LOCUS       NM_001199733            2698 bp    mRNA    linear   ROD 14-MAY-2024
DEFINITION  Mus musculus Fas death domain-associated protein (Daxx), transcript
            variant 1, mRNA.
ACCESSION   NM_001199733
VERSION     NM_001199733.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2698)
  AUTHORS   Leon,N.Y., Le,T.N.U., Garvie,A., Wong,L.H., Bagheri-Fam,S. and
            Harley,V.R.
  TITLE     Y chromosome damage underlies testicular abnormalities in ATR-X
            syndrome
  JOURNAL   iScience 27 (5), 109629 (2024)
   PUBMED   38616920
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2698)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2698)
  AUTHORS   Song,S., Wang,N., Huang,X.W., Jiang,Q., Cheng,X.R., Pang,N. and
            Lei,L.
  TITLE     Daxx knockdown promoted rDNA transcription without impairing H3.3
            expression in mouse preimplantation embryos
  JOURNAL   Anat Histol Embryol 53 (1), e12974 (2024)
   PUBMED   37767699
  REMARK    GeneRIF: Daxx knockdown promoted rDNA transcription without
            impairing H3.3 expression in mouse preimplantation embryos.
REFERENCE   4  (bases 1 to 2698)
  AUTHORS   Canat,A., Veillet,A., Batrin,R., Dubourg,C., Lhoumaud,P.,
            Arnau-Romero,P., Greenberg,M.V.C., Bonhomme,F., Arimondo,P.B.,
            Illingworth,R., Fabre,E. and Therizols,P.
  TITLE     DAXX safeguards heterochromatin formation in embryonic stem cells
  JOURNAL   J Cell Sci 136 (19) (2023)
   PUBMED   37655670
  REMARK    GeneRIF: DAXX safeguards heterochromatin formation in embryonic
            stem cells.
REFERENCE   5  (bases 1 to 2698)
  AUTHORS   Sun,C., Qi,Y., Fowlkes,N., Lazic,N., Su,X., Lozano,G. and
            Wasylishen,A.R.
  TITLE     The histone chaperone function of Daxx is dispensable for embryonic
            development
  JOURNAL   Cell Death Dis 14 (8), 565 (2023)
   PUBMED   37633949
  REMARK    GeneRIF: The histone chaperone function of Daxx is dispensable for
            embryonic development.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2698)
  AUTHORS   Rochat-Steiner,V., Becker,K., Micheau,O., Schneider,P., Burns,K.
            and Tschopp,J.
  TITLE     FIST/HIPK3: a Fas/FADD-interacting serine/threonine kinase that
            induces FADD phosphorylation and inhibits fas-mediated Jun
            NH(2)-terminal kinase activation
  JOURNAL   J Exp Med 192 (8), 1165-1174 (2000)
   PUBMED   11034606
REFERENCE   7  (bases 1 to 2698)
  AUTHORS   Zhong,S., Salomoni,P., Ronchetti,S., Guo,A., Ruggero,D. and
            Pandolfi,P.P.
  TITLE     Promyelocytic leukemia protein (PML) and Daxx participate in a
            novel nuclear pathway for apoptosis
  JOURNAL   J Exp Med 191 (4), 631-640 (2000)
   PUBMED   10684855
REFERENCE   8  (bases 1 to 2698)
  AUTHORS   Michaelson,J.S., Bader,D., Kuo,F., Kozak,C. and Leder,P.
  TITLE     Loss of Daxx, a promiscuously interacting protein, results in
            extensive apoptosis in early mouse development
  JOURNAL   Genes Dev 13 (15), 1918-1923 (1999)
   PUBMED   10444590
REFERENCE   9  (bases 1 to 2698)
  AUTHORS   Baker,S.J. and Reddy,E.P.
  TITLE     Modulation of life and death by the TNF receptor superfamily
  JOURNAL   Oncogene 17 (25), 3261-3270 (1998)
   PUBMED   9916988
  REMARK    Review article
REFERENCE   10 (bases 1 to 2698)
  AUTHORS   Yang,X., Khosravi-Far,R., Chang,H.Y. and Baltimore,D.
