LOCUS       NM_001276482            5447 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus dystroglycan 1 (Dag1), transcript variant 3, mRNA.
ACCESSION   NM_001276482
VERSION     NM_001276482.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5447)
  AUTHORS   Jahncke,J.N. and Wright,K.M.
  TITLE     Tools for Cre-Mediated Conditional Deletion of Floxed Alleles from
            Developing Cerebellar Purkinje Cells
  JOURNAL   eNeuro 11 (6) (2024)
   PUBMED   38777609
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5447)
  AUTHORS   Tan,R.L., Sciandra,F., Hubner,W., Bozzi,M., Reimann,J., Schoch,S.,
            Brancaccio,A. and Blaess,S.
  TITLE     The missense mutation C667F in murine beta-dystroglycan causes
            embryonic lethality, myopathy and blood-brain barrier
            destabilization
  JOURNAL   Dis Model Mech 17 (6) (2024)
   PUBMED   38616731
REFERENCE   3  (bases 1 to 5447)
  AUTHORS   Wong,W., Estep,J.A., Treptow,A.M., Rajabli,N., Jahncke,J.N.,
            Ubina,T., Wright,K.M. and Riccomagno,M.M.
  TITLE     An adhesion signaling axis involving Dystroglycan, beta1-Integrin,
            and Cas adaptor proteins regulates the establishment of the
            cortical glial scaffold
  JOURNAL   PLoS Biol 21 (8), e3002212 (2023)
   PUBMED   37540708
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5447)
  AUTHORS   Okuma,H., Hord,J.M., Chandel,I., Venzke,D., Anderson,M.E.,
            Walimbe,A.S., Joseph,S., Gastel,Z., Hara,Y., Saito,F., Matsumura,K.
            and Campbell,K.P.
  TITLE     N-terminal domain on dystroglycan enables LARGE1 to extend
            matriglycan on alpha-dystroglycan and prevents muscular dystrophy
  JOURNAL   Elife 12, e82811 (2023)
   PUBMED   36723429
  REMARK    GeneRIF: N-terminal domain on dystroglycan enables LARGE1 to extend
            matriglycan on alpha-dystroglycan and prevents muscular dystrophy.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5447)
  AUTHORS   Wu,T., Xu,Y., Zhang,L., Liang,Z., Zhou,X., Evans,S.M. and Chen,J.
  TITLE     Filamin C is Essential for mammalian myocardial integrity
  JOURNAL   PLoS Genet 19 (1), e1010630 (2023)
   PUBMED   36706168
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5447)
  AUTHORS   Madhavan,R. and Jarrett,H.W.
  TITLE     Interactions between dystrophin glycoprotein complex proteins
  JOURNAL   Biochemistry 34 (38), 12204-12209 (1995)
   PUBMED   7547961
REFERENCE   7  (bases 1 to 5447)
  AUTHORS   Durbeej,M., Larsson,E., Ibraghimov-Beskrovnaya,O., Roberds,S.L.,
            Campbell,K.P. and Ekblom,P.
  TITLE     Non-muscle alpha-dystroglycan is involved in epithelial development
  JOURNAL   J Cell Biol 130 (1), 79-91 (1995)
   PUBMED   7790379
REFERENCE   8  (bases 1 to 5447)
  AUTHORS   Skynner,M.J., Gangadharan,U., Coulton,G.R., Mason,R.M.,
            Nikitopoulou,A., Brown,S.D. and Blanco,G.
  TITLE     Genetic mapping of the mouse neuromuscular mutation kyphoscoliosis
  JOURNAL   Genomics 25 (1), 207-213 (1995)
   PUBMED   7774920
REFERENCE   9  (bases 1 to 5447)
  AUTHORS   Matsumura,K., Ervasti,J.M., Ohlendieck,K., Kahl,S.D. and
            Campbell,K.P.
  TITLE     Association of dystrophin-related protein with
            dystrophin-associated proteins in mdx mouse muscle
  JOURNAL   Nature 360 (6404), 588-591 (1992)
   PUBMED   1461282
REFERENCE   10 (bases 1 to 5447)
  AUTHORS   Ohlendieck,K. and Campbell,K.P.
