LOCUS       NM_011932               3096 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus dual adaptor for phosphotyrosine and
            3-phosphoinositides 1 (Dapp1), transcript variant 1, mRNA.
ACCESSION   NM_011932
VERSION     NM_011932.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3096)
  AUTHORS   Hao,L., Marshall,A.J. and Liu,L.
  TITLE     Suppressive Role of Bam32/DAPP1 in Chemokine-Induced Neutrophil
            Recruitment
  JOURNAL   Int J Mol Sci 22 (4), 1825 (2021)
   PUBMED   33673180
  REMARK    GeneRIF: Suppressive Role of Bam32/DAPP1 in Chemokine-Induced
            Neutrophil Recruitment.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3096)
  AUTHORS   Hao,L., Marshall,A.J. and Liu,L.
  TITLE     Bam32/DAPP1-Dependent Neutrophil Reactive Oxygen Species in
            WKYMVm-Induced Microvascular Hyperpermeability
  JOURNAL   Front Immunol 11, 1028 (2020)
   PUBMED   32536926
  REMARK    GeneRIF: Bam32/DAPP1-Dependent Neutrophil Reactive Oxygen Species
            in WKYMVm-Induced Microvascular Hyperpermeability.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3096)
  AUTHORS   Maazi,H., Hartiala,J.A., Suzuki,Y., Crow,A.L., Shafiei Jahani,P.,
            Lam,J., Patel,N., Rigas,D., Han,Y., Huang,P., Eskin,E., Lusis,A.J.,
            Gilliland,F.D., Akbari,O. and Allayee,H.
  TITLE     A GWAS approach identifies Dapp1 as a determinant of air
            pollution-induced airway hyperreactivity
  JOURNAL   PLoS Genet 15 (12), e1008528 (2019)
   PUBMED   31869344
  REMARK    GeneRIF: Results functionally demonstrated that Dapp1 modulates
            lung resistance in response to diesel exhaust particles exposure,
            thus providing evidence for a novel gene-environment interaction
            that influences asthma-related traits in mice.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3096)
  AUTHORS   Onyilagha,C., Jia,P., Jayachandran,N., Hou,S., Okwor,I.,
            Kuriakose,S., Marshall,A. and Uzonna,J.E.
  TITLE     The B cell adaptor molecule Bam32 is critically important for
            optimal antibody response and resistance to Trypanosoma congolense
            infection in mice
  JOURNAL   PLoS Negl Trop Dis 9 (4), e0003716 (2015)
   PUBMED   25875604
  REMARK    GeneRIF: These data show that Bam32 is important for optimal
            anti-trypanosome IgG antibody response and suppression of
            disease-promoting proinflammatory cytokines.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3096)
  AUTHORS   Rouquette-Jazdanian,A.K., Sommers,C.L., Kortum,R.L., Morrison,D.K.
            and Samelson,L.E.
  TITLE     LAT-independent Erk activation via Bam32-PLC-gamma1-Pak1 complexes:
            GTPase-independent Pak1 activation
  JOURNAL   Mol Cell 48 (2), 298-312 (2012)
   PUBMED   22981863
REFERENCE   6  (bases 1 to 3096)
  AUTHORS   Cheng,X.X. and Jian,R.
  TITLE     [Identification of proteins interacting with adaptor protein Bam32]
  JOURNAL   Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 21 (4), 432-434 (2005)
   PUBMED   15989784
  REMARK    GeneRIF: The interaction of Bam32 with Lyn leads to Bam32
            phosphorylation, which might play an important role in activating
            downstream signaling molecules.
REFERENCE   7  (bases 1 to 3096)
  AUTHORS   Fournier,E., Isakoff,S.J., Ko,K., Cardinale,C.J., Inghirami,G.G.,
            Li,Z., Curotto de Lafaille,M.A. and Skolnik,E.Y.
  TITLE     The B cell SH2/PH domain-containing adaptor Bam32/DAPP1 is required
            for T cell-independent II antigen responses
  JOURNAL   Curr Biol 13 (21), 1858-1866 (2003)
   PUBMED   14588241
REFERENCE   8  (bases 1 to 3096)
  AUTHORS   Han,A., Saijo,K., Mecklenbrauker,I., Tarakhovsky,A. and
            Nussenzweig,M.C.
  TITLE     Bam32 links the B cell receptor to ERK and JNK and mediates B cell
            proliferation but not survival
  JOURNAL   Immunity 19 (4), 621-632 (2003)
   PUBMED   14563325
REFERENCE   9  (bases 1 to 3096)
  AUTHORS   Marshall,A.J., Niiro,H., Lerner,C.G., Yun,T.J., Thomas,S.,
            Disteche,C.M. and Clark,E.A.
  TITLE     A novel B lymphocyte-associated adaptor protein, Bam32, regulates
            antigen receptor signaling downstream of phosphatidylinositol
            3-kinase
  JOURNAL   J Exp Med 191 (8), 1319-1332 (2000)
   PUBMED   10770799
REFERENCE   10 (bases 1 to 3096)
  AUTHORS   Dowler,S., Currie,R.A., Downes,C.P. and Alessi,D.R.
