LOCUS       NM_022994               4628 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus death associated protein 3 (Dap3), transcript variant
            2, mRNA.
ACCESSION   NM_022994
VERSION     NM_022994.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4628)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4628)
  AUTHORS   Greber,B.J. and Ban,N.
  TITLE     Structure and Function of the Mitochondrial Ribosome
  JOURNAL   Annu Rev Biochem 85, 103-132 (2016)
   PUBMED   27023846
  REMARK    Review article
REFERENCE   3  (bases 1 to 4628)
  AUTHORS   Xiao,L., Xian,H., Lee,K.Y., Xiao,B., Wang,H., Yu,F., Shen,H.M. and
            Liou,Y.C.
  TITLE     Death-associated Protein 3 Regulates Mitochondrial-encoded Protein
            Synthesis and Mitochondrial Dynamics
  JOURNAL   J Biol Chem 290 (41), 24961-24974 (2015)
   PUBMED   26306039
  REMARK    GeneRIF: DAP3 plays important roles in mitochondrial function and
            dynamics
REFERENCE   4  (bases 1 to 4628)
  AUTHORS   Amunts,A., Brown,A., Toots,J., Scheres,S.H.W. and Ramakrishnan,V.
  TITLE     Ribosome. The structure of the human mitochondrial ribosome
  JOURNAL   Science 348 (6230), 95-98 (2015)
   PUBMED   25838379
REFERENCE   5  (bases 1 to 4628)
  AUTHORS   Tosa,N., Iwai,A., Tanaka,T., Kumagai,T., Nitta,T., Chiba,S.,
            Maeda,M., Takahama,Y., Uede,T. and Miyazaki,T.
  TITLE     Critical function of death-associated protein 3 in T cell
            receptor-mediated apoptosis induction
  JOURNAL   Biochem Biophys Res Commun 395 (3), 356-360 (2010)
   PUBMED   20381457
  REMARK    GeneRIF: DAP3 is critical for TCR-mediated induction of apoptosis
            at the downstream of Nur77.
REFERENCE   6  (bases 1 to 4628)
  AUTHORS   Murata,Y., Wakoh,T., Uekawa,N., Sugimoto,M., Asai,A., Miyazaki,T.
            and Maruyama,M.
  TITLE     Death-associated protein 3 regulates cellular senescence through
            oxidative stress response
  JOURNAL   FEBS Lett 580 (26), 6093-6099 (2006)
   PUBMED   17056041
  REMARK    GeneRIF: DAP3 is reduced in both replicative and premature
            senescence induced by oxidative stress, and the DAP3 reduction
            induced by oxidative stress is observed mostly in a mitochondrial
            fraction.
REFERENCE   7  (bases 1 to 4628)
  AUTHORS   Mukamel,Z. and Kimchi,A.
  TITLE     Death-associated protein 3 localizes to the mitochondria and is
            involved in the process of mitochondrial fragmentation during cell
            death
  JOURNAL   J Biol Chem 279 (35), 36732-36738 (2004)
   PUBMED   15175341
  REMARK    GeneRIF: DAP3 has a role in the molecular pathway that culminates
            in fragmented mitochondria
REFERENCE   8  (bases 1 to 4628)
  AUTHORS   Karim,S.A., Johnson,K.J., Griffiths,I.R. and Vouyiouklis,D.A.
  TITLE     A physical map of the genomic region on mouse chromosome 3
            containing the hindshaker (hsh) mutation
  JOURNAL   Genomics 83 (2), 225-230 (2004)
   PUBMED   14706451
REFERENCE   9  (bases 1 to 4628)
  AUTHORS   Reed,J.C., Doctor,K., Rojas,A., Zapata,J.M., Stehlik,C.,
            Fiorentino,L., Damiano,J., Roth,W., Matsuzawa,S., Newman,R.,
            Takayama,S., Marusawa,H., Xu,F., Salvesen,G. and Godzik,A.