  TITLE     Dystrophin-associated proteins are greatly reduced in skeletal
            muscle from mdx mice
  JOURNAL   J Cell Biol 115 (6), 1685-1694 (1991)
   PUBMED   1757468
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC168217.2, CB289895.1,
            CD578569.1, AK038702.1, U43512.1 and AV085570.1.
            
            Summary: This gene encodes dystroglycan, a central component of
            dystrophin-glycoprotein complex that links the extracellular matrix
            and the cytoskeleton in the skeletal muscle. The encoded
            preproprotein undergoes O- and N-glycosylation, and proteolytic
            processing to generate alpha and beta subunits. A complete lack of
            the encoded protein in mice results in embryonic lethality due to
            the disorganization of Reichert's membrane. Chimeric mice deficient
            in the encoded protein overcome embryonic lethality but develop a
            progressive muscular dystrophy. Alternative splicing results in
            multiple transcript variants, all encoding the same protein.
            [provided by RefSeq, Nov 2015].
            
            Transcript Variant: This variant (3) differs in the 5' UTR,
            compared to variant 1. Variants 1-8 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC007150.1, SRR10223971.9683.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-35                AC168217.2         11345-11379
            36-41               CB289895.1         1-6
            42-709              CD578569.1         1-668
            710-4350            AK038702.1         776-4416
            4351-5341           U43512.1           2082-3072
            5342-5445           AV085570.1         172-275
            5446-5447           AC168217.2         70298-70299
FEATURES             Location/Qualifiers
     source          1..5447
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 59.08 cM"
     gene            1..5447
                     /gene="Dag1"
                     /gene_synonym="D9Wsu13e; DG; Dp427; Dp71"
                     /note="dystroglycan 1"
                     /db_xref="GeneID:13138"
                     /db_xref="MGI:MGI:101864"
     exon            1..191
                     /gene="Dag1"
                     /gene_synonym="D9Wsu13e; DG; Dp427; Dp71"
                     /inference="alignment:Splign:2.1.0"
     exon            192..248
                     /gene="Dag1"
                     /gene_synonym="D9Wsu13e; DG; Dp427; Dp71"
                     /inference="alignment:Splign:2.1.0"
     exon            249..646
                     /gene="Dag1"
                     /gene_synonym="D9Wsu13e; DG; Dp427; Dp71"
                     /inference="alignment:Splign:2.1.0"
     CDS             368..3049
                     /gene="Dag1"
                     /gene_synonym="D9Wsu13e; DG; Dp427; Dp71"
                     /note="dystrophin associated glycoprotein 1"
                     /codon_start=1
