LOCUS       NM_201227               1584 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus DAN domain family member 5, BMP antagonist (Dand5),
            transcript variant 1, mRNA.
ACCESSION   NM_201227
VERSION     NM_201227.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1584)
  AUTHORS   Matsuoka,R., Kitajima,K., Nii,T., Zou,Z., Tanaka,K., Joo,K.,
            Ohkawa,Y., Ohga,S. and Meno,C.
  TITLE     Hyperglycaemia induces diet-dependent defects of the left-right
            axis by lowering intracellular pH
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1871 (1), 167550 (2025)
   PUBMED   39442590
REFERENCE   2  (bases 1 to 1584)
  AUTHORS   Gui,M., Farley,H., Anujan,P., Anderson,J.R., Maxwell,D.W.,
            Whitchurch,J.B., Botsch,J.J., Qiu,T., Meleppattu,S., Singh,S.K.,
            Zhang,Q., Thompson,J., Lucas,J.S., Bingle,C.D., Norris,D.P., Roy,S.
            and Brown,A.
  TITLE     De novo identification of mammalian ciliary motility proteins using
            cryo-EM
  JOURNAL   Cell 184 (23), 5791-5806 (2021)
   PUBMED   34715025
REFERENCE   3  (bases 1 to 1584)
  AUTHORS   Minegishi,K., Rothe,B., Komatsu,K.R., Ono,H., Ikawa,Y.,
            Nishimura,H., Katoh,T.A., Kajikawa,E., Sai,X., Miyashita,E.,
            Takaoka,K., Bando,K., Kiyonari,H., Yamamoto,T., Saito,H.,
            Constam,D.B. and Hamada,H.
  TITLE     Fluid flow-induced left-right asymmetric decay of Dand5 mRNA in the
            mouse embryo requires a Bicc1-Ccr4 RNA degradation complex
  JOURNAL   Nat Commun 12 (1), 4071 (2021)
   PUBMED   34210974
  REMARK    GeneRIF: Fluid flow-induced left-right asymmetric decay of Dand5
            mRNA in the mouse embryo requires a Bicc1-Ccr4 RNA degradation
            complex.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1584)
  AUTHORS   Mizuno,K., Shiozawa,K., Katoh,T.A., Minegishi,K., Ide,T., Ikawa,Y.,
            Nishimura,H., Takaoka,K., Itabashi,T., Iwane,A.H., Nakai,J.,
            Shiratori,H. and Hamada,H.
  TITLE     Role of Ca2+ transients at the node of the mouse embryo in breaking
            of left-right symmetry
  JOURNAL   Sci Adv 6 (30), eaba1195 (2020)
   PUBMED   32743070
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1584)
  AUTHORS   Shylo,N.A., Emmanouil,E., Ramrattan,D. and Weatherbee,S.D.
  TITLE     Loss of ciliary transition zone protein TMEM107 leads to heterotaxy
            in mice
  JOURNAL   Dev Biol 460 (2), 187-199 (2020)
   PUBMED   31887266
REFERENCE   6  (bases 1 to 1584)
  AUTHORS   Avsian-Kretchmer,O. and Hsueh,A.J.
  TITLE     Comparative genomic analysis of the eight-membered ring cystine
            knot-containing bone morphogenetic protein antagonists
  JOURNAL   Mol Endocrinol 18 (1), 1-12 (2004)
   PUBMED   14525956
  REMARK    Review article
REFERENCE   7  (bases 1 to 1584)
  AUTHORS   Mastrangeli,R., Donini,S., Kelton,C.A., He,C., Bressan,A.,
            Milazzo,F., Ciolli,V., Borrelli,F., Martelli,F., Biffoni,M.,
            Serlupi-Crescenzi,O., Serani,S., Micangeli,E., El Tayar,N.,
            Vaccaro,R., Renda,T., Lisciani,R., Rossi,M. and Papoian,R.
  TITLE     ARS Component B: structural characterization, tissue expression and
            regulation of the gene and protein (SLURP-1) associated with Mal de
            Meleda
  JOURNAL   Eur J Dermatol 13 (6), 560-570 (2003)
   PUBMED   14721776
REFERENCE   8  (bases 1 to 1584)
  AUTHORS   Fujiwara,T., Dehart,D.B., Sulik,K.K. and Hogan,B.L.
  TITLE     Distinct requirements for extra-embryonic and embryonic bone
            morphogenetic protein 4 in the formation of the node and primitive
            streak and coordination of left-right asymmetry in the mouse
  JOURNAL   Development 129 (20), 4685-4696 (2002)
   PUBMED   12361961
REFERENCE   9  (bases 1 to 1584)
  AUTHORS   Pearce,J.J., Penny,G. and Rossant,J.
  TITLE     A mouse cerberus/Dan-related gene family
  JOURNAL   Dev Biol 209 (1), 98-110 (1999)
   PUBMED   10208746
REFERENCE   10 (bases 1 to 1584)
  AUTHORS   Sharp,R., Babyatsky,M.W., Takagi,H., Tagerud,S., Wang,T.C.,
            Bockman,D.E., Brand,S.J. and Merlino,G.