  CONSRTM   RIKEN GER Group; GSL Members
  TITLE     Comparative analysis of apoptosis and inflammation genes of mice
            and humans
  JOURNAL   Genome Res 13 (6B), 1376-1388 (2003)
   PUBMED   12819136
REFERENCE   10 (bases 1 to 4628)
  AUTHORS   Berger,T., Brigl,M., Herrmann,J.M., Vielhauer,V., Luckow,B.,
            Schlondorff,D. and Kretzler,M.
  TITLE     The apoptosis mediator mDAP-3 is a novel member of a conserved
            family of mitochondrial proteins
  JOURNAL   J Cell Sci 113 (Pt 20), 3603-3612 (2000)
   PUBMED   11017876
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC127377.4, AJ250375.1 and AV340314.2.
            
            On Sep 1, 2009 this sequence version replaced NM_022994.2.
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon in the 3' coding region, compared to variant 1, resulting in
            an isoform (2) that is shorter than isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            CCDS Note: The coding region has been updated to extend the
            N-terminus. The use of an alternative upstream start codon, which
            appears to be rodent-specific, would result in a protein that is 5
            aa longer at the N-terminal. The second AUG, 5 aa downstream the
            rodent start codon, which is better conserved in mammals, could be
            used at least some of the time.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK032275.1, BC019566.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-256               AC127377.4         167334-167589       c
            257-1903            AJ250375.1         1-1647
            1904-4527           AC127377.4         138211-140834       c
            4528-4628           AV340314.2         555-655
FEATURES             Location/Qualifiers
     source          1..4628
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 39.01 cM"
     gene            1..4628
                     /gene="Dap3"
                     /gene_synonym="4921514D13Rik; DAP-3; MRP-S29; S29mt"
                     /note="death associated protein 3"
                     /db_xref="GeneID:65111"
                     /db_xref="MGI:MGI:1929538"
     exon            1..415
                     /gene="Dap3"
                     /gene_synonym="4921514D13Rik; DAP-3; MRP-S29; S29mt"
                     /inference="alignment:Splign:2.1.0"
     CDS             413..1603
                     /gene="Dap3"
                     /gene_synonym="4921514D13Rik; DAP-3; MRP-S29; S29mt"
                     /note="isoform 2 is encoded by transcript variant 2; 28S
                     ribosomal protein S29, mitochondrial; small ribosomal
                     subunit protein mS29"
                     /codon_start=1
                     /product="small ribosomal subunit protein mS29 isoform 2"
                     /protein_id="NP_075370.2"
                     /db_xref="CCDS:CCDS17486.2"
                     /db_xref="GeneID:65111"
                     /db_xref="MGI:MGI:1929538"
                     /translation="MRAKTMLTGITRLFSRVQKLDPRCFLHMSVQATQNSQVPAERPR
                     TVSRTSDSDPAKHGEQHEGQHYSIPLQDLKTVFPHGLPPRYMMQVKTFGEACLMVRKP
                     ALELLGYLKNTNFAHPAVRYLLYGEKGTGKTLSLCHAVHFCARHDWLILHIPDAHLWV
                     KNCRELLQSTHNKQRFDQPLEASTWLKNFKTTNERFLSQIKVQEKYVWNKRESTEKGS
                     PLGEVVEQGLTRVRNATDAVGVVLKELKAQSALGLFHLLVAVDGVNALWGRTTLKKED
