LOCUS       NM_007829               2598 bp    mRNA    linear   ROD 14-MAY-2024
DEFINITION  Mus musculus Fas death domain-associated protein (Daxx), transcript
            variant 2, mRNA.
ACCESSION   NM_007829 XM_993766
VERSION     NM_007829.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2598)
  AUTHORS   Leon,N.Y., Le,T.N.U., Garvie,A., Wong,L.H., Bagheri-Fam,S. and
            Harley,V.R.
  TITLE     Y chromosome damage underlies testicular abnormalities in ATR-X
            syndrome
  JOURNAL   iScience 27 (5), 109629 (2024)
   PUBMED   38616920
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2598)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2598)
  AUTHORS   Song,S., Wang,N., Huang,X.W., Jiang,Q., Cheng,X.R., Pang,N. and
            Lei,L.
  TITLE     Daxx knockdown promoted rDNA transcription without impairing H3.3
            expression in mouse preimplantation embryos
  JOURNAL   Anat Histol Embryol 53 (1), e12974 (2024)
   PUBMED   37767699
  REMARK    GeneRIF: Daxx knockdown promoted rDNA transcription without
            impairing H3.3 expression in mouse preimplantation embryos.
REFERENCE   4  (bases 1 to 2598)
  AUTHORS   Canat,A., Veillet,A., Batrin,R., Dubourg,C., Lhoumaud,P.,
            Arnau-Romero,P., Greenberg,M.V.C., Bonhomme,F., Arimondo,P.B.,
            Illingworth,R., Fabre,E. and Therizols,P.
  TITLE     DAXX safeguards heterochromatin formation in embryonic stem cells
  JOURNAL   J Cell Sci 136 (19) (2023)
   PUBMED   37655670
  REMARK    GeneRIF: DAXX safeguards heterochromatin formation in embryonic
            stem cells.
REFERENCE   5  (bases 1 to 2598)
  AUTHORS   Sun,C., Qi,Y., Fowlkes,N., Lazic,N., Su,X., Lozano,G. and
            Wasylishen,A.R.
  TITLE     The histone chaperone function of Daxx is dispensable for embryonic
            development
  JOURNAL   Cell Death Dis 14 (8), 565 (2023)
   PUBMED   37633949
  REMARK    GeneRIF: The histone chaperone function of Daxx is dispensable for
            embryonic development.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2598)
  AUTHORS   Rochat-Steiner,V., Becker,K., Micheau,O., Schneider,P., Burns,K.
            and Tschopp,J.
  TITLE     FIST/HIPK3: a Fas/FADD-interacting serine/threonine kinase that
            induces FADD phosphorylation and inhibits fas-mediated Jun
            NH(2)-terminal kinase activation
  JOURNAL   J Exp Med 192 (8), 1165-1174 (2000)
   PUBMED   11034606
REFERENCE   7  (bases 1 to 2598)
  AUTHORS   Zhong,S., Salomoni,P., Ronchetti,S., Guo,A., Ruggero,D. and
            Pandolfi,P.P.
  TITLE     Promyelocytic leukemia protein (PML) and Daxx participate in a
            novel nuclear pathway for apoptosis
  JOURNAL   J Exp Med 191 (4), 631-640 (2000)
   PUBMED   10684855
REFERENCE   8  (bases 1 to 2598)
  AUTHORS   Michaelson,J.S., Bader,D., Kuo,F., Kozak,C. and Leder,P.
  TITLE     Loss of Daxx, a promiscuously interacting protein, results in
            extensive apoptosis in early mouse development
  JOURNAL   Genes Dev 13 (15), 1918-1923 (1999)
   PUBMED   10444590
REFERENCE   9  (bases 1 to 2598)
  AUTHORS   Baker,S.J. and Reddy,E.P.
  TITLE     Modulation of life and death by the TNF receptor superfamily
  JOURNAL   Oncogene 17 (25), 3261-3270 (1998)
   PUBMED   9916988
  REMARK    Review article
REFERENCE   10 (bases 1 to 2598)
  AUTHORS   Yang,X., Khosravi-Far,R., Chang,H.Y. and Baltimore,D.
  TITLE     Daxx, a novel Fas-binding protein that activates JNK and apoptosis
  JOURNAL   Cell 89 (7), 1067-1076 (1997)
   PUBMED   9215629
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CR974462.5, AK145906.1 and BQ176437.1.