                     /product="dystroglycan 1 preproprotein"
                     /protein_id="NP_001263411.1"
                     /db_xref="CCDS:CCDS23518.1"
                     /db_xref="GeneID:13138"
                     /db_xref="MGI:MGI:101864"
                     /translation="MSVDNWLLHPLWGQTFLLLLSVAVAQAHWPSEPSEAVRDWKNQL
                     EASMHSVLSDFQEAVPTVVGIPDGTAVVGRSFRVSIPTDLIASSGEIIKVSAAGKEAL
                     PSWLHWDPHSHILEGLPLDTDKGVHYISVSAARLGANGSHVPQTSSVFSIEVYPEDHN
                     EPQSVRAASSDPGEVVPSACAADEPVTVLTVILDADLTKMTPKQRIDLLNRMQSFSEV
                     ELHNMKLVPVVNNRLFDMSAFMAGPGNAKKVVENGALLSWKLGCSLNQNSVPDIRGVE
                     TPAREGAMSAQLGYPVVGWHIANKKPTLPKRLRRQIHATPTPVTAIGPPTTAIQEPPS
                     RIVPTPTSPAIAPPTETMAPPVRDPVPGKPTVTIRTRGAIIQTPTLGPIQPTRVSEAG
                     TTVPGQIRPTLTIPGYVEPTAVITPPTTTTKKPRVSTPKPATPSTDSSTTTTRRPTKK
                     PRTPRPVPRVTTKAPITRLETASPPTRIRTTTSGVPRGGEPNQRPELKNHIDRVDAWV
                     GTYFEVKIPSDTFYDNEDTTTDKLKLTLKLREQQLVGEKSWVQFNSNSQLMYGLPDSS
                     HVGKHEYFMHATDKGGLSAVDAFEIHVHKRPQGDKAPARFKARLAGDPAPVVNDIHKK
                     IALVKKLAFAFGDRNCSSITLQNITRGSIVVEWTNNTLPLEPCPKEQIIGLSRRIADE
                     NGKPRPAFSNALEPDFKALSIAVTGSGSCRHLQFIPVAPPSPGSSAAPATEVPDRDPE
                     KSSEDDVYLHTVIPAVVVAAILLIAGIIAMICYRKKRKGKLTLEDQATFIKKGVPIIF
                     ADELDDSKPPPSSSMPLILQEEKAPLPPPEYPNQSMPETTPLNQDTVGEYTPLRDEDP
                     NAPPYQPPPPFTAPMEGKGSRPKNMTPYRSPPPYVPP"
     exon            647..5447
                     /gene="Dag1"
                     /gene_synonym="D9Wsu13e; DG; Dp427; Dp71"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5418..5423
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dag1"
                     /gene_synonym="D9Wsu13e; DG; Dp427; Dp71"
                     /note="hexamer: AATAAA"
     polyA_site      5442
                     /gene="Dag1"
                     /gene_synonym="D9Wsu13e; DG; Dp427; Dp71"
                     /note="major polyA site"
ORIGIN      
        1 gccccgccct cgcgctcggc gccctctcac cgctcggtac gtgatcgcgc ggaggctgcg
       61 gcgcggcgct cgcgctcctg gggctcgggg gcggcagcgg cggtagcttc gcgcggagtc
      121 cccggggagt ggcggcggtg tccctgggcc cggaggagcg aacacctgcc gcggcctgcc
      181 cgtggtgctg gggcctgtgc tctctaggaa gataaggttt tcaacactgc ctggcactgg
      241 agggtgaggc tctgggtgct ctaggatgga acagctgtgc agagggtgag gatccaaccc
      301 tgggaccaca tcatttgctt tcttccttag caactggtgg cttgaacaaa cactagcctg
      361 ggtgaggatg tctgtggaca actggctact gcaccccctc tggggacaga cctttctcct
      421 cctcctgtct gtggctgtgg ctcaggccca ctggcccagt gaaccctcag aggctgtgag
      481 ggactggaag aaccagcttg aggcgtccat gcactcagtt ctctccgact tccaggaggc
      541 tgttcccacc gtggttggca ttccagacgg tacggctgtt gtcgggcgct catttcgagt
      601 gagcattcca acggatttaa ttgcctccag tggggagatc atcaaggtgt ctgcagcagg
      661 gaaggaggcc ttaccgtctt ggctacactg ggacccacac agtcatattt tggaaggcct
