LOCUS       NM_001190474            1728 bp    mRNA    linear   ROD 10-MAR-2024
DEFINITION  Mus musculus death-associated protein kinase 3 (Dapk3), transcript
            variant 1, mRNA.
ACCESSION   NM_001190474
VERSION     NM_001190474.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1728)
  AUTHORS   Choo,Y.Y., Sakai,T., Ikebe,R., Jeffers,A., Idell,S., Tucker,T.A.
            and Ikebe,M.
  TITLE     Role of ZIP kinase in development of myofibroblast differentiation
            from HPMCs
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 326 (3), L353-L366 (2024)
   PUBMED   38252666
  REMARK    GeneRIF: Role of ZIP kinase in development of myofibroblast
            differentiation from HPMCs.
REFERENCE   2  (bases 1 to 1728)
  AUTHORS   Takahashi,M., Lio,C.J., Campeau,A., Steger,M., Ay,F., Mann,M.,
            Gonzalez,D.J., Jain,M. and Sharma,S.
  TITLE     The tumor suppressor kinase DAPK3 drives tumor-intrinsic immunity
            through the STING-IFN-beta pathway
  JOURNAL   Nat Immunol 22 (4), 485-496 (2021)
   PUBMED   33767426
  REMARK    GeneRIF: The tumor suppressor kinase DAPK3 drives tumor-intrinsic
            immunity through the STING-IFN-beta pathway.
REFERENCE   3  (bases 1 to 1728)
  AUTHORS   Zhang,Y., Zhang,C., Zhang,H., Zeng,W., Li,S., Chen,C., Song,X.,
            Sun,J., Sun,Z., Cui,C., Cao,X., Zheng,L., Wang,P., Zhao,W.,
            Zhang,Z., Xu,Y., Zhu,M. and Chen,H.
  TITLE     ZIPK mediates endothelial cell contraction through myosin light
            chain phosphorylation and is required for ischemic-reperfusion
            injury
  JOURNAL   FASEB J 33 (8), 9062-9074 (2019)
   PUBMED   31180722
  REMARK    GeneRIF: The induced deletion of Zipk significantly inhibited
            ischemia-reperfusion-induced blood-brain barrier dysfunction and
            neuronal injuries from middle cerebral artery occlusion and
            reperfusion, as evidenced by reduced infarct and edema volume,
            attenuated Evans blue dye leakage, and improved neuronal behavior.
REFERENCE   4  (bases 1 to 1728)
  AUTHORS   Cai,Z., Cao,R., Zhang,K., Xue,Y., Zhang,C., Zhou,Y., Zhou,J.,
            Sun,H. and Fu,X.D.
  TITLE     Oncogenic miR-17/20a Forms a Positive Feed-forward Loop with the
            p53 Kinase DAPK3 to Promote Tumorigenesis
  JOURNAL   J Biol Chem 290 (32), 19967-19975 (2015)
   PUBMED   26117336
  REMARK    GeneRIF: DAPK3 plays a central role in preventing miR-17/miR-20a
            depletion-induced genome instability and in miR-17/miR-20a
            overexpression-triggered tumor formation.
REFERENCE   5  (bases 1 to 1728)
  AUTHORS   Kocher,B.A., White,L.S. and Piwnica-Worms,D.
  TITLE     DAPK3 suppresses acini morphogenesis and is required for mouse
            development
  JOURNAL   Mol Cancer Res 13 (2), 358-367 (2015)
   PUBMED   25304685
  REMARK    GeneRIF: Cellular and mouse modeling studies show that DAPK3 is a
            tumor suppressor gene and is important in early development.
REFERENCE   6  (bases 1 to 1728)
  AUTHORS   Bomar,J.M., Benke,P.J., Slattery,E.L., Puttagunta,R., Taylor,L.P.,
            Seong,E., Nystuen,A., Chen,W., Albin,R.L., Patel,P.D.,
            Kittles,R.A., Sheffield,V.C. and Burmeister,M.
  TITLE     Mutations in a novel gene encoding a CRAL-TRIO domain cause human
            Cayman ataxia and ataxia/dystonia in the jittery mouse
  JOURNAL   Nat Genet 35 (3), 264-269 (2003)
   PUBMED   14556008
  REMARK    Erratum:[Nat Genet. 2005 May;37(5):555]
REFERENCE   7  (bases 1 to 1728)
  AUTHORS   Kawai,T., Akira,S. and Reed,J.C.
