LOCUS       NM_198114               5652 bp    mRNA    linear   ROD 05-DEC-2024
DEFINITION  Mus musculus diacylglycerol lipase, alpha (Dagla), mRNA.
ACCESSION   NM_198114 XM_983928
VERSION     NM_198114.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5652)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5652)
  AUTHORS   Leidmaa,E., Prodan,A.M., Depner,L.L., Komorowska-Muller,J.A.,
            Beins,E.C., Schuermann,B., Kolbe,C.C. and Zimmer,A.
  TITLE     Astrocytic Dagla Deletion Decreases Hedonic Feeding in Female Mice
  JOURNAL   Cannabis Cannabinoid Res 9 (1), 74-88 (2024)
   PUBMED   38265773
  REMARK    GeneRIF: Astrocytic Dagla Deletion Decreases Hedonic Feeding in
            Female Mice.
REFERENCE   3  (bases 1 to 5652)
  AUTHORS   Buzzi,B., Koseli,E., Alkhlaif,Y., Parker,A., Mustafa,M.A.,
            Lichtman,A.H., Buczynski,M.W. and Damaj,M.I.
  TITLE     Differential roles of diacylglycerol lipase (DAGL) enzymes in
            nicotine withdrawal
  JOURNAL   Brain Res 1817, 148483 (2023)
   PUBMED   37442250
REFERENCE   4  (bases 1 to 5652)
  AUTHORS   Schuele,L.L., Schuermann,B., Bilkei-Gorzo,A., Gorgzadeh,S.,
            Zimmer,A. and Leidmaa,E.
  TITLE     Regulation of adult neurogenesis by the endocannabinoid-producing
            enzyme diacylglycerol lipase alpha (DAGLa)
  JOURNAL   Sci Rep 12 (1), 633 (2022)
   PUBMED   35022487
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5652)
  AUTHORS   Kovari,D., Penksza,V., Szilvasy-Szabo,A., Sinko,R., Gereben,B.,
            Mackie,K. and Fekete,C.
  TITLE     Tanycyte specific ablation of diacylglycerol lipase alpha
            stimulates the hypothalamic-pituitary-thyroid axis by decreasing
            the endocannabinoid mediated inhibition of TRH release
  JOURNAL   J Neuroendocrinol 34 (1), e13079 (2022)
   PUBMED   34970803
  REMARK    GeneRIF: Tanycyte specific ablation of diacylglycerol lipase alpha
            stimulates the hypothalamic-pituitary-thyroid axis by decreasing
            the endocannabinoid mediated inhibition of TRH release.
REFERENCE   6  (bases 1 to 5652)
  AUTHORS   Trinidad,J.C., Specht,C.G., Thalhammer,A., Schoepfer,R. and
            Burlingame,A.L.
  TITLE     Comprehensive identification of phosphorylation sites in
            postsynaptic density preparations
  JOURNAL   Mol Cell Proteomics 5 (5), 914-922 (2006)
   PUBMED   16452087
REFERENCE   7  (bases 1 to 5652)
  AUTHORS   Nishimura,M., Yokoi,N., Miki,T., Horikawa,Y., Yoshioka,H.,
            Takeda,J., Ohara,O. and Seino,S.
  TITLE     Construction of a multi-functional cDNA library specific for mouse
            pancreatic islets and its application to microarray
  JOURNAL   DNA Res 11 (5), 315-323 (2004)
   PUBMED   15747579
REFERENCE   8  (bases 1 to 5652)
  AUTHORS   Bisogno,T., Howell,F., Williams,G., Minassi,A., Cascio,M.G.,
            Ligresti,A., Matias,I., Schiano-Moriello,A., Paul,P.,
            Williams,E.J., Gangadharan,U., Hobbs,C., Di Marzo,V. and Doherty,P.
  TITLE     Cloning of the first sn1-DAG lipases points to the spatial and
            temporal regulation of endocannabinoid signaling in the brain
  JOURNAL   J Cell Biol 163 (3), 463-468 (2003)
   PUBMED   14610053
REFERENCE   9  (bases 1 to 5652)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   10 (bases 1 to 5652)
  AUTHORS   Mu,X., Zhao,S., Pershad,R., Hsieh,T.F., Scarpa,A., Wang,S.W.,
            White,R.A., Beremand,P.D., Thomas,T.L., Gan,L. and Klein,W.H.
  TITLE     Gene expression in the developing mouse retina by EST sequencing
            and microarray analysis
  JOURNAL   Nucleic Acids Res 29 (24), 4983-4993 (2001)
   PUBMED   11812828
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ127451.1, AK147384.1, BC112414.1, CF539357.1 and BP765314.1.