  TITLE     Daxx, a novel Fas-binding protein that activates JNK and apoptosis
  JOURNAL   Cell 89 (7), 1067-1076 (1997)
   PUBMED   9215629
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CR974462.5, AK145906.1 and BQ176437.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK156425.1, AK172616.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-254               CR974462.5         2773-3026
            255-495             CR974462.5         3603-3843
            496-563             CR974462.5         4410-4477
            564-2680            AK145906.1         395-2511
            2681-2698           BQ176437.1         1-18                c
FEATURES             Location/Qualifiers
     source          1..2698
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 17.98 cM"
     gene            1..2698
                     /gene="Daxx"
                     /note="Fas death domain-associated protein"
                     /db_xref="GeneID:13163"
                     /db_xref="MGI:MGI:1197015"
     exon            1..254
                     /gene="Daxx"
                     /inference="alignment:Splign:2.1.0"
     exon            255..495
                     /gene="Daxx"
                     /inference="alignment:Splign:2.1.0"
     CDS             271..2493
                     /gene="Daxx"
                     /note="death-domain associated protein"
                     /codon_start=1
                     /product="death domain-associated protein 6"
                     /protein_id="NP_001186662.1"
                     /db_xref="CCDS:CCDS28633.1"
                     /db_xref="GeneID:13163"
                     /db_xref="MGI:MGI:1197015"
                     /translation="MATDDSIIVLDDDDEDEAAAQPGPSNLPPNPASTGPGPGLSQQA
                     TGLSEPRVDGGSSNSGSRKCYKLDNEKLFEEFLELCKTETSDHPEVVPFLHKLQQRAQ
                     SVFLASAEFCNILSRVLARSRKRPAKIYVYINELCTVLKAHSIKKKLNLAPAASTTSE
                     ASGPNPPTEPPSDLTNTENTASEASRTRGSRRQIQRLEQLLALYVAEIRRLQEKELDL
                     SELDDPDSSYLQEARLKRKLIRLFGRLCELKDCSSLTGRVIEQRIPYRGTRYPEVNRR
                     IERLINKPGLDTFPDYGDVLRAVEKAATRHSLGLPRQQLQLLAQDAFRDVGVRLQERR
                     HLDLIYNFGCHLTDDYRPGVDPALSDPTLARRLRENRTLAMNRLDEVISKYAMMQDKT
                     EEGERQKRRARLLGTAPQPSDPPKASSESGEGPSGMASQECPTTSKAETDDDDDDDDD
                     DDDEDNEESEEEEEEEEEEKEATEDEDEDLEQLQEDQGGDEEEEGGDNEGNESPTSPS
                     DFFHRRNSEPAEGLRTPEGQQKRGLTETPASPPGASLDPPSTDAESSGEQLLEPLLGD
                     ESPVSQLAELEMEALPEERDISSSRKKSEDSLPTILENGAAVVTSTSVNGRVSSHTWR
                     DASPPSKRFRKEKKQLGSGLLGNSYIKEPMAQQDSGQNTSVQPMPSPPLASVASVADS
                     STRVDSPSHELVTSSLCSPSPSLLLQTPQAQSLRQCIYKTSVATQCDPEEIIVLSDSD
                     "
     exon            496..1327
                     /gene="Daxx"
                     /inference="alignment:Splign:2.1.0"
     exon            1328..1539
                     /gene="Daxx"
                     /inference="alignment:Splign:2.1.0"
     exon            1540..1759
                     /gene="Daxx"
                     /inference="alignment:Splign:2.1.0"
     exon            1760..2213
                     /gene="Daxx"
                     /inference="alignment:Splign:2.1.0"
     exon            2214..2433
                     /gene="Daxx"
                     /inference="alignment:Splign:2.1.0"
     exon            2434..2681
                     /gene="Daxx"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2654..2659
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Daxx"
                     /note="hexamer: AATAAA"
