LOCUS       NM_001404683            2033 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus death-associated protein kinase 2 (Dapk2), transcript
            variant 1, mRNA.
ACCESSION   NM_001404683 XM_036154595
VERSION     NM_001404683.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2033)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2033)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2033)
  AUTHORS   Chi,H.C., Chen,S.L., Tsai,C.Y., Chuang,W.Y., Huang,Y.H., Tsai,M.M.,
            Wu,S.M., Sun,C.P., Yeh,C.T. and Lin,K.H.
  TITLE     Thyroid hormone suppresses hepatocarcinogenesis via DAPK2 and
            SQSTM1-dependent selective autophagy
  JOURNAL   Autophagy 12 (12), 2271-2285 (2016)
   PUBMED   27653365
  REMARK    GeneRIF: Thyroid hormone promotes selective autophagy via induction
            of DAPK2-SQSTM1 cascade, which in turn protects hepatocytes from
            diethylnitrosamine-induced hepatotoxicity or carcinogenesis.
REFERENCE   4  (bases 1 to 2033)
  AUTHORS   Ray,J.P., Staron,M.M., Shyer,J.A., Ho,P.C., Marshall,H.D.,
            Gray,S.M., Laidlaw,B.J., Araki,K., Ahmed,R., Kaech,S.M. and
            Craft,J.
  TITLE     The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling,
            Differentiation, and Metabolism of T Helper 1 and Follicular B
            Helper T Cells
  JOURNAL   Immunity 43 (4), 690-702 (2015)
   PUBMED   26410627
REFERENCE   5  (bases 1 to 2033)
  AUTHORS   Soussi,H., Reggio,S., Alili,R., Prado,C., Mutel,S., Pini,M.,
            Rouault,C., Clement,K. and Dugail,I.
  TITLE     DAPK2 Downregulation Associates With Attenuated Adipocyte
            Autophagic Clearance in Human Obesity
  JOURNAL   Diabetes 64 (10), 3452-3463 (2015)
   PUBMED   26038578
  REMARK    GeneRIF: This study links adipocyte expression of an
            autophagy-regulating kinase, lysosome-mediated clearance and fat
            cell lipid accumulation; it demonstrates obesity-related attenuated
            autophagy in adipocytes, and identifies DAPK2 dependence in this
            regulation.
REFERENCE   6  (bases 1 to 2033)
  AUTHORS   Liljander,M., Andersson,A., Holmdahl,R. and Mattsson,R.
  TITLE     Increased litter size and super-ovulation rate in congenic C57BL
            mice carrying a polymorphic fragment of NFR/N origin at the Fecq4
            locus of chromosome 9
  JOURNAL   Genet Res (Camb) 91 (4), 259-265 (2009)
   PUBMED   19640321
REFERENCE   7  (bases 1 to 2033)
  AUTHORS   Fang,J., Menon,M., Zhang,D., Torbett,B., Oxburgh,L., Tschan,M.,
            Houde,E. and Wojchowski,D.M.
  TITLE     Attenuation of EPO-dependent erythroblast formation by
            death-associated protein kinase-2
  JOURNAL   Blood 112 (3), 886-890 (2008)
   PUBMED   18535204
  REMARK    GeneRIF: DAPK2 was substantially up-modulated during late
            erythropoiesis
REFERENCE   8  (bases 1 to 2033)
  AUTHORS   Shimoda,M., Nakamura,T., Takahashi,Y., Asanuma,H., Tamura,S.,
            Kurata,T., Mizuochi,T., Azuma,N., Kanno,C. and Takemori,T.
  TITLE     Isotype-specific selection of high affinity memory B cells in
            nasal-associated lymphoid tissue
  JOURNAL   J Exp Med 194 (11), 1597-1607 (2001)
   PUBMED   11733574
REFERENCE   9  (bases 1 to 2033)
  AUTHORS   Inbal,B., Shani,G., Cohen,O., Kissil,J.L. and Kimchi,A.