            
            On Jul 27, 2007 this sequence version replaced NM_198114.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219381.82575.1,
                                           SRR13948564.1807010.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                CJ127451.1         1-20
            21-101              AK147384.1         2-82
            102-3235            BC112414.1         1-3134
            3236-4186           AK147384.1         3194-4144
            4187-4187           CF539357.1         634-634
            4188-5631           AK147384.1         4145-5588
            5632-5652           BP765314.1         1-21                c
FEATURES             Location/Qualifiers
     source          1..5652
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 6.55 cM"
     gene            1..5652
                     /gene="Dagla"
                     /gene_synonym="Nsddr"
                     /note="diacylglycerol lipase, alpha"
                     /db_xref="GeneID:269060"
                     /db_xref="MGI:MGI:2677061"
     exon            1..57
                     /gene="Dagla"
                     /gene_synonym="Nsddr"
                     /inference="alignment:Splign:2.1.0"
     exon            58..195
                     /gene="Dagla"
                     /gene_synonym="Nsddr"
                     /inference="alignment:Splign:2.1.0"
     CDS             101..3235
                     /gene="Dagla"
                     /gene_synonym="Nsddr"
                     /EC_number="3.1.1.116"
                     /note="neural stem cell-derived dendrite regulator;
                     sn1-specific diacylglycerol lipase alpha; DGL-alpha;
                     DAGL-alpha"
                     /codon_start=1
                     /product="diacylglycerol lipase-alpha"
                     /protein_id="NP_932782.2"
                     /db_xref="CCDS:CCDS29574.1"
                     /db_xref="GeneID:269060"
                     /db_xref="MGI:MGI:2677061"
                     /translation="MPGIVVFRRRWSVGSDDLVLPAIFLFLLHTTWFVILSVVLFGLV
                     YNPHEACSLNLVDHGRGYLGILLSCMIAEMAIIWLSMRGGILYTEPRDSMQYVLYVRL
                     AILVIEFIYAIVGIVWLTQYYTSCNDLTAKNVTLGMVVCNWVVILSVCITVLCVFDPT
                     GRTFVKLRATKRRQRNLRTYNLRHRLEEGQATSWSRRLKVFLCCTRTKDSQSDAYSEI
                     AYLFAEFFRDLDIVPSDIIAGLVLLRQRQRAKRNAVLDEANNDILAFLSGMPVTRNTK
                     YLDLKNSHEMLRYKEVCYYMLFALAAYGWPMYLMRKPTCGLCQLARSCSCCLCPARPR
                     FAPGVTIEEDNCCGCNAIAIRRHFLDENMTAVDIVYTSCHDAVYETPFYVAVDHDKKK
                     VVISIRGTLSPKDALTDLTGDAERLPVEGHRGTWLGHKGMVLSAEYIKKKLEQEMVLS
                     QAFGRDLGRGTKHYGLIVVGHSLGAGTAAILSFLLRPQYPTLKCFAYSPPGGLLSEDA
                     MEYSKEFVTAVVLGKDLVPRIGLSQLEGFRRQLLDVLQRSTKPKWRIIVGATKCIPKS
                     ELPEDQVEVTTLASTRLWTHPSDLTIALSASTPLYPPGRIIHVVHNHPAEQCCCCEQE
                     EPTYFAIWGDNKAFNEVIISPAMLHEHLPYVVMEGLNKVLENYNKGKTALLSAAKVMV
                     SPTEVDLTPELIFQQQPLPTGPPLPTGLALELPATEHRNSSVRSKSQSEMSLEGFSEG
                     RLLSPVAAASAARQDPVELLLLSTQERLAAELQSRRAPLATMESLSDTESLYSFDSRR
                     SSGFRSIRGSPSLHAVLERDEGHLFYIDPAIPEENPSLSSRTELLAADSLSKHSQDTQ
                     PLEAALGSGGVTPERPPSATIEEEEAAGGSEGGGVAPRGELALHNGRLGDSPSPQVLE
                     FAEFIDSLFNLDSKSSSFQDLYCMMVPESPTSDYTEGPKSPSQQEILLRAQFEPNLVP
                     KPPRLFAGSAEPSSGISLSPSFPLSSSGELMDLTPTGLSSQECLATDKIRTSTPTGHG
                     ASPTKQDDLVISAR"