                     RTLIAPEELSLVHNLRKMVKNDWHGGAIVLSLSQTGSLFKSRTAYLPHELLGKEGFNA
                     LEPFLPILIPNYNPKEFESSFQYYLENNWLQHEKASTEEGRKELRFLSNCNPEQLERL
                     CASL"
     exon            416..469
                     /gene="Dap3"
                     /gene_synonym="4921514D13Rik; DAP-3; MRP-S29; S29mt"
                     /inference="alignment:Splign:2.1.0"
     exon            470..574
                     /gene="Dap3"
                     /gene_synonym="4921514D13Rik; DAP-3; MRP-S29; S29mt"
                     /inference="alignment:Splign:2.1.0"
     exon            575..676
                     /gene="Dap3"
                     /gene_synonym="4921514D13Rik; DAP-3; MRP-S29; S29mt"
                     /inference="alignment:Splign:2.1.0"
     exon            677..785
                     /gene="Dap3"
                     /gene_synonym="4921514D13Rik; DAP-3; MRP-S29; S29mt"
                     /inference="alignment:Splign:2.1.0"
     exon            786..878
                     /gene="Dap3"
                     /gene_synonym="4921514D13Rik; DAP-3; MRP-S29; S29mt"
                     /inference="alignment:Splign:2.1.0"
     exon            879..1009
                     /gene="Dap3"
                     /gene_synonym="4921514D13Rik; DAP-3; MRP-S29; S29mt"
                     /inference="alignment:Splign:2.1.0"
     exon            1010..1090
                     /gene="Dap3"
                     /gene_synonym="4921514D13Rik; DAP-3; MRP-S29; S29mt"
                     /inference="alignment:Splign:2.1.0"
     exon            1091..1249
                     /gene="Dap3"
                     /gene_synonym="4921514D13Rik; DAP-3; MRP-S29; S29mt"
                     /inference="alignment:Splign:2.1.0"
     exon            1250..1309
                     /gene="Dap3"
                     /gene_synonym="4921514D13Rik; DAP-3; MRP-S29; S29mt"
                     /inference="alignment:Splign:2.1.0"
     exon            1310..1399
                     /gene="Dap3"
                     /gene_synonym="4921514D13Rik; DAP-3; MRP-S29; S29mt"
                     /inference="alignment:Splign:2.1.0"
     exon            1400..1517
                     /gene="Dap3"
                     /gene_synonym="4921514D13Rik; DAP-3; MRP-S29; S29mt"
                     /inference="alignment:Splign:2.1.0"
     exon            1518..4628
                     /gene="Dap3"
                     /gene_synonym="4921514D13Rik; DAP-3; MRP-S29; S29mt"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1775..1780
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dap3"
                     /gene_synonym="4921514D13Rik; DAP-3; MRP-S29; S29mt"
                     /note="hexamer: ATTAAA"
     polyA_site      1796
                     /gene="Dap3"
                     /gene_synonym="4921514D13Rik; DAP-3; MRP-S29; S29mt"
                     /note="major polyA site"
     regulatory      1815..1820
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dap3"
                     /gene_synonym="4921514D13Rik; DAP-3; MRP-S29; S29mt"
                     /note="hexamer: AACAAG"
     polyA_site      1836
                     /gene="Dap3"
                     /gene_synonym="4921514D13Rik; DAP-3; MRP-S29; S29mt"
     regulatory      1882..1887
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dap3"
                     /gene_synonym="4921514D13Rik; DAP-3; MRP-S29; S29mt"
