LOCUS       NM_144915               3257 bp    mRNA    linear   ROD 05-DEC-2024
DEFINITION  Mus musculus diacylglycerol lipase, beta (Daglb), mRNA.
ACCESSION   NM_144915
VERSION     NM_144915.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3257)
  AUTHORS   Buzzi,B., Koseli,E., Alkhlaif,Y., Parker,A., Mustafa,M.A.,
            Lichtman,A.H., Buczynski,M.W. and Damaj,M.I.
  TITLE     Differential roles of diacylglycerol lipase (DAGL) enzymes in
            nicotine withdrawal
  JOURNAL   Brain Res 1817, 148483 (2023)
   PUBMED   37442250
REFERENCE   2  (bases 1 to 3257)
  AUTHORS   Liu,Z., Yang,N., Dong,J., Tian,W., Chang,L., Ma,J., Guo,J., Tan,J.,
            Dong,A., He,K., Zhou,J., Cinar,R., Wu,J., Salinas,A.G., Sun,L.,
            Kumar,M., Sullivan,B.T., Oldham,B.B., Pitz,V., Makarious,M.B.,
            Ding,J., Kung,J., Xie,C., Hawes,S.L., Wang,L., Wang,T., Chan,P.,
            Zhang,Z., Le,W., Chen,S., Lovinger,D.M., Blauwendraat,C.,
            Singleton,A.B., Cui,G., Li,Y., Cai,H. and Tang,B.
  TITLE     Deficiency in endocannabinoid synthase DAGLB contributes to early
            onset Parkinsonism and murine nigral dopaminergic neuron
            dysfunction
  JOURNAL   Nat Commun 13 (1), 3490 (2022)
   PUBMED   35715418
  REMARK    GeneRIF: Deficiency in endocannabinoid synthase DAGLB contributes
            to early onset Parkinsonism and murine nigral dopaminergic neuron
            dysfunction.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3257)
  AUTHORS   Shin,M., Ware,T.B. and Hsu,K.L.
  TITLE     DAGL-Beta Functions as a PUFA-Specific Triacylglycerol Lipase in
            Macrophages
  JOURNAL   Cell Chem Biol 27 (3), 314-321 (2020)
   PUBMED   31991095
  REMARK    GeneRIF: DAGL-Beta Functions as a PUFA-Specific Triacylglycerol
            Lipase in Macrophages.
REFERENCE   4  (bases 1 to 3257)
  AUTHORS   Shin,M., Buckner,A., Prince,J., Bullock,T.N.J. and Hsu,K.L.
  TITLE     Diacylglycerol Lipase-beta Is Required for TNF-alpha Response but
            Not CD8+ T Cell Priming Capacity of Dendritic Cells
  JOURNAL   Cell Chem Biol 26 (7), 1036-1041 (2019)
   PUBMED   31105063
  REMARK    GeneRIF: Authors identify DAGLbeta pathways as a means for
            attenuating DC inflammatory signaling while sparing critical
            adaptive immune functions and further expand the utility of
            targeting lipid pathways for immunomodulation.
REFERENCE   5  (bases 1 to 3257)
  AUTHORS   Viader,A., Ogasawara,D., Joslyn,C.M., Sanchez-Alavez,M., Mori,S.,
            Nguyen,W., Conti,B. and Cravatt,B.F.
  TITLE     A chemical proteomic atlas of brain serine hydrolases identifies
            cell type-specific pathways regulating neuroinflammation
  JOURNAL   Elife 5, e12345 (2016)
   PUBMED   26779719
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3257)
  AUTHORS   Tanimura,A., Yamazaki,M., Hashimotodani,Y., Uchigashima,M.,
            Kawata,S., Abe,M., Kita,Y., Hashimoto,K., Shimizu,T., Watanabe,M.,
            Sakimura,K. and Kano,M.
  TITLE     The endocannabinoid 2-arachidonoylglycerol produced by
            diacylglycerol lipase alpha mediates retrograde suppression of
            synaptic transmission
  JOURNAL   Neuron 65 (3), 320-327 (2010)
   PUBMED   20159446
REFERENCE   7  (bases 1 to 3257)
  AUTHORS   Gao,Y., Vasilyev,D.V., Goncalves,M.B., Howell,F.V., Hobbs,C.,
            Reisenberg,M., Shen,R., Zhang,M.Y., Strassle,B.W., Lu,P., Mark,L.,
            Piesla,M.J., Deng,K., Kouranova,E.V., Ring,R.H., Whiteside,G.T.,
            Bates,B., Walsh,F.S., Williams,G., Pangalos,M.N., Samad,T.A. and
            Doherty,P.