  TITLE     DAPP1: a dual adaptor for phosphotyrosine and 3-phosphoinositides
  JOURNAL   Biochem J 342 (Pt 1) (Pt 1), 7-12 (1999)
   PUBMED   10432293
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC146607.2, AK145745.1, AK169584.1 and BF714724.1.
            
            On Jul 18, 2015 this sequence version replaced NM_011932.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK145745.1, AF186023.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164137
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-35                AC146607.2         34878-34912
            36-565              AK145745.1         2-531
            566-3086            AK169584.1         431-2951
            3087-3096           BF714724.1         1-10                c
FEATURES             Location/Qualifiers
     source          1..3096
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 63.98 cM"
     gene            1..3096
                     /gene="Dapp1"
                     /gene_synonym="Bam32"
                     /note="dual adaptor for phosphotyrosine and
                     3-phosphoinositides 1"
                     /db_xref="GeneID:26377"
                     /db_xref="MGI:MGI:1347063"
     exon            1..231
                     /gene="Dapp1"
                     /gene_synonym="Bam32"
                     /inference="alignment:Splign:2.1.0"
     CDS             131..973
                     /gene="Dapp1"
                     /gene_synonym="Bam32"
                     /note="isoform 1 is encoded by transcript variant 1; dual
                     adapter for phosphotyrosine and 3-phosphotyrosine and
                     3-phosphoinositide; B-cell adapter molecule of 32 kDa; b
                     lymphocyte adapter protein Bam32"
                     /codon_start=1
                     /product="dual adapter for phosphotyrosine and
                     3-phosphotyrosine and 3-phosphoinositide isoform 1"
                     /protein_id="NP_036062.1"
                     /db_xref="CCDS:CCDS17864.1"
                     /db_xref="GeneID:26377"
                     /db_xref="MGI:MGI:1347063"
                     /translation="MGRAELLGGNMSTQDPSELWGRADGGTDLLQDLGWYHGNLTRHA
                     AEALLLSNGRDGSYLLRDSNEQTGLYSLSVRAKDSVKHFHVEYTGYSFKFGFNEYSSL
                     KDFVKHFANQPLIGSETGTLMVLKHPYPREVEEPCIYESVRVHTAMQTGRTENDLVPT
                     APSLGTKEGYLTKQGGLVKTWKTRWFTLQRNELKYFKDQMSPEPIRILDLTECSAVQF
                     DYSQERVNCFCLVFPFRTFYLCAKTGVEADEWIKILRWKLSKIRKQLDQGEDTVRSRS
                     FIFK"
     exon            232..354
                     /gene="Dapp1"
                     /gene_synonym="Bam32"
                     /inference="alignment:Splign:2.1.0"
     exon            355..488
                     /gene="Dapp1"
                     /gene_synonym="Bam32"
                     /inference="alignment:Splign:2.1.0"
     exon            489..619
                     /gene="Dapp1"
                     /gene_synonym="Bam32"
                     /inference="alignment:Splign:2.1.0"
     exon            620..667
                     /gene="Dapp1"
                     /gene_synonym="Bam32"
                     /inference="alignment:Splign:2.1.0"
     exon            668..730
                     /gene="Dapp1"
                     /gene_synonym="Bam32"
                     /inference="alignment:Splign:2.1.0"
     exon            731..816
                     /gene="Dapp1"
                     /gene_synonym="Bam32"
                     /inference="alignment:Splign:2.1.0"
     exon            817..904
                     /gene="Dapp1"
                     /gene_synonym="Bam32"
                     /inference="alignment:Splign:2.1.0"
     exon            905..3087
                     /gene="Dapp1"
                     /gene_synonym="Bam32"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1387..1392
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dapp1"
                     /gene_synonym="Bam32"
                     /note="hexamer: AATAAA"
     polyA_site      1409
                     /gene="Dapp1"
                     /gene_synonym="Bam32"
                     /note="major polyA site"
     regulatory      2881..2886
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dapp1"
                     /gene_synonym="Bam32"
                     /note="hexamer: AATAAA"
