LOCUS       NM_029723                589 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus death associated protein-like 1 (Dapl1), mRNA.
ACCESSION   NM_029723 XM_130301
VERSION     NM_029723.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 589)
  AUTHORS   Shigesawa,I., Nakamura,A., Yamauchi,Y., Kawata,S., Miyazaki,A.,
            Nomoto,H., Kameda,H., Terauchi,Y. and Atsumi,T.
  TITLE     Effects of glucokinase haploinsufficiency on the pancreatic
            beta-cell mass and function of long-term high-fat, high-sucrose
            diet-fed mice
  JOURNAL   J Diabetes Investig 15 (12), 1732-1742 (2024)
   PUBMED   39305123
REFERENCE   2  (bases 1 to 589)
  AUTHORS   Ma,X., Chen,H., Jian,S., He,J., Liu,Y., Han,S., Chang,L., Li,P.,
            Chen,Y.A., Liu,X., Hu,X., Chen,Y. and Hou,L.
  TITLE     DAPL1 deficiency in mice impairs antioxidant defenses in the RPE
            and leads to retinal degeneration with AMD-like features
  JOURNAL   Redox Biol 62, 102675 (2023)
   PUBMED   36933392
  REMARK    GeneRIF: DAPL1 deficiency in mice impairs antioxidant defenses in
            the RPE and leads to retinal degeneration with AMD-like features.
REFERENCE   3  (bases 1 to 589)
  AUTHORS   Ma,X., Han,S., Liu,Y., Chen,Y., Li,P., Liu,X., Chang,L., Chen,Y.A.,
            Chen,F., Hou,Q. and Hou,L.
  TITLE     DAPL1 prevents epithelial-mesenchymal transition in the retinal
            pigment epithelium and experimental proliferative vitreoretinopathy
  JOURNAL   Cell Death Dis 14 (2), 158 (2023)
   PUBMED   36841807
  REMARK    GeneRIF: DAPL1 prevents epithelial-mesenchymal transition in the
            retinal pigment epithelium and experimental proliferative
            vitreoretinopathy.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 589)
  AUTHORS   Zhu,L., Zhou,X., Gu,M., Kim,J., Li,Y., Ko,C.J., Xie,X., Gao,T.,
            Cheng,X. and Sun,S.C.
  TITLE     Dapl1 controls NFATc2 activation to regulate CD8+ T cell exhaustion
            and responses in chronic infection and cancer
  JOURNAL   Nat Cell Biol 24 (7), 1165-1176 (2022)
   PUBMED   35773432
REFERENCE   5  (bases 1 to 589)
  AUTHORS   Chen,H.B., Pineda Garcia,J.C., Arizono,S., Takeda,T., Li,R.S.,
            Hattori,Y., Sano,H., Miyauchi,Y., Hirota,Y., Tanaka,Y. and Ishii,Y.
  TITLE     DAPL1 is a novel regulator of testosterone production in Leydig
            cells of mouse testis
  JOURNAL   Sci Rep 11 (1), 18532 (2021)
   PUBMED   34535743
  REMARK    GeneRIF: DAPL1 is a novel regulator of testosterone production in
            Leydig cells of mouse testis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 589)
  AUTHORS   Lindstrom,N.O., Guo,J., Kim,A.D., Tran,T., Guo,Q., De Sena
            Brandine,G., Ransick,A., Parvez,R.K., Thornton,M.E., Baskin,L.,
            Grubbs,B., McMahon,J.A., Smith,A.D. and McMahon,A.P.
  TITLE     Conserved and Divergent Features of Mesenchymal Progenitor Cell
            Types within the Cortical Nephrogenic Niche of the Human and Mouse
            Kidney
  JOURNAL   J Am Soc Nephrol 29 (3), 806-824 (2018)
   PUBMED   29449449
REFERENCE   7  (bases 1 to 589)
  AUTHORS   Ma,X., Li,H., Wang,Y., Wang,J., Zheng,Q., Hua,J., Yang,J., Pan,L.,
            Lu,F., Qu,J. and Hou,L.
  TITLE     DAPL1, a susceptibility locus for age-related macular degeneration,
            acts as a novel suppressor of cell proliferation in the retinal
            pigment epithelium
  JOURNAL   Hum Mol Genet 26 (9), 1612-1621 (2017)
   PUBMED   28334846
  REMARK    GeneRIF: Authors show that DAPL1 is a novel regulator of RPE cell
            proliferation that is important for the maintenance of the RPE as a
            monolayer. The findings suggest that DAPL1 dysregulation may be
            involved in abnormal RPE-related proliferative diseases and
            corresponding retinal dysfunctions in humans.
REFERENCE   8  (bases 1 to 589)
  AUTHORS   Abe,K., Yamamoto,R., Franke,V., Cao,M., Suzuki,Y., Suzuki,M.G.,
            Vlahovicek,K., Svoboda,P., Schultz,R.M. and Aoki,F.
