LOCUS       NM_010018               2033 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus D-amino acid oxidase (Dao), transcript variant 1,
            mRNA.
ACCESSION   NM_010018 XM_990646
VERSION     NM_010018.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2033)
  AUTHORS   Oshima,Y., Wakino,S., Kanda,T., Tajima,T., Itoh,T., Uchiyama,K.,
            Yoshimoto,K., Sasabe,J., Yasui,M. and Itoh,H.
  TITLE     Sodium benzoate attenuates 2,8-dihydroxyadenine nephropathy by
            inhibiting monocyte/macrophage TNF-alpha expression
  JOURNAL   Sci Rep 13 (1), 3331 (2023)
   PUBMED   36849798
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2033)
  AUTHORS   Gonda,Y., Ishii,C., Mita,M., Nishizaki,N., Ohtomo,Y., Hamase,K.,
            Shimizu,T. and Sasabe,J.
  TITLE     Astrocytic d-amino acid oxidase degrades d-serine in the hindbrain
  JOURNAL   FEBS Lett 596 (22), 2889-2897 (2022)
   PUBMED   35665501
REFERENCE   3  (bases 1 to 2033)
  AUTHORS   Hasin,N., Riggs,L.M., Shekhtman,T., Ashworth,J., Lease,R.,
            Oshone,R.T., Humphries,E.M., Badner,J.A., Thomson,P.A., Glahn,D.C.,
            Craig,D.W., Edenberg,H.J., Gershon,E.S., McMahon,F.J.,
            Nurnberger,J.I., Zandi,P.P., Kelsoe,J.R., Roach,J.C., Gould,T.D.
            and Ament,S.A.
  TITLE     Rare variants implicate NMDA receptor signaling and cerebellar gene
            networks in risk for bipolar disorder
  JOURNAL   Mol Psychiatry 27 (9), 3842-3856 (2022)
   PUBMED   35546635
REFERENCE   4  (bases 1 to 2033)
  AUTHORS   Murtas,G., Sacchi,S., Tedeschi,G., Maffioli,E., Notomista,E.,
            Cafaro,V., Abbondi,M., Mothet,J.P. and Pollegioni,L.
  TITLE     Antimicrobial D-amino acid oxidase-derived peptides specify gut
            microbiota
  JOURNAL   Cell Mol Life Sci 78 (7), 3607-3620 (2021)
   PUBMED   33484270
REFERENCE   5  (bases 1 to 2033)
  AUTHORS   Takagi,S., Balu,D.T. and Coyle,J.T.
  TITLE     Factors regulating serine racemase and d-amino acid oxidase
            expression in the mouse striatum
  JOURNAL   Brain Res 1751, 147202 (2021)
   PUBMED   33171153
  REMARK    GeneRIF: Factors regulating serine racemase and d-amino acid
            oxidase expression in the mouse striatum.
REFERENCE   6  (bases 1 to 2033)
  AUTHORS   Sasaki,M., Konno,R., Nishio,M., Niwa,A., Yasumura,Y. and Enami,J.
  TITLE     A single-base-pair substitution abolishes D-amino-acid oxidase
            activity in the mouse
  JOURNAL   Biochim Biophys Acta 1139 (4), 315-318 (1992)
   PUBMED   1355365
REFERENCE   7  (bases 1 to 2033)
  AUTHORS   Nagata,Y.
  TITLE     Involvement of D-amino acid oxidase in elimination of D-serine in
            mouse brain
  JOURNAL   Experientia 48 (8), 753-755 (1992)
   PUBMED   1355447
REFERENCE   8  (bases 1 to 2033)
  AUTHORS   Hamilton,G.A., Buckthal,D.J., Mortensen,R.M. and Zerby,K.W.
  TITLE     Reactions of cysteamine and other amine metabolites with glyoxylate
            and oxygen catalyzed by mammalian D-amino acid oxidase
  JOURNAL   Proc Natl Acad Sci U S A 76 (6), 2625-2629 (1979)
   PUBMED   37501
REFERENCE   9  (bases 1 to 2033)
  AUTHORS   Holmes,R.S. and Masters,C.J.
  TITLE     Genetic control and ontogeny of microbody enzymes: a review
  JOURNAL   Biochem Genet 16 (3-4), 171-190 (1978)
   PUBMED   28117
  REMARK    Review article
REFERENCE   10 (bases 1 to 2033)
  AUTHORS   Holmes,R.S.
