazap1"
                     /gene_synonym="2410042M16Rik; mPrrp"
                     /note="hexamer: AATAAA"
     polyA_site      2051
                     /gene="Dazap1"
                     /gene_synonym="2410042M16Rik; mPrrp"
                     /note="major polyA site"
ORIGIN      
        1 gacgcgcagc gaccgttggc gcggagggag gaggctcagc gccgccgccg ttgcgcagat
       61 ccgggccgcg gctgcgggga gggacgagcg gtgaccttcc ggaggagcgg ggcgcagcgg
      121 gccgggacgg ggcgccatga acagcgcggg cgccgacgaa atcgggaagc tctttgtggg
      181 cggcctggac tggagtacca ctcaagagac tctacgcagc tacttttccc agtatggtga
      241 ggttgtggat tgtgtcatca tgaaagataa aaccaccaac cagtctagag gctttggatt
      301 tgtcaagttt aaagacccca attgtgtggg gacagtgctg gccagcagac cacacaccct
      361 agatggccga aatatcgacc cgaagccgtg cacacctcgg gggatgcagc cagagcgaac
      421 acggcccaag gaaggctgga aaggacccag gagcgacagc agcaaatcca acaagatctt
      481 tgtcgggggc attccccaca actgcgggga gacggagctc agggagtact tcaagaagtt
      541 tggagtggtc acagaggtgg ttatgatcta tgatgcggag aagcagcggc ctcgaggttt
      601 tggatttatt actttcgagg acgaacaatc agtggaccag gctgtcaaca tgcattttca
      661 cgacatcatg ggcaaaaaag tggaggttaa acgggctgaa ccacgggaca gcaagaatca
      721 agctccagga cagccaggag ccagccagtg gggcagccgc gtggcgccca gtgcagccaa
      781 cggctgggca ggccagcccc cgcccacgtg gcaacaagga tatggcccac aaggaatgtg
      841 ggtgccagca ggacaggcca ttggtggcta tggcccaccc cctgcgggca gaggagcccc
      901 gcccccgccc ccacccttca cctcctacat tgtatccaca ccgcctggag gcttcccccc
      961 accacagggc ttcccacagg gctatggcgc cccaccacag ttcagttttg gctacggtcc
     1021 tcctccccca ccccctgatc agtttgcccc tccaggggtc cctcctccac ctgccacccc
     1081 aggggctgcc ccgctggcct tcccaccacc tccgtctcag gctgccccag acatgagcaa
     1141 acccccaaca gcccagccgg acttccccta tggtcaatat ggttacgggc aggacttgag
     1201 tggcttcggc cagggcttct cggaccccag ccagcagccg ccctcctatg ggggcccctc
     1261 tgtaccaggt tcggggggtc cccccgctgg cggcagtggc ttcggacgcg ggcagaacca
     1321 caacgtgcag ggcttccatc cctaccggcg ctagccaggg gcatggcggc ggggcaggca
     1381 ggattcggga ctggtgaact tgtgacaatc acactcggga caaaataaat gaccactcga
     1441 cctgggggga ggggcagcgg aggccgcatc tggactgagg ttttaaatat atttcttttc
     1501 tctgacccat cagcacaata aaaacacgtc actggttcaa caacagggtt taaaaaacgc
     1561 cttcagcttt aattcagaat ttcaggtttc tttttcttct tccttttttt tccttttttt
     1621 gagattattt tcttgagcct tttgttttat ggtatattgt aaacttttat gttaaagaaa
     1681 aaatatacat ttacaaattg tgagattttt aagagaaatt ttctacaatg tatactggct
     1741 tattttttaa tttaaagcag ggttcgggtg tgggaagcgg gagccctggc tcccgccggc
     1801 gcgggctggg gtgcgggcag agactactgc gtgcatttgg ttttttgttc attccttgct
     1861 ttgagcggct tgtgtggctg caggtgcaac agggcccctg gcacaggtgg cagtgctgaa
     1921 gtctcgggtg gcctgggccc cacccacaca ggtgtggcag gcaaggcctt gctggaggcc
     1981 cctcagtagg gctcaggttc ccattgacca gtttgacccg gtttgaataa aacagcgtgt
     2041 ttggatcaga a
//