     exon            196..407
                     /gene="Dagla"
                     /gene_synonym="Nsddr"
                     /inference="alignment:Splign:2.1.0"
     exon            408..509
                     /gene="Dagla"
                     /gene_synonym="Nsddr"
                     /inference="alignment:Splign:2.1.0"
     exon            510..648
                     /gene="Dagla"
                     /gene_synonym="Nsddr"
                     /inference="alignment:Splign:2.1.0"
     exon            649..736
                     /gene="Dagla"
                     /gene_synonym="Nsddr"
                     /inference="alignment:Splign:2.1.0"
     exon            737..871
                     /gene="Dagla"
                     /gene_synonym="Nsddr"
                     /inference="alignment:Splign:2.1.0"
     exon            872..949
                     /gene="Dagla"
                     /gene_synonym="Nsddr"
                     /inference="alignment:Splign:2.1.0"
     exon            950..1074
                     /gene="Dagla"
                     /gene_synonym="Nsddr"
                     /inference="alignment:Splign:2.1.0"
     exon            1075..1228
                     /gene="Dagla"
                     /gene_synonym="Nsddr"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..1312
                     /gene="Dagla"
                     /gene_synonym="Nsddr"
                     /inference="alignment:Splign:2.1.0"
     exon            1313..1390
                     /gene="Dagla"
                     /gene_synonym="Nsddr"
                     /inference="alignment:Splign:2.1.0"
     exon            1391..1471
                     /gene="Dagla"
                     /gene_synonym="Nsddr"
                     /inference="alignment:Splign:2.1.0"
     exon            1472..1614
                     /gene="Dagla"
                     /gene_synonym="Nsddr"
                     /inference="alignment:Splign:2.1.0"
     exon            1615..1683
                     /gene="Dagla"
                     /gene_synonym="Nsddr"
                     /inference="alignment:Splign:2.1.0"
     exon            1684..1756
                     /gene="Dagla"
                     /gene_synonym="Nsddr"
                     /inference="alignment:Splign:2.1.0"
     exon            1757..1956
                     /gene="Dagla"
                     /gene_synonym="Nsddr"
                     /inference="alignment:Splign:2.1.0"
     exon            1957..2086
                     /gene="Dagla"
                     /gene_synonym="Nsddr"
                     /inference="alignment:Splign:2.1.0"
     exon            2087..2274
                     /gene="Dagla"
                     /gene_synonym="Nsddr"
                     /inference="alignment:Splign:2.1.0"
     exon            2275..5634
                     /gene="Dagla"
                     /gene_synonym="Nsddr"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5612..5617
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dagla"
                     /gene_synonym="Nsddr"
                     /note="hexamer: TATAAA"
     polyA_site      5634
                     /gene="Dagla"
                     /gene_synonym="Nsddr"
                     /note="major polyA site"
ORIGIN      
        1 ggatggaggt ggcggtcgca gtggccgcgg cgggccgagc cctgcggcgg gccggaggag
       61 gtgagcgcct ggcccgctga gcctcccaga gctgccagcc atgcccggga tcgtggtgtt
      121 ccggcggcgc tggtctgtgg gcagcgatga cctcgtcctg ccagctatct tcctcttcct