  TITLE     Loss of retrograde endocannabinoid signaling and reduced adult
            neurogenesis in diacylglycerol lipase knock-out mice
  JOURNAL   J Neurosci 30 (6), 2017-2024 (2010)
   PUBMED   20147530
  REMARK    GeneRIF: The control of adult neurogenesis in the hippocampus and
            subventricular zone is compromised in the DAGLalpha(-/-) and/or
            DAGLbeta(-/-) mice.
REFERENCE   8  (bases 1 to 3257)
  AUTHORS   Mulder,J., Aguado,T., Keimpema,E., Barabas,K., Ballester
            Rosado,C.J., Nguyen,L., Monory,K., Marsicano,G., Di Marzo,V.,
            Hurd,Y.L., Guillemot,F., Mackie,K., Lutz,B., Guzman,M., Lu,H.C.,
            Galve-Roperh,I. and Harkany,T.
  TITLE     Endocannabinoid signaling controls pyramidal cell specification and
            long-range axon patterning
  JOURNAL   Proc Natl Acad Sci U S A 105 (25), 8760-8765 (2008)
   PUBMED   18562289
REFERENCE   9  (bases 1 to 3257)
  AUTHORS   Mager,J., Schultz,R.M., Brunk,B.P. and Bartolomei,M.S.
  TITLE     Identification of candidate maternal-effect genes through
            comparison of multiple microarray data sets
  JOURNAL   Mamm Genome 17 (9), 941-949 (2006)
   PUBMED   16964442
REFERENCE   10 (bases 1 to 3257)
  AUTHORS   Bisogno,T., Howell,F., Williams,G., Minassi,A., Cascio,M.G.,
            Ligresti,A., Matias,I., Schiano-Moriello,A., Paul,P.,
            Williams,E.J., Gangadharan,U., Hobbs,C., Di Marzo,V. and Doherty,P.
  TITLE     Cloning of the first sn1-DAG lipases points to the spatial and
            temporal regulation of endocannabinoid signaling in the brain
  JOURNAL   J Cell Biol 163 (3), 463-468 (2003)
   PUBMED   14610053
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY314231.1, AK136372.1, CO043884.1 and BE992098.1.
            
            On Mar 23, 2007 this sequence version replaced NM_144915.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK086747.1, SRR1660817.241345.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-143               BY314231.1         2-144
            144-2433            AK136372.1         2-2291
            2434-2997           CO043884.1         15-578              c
            2998-3257           BE992098.1         1-260               c
FEATURES             Location/Qualifiers
     source          1..3257
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 82.19 cM"
     gene            1..3257
                     /gene="Daglb"
                     /gene_synonym="E330036I19Rik"
                     /note="diacylglycerol lipase, beta"
                     /db_xref="GeneID:231871"
                     /db_xref="MGI:MGI:2442032"
     exon            1..284
                     /gene="Daglb"
                     /gene_synonym="E330036I19Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             190..2199
                     /gene="Daglb"
                     /gene_synonym="E330036I19Rik"
                     /EC_number="3.1.1.3"
                     /EC_number="3.1.1.116"
                     /note="sn1-specific diacylglycerol lipase beta; DGL-beta;
                     DAGLbeta; DAGL-beta; PUFA-specific triacylglycerol lipase"
                     /codon_start=1
                     /product="diacylglycerol lipase-beta"
                     /protein_id="NP_659164.2"
                     /db_xref="CCDS:CCDS39370.1"
                     /db_xref="GeneID:231871"
                     /db_xref="MGI:MGI:2442032"
                     /translation="MPGMVLFGRRWSLASDDLVFPGSFELFLRVLWWIVSLTLYLTHR
                     RRLDCPGGVLLSTYLIVLLVLLAVIICTVLAIVCVSMRGTICNPGPRKSMSKLLYIRL
                     ALFLPEMVWASLGAAWVAKGIQCDRTVVIGIIATVIVSWIVIAATMVTIIFVFDPLGG