                     /note="hexamer: AAGAAA"
     polyA_site      1903
                     /gene="Dap3"
                     /gene_synonym="4921514D13Rik; DAP-3; MRP-S29; S29mt"
     regulatory      1967..1972
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dap3"
                     /gene_synonym="4921514D13Rik; DAP-3; MRP-S29; S29mt"
                     /note="hexamer: AATAAG"
     polyA_site      1990
                     /gene="Dap3"
                     /gene_synonym="4921514D13Rik; DAP-3; MRP-S29; S29mt"
     regulatory      4609..4614
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dap3"
                     /gene_synonym="4921514D13Rik; DAP-3; MRP-S29; S29mt"
                     /note="hexamer: AATAAA"
     polyA_site      4628
                     /gene="Dap3"
                     /gene_synonym="4921514D13Rik; DAP-3; MRP-S29; S29mt"
ORIGIN      
        1 gccacggctg ccgccgcctt cgcccccacc cctcgaacgt gcgcctccca caatcccccc
       61 cgcgggacgt tccattgcgc gcccctgctg gggccgggga gaagcgggca cgcccgcgca
      121 gacgaggctg gccacggtga ccggaatgtt ttgaagagcg agcgaaggta cctaggcgcg
      181 gacctcctgg gacgggccac cgcgacgccg aggcttgctg cccgcttccg gccgcggggc
      241 gggtggcgcg gtgcccctcc gctgggctgt ggttgcagcc gcggcgactg cgcgttgggt
      301 agcttcctgc cacacgaccc gagcttgctt cacaactgca ggacgggtgc ctgggatcca
      361 gccgctggcg gtgtgtgcgg gtcaccggag caggagtcct agtgttggac tcatgagagc
      421 aaagaccatg ctgacaggaa taacaaggct tttctccagg gtccagaagt tggacccgag
      481 gtgttttttg cacatgagtg ttcaagcgac tcagaacagt caggttccag ctgagcgtcc
      541 cagaactgtt tcccgcacca gtgacagtga cccggctaag catggggagc agcatgaggg
      601 tcagcactac agcatccccc tccaggatct gaagacagtg tttcctcacg gcctgcctcc
      661 tcggtacatg atgcaggtga agacttttgg cgaagcttgt ctgatggtca ggaagccagc
      721 tctcgagctt ctgggctacc tgaaaaatac caattttgct catccagctg tgcgatatct
      781 tctttatggg gagaagggga caggaaagac cctcagtctc tgccatgctg ttcatttttg
      841 tgcaagacat gactggctga ttctgcatat cccagatgct catctttggg taaaaaactg
      901 ccgggagctt ctacagtcca ctcacaacaa acagcgcttt gatcaaccct tagaggcctc
      961 tacctggctg aagaatttca aaactaccaa tgagcgcttc ctgagtcaga taaaagttca
     1021 agagaagtat gtttggaata agagagaaag cactgagaaa ggcagtcctc tgggagaagt
     1081 tgttgaacag ggcctaaccc gagtgaggaa tgccactgac gctgttgggg tcgtgctgaa
     1141 ggagctgaag gctcagagcg ccctagggct ctttcacctc ctggtggctg tggatggagt
     1201 caatgccctc tggggaagga ccacactgaa aaaagaagat agaaccttga ttgccccaga
     1261 ggaactctcc cttgtccaca atctaaggaa aatggtgaaa aatgactggc atggaggtgc
     1321 aatcgtgttg agcttgagcc aaaccgggtc tctctttaag tccagaacag cctatttgcc
     1381 gcatgagctg ctgggaaagg aaggatttaa tgccctggag ccttttcttc ccatcctcat
     1441 tcccaactat aatccaaagg agtttgaaag ttccttccag tactacttag agaacaactg
     1501 gcttcaacat gagaaagctt caacagaaga agggaggaag gagctgaggt tcctgagtaa
     1561 ctgcaaccct gagcagctgg agcggctctg tgcctcgctg taagcacgga cagcggcggt
     1621 ggcatgctgg gaagacaggc ttccttcagc taccgtgcgc gcatgaggaa gtcccaaggt
     1681 tccaagctga acaccctgac ctgcactgat ggatatgaaa tgataggatg ttgttgtcct
     1741 acagctaaca ccagttttct gttcgagttt ttacattaaa gtagatctgc tcctgagtgc
     1801 tgtattggat ttgcaacaag gaaggttctc accctggcca gactctgtca gtttctctgg
     1861 tgttctgttt gctggcatct gaagaaactc agttctacag aaattagtag ttctgtctcc
     1921 tggatttaaa tctgttcagg agaccaagat ttacagccga attcctaata agacaggtaa