      721 tcctcttgac actgataaag gtgtgcatta catctcagtg agtgctgcac gcctgggagc
      781 caatggaagc cacgtccccc agacttccag tgtgttctct atcgaggtct accctgaaga
      841 ccacaatgag ccacagtctg tacgggcagc ctcatcagac cctggtgagg tagtgccatc
      901 tgcctgtgct gctgatgagc cagtgactgt ccttacagtg attctggatg ctgacctcac
      961 caagatgacc ccaaagcaaa ggatcgatct gttgaacaga atgcagagct tctcagaagt
     1021 agaacttcac aacatgaagt tggtgcctgt agtgaataat agactatttg acatgtcggc
     1081 cttcatggct ggcccaggaa atgcaaagaa agtggtagag aatggggctc tcctgtcctg
     1141 gaaactaggc tgctccttga accagaatag cgtccctgac atccgtggtg tagaaacccc
     1201 tgctagggag ggtgctatgt ctgcccaact tggttatcct gtggtgggtt ggcacattgc
     1261 caataagaag cccactctcc ccaaacgact ccggaggcag atccacgcca cacctacacc
     1321 tgttactgcc attggacccc caaccacggc cattcaggag ccaccatcgc ggatagtgcc
     1381 tacgcctaca tctccagcca ttgcacctcc aacagagacc atggctcctc ctgtcaggga
     1441 tcctgttcca gggaagccca cggtcaccat tcggacgcga ggtgccatta ttcagacccc
     1501 aactctgggc cctatccagc ctactcgggt gtcagaagct ggtaccacgg ttcctggcca
     1561 gattcgccca acactgacaa ttcctggcta tgtagagccc acagccgtta ttactcctcc
     1621 aacaactacc acaaagaagc cacgagtgtc cacgccaaag ccagcaacgc cttcaactga
     1681 ttcgtcaact accacaactc ggaggccaac caaaaaacca cggacacccc gaccagtgcc
     1741 ccgagtcacc accaaagcac ccatcaccag gttggagaca gcttccccac ccactcgaat
     1801 ccgtactacc accagtggag tgccccgtgg gggagaacct aaccagcggc cagagctcaa
     1861 gaatcacatt gacagggtag atgcctgggt gggaacctat tttgaggtaa agattccatc
     1921 agacaccttc tatgacaatg aggataccac taccgacaag ctcaagctga ccctgaagct
     1981 tcgagagcag cagttagtag gtgagaaatc gtgggttcag tttaacagca acagccagct
     2041 catgtatggc ctgcctgaca gcagccatgt gggaaaacat gagtatttta tgcatgccac
     2101 agacaaaggg ggcctctccg ctgtggatgc cttcgagatc catgttcaca agcgcccaca
     2161 aggggacaag gctcctgcac ggttcaaggc caggcttgca ggggatccag caccggtggt
     2221 gaatgacatt cacaagaaaa ttgctttggt aaagaagcta gcttttgctt ttggggatcg
     2281 aaactgcagc tccatcaccc ttcagaacat cactcggggc tctatcgtgg tggaatggac
     2341 caacaacact ctgcccctgg agccctgccc caaggagcag atcatagggc tgagccgcag
     2401 gattgctgat gaaaatggga agcctcgtcc tgccttctcc aatgctctgg agcctgactt
     2461 taaggctctg agtattgctg tgacgggctc tggcagttgt cggcacctcc agtttatccc
     2521 tgtggcacca ccctctcctg gaagctcagc tgcaccagcc acagaggttc cagacaggga
     2581 ccccgagaag agcagtgagg acgatgttta cctgcacacc gttatcccag ccgtggtggt
     2641 cgcggccatc ctgctcattg ctggaatcat tgctatgatc tgctatcgca agaagaggaa
     2701 gggcaagctg acccttgagg accaggccac ctttattaag aagggggtgc ctatcatctt
     2761 tgcggatgag ctggatgact ctaagccccc gccctcttcc agcatgccgc tcatcttgca
     2821 ggaagagaag gctcccctcc cacctcctga gtaccccaac cagagtatgc ccgagaccac
     2881 tcctctgaac caggacactg tgggagagta cacacccctg cgggatgagg atcctaacgc
     2941 acctccctat cagccacccc cacccttcac ggctcccatg gagggcaagg gctcccgtcc
     3001 caagaacatg accccatacc gatcaccccc tccgtatgtt cccccttaac ccacaagcgc
     3061 ctgggtggag gcaggggtag ggcaggggcc tggagacaac ttggtgttgt ctgtagagac