            
            On Dec 14, 2010 this sequence version replaced NM_007829.3.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK133863.1, AK145906.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-70                CR974462.5         2617-2686
            71-2580             AK145906.1         2-2511
            2581-2598           BQ176437.1         1-18                c
FEATURES             Location/Qualifiers
     source          1..2598
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 17.98 cM"
     gene            1..2598
                     /gene="Daxx"
                     /note="Fas death domain-associated protein"
                     /db_xref="GeneID:13163"
                     /db_xref="MGI:MGI:1197015"
     exon            1..154
                     /gene="Daxx"
                     /inference="alignment:Splign:2.1.0"
     exon            155..395
                     /gene="Daxx"
                     /inference="alignment:Splign:2.1.0"
     CDS             171..2393
                     /gene="Daxx"
                     /note="death-domain associated protein"
                     /codon_start=1
                     /product="death domain-associated protein 6"
                     /protein_id="NP_031855.3"
                     /db_xref="CCDS:CCDS28633.1"
                     /db_xref="GeneID:13163"
                     /db_xref="MGI:MGI:1197015"
                     /translation="MATDDSIIVLDDDDEDEAAAQPGPSNLPPNPASTGPGPGLSQQA
                     TGLSEPRVDGGSSNSGSRKCYKLDNEKLFEEFLELCKTETSDHPEVVPFLHKLQQRAQ
                     SVFLASAEFCNILSRVLARSRKRPAKIYVYINELCTVLKAHSIKKKLNLAPAASTTSE
                     ASGPNPPTEPPSDLTNTENTASEASRTRGSRRQIQRLEQLLALYVAEIRRLQEKELDL
                     SELDDPDSSYLQEARLKRKLIRLFGRLCELKDCSSLTGRVIEQRIPYRGTRYPEVNRR
                     IERLINKPGLDTFPDYGDVLRAVEKAATRHSLGLPRQQLQLLAQDAFRDVGVRLQERR
                     HLDLIYNFGCHLTDDYRPGVDPALSDPTLARRLRENRTLAMNRLDEVISKYAMMQDKT
                     EEGERQKRRARLLGTAPQPSDPPKASSESGEGPSGMASQECPTTSKAETDDDDDDDDD
                     DDDEDNEESEEEEEEEEEEKEATEDEDEDLEQLQEDQGGDEEEEGGDNEGNESPTSPS
                     DFFHRRNSEPAEGLRTPEGQQKRGLTETPASPPGASLDPPSTDAESSGEQLLEPLLGD
                     ESPVSQLAELEMEALPEERDISSSRKKSEDSLPTILENGAAVVTSTSVNGRVSSHTWR
                     DASPPSKRFRKEKKQLGSGLLGNSYIKEPMAQQDSGQNTSVQPMPSPPLASVASVADS
                     STRVDSPSHELVTSSLCSPSPSLLLQTPQAQSLRQCIYKTSVATQCDPEEIIVLSDSD
                     "
     exon            396..1227
                     /gene="Daxx"
                     /inference="alignment:Splign:2.1.0"
     exon            1228..1439
                     /gene="Daxx"
                     /inference="alignment:Splign:2.1.0"
     exon            1440..1659
                     /gene="Daxx"
                     /inference="alignment:Splign:2.1.0"
     exon            1660..2113
                     /gene="Daxx"
                     /inference="alignment:Splign:2.1.0"
     exon            2114..2333
                     /gene="Daxx"
                     /inference="alignment:Splign:2.1.0"
     exon            2334..2581
                     /gene="Daxx"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2554..2559
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Daxx"
                     /note="hexamer: AATAAA"
     polyA_site      2581
                     /gene="Daxx"