      181 gctacacacc acctggtttg taatcctgtc tgtggtgctc ttcggcttgg tctataaccc
      241 acacgaggcc tgctccctga acctggtgga ccacggccga ggctacctgg gcatccttct
      301 gagctgtatg attgccgaaa tggctatcat ctggctgagc atgcgtgggg gcatcctcta
      361 cacagaaccc cgggactcca tgcagtacgt gctctacgtg cgcctggcca tcttggtgat
      421 tgagttcatc tacgctatcg tgggcatcgt ctggctcaca cagtactaca cctcctgcaa
      481 tgacctcact gctaagaatg tcaccctcgg aatggtcgtc tgcaactggg tggtcattct
      541 cagcgtctgc atcactgtcc tctgcgtctt tgaccccacg ggccgcacct tcgtcaagct
      601 gagagccacc aagaggaggc agcgcaatct gcggacttac aacctgcggc accggttaga
      661 ggagggtcag gccaccagct ggtcccgccg tctaaaagtg ttcctctgtt gcacccggac
      721 aaaggattcc cagtcagatg cctactcaga aatcgcctac ctctttgctg aatttttccg
      781 tgacctcgac atcgtgccct ccgacatcat tgctggcctg gtgctgctta gacagcggca
      841 gcgagccaaa cgcaatgcgg tgctggacga ggcaaacaat gacatcttgg ctttcctgtc
      901 tgggatgcca gtgaccagaa acaccaagta cctcgacctc aagaactcgc acgagatgct
      961 acgctacaaa gaagtctgct actacatgct ctttgcccta gccgcctatg gctggcccat
     1021 gtacctgatg aggaagccca cctgtggtct ctgccagctg gctcggtcct gctcgtgctg
     1081 tctctgccct gcacgacccc gattcgcccc tggggtcacc attgaggaag acaactgttg
     1141 tggctgcaac gcaatcgcta tccgccgtca cttcctggat gagaacatga ctgctgtaga
     1201 tattgtctac acctcctgtc acgatgcggt ctatgaaact cccttctacg tagctgtgga
     1261 ccatgacaag aagaaagtgg tgatcagtat ccggggaaca ctgtccccca aggatgccct
     1321 gactgacctg acaggcgatg ctgagcgcct ccctgtggag ggacacagag gcacctggtt
     1381 gggccacaag ggcatggtac tctcagctga gtacatcaag aagaagttgg agcaggagat
     1441 ggtcctgtcc caggcctttg ggcgagacct gggccgtgga accaaacact atggcctgat
     1501 tgtggtaggc cactccttgg gagcaggcac agccgccatc ctctccttcc tcctgcgccc
     1561 ccagtacccg accctcaagt gcttcgctta ctccccacca ggaggcctgc taagtgagga
     1621 tgctatggaa tactccaaag agtttgtgac tgctgtggtt ctgggcaaag accttgtccc
     1681 caggattggc ctttcccagc tggaaggttt ccgtcggcag cttctggatg tcctgcagcg
     1741 gagcaccaag cccaaatggc ggatcatcgt gggggccacc aagtgtatcc ccaagtcgga
     1801 gctgcccgag gatcaggtgg aggtgaccac tctggccagc acacgactct ggacacaccc
     1861 cagtgatttg accatcgccc tttcggctag caccccactc tacccacctg gccgcatcat
     1921 ccacgtggtt cacaaccatc ctgctgagca gtgctgctgc tgtgagcagg aggagcccac
     1981 atactttgcc atctggggcg acaataaagc ctttaacgag gtgatcatct caccagccat
     2041 gctgcatgag cacctgccct atgtggtcat ggaggggctc aataaggtgc tggagaatta
     2101 caacaaagga aagacagcgc tgctgtctgc tgcaaaggtc atggtgagcc ccaccgaggt
     2161 agacctcact cccgagctca tcttccagca acagccgttg cccacgggcc cacctctgcc
     2221 cactggcctg gccctggagc tgcctgccac agagcatcgc aacagcagtg tcaggagcaa
     2281 gtctcagtct gagatgagtc tggagggctt ctctgagggc cggctgctgt ccccagtggc
     2341 tgctgcatca gcagcccgac aagaccccgt agagcttctg ctgctgtcca cccaggagcg
     2401 actggcagca gagctgcagt cccggcgggc accactggcc accatggaga gcctctcaga
     2461 cactgagtca ctgtacagct tcgactcacg ccgctcctca ggcttccgaa gcatcagagg
     2521 ctcgcccagc ctccatgcag tactggagcg tgacgagggc cacctgtttt acatcgaccc
     2581 ggccattccc gaggagaacc cgtccctcag ctcacgcaca gagctgctgg cagccgacag
     2641 tctgtccaag cactcacagg acacccaacc cctggaggcg gctctaggca gcgggggtgt
     2701 gactcctgag cgaccaccaa gtgcaaccat tgaagaggag gaggccgcag gtggcagtga
     2761 gggtggtggg gtggcccccc ggggagagct ggcactgcac aatgggcgcc tgggggactc
     2821 acccagccct caggtgctag aattcgccga gttcattgac agcctcttca acctggacag