                     KMAPYPPCIPEHLDSNSSNRLLTGLKTAAKSVWETRVQFCCCCVGQDDNTRVAFSSTA
                     DLFSTYFSDTDLVPSDIAAGFTLLHQQQDNISHSREPPEVVTHTPGQPQETELDAEVE
                     NCHHYMPFAAAAYGWPLYIYRNPFTGLCRIGGDCCRARDIEYDAVEGDQHNCHFASIL
                     KTTGLQYRDFIHISFHDKVYELPFIVVLDHRKESVVVAVRGTMSLQDVLTDLSAESET
                     LELGIELQDCVAHKGIAQAARYIHRRLVNDGILSQAFSVAPEYQLVLVGHSLGAGAAA
                     LLAIMLRGAYPQVRAYAFSPPRGLLSKSLYEYSKDFVVSLILGMDVIPRLSVTNMEDL
                     KRRILRVIANCNKPKYKILLHGCWYGLFGGSPDNFPTELDEGTQGALTQPLLGEQTLL
                     TRYSPGYCSSDSPLDSPTKYPTLYPPGRIIHLEEEGGSGRFGCCSAAQYRARWAHEAE
                     FSKILIGPKMLIDHMPDVMIRALDRVLADRTACVSCPGQGGSSVP"
     exon            285..436
                     /gene="Daglb"
                     /gene_synonym="E330036I19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            437..608
                     /gene="Daglb"
                     /gene_synonym="E330036I19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            609..867
                     /gene="Daglb"
                     /gene_synonym="E330036I19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            868..990
                     /gene="Daglb"
                     /gene_synonym="E330036I19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1118
                     /gene="Daglb"
                     /gene_synonym="E330036I19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1119..1245
                     /gene="Daglb"
                     /gene_synonym="E330036I19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1246..1329
                     /gene="Daglb"
                     /gene_synonym="E330036I19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1330..1407
                     /gene="Daglb"
                     /gene_synonym="E330036I19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1408..1488
                     /gene="Daglb"
                     /gene_synonym="E330036I19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1489..1616
                     /gene="Daglb"
                     /gene_synonym="E330036I19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1617..1685
                     /gene="Daglb"
                     /gene_synonym="E330036I19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1686..1758
                     /gene="Daglb"
                     /gene_synonym="E330036I19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1759..2006
                     /gene="Daglb"
                     /gene_synonym="E330036I19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2007..3242
                     /gene="Daglb"
                     /gene_synonym="E330036I19Rik"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2397
                     /gene="Daglb"
                     /gene_synonym="E330036I19Rik"
     regulatory      2971..2976
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Daglb"
                     /gene_synonym="E330036I19Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2997
                     /gene="Daglb"
                     /gene_synonym="E330036I19Rik"
                     /note="major polyA site"
ORIGIN      
        1 aggggacctg ggaaggaggc aaagacagca aagtgcgcgt ctcttgtggg cgcgctccgg
       61 actcgggccg gaggcgcatg cgcgggtctt tacgtaggct tgcgccttgg cgctgctggg
      121 gaccccctcc agacacgcgc ggagtcagaa gggtgcgcgc ggcttaggcg gcgcggtggg
      181 aggtgcgcca tgccggggat ggtgctgttc ggccggcgct ggtctctagc cagcgacgac
      241 ttggtgttcc ccgggtcttt tgagctgttc ctgcgtgtgc tgtggtggat tgtcagtctg
      301 acgttgtatc tcacgcacag aaggaggctg gactgtcccg gtggagtctt gctcagcacg