  TITLE     Genetics of peroxisomal enzymes in the mouse: nonlinkage of D-amino
            acid oxidase locus (Dao) to catalase (Cs) and L-alpha-hydroxyacid
            oxidase (Hao-1) loci on chromosome 2
  JOURNAL   Biochem Genet 14 (11-12), 981-987 (1976)
   PUBMED   13782
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC145559.4, AK134813.1, BU755879.1 and AW492600.1.
            
            On Nov 5, 2013 this sequence version replaced NM_010018.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer protein (isoform 1). Variants 1
            and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK134813.1, M32299.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-202               AC145559.4         179639-179840
            203-385             AC145559.4         185734-185916
            386-1402            AK134813.1         247-1263
            1403-1792           BU755879.1         16-405              c
            1793-2033           AW492600.1         1-241               c
FEATURES             Location/Qualifiers
     source          1..2033
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 55.93 cM"
     gene            1..2033
                     /gene="Dao"
                     /gene_synonym="DAAO; DAMOX; Dao-1; Dao1"
                     /note="D-amino acid oxidase"
                     /db_xref="GeneID:13142"
                     /db_xref="MGI:MGI:94859"
     exon            1..202
                     /gene="Dao"
                     /gene_synonym="DAAO; DAMOX; Dao-1; Dao1"
                     /inference="alignment:Splign:2.1.0"
     exon            203..402
                     /gene="Dao"
                     /gene_synonym="DAAO; DAMOX; Dao-1; Dao1"
                     /inference="alignment:Splign:2.1.0"
     CDS             212..1249
                     /gene="Dao"
                     /gene_synonym="DAAO; DAMOX; Dao-1; Dao1"
                     /EC_number="1.4.3.3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     D-amino acid oxidase 1"
                     /codon_start=1
                     /product="D-amino-acid oxidase isoform 1"
                     /protein_id="NP_034148.2"
                     /db_xref="CCDS:CCDS19557.1"
                     /db_xref="GeneID:13142"
                     /db_xref="MGI:MGI:94859"
                     /translation="MRVAVIGAGVIGLSTALCIHERYHPTQPLHMKIYADRFTPFTTS
                     DVAAGLWQPYLSDPSNPQEAEWSQQTFDYLLSCLHSPNAEKMGLALISGYNLFRDEVP
                     DPFWKNAVLGFRKLTPSEMDLFPDYGYGWFNTSLLLEGKSYLPWLTERLTERGVKLIH
                     RKVESLEEVARGVDVIINCTGVWAGALQADASLQPGRGQIIQVEAPWIKHFILTHDPS
                     LGIYNSPYIIPGSKTVTLGGIFQLGNWSGLNSVRDHNTIWKSCCKLEPTLKNARIVGE
                     LTGFRPVRPQVRLEREWLHFGSSSAEVIHNYGHGGYGLTIHWGCAMEAANLFGKILEE
                     KKLSRLPPSHL"
     exon            403..517
                     /gene="Dao"
                     /gene_synonym="DAAO; DAMOX; Dao-1; Dao1"
                     /inference="alignment:Splign:2.1.0"
     exon            518..594
                     /gene="Dao"
                     /gene_synonym="DAAO; DAMOX; Dao-1; Dao1"
                     /inference="alignment:Splign:2.1.0"
     exon            595..660
                     /gene="Dao"
                     /gene_synonym="DAAO; DAMOX; Dao-1; Dao1"
                     /inference="alignment:Splign:2.1.0"
     exon            661..715
                     /gene="Dao"
                     /gene_synonym="DAAO; DAMOX; Dao-1; Dao1"
                     /inference="alignment:Splign:2.1.0"
     exon            716..817
                     /gene="Dao"
                     /gene_synonym="DAAO; DAMOX; Dao-1; Dao1"
                     /inference="alignment:Splign:2.1.0"