     1981 cgcttctcaa ttcctgtttg tactttgatt ccgtggaaca tcgctgaagc tccagctgag
     2041 ttctggcagg atggtgtggc cagccccttg ccacgtcgtc catgccatga gagcacccat
     2101 gatgtatagt gcattgacac tactgcagag ttaacacttt ttactcttgt atcattgttt
     2161 gcacacatcc agaggtcagg acaacggtgt aactgagccc tctccttctg tgttcattgt
     2221 caggcttgca gatggcaaat gccaccacca tctcattggc cccaggaagc taccacaccc
     2281 aggctgctgc cgtgggtttg ctttcttttc tgaaaccaaa cctcatgtag cccagactga
     2341 ccagaactta gtgtgctggc aggatcatct taaactcccc ccaactccac ctaggtgctt
     2401 agggtagtta gaggtgccat gcccagtgag aatccagatc ccatttccac atttctcatg
     2461 tactagctct tggcttctct tgtttcacct tgcctggtgg tacaatgatg ctaaactgtt
     2521 agggcattgt gagcacctcg tactccacct cttactcggc aggcaactgt taactgctag
     2581 gtagtttctt ccctgtcttt gaggtttgat gctttatttg aagaattttc tgtgaaaacc
     2641 tgaacaccca ccatgatgtt atcctgtctc cgaggactct gggttcaaca agagatcact
     2701 cacatcagat tcaggaccaa ctcccacaac tgcaaaggct gttagtgaaa cagtatccca
     2761 cagtactggg atgcatccta gggacctgcc tctgctgggc caatgttggc tctccactga
     2821 gctacaaccc catcctacaa gtcattgtat gtgtctcctg gggcttctgc ttccatattg
     2881 agcactgatt gacaggccct ggtgtgggtc agtaagcctt ctgctgtact gtcagtagga
     2941 gctcaggtac ttctgaggtg ggccaggctg cactgacttc ccagtcctgc ctcagcctcc
     3001 tgagtgttgg cattatcatg taccactaca cccagccgtg cttctgtcgg ctcttttatt
     3061 tttcactaat tgcccactca taattcataa tttgaaacaa agccagtagc acagcatggc
     3121 catgaaggca ttgcctcagg ctctgtacct ctgtacacta gagagtgctg tgctgagcta
     3181 tcacacctgt gggcatccgc tgaacttggg aaattatacc ttgtgccttt gggaagctca
     3241 tcacattgta aggctctcac tggtaccacc cagtcctaat caagaatggc atttctgggt
     3301 gtttcaaagg taaagttcaa ggctagcctg gtctacatag ttcctgaaga actgaagaaa
     3361 acggtctcaa agcaaaaagt agcctcatta ttccctaagt aactaaacac agacctttta
     3421 ctttgcttag tttggggagg tttactacag cagtaggatg ccttgtgtgt gaagccaaag
     3481 actgacgtcc atggtcttcc tcagtcactc tctgctggaa ctttaagttt tttcaaacac
     3541 ctatttttaa tgatggtagc ttgctccact cccaaacact tcacaggtac accagcagtt
     3601 caaatcagca gtggtggcac tacctacaga gacagccagg cctcaacctt ggcatgagtc
     3661 agcaggaggg acaaggagga atgccagaag ctcacagcac acctctctta gggcacaaag
     3721 attcaagaca cagaagtgtt gaactgctag ctctataagc gagcctggct cagcctccgt
     3781 cattgtcaag tcctatttat accctccaaa catcgtgcgt ccttcatgag tattgcttca
     3841 gcacgtgcag ctgtcatcac tctgccagtc agcccgagtc cacggtagcg gcaagaaacc
     3901 gcagcacacc accagaagtt ttgattcatt tctctctgga gtcctgacaa atgcagctca
     3961 gctacacagt gtaaggcaga ccaatacatg ggcattatta gcaacaaatc cttcatcaca
     4021 tgtcctttca ggtgcttgct ttagcagaac atcctctctc ctgggtctgc ttcagtgaag
     4081 cgttccttca cgagtctgcc ttagtctttc acctatgtcc acttcagcaa aatgttcctt
     4141 cacttgtttg ccacaacgaa acaccatcca accagctttc cagagaatcc ttaaatttcc
     4201 actttaccgt ggccgtggtt tttttttgtt tgtttgtttt ttgtttttgt tttttttttt
     4261 tttgaggcag attttgttga ctgcagcctg gctagctggc cagtgagttc gcaagctctt
     4321 ccacctactt tcgtagcact aacacttgac agaccgtggt gcctggcgtt tacctgactg
     4381 caagggatct gagtccacag ggcttcacta tcagttgtat taatcaggta tctggagaaa
     4441 ccatatggtg ggcttattta atatagtata catgtattta tttataaagg caggagtgct
     4501 gttaacactt ggtaggcaga ggccactcaa tctctaattt caggctagct tgctctacag
     4561 cacttgttcc agggcagcca gggccacaca gaaaaaccct gtttcaaaaa taaaattata
     4621 tgtgtgtg
//