      361 tacctgatag tcctccttgt tctcctggca gttattatat gcaccgtgtt ggccatcgtg
      421 tgtgtcagca tgagaggaac catttgtaac cctggacctc ggaagtctat gtctaagctg
      481 ctctatatcc gcctggcgct cttcctgcca gagatggtct gggcttctct gggggccgcc
      541 tgggtggcaa aaggtatcca gtgtgacagg acagttgtca ttggcatcat cgccaccgtc
      601 attgtcagct ggattgtcat tgctgccacc atggtcacca tcatctttgt ctttgacccg
      661 ctgggcggga agatggctcc gtatccccca tgcatcccgg agcacctgga cagtaacagc
      721 tcaaaccggt tactgactgg cctgaagacg gctgcgaaga gcgtgtggga gacccgggtg
      781 cagttctgct gctgctgcgt tgggcaggat gataacacca gggtggcgtt ttccagcact
      841 gccgacctgt tctccaccta cttctctgac acagacctgg tgcctagtga tatcgcagca
      901 ggcttcaccc ttctccacca gcaacaagac aatatcagcc acagccggga gcctccggag
      961 gtcgtgaccc acacaccagg acagcctcag gaaactgagt tagatgcaga agtggagaac
     1021 tgccatcatt acatgccgtt tgcagcagct gcctatgggt ggccgctcta catctacagg
     1081 aacccgttca cggggctgtg caggattggt ggcgactgtt gcagagccag agacatagag
     1141 tacgatgcag tggaaggtga ccagcacaac tgccacttcg cctccatcct gaagaccaca
     1201 gggctgcagt acagggattt cattcacata agctttcacg acaaggtgta tgagctgccc
     1261 ttcatagtgg ttctggacca caggaaggag tctgttgtgg tcgccgtgag agggaccatg
     1321 tctctccagg acgtcctgac cgacctgtct gccgagagtg agaccctgga gctggggatt
     1381 gagctacagg actgtgtggc ccacaaggga attgctcaag cggccagata cattcaccgc
     1441 agactggtca atgatgggat tctgagccaa gccttcagtg tcgctccgga gtaccagctc
     1501 gttctggtgg ggcacagcct aggagccggc gctgcggccc tgttagccat catgctccgg
     1561 ggggcctacc cacaagtccg tgcttatgcc ttctccccgc ccagggggct gctcagcaaa
     1621 tccctttacg agtactccaa ggactttgtc gtgtcgctta tcctagggat ggatgtgatc
     1681 cccaggttaa gtgtgaccaa catggaggac ctcaagagga ggatcctgag agtgatcgct
     1741 aactgcaata agccgaagta caagatcttg ctgcatggct gttggtacgg actgttcgga
     1801 ggaagccctg ataactttcc aactgaactg gatgagggca cccagggggc cctgactcag
     1861 cctcttcttg gagagcagac acttctaacc cgatactccc cgggctactg ttccagcgac
     1921 tccccactgg actcccccac caagtacccc actctgtacc cacctggcag gatcatccac
     1981 ctggaagagg agggtggttc agggaggttt ggctgctgtt ctgctgccca gtacagagcg
     2041 aggtgggcac acgaagcaga attcagtaag atcctgatag gcccaaagat gctgattgac
     2101 cacatgcctg acgtcatgat tcgggccctg gacagagtgc ttgccgacag gacagcctgc
     2161 gtctcctgcc cagggcaagg cggctcaagt gtaccgtagt cagctctact ggaccctgac
     2221 cggtacaacg gactggcagt ttcaggaggt ttttttgttg ttgcttttgt ttttttctta
     2281 agactgattg actgtgcgtg gcttctgtga ggctggtatg gtggtatctg tctatcaaca
     2341 gttacctgag gggtccctgc agaaatggac accaaaatga ccatacaatt tatacaacct
     2401 tttctttctt tctttctttt tttttttttt tttgcttgtt ttgatttttc aagaccgggt
     2461 tcctctgtgt ggcgctggct gtcctggact caccctgtag accaggctgg cctcaaaact
     2521 cagatttgcc tgcctctgcc tctgagtgtt gggactaacg gcatgggcca ccactgcctg
     2581 gcctatggaa ccacttttaa ccatagtatt aacaggatcc ggagttggga acacgcatag
     2641 gtgttgggac ttgtaggcca gcccatggca taagccacct aagaagtcta catctgaaga
     2701 cccttagtgg gtctgcaagg cccctgctcc tgatgggctc ccatcctgct gtttacacga
     2761 gtctgaactt taagacaaca gatgagcact ttatacttgc ctgcgtcttt ccggggtcac
     2821 taggacagcc tgagtgtcct ctgagctggc actgcagccc ctccctcatg gatacatgag
     2881 ctagctgatc actaactctt atgtatgctt aattctcaca ttatcagacc tctgagccag
     2941 gtggtaggct caggggaatt taaataaata aataaagtag ttggtatacc atcaaaagcc
     3001 tgcaaggaag gtgtgggatt cctgagagcc aggaacttgc tgagttccag tgtgccattt
     3061 ccccgtgtca gtcaggacac tgggattaca agcatggact actgtaccca ggggtgatga
     3121 ggtttcacct ttccattcta aatcaagttg ccttgtctct ctggttacta agaactacat
     3181 acattacgga atccaacaag cacagaacac aattaaaaat aaaaaaaaaa tccagaaaac
     3241 aaaaaaaaaa aaaaaaa
//