     3121 cggtggccca caggccattg cccactggtc cccaacacct gacctagcac acactgacaa
     3181 cagggcctgg acaagcccgc cctctctggt cctcccaaac cccaaagctg ctggagagac
     3241 tttgggggac ttttttattt tcattttttg cctaacagct ttttgtttgt tcatagaaaa
     3301 gtcttcgctg cgttttttga tggctctgaa gcactgtttg agtagaggta gaaggaggga
     3361 gcgaggaacc gtgaatgaac tcgcaggcag tgctgggcgg ccccagctct ctgcattttg
     3421 cctttaacac taactgtact gttttttcta ttcacgtgtg tctagctgca ggatgtaaca
     3481 tggaaaacag tagctaaaga ttacattcaa aggactttca gaaattaagg ttaagttttt
     3541 acatttaatc tgctgtttac ctaaacttgt acgtataatt tttgggtggg tatgggaaat
     3601 tgctttgcta aaaataagat cccagggtgt ttcaaactta gagaagacca agggacagta
     3661 ttttttatca aaggaatcct attttttcac actatgtcaa cttggttgct ctgatatccc
     3721 agagcctgac tgagggcctc ctggtcctgg ctcgggtgcc agggccctgg tgctgggttc
     3781 gctctcccgc tgttgccagg ggctggaagc tggaggggcc tcttgggcca tggacatcct
     3841 gacctctacc ccatgcacgc tagtggccta ccaccaaggg ggtcttcatt tctgtgggaa
     3901 agggactcca aaaggcattg gtggctatgg cctccaacct aggtgctcca aggtgggcca
     3961 gctgctcgta ggggcacctg ggaaggtcga aggactccac ctcatcaacc tttcttttcc
     4021 cttctctgtg gtttggtttg gtttggttct gttctttccc ttccctctta aaaggaatat
     4081 cacggtcttt gaaacactca gtgggggaca ttttggtgaa gatgcaatat ttttatgtca
     4141 tgtgatgctc tttcctcact tgaccttggc cactttgtcc caacagtcca cagccctacc
     4201 ccatataccc tgcccctctt ctctggcgct ccagtcctgg gccgtgggcc tgtggctggg
     4261 gaggagtgcc agcaatagtt catagtaaaa gtctgtgggc tctcaaagct aattttttac
     4321 taaagttttt atacagcctc aaattgtttt attaaaaaaa aaaagattaa aaaatggtga
     4381 tgcttagcag cagtttgtat aagctcctag tgtcaactcc atgggactga tggctttgct
     4441 catttggacc ctcccctcct tcttttccta atgggttaaa ttctggatta catagaggct
     4501 tcctttgcct tttttagcag aacatcgtcc atctgtctgc atctctgtcc catgactcag
     4561 gggcacccac tctgctttga ttctcctcct ttggaagaaa ccattttgag catgcctttt
     4621 cttgatgtct gagttatttc gggtaccttt tagggaggaa tgccttttgc aataatgtat
     4681 cccttccctg atggagggtg ggtgggtgga cccaggctcc ctttgcacac ggagcagtac
     4741 cttctaagcc atatcgactg ttgagcagag ggtgtgctgt ctcaggaagg aaaggccagt
     4801 agttcagaag ggttgcttcc aaatggtggt tcttctgctt tctccacaag gcctaccctt
     4861 cctgctcagc ccccaggagg gttctttgta gtgagcactc cccatgcggg agtctgccga
     4921 tgagtgcttc atggatggct ggtgactggg ccttgtgctc ccaagctctg gtccgagctg
     4981 gagtttccct gatgtcccag agtcaagagc agggatctga tccgatgaaa ttatttctgg
     5041 tgacctcatc aaaaataaat aaataaataa acaaataaac aaatcccagt attccaggtg
     5101 agggctttgg gaagccctcc agataactct tgttgctctt agcaacccca ccattgggca
     5161 ttgccatgta gagaggaggc aggcccaaag tggcctgttg tcatagcaac tggaggcagt
     5221 ggggcagtga acagaataac aacagcaaca atgcctttgc aggcagcccc ctccctgagc
     5281 cggcgatggc catcagactc tgagacagag agccaatctc acattcaagt gttcaccaac
     5341 cactgacgtg tttttatttc cttctatatg attttaagat gtgttttctg cattctgtat
     5401 agaaacatat caaactaaat aaaagcagtg tctttattac aatgtca
//