  TITLE     Transforming growth factor alpha disrupts the normal program of
            cellular differentiation in the gastric mucosa of transgenic mice
  JOURNAL   Development 121 (1), 149-161 (1995)
   PUBMED   7867496
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC155163.4, AY387409.1 and AK143395.1.
            
            On Dec 12, 2009 this sequence version replaced NM_201227.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and is the protein-coding transcript.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY387409.1, BC115659.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164136
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-55                AC155163.4         167429-167483       c
            56-541              AY387409.1         52-537
            542-803             AK143395.1         162-423
            804-1584            AY387409.1         800-1580
FEATURES             Location/Qualifiers
     source          1..1584
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 41.17 cM"
     gene            1..1584
                     /gene="Dand5"
                     /gene_synonym="Cerl-2; Cerl2; Cerr2; coco; Dte; GREM3"
                     /note="DAN domain family member 5, BMP antagonist"
                     /db_xref="GeneID:23863"
                     /db_xref="MGI:MGI:1344365"
     exon            1..455
                     /gene="Dand5"
                     /gene_synonym="Cerl-2; Cerl2; Cerr2; coco; Dte; GREM3"
                     /inference="alignment:Splign:2.1.0"
     CDS             144..701
                     /gene="Dand5"
                     /gene_synonym="Cerl-2; Cerl2; Cerr2; coco; Dte; GREM3"
                     /note="dante; cerberus-like protein 2; DAN domain family,
                     member 5"
                     /codon_start=1
                     /product="DAN domain family member 5 precursor"
                     /protein_id="NP_957679.1"
                     /db_xref="CCDS:CCDS22477.1"
                     /db_xref="GeneID:23863"
                     /db_xref="MGI:MGI:1344365"
                     /translation="MFRSQFTTLLGLFSGAWLPTGSGRPGAPATPVQSGTAINQSWTL
                     DPLVPISALGSWEAFLGLQNKQQGTGELQGGGQRVAAGVPLPLAPQEVLQETCKALSF
                     VQVISRPGCTSARVLNHLCFGRCSSFYIPSSDPTPVVFCNSCVPARKRWTSVTLWCGA
                     GQLASPRRVRISTVLVQKCQCRPKL"
     exon            456..1584
                     /gene="Dand5"
                     /gene_synonym="Cerl-2; Cerl2; Cerr2; coco; Dte; GREM3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aactctcaag ctgctctcca gggaacagtg ataaaaagca gacctctgag ggcccgcact
       61 ccacacacta gacagcaggg cccactgcga aggaccctga gcccatttta agacaaacag
      121 acaaacgact gcacagccaa gtgatgttcc gtagccagtt caccacgctg ctgggtctgt
      181 tcagtggggc ctggctaccc acaggctcag ggaggcctgg ggccccagcg acccctgttc
      241 agtccgggac tgctatcaat cagagctgga ctctggatcc cctggtgccc atctctgccc
      301 tgggtagctg ggaggccttc ctgggcctgc agaacaaaca gcaggggaca ggtgagctgc
      361 agggaggagg gcagagagta gctgctggtg tgcctttgcc cttggctcct caagaagtgc
      421 ttcaggagac ttgtaaagct ctgtcctttg ttcaggtgat ctccaggcct ggttgcacaa
      481 gtgcccgggt ccttaatcat ctctgttttg gccgctgttc ctccttctac attcccagct
      541 cggatcccac ccctgtagtc ttctgcaaca gctgtgtgcc ggctcgaaag cgctggacat
      601 cggtgacgct gtggtgtgga gctggccaat tagcctcccc tcggcgggtg aggatttcca
      661 cggtattggt ccagaagtgt cagtgccgcc cgaagctgtg agctgagcat cctagaggaa
      721 tgcgcaggac atgaatgaac cttggcaaga agcaggagac gcaatagaaa gacgtgacct
      781 gaatgatgtg catcgggtca agagagcaga attggacagg gccagaatac tagacatggt
      841 cccccagtca tgggtttaga ccactaatag tcgtagaatg tggggctagg gtataactca
      901 gtgggagagg gcttgcctag catgcatgaa gccctgggtt ctattcgtat gtgatatgtg
      961 gaggttaaaa aaaggtgaaa attagctata gtgtatgatt agccctgtgt gagagggaac
     1021 attcatgcca caatcactaa ctcacgtcct cctcaggaat cctcagcagt cccgcaaggt
     1081 agaatttcac catgggtcat tttacagatg aggaaaccga agctatttag gcactgtcac
     1141 ttttggagag gggtggaata gggagagggc ttcagacaca gccctgacgc acgcgcagca
     1201 cagctccctg ctgagctcct cccccagcct ggggttccgc ttttagccac taggtggcac
     1261 cgcgtcccag tgtccaagac agacactccc aactgttatg atgacagcac tacccaaacc
     1321 tggacactca gcaaagatga ccctgttctg gggacaccag aataacagca gcagcagcaa
     1381 caacaacagc aacaaactat ggcaggcaag caggaagcag ctgctaggaa aacctggccc
     1441 caaccagagg cgaccccgca tgtgtgcagc tgcctctctc atcgacagta gccaggggtt
     1501 tccctttttg ccccacccga gaccccgcag cagcctcatg cccagcctgg cattccgtgg
     1561 gaaccataaa ggttggccaa gtcc
//