  TITLE     ZIP kinase triggers apoptosis from nuclear PML oncogenic domains
  JOURNAL   Mol Cell Biol 23 (17), 6174-6186 (2003)
   PUBMED   12917339
REFERENCE   8  (bases 1 to 1728)
  AUTHORS   Puttagunta,R., Gordon,L.A., Meyer,G.E., Kapfhamer,D.,
            Lamerdin,J.E., Kantheti,P., Portman,K.M., Chung,W.K., Jenne,D.E.,
            Olsen,A.S. and Burmeister,M.
  TITLE     Comparative maps of human 19p13.3 and mouse chromosome 10 allow
            identification of sequences at evolutionary breakpoints
  JOURNAL   Genome Res 10 (9), 1369-1380 (2000)
   PUBMED   10984455
REFERENCE   9  (bases 1 to 1728)
  AUTHORS   Levy-Strumpf,N. and Kimchi,A.
  TITLE     Death associated proteins (DAPs): from gene identification to the
            analysis of their apoptotic and tumor suppressive functions
  JOURNAL   Oncogene 17 (25), 3331-3340 (1998)
   PUBMED   9916995
  REMARK    Review article
REFERENCE   10 (bases 1 to 1728)
  AUTHORS   Kawai,T., Matsumoto,M., Takeda,K., Sanjo,H. and Akira,S.
  TITLE     ZIP kinase, a novel serine/threonine kinase which mediates
            apoptosis
  JOURNAL   Mol Cell Biol 18 (3), 1642-1651 (1998)
   PUBMED   9488481
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC155932.6.
            
            [WARNING] On Mar 12, 2024 this sequence was replaced by
            NM_001190474.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (a).
            
            Sequence Note: This RefSeq record was created from genomic sequence
            data to make the sequence consistent with the reference genome
            assembly. The genomic coordinates used for the transcript record
            were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC012210.1, SRR7652917.436835.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-90                AC155932.6         142613-142702
            91-190              AC155932.6         143582-143681
            191-551             AC155932.6         149545-149905
            552-681             AC155932.6         149988-150117
            682-730             AC155932.6         150204-150252
            731-757             AC155932.6         150648-150674
            758-910             AC155932.6         151365-151517
            911-956             AC155932.6         151903-151948
            957-1728            AC155932.6         152032-152803
FEATURES             Location/Qualifiers
     source          1..1728
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 39.72 cM"
     gene            1..1728
                     /gene="Dapk3"
                     /gene_synonym="dlk; ZIPK"
                     /note="death-associated protein kinase 3"
                     /db_xref="GeneID:13144"
                     /db_xref="MGI:MGI:1203520"
     exon            1..90
                     /gene="Dapk3"
                     /gene_synonym="dlk; ZIPK"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..1475
                     /gene="Dapk3"
                     /gene_synonym="dlk; ZIPK"
                     /EC_number="2.7.11.1"
                     /note="isoform a is encoded by transcript variant 1;
                     ZIP-kinase; DAP kinase 3; DAP-like kinase;
                     death-associated kinase 3; MYPT1 kinase"
                     /codon_start=1
                     /product="death-associated protein kinase 3 isoform a"
                     /protein_id="NP_001177403.2"
                     /db_xref="GeneID:13144"
                     /db_xref="MGI:MGI:1203520"
                     /translation="MAEDAPVSPESFRRPAAMSTFRQEDVEDHYEMGEELGSGQFAIV
                     RKCQQKGTGMEYAAKFIKKRRLPSSRRGVSREEIEREVSILREIRHPNIITLHDVFEN
                     KTDVVLILELVSGGELFDFLAEKESLTEDEATQFLKQILDGVHYLHSKRIAHFDLKPE
                     NIMLLDKHAASPRIKLIDFGIAHRIEAGSEFKNIFGTPEFVAPEIVNYEPLGLEADMW