     polyA_site      2681
                     /gene="Daxx"
                     /note="major polyA site"
ORIGIN      
        1 gggggccagg tcgtgcgcgg agcgggggtg gcggcgcagg agtggcgaag gcgacggctc
       61 ggcagggcct gcccgacgag gctcagggcc gagctggtag ggtaccttgc tagccctgaa
      121 ggcgagtgtg gcggcctagg gctgaacgcc gagagagggc tccttggcgg gaagctgagg
      181 cccagacagg aggaatggcg agtggtgggc tcgctgtcgg gtaccgtcgc tgagagttgg
      241 ctgggaaaac cagggggaat ttgaaccccc atggccaccg atgacagcat cattgtactt
      301 gatgatgacg atgaagatga agctgctgct caaccagggc cctccaacct accccccaat
      361 cctgcctcaa caggacctgg tcctggcctg tctcaacagg ccactggtct ctccgagccc
      421 cgtgtggatg gagggagcag taactccggt agtaggaagt gctacaagtt ggataatgag
      481 aagctctttg aagagttcct tgaactgtgt aagacggaga catcagacca ccctgaggtg
      541 gttccgttcc tccacaaact gcagcagcgt gcccagtctg tgtttctggc ctctgcagag
      601 ttctgcaaca tcctctccag ggttctggct cggtctcgga agcggcccgc taagatctat
      661 gtgtacatta acgagctctg cactgttctt aaagctcact ccatcaagaa gaagttgaac
      721 ttagctcctg cagcctcaac gaccagtgag gcgtcgggcc ctaaccctcc cacagagccc
      781 ccctctgacc ttacaaacac tgaaaacact gcctctgagg cctcaaggac tcgcggttcc
      841 cggaggcaga tccagcgcct ggagcagctg ctggcactgt acgtagccga gattcggcgg
      901 ctgcaggaga aggagttgga cctgtcagag ctggatgacc cagactcctc gtatttgcag
      961 gaggcccgct tgaagaggaa gttgatccgc ctcttcgggc ggttgtgtga gttgaaggac
     1021 tgctcttctc tgacggggcg ggtcatagag cagcgaattc cgtaccgagg cacccggtac
     1081 ccagaggtca acaggcgcat tgaacggctc attaacaagc cggggctgga caccttcccc
     1141 gattatggag atgtgctgag agccgtggag aaggcggcga cccggcacag cctgggcctt
     1201 cccagacagc agcttcagct cctggctcag gatgccttcc gggacgtggg cgtcaggtta
     1261 caggagcggc gccacctgga tctcatctac aactttggct gtcacctcac agatgactat
     1321 aggccaggcg ttgaccccgc actgtctgat cccacattgg ctcgccgcct tcgggaaaat
     1381 cgaaccttgg ccatgaaccg gctggatgag gtcatctcca agtatgcaat gatgcaagac
     1441 aagactgagg agggcgagag acagaagaga cgagcccggc tcttaggcac cgccccccaa
     1501 ccttcagacc cccccaaagc ctcctcggaa tctggtgagg gtcctagcgg aatggcatcc
     1561 caggagtgcc ctactacctc caaagctgag actgatgatg acgatgatga cgatgatgat
     1621 gacgacgacg aagataacga ggaaagtgag gaggaggagg aggaggaaga ggaggagaaa
     1681 gaggctactg aagatgaaga tgaggatcta gaacagttgc aggaagatca ggggggtgat
     1741 gaagaagagg aaggaggaga taatgaagga aatgagagtc ccacatcgcc ttcagacttt
     1801 ttccatagaa ggaattcaga gcctgcagaa gggctcagga cccccgaggg gcagcaaaag
     1861 agaggactga cagagacccc agcatccccg ccaggggcat ccctggaccc tcccagcact
     1921 gacgctgaga gcagtggaga gcagctcctc gagccgctcc tgggagacga gagtcctgtg
     1981 tcccagctcg ctgagctaga gatggaagct ttgcctgagg aaagggacat ttcctcctcc
     2041 aggaaaaagt cggaagattc cctccccacc atcttggaaa atggggcagc tgtggttacc
     2101 tctacatctg tcaatgggcg tgtctcttct cacacttgga gagatgccag tccccccagc
     2161 aagagatttc ggaaggaaaa gaagcaactg ggctctggac tgttaggaaa cagctatata
     2221 aaagaaccga tggcacagca ggacagtggg cagaacacaa gtgtccagcc tatgccatcc
     2281 ccccccttgg cctctgtggc ttctgtcgct gattcctcca caagggtgga ctctcccagc
     2341 catgaactgg tgaccagctc tctgtgcagc ccttctccat ccctgcttct ccagacaccc
     2401 caggctcagt ctctccggca gtgtatttat aagaccagtg tggccacaca gtgcgacccg
     2461 gaggagatca tcgtgctttc agactctgat tagcaggccc catgctcccc gtgctccctg
     2521 catccagaag gttttttgta tggctgttgg aagatgatgg agtaaaagat ggacagagct
     2581 cctcccgttt tgatggtgtt tcttttgaca aaaaaaaaaa atcaaaatgt tttaagtttt
     2641 acacagacac attaataaac aatgaatttc tttttattgt aaaaaaaaaa aaaaaaaa
//