     exon            818..900
                     /gene="Dao"
                     /gene_synonym="DAAO; DAMOX; Dao-1; Dao1"
                     /inference="alignment:Splign:2.1.0"
     exon            901..1018
                     /gene="Dao"
                     /gene_synonym="DAAO; DAMOX; Dao-1; Dao1"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..1117
                     /gene="Dao"
                     /gene_synonym="DAAO; DAMOX; Dao-1; Dao1"
                     /inference="alignment:Splign:2.1.0"
     exon            1118..2018
                     /gene="Dao"
                     /gene_synonym="DAAO; DAMOX; Dao-1; Dao1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1771..1776
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dao"
                     /gene_synonym="DAAO; DAMOX; Dao-1; Dao1"
                     /note="hexamer: ATTAAA"
     polyA_site      1792
                     /gene="Dao"
                     /gene_synonym="DAAO; DAMOX; Dao-1; Dao1"
                     /note="major polyA site"
     polyA_site      2018
                     /gene="Dao"
                     /gene_synonym="DAAO; DAMOX; Dao-1; Dao1"
ORIGIN      
        1 gactgagtcc tacttctgga ggaacacagt gcccagcccc accccttgct ctgtgccccc
       61 tccattgccg aagactttga ccttgtgttt cattcctggc tggtgggcag agggctgaag
      121 tcaacacagc ccagagagtc aggagcagtc ctgctggaac ctgcacccca ggttattttt
      181 ctcccgacac ctggcaccag tggctgctgt gatgcgcgtg gccgtgatcg gagcaggagt
      241 cattgggctc tccacagccc tctgcattca tgagcgttac cacccaacac agccactgca
      301 catgaagatc tatgcagatc gattcacccc gttcaccacg agcgatgtgg ccgccggcct
      361 ctggcagcct tatctctctg accccagcaa ccctcaggag gcggagtgga gccagcaaac
      421 gtttgattac ctgctgagct gcctccattc tccaaacgct gaaaaaatgg gcctggccct
      481 aatctcaggc tacaacctct tccgagatga agttccggac cctttctgga aaaacgcagt
      541 tctgggattc cggaagctga cccccagtga gatggacctg ttccctgatt atggctacgg
      601 ctggttcaat acaagcctcc ttctagaggg gaagagctac ctgccatggc taactgagag
      661 gttaactgag aggggagtga agcttatcca tcggaaggtg gagtctctcg aagaggtggc
      721 aagaggagtg gatgtgatta tcaactgcac cggggtgtgg gccggggccc tgcaagcaga
      781 tgcctccctg cagccaggcc ggggccagat catccaggtg gaggcccctt ggattaaaca
      841 cttcatcctc acccatgatc ctagccttgg tatctacaac tctccgtaca tcatcccagg
      901 ttccaagaca gttacgctcg ggggtatatt ccagctgggg aactggagcg ggttaaacag
      961 cgtccgtgac cacaatacca tttggaagag ctgctgtaaa ctggagccca ccctgaagaa
     1021 tgcaagaatt gtgggtgaac tcactggctt ccggccagtc cggcctcagg tccggctaga
     1081 aagagaatgg cttcattttg gatcttcaag tgcagaggtc atccacaact atggtcatgg
     1141 aggttacggg ctcacaatcc actggggttg tgcaatggag gcggccaacc tcttcgggaa
     1201 aattctagag gaaaagaagt tgtccaggtt gcctccctcc cacctctgag gactctagtg
     1261 atcaccgtgt gccccaagac gacacccccc cttcggccaa tgatatgtga tgctcctgga
     1321 tgatgctctc tccccagccc cacccccagc cactccccaa cccaccccga ccactccccc
     1381 agccccgccg gccactcccc cagccccacc cctggcttcc tctggcaaag gcatgaaggg
     1441 aggaaatctt gctgctcctg ccactcatcc actgctgcct ggtccttcca gtgcagtgat
     1501 tcttgctggt cctaaccaag gcttgggtga gataggctgc gtggtgcaat tcttctcaag
     1561 ccgtagtgac tgtactgagg ctggtggtac cgggtggcag gacctgcgtt cagacctata
     1621 aggagtggtc tggatctttt gcttagaact ctgacgaatg gttcacaaca cactccatgc
     1681 gtatctgtag tgatgggagg agggggttag gagcaggacg ttggggagag gaggaggagt
     1741 tggaggagga gcactccact ggtcaacatt attaaaacac tggatatcca aactcttcag
     1801 gattgatcct gagacatgac ttcccctcat tctcaccacc tccaagaaca ctgtggcctt
     1861 gaggagagtt aatctagctt gtatgtgtga gaggagggga aaggcaggag ggtatggctc
     1921 aggccttaga gtaggctcta aggtgctcta ccactgagtg gaaccctgtc ctcttgaggt
     1981 ctgaaatcag agaaacatat caccttggac acagtgaaaa aaaaaaaaaa aaa
//