                     /note="major polyA site"
ORIGIN      
        1 gcaatatggc cgccctcagg tgctccaggc ggaagcgcta aggcttccgg tctgttgtgg
       61 ggtctgcggt gggggttggg gagaggaagg cggagggaac tatgcgagga tttgtgatcc
      121 gcgctcaggg gatcctcgag agaccgtttc tgaggggaat ttgaaccccc atggccaccg
      181 atgacagcat cattgtactt gatgatgacg atgaagatga agctgctgct caaccagggc
      241 cctccaacct accccccaat cctgcctcaa caggacctgg tcctggcctg tctcaacagg
      301 ccactggtct ctccgagccc cgtgtggatg gagggagcag taactccggt agtaggaagt
      361 gctacaagtt ggataatgag aagctctttg aagagttcct tgaactgtgt aagacggaga
      421 catcagacca ccctgaggtg gttccgttcc tccacaaact gcagcagcgt gcccagtctg
      481 tgtttctggc ctctgcagag ttctgcaaca tcctctccag ggttctggct cggtctcgga
      541 agcggcccgc taagatctat gtgtacatta acgagctctg cactgttctt aaagctcact
      601 ccatcaagaa gaagttgaac ttagctcctg cagcctcaac gaccagtgag gcgtcgggcc
      661 ctaaccctcc cacagagccc ccctctgacc ttacaaacac tgaaaacact gcctctgagg
      721 cctcaaggac tcgcggttcc cggaggcaga tccagcgcct ggagcagctg ctggcactgt
      781 acgtagccga gattcggcgg ctgcaggaga aggagttgga cctgtcagag ctggatgacc
      841 cagactcctc gtatttgcag gaggcccgct tgaagaggaa gttgatccgc ctcttcgggc
      901 ggttgtgtga gttgaaggac tgctcttctc tgacggggcg ggtcatagag cagcgaattc
      961 cgtaccgagg cacccggtac ccagaggtca acaggcgcat tgaacggctc attaacaagc
     1021 cggggctgga caccttcccc gattatggag atgtgctgag agccgtggag aaggcggcga
     1081 cccggcacag cctgggcctt cccagacagc agcttcagct cctggctcag gatgccttcc
     1141 gggacgtggg cgtcaggtta caggagcggc gccacctgga tctcatctac aactttggct
     1201 gtcacctcac agatgactat aggccaggcg ttgaccccgc actgtctgat cccacattgg
     1261 ctcgccgcct tcgggaaaat cgaaccttgg ccatgaaccg gctggatgag gtcatctcca
     1321 agtatgcaat gatgcaagac aagactgagg agggcgagag acagaagaga cgagcccggc
     1381 tcttaggcac cgccccccaa ccttcagacc cccccaaagc ctcctcggaa tctggtgagg
     1441 gtcctagcgg aatggcatcc caggagtgcc ctactacctc caaagctgag actgatgatg
     1501 acgatgatga cgatgatgat gacgacgacg aagataacga ggaaagtgag gaggaggagg
     1561 aggaggaaga ggaggagaaa gaggctactg aagatgaaga tgaggatcta gaacagttgc
     1621 aggaagatca ggggggtgat gaagaagagg aaggaggaga taatgaagga aatgagagtc
     1681 ccacatcgcc ttcagacttt ttccatagaa ggaattcaga gcctgcagaa gggctcagga
     1741 cccccgaggg gcagcaaaag agaggactga cagagacccc agcatccccg ccaggggcat
     1801 ccctggaccc tcccagcact gacgctgaga gcagtggaga gcagctcctc gagccgctcc
     1861 tgggagacga gagtcctgtg tcccagctcg ctgagctaga gatggaagct ttgcctgagg
     1921 aaagggacat ttcctcctcc aggaaaaagt cggaagattc cctccccacc atcttggaaa
     1981 atggggcagc tgtggttacc tctacatctg tcaatgggcg tgtctcttct cacacttgga
     2041 gagatgccag tccccccagc aagagatttc ggaaggaaaa gaagcaactg ggctctggac
     2101 tgttaggaaa cagctatata aaagaaccga tggcacagca ggacagtggg cagaacacaa
     2161 gtgtccagcc tatgccatcc ccccccttgg cctctgtggc ttctgtcgct gattcctcca
     2221 caagggtgga ctctcccagc catgaactgg tgaccagctc tctgtgcagc ccttctccat
     2281 ccctgcttct ccagacaccc caggctcagt ctctccggca gtgtatttat aagaccagtg
     2341 tggccacaca gtgcgacccg gaggagatca tcgtgctttc agactctgat tagcaggccc
     2401 catgctcccc gtgctccctg catccagaag gttttttgta tggctgttgg aagatgatgg
     2461 agtaaaagat ggacagagct cctcccgttt tgatggtgtt tcttttgaca aaaaaaaaaa
     2521 atcaaaatgt tttaagtttt acacagacac attaataaac aatgaatttc tttttattgt
     2581 aaaaaaaaaa aaaaaaaa
//