  TITLE     Death-associated protein kinase-related protein 1, a novel
            serine/threonine kinase involved in apoptosis
  JOURNAL   Mol Cell Biol 20 (3), 1044-1054 (2000)
   PUBMED   10629061
REFERENCE   10 (bases 1 to 2033)
  AUTHORS   Kawai,T., Nomura,F., Hoshino,K., Copeland,N.G., Gilbert,D.J.,
            Jenkins,N.A. and Akira,S.
  TITLE     Death-associated protein kinase 2 is a new
            calcium/calmodulin-dependent protein kinase that signals apoptosis
            through its catalytic activity
  JOURNAL   Oncogene 18 (23), 3471-3480 (1999)
   PUBMED   10376525
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124439.4.
            
            On Apr 13, 2022 this sequence version replaced XM_036154595.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10223971.9332.1,
                                           SRR10223970.11407.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849385, SAMN01164133
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-80                AC124439.4         33875-33954
            81-178              AC124439.4         40952-41049
            179-400             AC124439.4         96148-96369
            401-539             AC124439.4         107327-107465
            540-669             AC124439.4         122031-122160
            670-718             AC124439.4         125951-125999
            719-745             AC124439.4         126689-126715
            746-898             AC124439.4         130085-130237
            899-944             AC124439.4         130945-130990
            945-2033            AC124439.4         132322-133410
FEATURES             Location/Qualifiers
     source          1..2033
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 35.75 cM"
     gene            1..2033
                     /gene="Dapk2"
                     /note="death-associated protein kinase 2"
                     /db_xref="GeneID:13143"
                     /db_xref="MGI:MGI:1341297"
     exon            1..80
                     /gene="Dapk2"
                     /inference="alignment:Splign:2.1.0"
     exon            81..178
                     /gene="Dapk2"
                     /inference="alignment:Splign:2.1.0"
     CDS             87..1559
                     /gene="Dapk2"
                     /EC_number="2.7.11.1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     DRP-1; DAP kinase 2; death-associated kinase 2"
                     /codon_start=1
                     /product="death-associated protein kinase 2 isoform 1"
                     /protein_id="NP_001391612.1"
                     /db_xref="GeneID:13143"
                     /db_xref="MGI:MGI:1341297"
                     /translation="MVQASMRSPNMETFKQQKVEDFYDIGEELGSGQFAIVKKCREKS
                     TGLEYAAKFIKKRQSRASRRGVCREEIEREVSILRQVLHPNIITLHDVYENRTDVVLI
                     LELVSGGELFDFLAQKESLSEEEATSFIKQILDGVNYLHTKKIAHFDLKPENIMLLDK
                     NIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAPEIVNYEPLGLEADMWSIGVITY
                     ILLSGASPFLGDTKQETLANITAVSYDFDEEFFSQTSELAKDFIRKLLVKETRKRLTI
                     QEALRHPWITSKGEARAPEQWKAQPAQLKTKRLREYTLKCHSSMPPNNTYVNFERFAH
                     VVEDVARVDKGCRALAGAHDTLQDDVESLVSIYNEKEAWYREENENARHNLSQLKYEY
                     RKVESLKKLLREDIQATGASLGGVARKLDHLQAQFETLRQQLSADIQWMQELVGIFQL
                     ESENTDSHSLGFMFHRDPSESLSELLNRSHAEEVLAGLSL"
     exon            179..400
                     /gene="Dapk2"
                     /inference="alignment:Splign:2.1.0"
     exon            401..539
                     /gene="Dapk2"