     2881 caagagcagc tccttccagg acctctactg catgatggtg cctgagagcc ccactagtga
     2941 ctacactgag ggccccaagt cccccagcca acaggaaatc ttgcttcggg ctcagtttga
     3001 gcccaacctg gtacccaagc cccccaggct ctttgcagga tctgctgaac cctcctctgg
     3061 catctcgctc tcaccctcct tcccactcag ctcctcgggg gagctcatgg acctgacccc
     3121 cacgggcctc agcagccagg agtgtctggc cacagacaag atccggactt ccacccccac
     3181 aggccacggg gccagcccca ccaagcagga tgacctggtc atctcggcac gctagcactt
     3241 ggcagtggcc accagctcct tcccagccag agctcaaggc cttgtgggta cctaacaacc
     3301 actcagggcc cagtagcttt ggggagaggc tcccagaggc caaatggtct caggccctgg
     3361 agcattgctg ctgaacaggg ggtccgcatc cctacctcag cctaggaccc ccagaaccaa
     3421 gatgtctggg aaaagcaggg gtggctttgg taacagggag gagatgtcag gttggatggt
     3481 cctcagccct cagcctgact cctctgtatg ggcggcatga cgtctctgtt ctgggtctgg
     3541 cactaggcaa gctagcttcc tgtcactgcc ctccagctac tctcccagag ccgcggcaga
     3601 aagcagcccc acccccaccc tcactcccac atattctcac acgtagttca agttggcacc
     3661 ttgccctggc cactctcccc ccagatctgg tgcctgctgg ccagccccct ggggtgaccc
     3721 ccaccaaggt ggcccgcagt gctgtatgtg tttacagaat ctgctgggct tggctcaggt
     3781 tgtgtcctgg gttcgtaagc cccaactccc agtcatgtat ttagttgtcc tcccttctga
     3841 gtgggaccta aggaccagag gggccccgaa gggaggtggg gtcagggatg ccccttcttt
     3901 gcctggtgcc ccttatcttc atgggtcctg gccactgggc ctgactacct acctgccact
     3961 ccctggcttc ctggctcgcc ttctaccccc aggactctgg ccattcaaag ggtggtggac
     4021 actcctgtga cctcacccct ggctgcagag tcagggccct gggaagaaag aaggcatcca
     4081 aaaccctgtc tctttggtgt cccgcctgac cccttctatc accccaccat gcctaggcag
     4141 ctctgggccc tggggtctga aaccaaacat gcctctgccc acttgctctc ctggatgcct
     4201 agctcctttc tgggtctggg ctccaactcc cactgtgtcc agcccataag atgaggggcc
     4261 aaaagtagag tattctggga cctggctgga aacccccgcc cattgccaac gggaggggcc
     4321 ggggactcag gggctgtccc aggttagcct gaggccttca taggttttcc tatgctttgg
     4381 agaagcagtt caggaggtag gaacccagcc ctttccccag gctgggggga gggggagggg
     4441 ggaggttgtg catggtagtg tcaggtgtgt gtgtgcatgt gcatgaatgt gcacaactcc
     4501 tgaggaaagg ggctgcagag ggctgcctgc cttctgcacg ttgcctgcct cctgctcctc
     4561 ctaacctgcc aagaatatag cctgtgaagt gaagccttgg gataagccag ccactggggt
     4621 gtgcaggcaa gcagctgccc acccttgtgc ccttgtctcc ttggaagcat ggtcccttcc
     4681 actctagccc cactcccagc ctctctgggc tgcctaggtt tccctgacca actcatgatt
     4741 cctggcatct gggcctgagt ctttactcta accccacagc tgaggtggcc tggatagcta
     4801 gctatctgcc ctaacaggta aggacagaga cctgggagct gggcctcccc ctgactctgt
     4861 gactccccca ccccacaaca gactcctggt caccctgccc cctgccgagg cagtgcctca
     4921 gcctagcaca gaagataaaa atcactggtt cttagaactc aaatattaga caaaaatctt
     4981 caatcagagg agtaacccag taagtacccc agccggcaca aggagagttg tgggtctggc
     5041 cttttatctc ttttcctctg tcagggtagg tctggggggg ggtccttcta gggtgtgccc
     5101 ctatgcccag gactgagcca tcagggacat accccccacc cccaaggctg cagccatact
     5161 gtgttacagg cttggggctg gggcaggctt ggactcagcc ctagacacga agggccagcc
     5221 cacccctccc tgcctgaccc tagaagggtg ggcatgatgc acgtcccctt cactccatgc
     5281 cacatctggg gggtctgagc caccccctcc gttccagttc agattgacac cccacacaca
     5341 cactgtcccc agacccgcag cacaagctct cccagccatg cgctggcctg tcctcccagg
     5401 gagctgggcg acttccatat gcaactagta gcgaacagcc aggctcccat gaaccctctg
     5461 cactccacgt gccattctcc catgaccttt ttgtacctaa tgtatgaaag atccacacta
     5521 atatcgctgt aaaaagaaga gacaaattaa tatagcttat tctatgaata tatctgtata
     5581 taaagttttc tgtatattgt atagagctgt gtataaactg aatgtagaag cacaaaaaaa
     5641 aaaaaaaaaa aa
//