  TITLE     The first murine zygotic transcription is promiscuous and uncoupled
            from splicing and 3' processing
  JOURNAL   EMBO J 34 (11), 1523-1537 (2015)
   PUBMED   25896510
REFERENCE   9  (bases 1 to 589)
  AUTHORS   Sun,L., Ryan,D.G., Zhou,M., Sun,T.T. and Lavker,R.M.
  TITLE     EEDA: a protein associated with an early stage of stratified
            epithelial differentiation
  JOURNAL   J Cell Physiol 206 (1), 103-111 (2006)
   PUBMED   15920738
REFERENCE   10 (bases 1 to 589)
  AUTHORS   Carninci,P., Waki,K., Shiraki,T., Konno,H., Shibata,K., Itoh,M.,
            Aizawa,K., Arakawa,T., Ishii,Y., Sasaki,D., Bono,H., Kondo,S.,
            Sugahara,Y., Saito,R., Osato,N., Fukuda,S., Sato,K., Watahiki,A.,
            Hirozane-Kishikawa,T., Nakamura,M., Shibata,Y., Yasunishi,A.,
            Kikuchi,N., Yoshiki,A., Kusakabe,M., Gustincich,S., Beisel,K.,
            Pavan,W., Aidinis,V., Nakagawara,A., Held,W.A., Iwata,H., Kono,T.,
            Nakauchi,H., Lyons,P., Wells,C., Hume,D.A., Fagiolini,M.,
            Hensch,T.K., Brinkmeier,M., Camper,S., Hirota,J., Mombaerts,P.,
            Muramatsu,M., Okazaki,Y., Kawai,J. and Hayashizaki,Y.
  TITLE     Targeting a complex transcriptome: the construction of the mouse
            full-length cDNA encyclopedia
  JOURNAL   Genome Res 13 (6B), 1273-1289 (2003)
   PUBMED   12819125
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY786476.1 and BC052745.1.
            
            On Jun 26, 2010 this sequence version replaced NM_029723.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CO041485.1, CX731774.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-348               BY786476.1         2-349
            349-589             BC052745.1         484-724
FEATURES             Location/Qualifiers
     source          1..589
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 33.81 cM"
     gene            1..589
                     /gene="Dapl1"
                     /gene_synonym="2310032F03Rik; EEDA"
                     /note="death associated protein-like 1"
                     /db_xref="GeneID:76747"
                     /db_xref="MGI:MGI:1923997"
     exon            1..114
                     /gene="Dapl1"
                     /gene_synonym="2310032F03Rik; EEDA"
                     /inference="alignment:Splign:2.1.0"
     CDS             57..380
                     /gene="Dapl1"
                     /gene_synonym="2310032F03Rik; EEDA"
                     /note="early epithelial differentiation-associated
                     protein"
                     /codon_start=1
                     /product="death-associated protein-like 1"
                     /protein_id="NP_083999.1"
                     /db_xref="CCDS:CCDS16053.1"
                     /db_xref="GeneID:76747"
                     /db_xref="MGI:MGI:1923997"
                     /translation="MANEVQVLPSPLKGRYAPAVKAGGMRISKKQEMGVLERHTKKTG
                     LEKTSAITNVAKIQMLDALTDTLDKLNHKFPATVHTAHQKPTPALEKAAPMKRAYIIQ
                     QPRKC"
     exon            115..202
                     /gene="Dapl1"
                     /gene_synonym="2310032F03Rik; EEDA"
                     /inference="alignment:Splign:2.1.0"
     exon            203..263
                     /gene="Dapl1"
                     /gene_synonym="2310032F03Rik; EEDA"
                     /inference="alignment:Splign:2.1.0"
     exon            264..573
                     /gene="Dapl1"
                     /gene_synonym="2310032F03Rik; EEDA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      546..551
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dapl1"
                     /gene_synonym="2310032F03Rik; EEDA"
                     /note="hexamer: AATAAA"
     polyA_site      573
                     /gene="Dapl1"
                     /gene_synonym="2310032F03Rik; EEDA"
                     /note="major polyA site"
ORIGIN      
        1 agttacaact ggcactcagc ctcagagcat cggcaaggca ctggcacaca ggcactatgg
       61 caaacgaagt acaagttctg ccgtccccgc tgaaagggcg gtatgcccca gcagtgaaag
      121 ctggagggat gcgaatctcc aaaaaacaag agatgggcgt tttggaaaga cacacgaaaa
      181 agacaggctt ggagaaaaca agtgccatca caaatgtcgc caagatacag atgttggatg
      241 ctctgacgga cacactggac aagctcaacc ataaatttcc agcgacagtt cacacggcac
      301 atcaaaagcc cacacccgct ctggagaagg ctgctccaat gaagagggcc tacattattc
      361 agcaacctcg aaaatgttag accaggacag aaaacacagc cacctggtca actctcccac
      421 aatctgacag ctcaggaaaa aaaaaaaaaa aaaaagaaaa aagaaaaggt caatacttcc
      481 tgtaggcctg ctgcccttgc ttggtaaata aaccaacttt tgtatcttcc cttttccctt
      541 tagataataa agtttccaaa attatgaatc caaaaaaaaa aaaaaaaaa
//