                     SIGVITYILLSGASPFLGETKQETLTNISAVNYDFDEEYFSSTSELAKDFIRRLLVKD
                     PKRRMTIAQSLEHSWIKVRRREDGARKPERRRLRAARLREYSLKSHSSMPRNTSYASF
                     ERFSRVLEDVAAAEQGLRELQRGRRQCRERVCALRAAAEQREARCRDGSAGLGRDLRR
                     LRTELGRTEALRTRAQEEARAALLGAGGLKRRLCRLENRYDALAAQVAAEVQFVRDLV
                     RALEQERLQAECGVR"
     exon            91..190
                     /gene="Dapk3"
                     /gene_synonym="dlk; ZIPK"
                     /inference="alignment:Splign:2.1.0"
     exon            191..551
                     /gene="Dapk3"
                     /gene_synonym="dlk; ZIPK"
                     /inference="alignment:Splign:2.1.0"
     exon            552..681
                     /gene="Dapk3"
                     /gene_synonym="dlk; ZIPK"
                     /inference="alignment:Splign:2.1.0"
     exon            682..730
                     /gene="Dapk3"
                     /gene_synonym="dlk; ZIPK"
                     /inference="alignment:Splign:2.1.0"
     exon            731..757
                     /gene="Dapk3"
                     /gene_synonym="dlk; ZIPK"
                     /inference="alignment:Splign:2.1.0"
     exon            758..910
                     /gene="Dapk3"
                     /gene_synonym="dlk; ZIPK"
                     /inference="alignment:Splign:2.1.0"
     exon            911..956
                     /gene="Dapk3"
                     /gene_synonym="dlk; ZIPK"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1728
                     /gene="Dapk3"
                     /gene_synonym="dlk; ZIPK"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgcatgcgt agatgccgtc tcaggatttg taccggaggt tctcgcgggg gcctcgctgg
       61 caccgggcgg ggactcgatg gctgaggacg ctcctgtgtc cccagaatcc ttcagaaggc
      121 cagccgccat gtccacattc aggcaagagg atgttgagga ccattatgag atgggagagg
      181 agcttggcag tggccaattt gccatcgtgc gcaagtgcca gcagaagggc acgggcatgg
      241 agtatgcagc caagttcatc aagaagcggc gcctgccatc cagccggcgc ggtgtgagcc
      301 gggaggagat cgaacgcgag gtgagcatcc tgcgcgagat ccgccacccc aacatcataa
      361 cactgcatga cgtgttcgag aacaagacag atgtggtgct gatcctggag ctggtgtccg
      421 gtggcgagct tttcgacttc ctggccgaga aggagtcatt gacggaggat gaggccacgc
      481 agttcctcaa acaaatccta gacggtgtcc actacctgca ctccaagcgc atcgcacact
      541 ttgacctgaa gcccgagaac atcatgttgc tggacaagca cgcagccagc ccccgcatta
      601 agctcatcga ctttggcatc gcgcacagga tcgaggctgg cagcgagttc aagaacatct
      661 ttggcacacc cgagtttgtc gcccccgaga tcgtgaacta tgagccactt ggcttggagg
      721 ctgacatgtg gagcattggc gtcatcacct acatcctcct gagcggagcg tccccattcc
      781 tgggcgagac caagcaggag acgctgacga acatctcagc agtgaactat gactttgatg
      841 aggaatactt cagcagcacc agcgagctgg ccaaggactt catccgcagg ctgctggtca
      901 aagaccccaa gaggaggatg accatcgcac agagcctgga gcattcctgg atcaaggtgc
      961 gcaggcgcga ggacggcgcc cggaagccag agcgacggcg gctgcgcgcc gcgcgcctgc
     1021 gcgagtacag cctcaagtcc cactcgagca tgccgcgcaa cacgagctac gccagcttcg
     1081 agcgcttctc acgcgtgctg gaggacgtgg cggcggcaga gcaggggctg cgcgagctgc
     1141 agcgaggcag gcgccagtgc cgggagcgcg tgtgtgcgct gcgcgcggcc gccgagcagc
     1201 gggaggcgcg ctgccgcgac gggagcgcag ggctagggcg cgacctgcga cgcctgcgca
     1261 cggagctggg gcgcaccgag gctctgcgca cgcgcgcgca ggaggaggcg cgggcggcgc
     1321 tgttgggtgc cgggggcctg aagcgtcgcc tgtgtcgcct ggagaaccgt tacgacgcgc
     1381 tagccgctca ggtggccgct gaggtgcaat tcgtgcgcga cctggtgcgt gcgctggagc
     1441 aggaacggct gcaggctgag tgcggcgtgc gctaggctgc ggcaccccca gaccccgacc
     1501 cacccccaga ataaagctgc tttccacgta ctgtcgcctg tctcccacgc cccgcaggga
     1561 gggtgggagc gagcaacccc acgataggtg ctctcctacg ccgccgaaga gattatggct
     1621 ctgccacacc acacaccaag ggtggtgtca cccacagttc acatagagac gtgcaaggct
     1681 caattggtaa agctgaatct cagtggggac ccgcagtatc acacagct
//