     polyA_site      2903
                     /gene="Dapp1"
                     /gene_synonym="Bam32"
                     /note="major polyA site"
     regulatory      3058..3063
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dapp1"
                     /gene_synonym="Bam32"
                     /note="hexamer: ATTAAA"
     polyA_site      3087
                     /gene="Dapp1"
                     /gene_synonym="Bam32"
ORIGIN      
        1 tagccagaga ctcagcccca gccggctcct gccttagcga ggaggagcag cgcgtccagc
       61 agcagccgat cccatctctc tcttcataca gcacctggcg gggagtcagc catcagaagc
      121 aaaggaactt atgggcagag cagaacttct aggagggaac atgagtaccc aggatccctc
      181 agagctgtgg ggcagagcag atggaggcac agacctgctc caggatttgg ggtggtatca
      241 cggcaacctc acccgccatg ctgccgaagc ccttctgctc tccaatggac gtgatggtag
      301 ctacctgctg cgggacagca atgagcagac tgggctctac tctctctctg tgagagccaa
      361 agactctgtc aaacactttc atgttgaata tactgggtac tcgtttaaat tcggctttaa
      421 tgagtattca tctctaaagg attttgtcaa gcattttgca aatcagcctt tgattggaag
      481 cgagacaggg actctgatgg ttttgaagca tccctatcca agggaagtgg aagaaccttg
      541 catttacgaa tcagtccggg ttcacacagc gatgcagaca ggaaggacag agaacgacct
      601 cgtgcccact gcgccttctc tgggcaccaa agaaggctat ctcaccaagc agggaggcct
      661 ggtaaagacc tggaaaacaa gatggtttac tttgcaaagg aacgaactga aatatttcaa
      721 agaccagatg tcaccagaac caattcggat cctagaccta acagagtgct cagctgttca
      781 atttgattac tcacaggaac gagtaaactg tttctgccta gtgtttccat tcaggacatt
      841 ttatctctgt gcaaagacgg gagttgaagc cgatgaatgg atcaaaatac tgagatggaa
      901 gttgtcaaaa ataagaaaac agctggatca aggagaagat accgtccgat ctaggtcatt
      961 tatcttcaaa tagacttgtg tgctcagggg cacggttgac tgttccaggt gtctgatctg
     1021 tggcagactt cagaggaaaa ctcattgaag tatttcctct aaaaacaaat caaaagtaga
     1081 tcgtggttgg gagctgtctg ctgtctgctg atccatggaa aacagctggc aggacctggc
     1141 catctgctcg agaacagaag cagcgccctg ctgatggcaa ctgcctagcg tccaggtgga
     1201 gccactctca gacacagcgc cagacaagag ctcattggct gtcccagtgg ctcaggctca
     1261 ttgactttag tttcctggag ttcagcccca agtcatggtc agcacaacta aacttcagga
     1321 cttgctacaa gcacaaggaa acagcagtgc atcagggagc tcgggctggg ctttaggaag
     1381 cagattaata aacaccaagg acattcaaag gatgggttgc ttttgttttg cttataaacg
     1441 agaacctcaa atagggctga agaggtggct cagccattaa aagtgcatct gctctcacag
     1501 agaacctgga ttcagtttcg aggacccaga tcgtggggct cattaatgcc tgcctgtaac
     1561 tccaggtgcg cgcacacaca cacacacaca cacacacaca cacacacaca cctacctttt
     1621 aaaaggtttg gtaagtcatc ttagcatttt ccatgtcaag cttgaccgct tgagtatggt
     1681 tcccaaaact cacacaaagg tagaaggaga gaagcaactc cacaaagttg ttctctgaca
     1741 tgtatgtccc agcacgtatg gtctcacatc acaaacacac aaataataat acaaatccag
     1801 tggatccttc acgtctaatg ataaactgag aactacatgc cttgtgggtg actaggtagg
     1861 gaaaagtata tgatgtatga taaagggtag gaatatctta aatagtaaga aaatgtacat
     1921 tgagaagggt ggtagtgaat gacttttagt ttaatggtta tcattacaaa tatacttata
     1981 agcactaatt aaaactcttt aactgtcatt tcttcaaatt catgtggact tctccacaaa
     2041 ggatgttctc tgtctctttt tccaaggatc agctgtatga gactggtcct atgaggtacc
     2101 caaacatcat taaagggcaa cttctgtttc caaggaaggg agtagatcaa atcttcgtga
     2161 aatccatgat acacagctgt tgcaaactag cagagcagga ctgaggtgca ctgacatact
     2221 ggggttcaga ggtcatgaac agacttaact tccaatcatt attgatctag cttttttaga
     2281 gaagggacac cagtgagtgc cgggccagca agtggtgcag agctgaagga actctgttct
     2341 tgcaggagaa aggggcaatg gttttcactt ttctcagtgt gaccaagatg cttgttccaa
     2401 cattgtaccg aacgattcgc tttactctgt ggttctaaga catttctgcc catcgcgctg
     2461 ggtagggtgt ggtacagctg ctcacgtcag agcctcagga agcaaagcaa ggcagcgaca
     2521 ggaaagggag aggacaagac agagacccca ggaatatatc tcacgtggca tgtttccacg
     2581 ttctgccact tcccaagagt ctgctcagat tccgattcag gaatggatta acccatccat
     2641 tatgtcagcc ttcagggaca cactcggagg gtactttact cctcttggta tttctcaaga
     2701 tggtgtcaaa attaattcct agaacgttgg tttaatattg ttccctgttg tttaaacacc
     2761 taagactcag aaattaaatt tttgttggct tcagagtttt gggagctaag gtgtgggtct
     2821 gtggtaaaac atctggcctg ggggctaagg ggatttactt gttctgtttg tattttatgg
     2881 aataaagcaa cgtcctgata aaatgcattg tgtcaagttt gcaaaataag gagtaacacg
     2941 tggctcctcc taaaatgtat ggcttttatg ttcttagaaa caataatctt tctctcctac
     3001 taaacagtct acttaccttc tgtaaaagga gtttatttgt atcctttagt tctgttcatt
     3061 aaatgaaaag tgcatgtttt tgtggtaaaa aaaaaa
//