                     /inference="alignment:Splign:2.1.0"
     exon            540..669
                     /gene="Dapk2"
                     /inference="alignment:Splign:2.1.0"
     exon            670..718
                     /gene="Dapk2"
                     /inference="alignment:Splign:2.1.0"
     exon            719..745
                     /gene="Dapk2"
                     /inference="alignment:Splign:2.1.0"
     exon            746..898
                     /gene="Dapk2"
                     /inference="alignment:Splign:2.1.0"
     exon            899..944
                     /gene="Dapk2"
                     /inference="alignment:Splign:2.1.0"
     exon            945..2033
                     /gene="Dapk2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2001..2006
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dapk2"
                     /note="hexamer: AATACA"
     polyA_site      2033
                     /gene="Dapk2"
                     /note="major polyA site"
ORIGIN      
        1 agagcagagc ggagcgccgc gcaccccgcc gcgccccggt gcacgtccag ctctccgcac
       61 atgcagcgca gcctttcgcc gattgtatgg tccaggcctc gatgaggagc ccaaatatgg
      121 agacgttcaa acagcagaag gtggaggact tttatgatat tggagaggag ctgggcagtg
      181 gccagtttgc catcgtgaag aagtgccggg agaagagcac ggggctggag tatgcagcca
      241 agttcattaa gaagaggcag agccgggcca gccgtcgggg cgtgtgccgg gaggaaatcg
      301 agcgggaggt gagcatcctg cggcaggtgc tgcaccccaa catcatcacg ctgcacgacg
      361 tctatgagaa ccgcaccgac gtggtgctca tccttgagct agtgtccgga ggagaactgt
      421 ttgatttcct ggcccagaag gagtcgttaa gtgaggagga agccaccagc ttcattaagc
      481 agatcctgga tggggtgaat taccttcaca caaagaaaat tgctcacttt gatctcaagc
      541 cagaaaacat catgttgtta gacaagaata tcccaattcc acacatcaag ctgattgact
      601 ttggcctggc tcacgaaata gaagatggag ttgaatttaa aaacattttt gggacacctg
      661 aatttgttgc tccagaaatc gtgaactatg agccactggg actggaggcc gacatgtgga
      721 gcattggagt catcacctat atccttctaa gtggagcgtc ccccttcctg ggagacacaa
      781 aacaagaaac cctggcaaat atcactgctg tgagttacga ctttgatgag gaattcttca
      841 gccagacaag cgagctggcc aaggacttca ttcggaagct tcttgtgaaa gagacccgga
      901 aacggcttac catccaagag gctctcagac atccctggat cacgtcaaaa ggagaagcca
      961 gagcccctga acagtggaag gcacaacctg cccagctgaa gaccaaacgc ctgagagagt
     1021 ataccctcaa atgtcattcg agcatgcccc ccaacaacac ttatgtcaac tttgagcgtt
     1081 tcgctcacgt ggtagaggat gtggctcggg tagacaaggg atgccgtgcc ctagcaggag
     1141 cccatgatac cctacaggat gatgtggagt ccttggtctc tatctacaat gagaaggaag
     1201 cttggtaccg agaggagaat gagaatgccc gccataacct gtcccagctc aagtatgagt
     1261 accgcaaggt ggagtccctg aagaagctcc tgagagaaga catccaggcc acaggggcca
     1321 gccttggagg cgtggccagg aagctagacc atctgcaggc acagtttgag actctgaggc
     1381 agcagctctc agcagacatc cagtggatgc aggaactggt tggcatcttc cagctggaga
     1441 gtgagaacac tgatagccac agcctgggct tcatgttcca ccgggacccc agtgagtccc
     1501 tatcggagct gctcaacaga tcacacgcag aggaagtcct ggccggcttg agtctctgag
     1561 caccaggatc tagtcagtag tgcattctca gggctttgta gaagcatgct gtcttcccct
     1621 ccgccaggtc atccaggtgg aaatatcctg cagggtgtgt gtttgcagcc ttccaccccc
     1681 tctagagttc cccagacact ggggtcctag ttagtggaac taatctgcac ctccctcacc
     1741 agcctggttt tctgagaggg cgctggcaac gcagctgagc tgtggaaacg attagaaaat
     1801 atcttccctc agcatgccct tctctggggg tgtcttccgg ccccaggaga tgctttatag
     1861 ctgggtaatg atgatggatc ggctcacctc tcacattcca cgtgcgtgcc attatgagtg
     1921 aagatcttga gtaatgatgg acatagctaa gaataacttg ttcttcaggg tactttcctg
     1981 ttacagagtc agggctttaa aatacacaga gaaaatatta agtttcactt gaa
//
