LOCUS       NM_001113358             713 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus defender against cell death 1 (Dad1), transcript
            variant 1, mRNA.
ACCESSION   NM_001113358 XM_001471644
VERSION     NM_001113358.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 713)
  AUTHORS   Ramirez,A.S., Kowal,J. and Locher,K.P.
  TITLE     Cryo-electron microscopy structures of human
            oligosaccharyltransferase complexes OST-A and OST-B
  JOURNAL   Science 366 (6471), 1372-1375 (2019)
   PUBMED   31831667
REFERENCE   2  (bases 1 to 713)
  AUTHORS   Hoffman,B.G., Zavaglia,B., Witzsche,J., Ruiz de Algara,T.,
            Beach,M., Hoodless,P.A., Jones,S.J., Marra,M.A. and Helgason,C.D.
  TITLE     Identification of transcripts with enriched expression in the
            developing and adult pancreas
  JOURNAL   Genome Biol 9 (6), R99 (2008)
   PUBMED   18554416
REFERENCE   3  (bases 1 to 713)
  AUTHORS   Krizhanovsky,V., Soreq,L., Kliminski,V. and Ben-Arie,N.
  TITLE     Math1 target genes are enriched with evolutionarily conserved
            clustered E-box binding sites
  JOURNAL   J Mol Neurosci 28 (2), 211-229 (2006)
   PUBMED   16679559
REFERENCE   4  (bases 1 to 713)
  AUTHORS   Ortiz,B.D., Harrow,F., Cado,D., Santoso,B. and Winoto,A.
  TITLE     Function and factor interactions of a locus control region element
            in the mouse T cell receptor-alpha/Dad1 gene locus
  JOURNAL   J Immunol 167 (7), 3836-3845 (2001)
   PUBMED   11564801
REFERENCE   5  (bases 1 to 713)
  AUTHORS   Jiang,C.H., Tsien,J.Z., Schultz,P.G. and Hu,Y.
  TITLE     The effects of aging on gene expression in the hypothalamus and
            cortex of mice
  JOURNAL   Proc Natl Acad Sci U S A 98 (4), 1930-1934 (2001)
   PUBMED   11172053
REFERENCE   6  (bases 1 to 713)
  AUTHORS   Ortiz,B.D., Cado,D., Chen,V., Diaz,P.W. and Winoto,A.
  TITLE     Adjacent DNA elements dominantly restrict the ubiquitous activity
            of a novel chromatin-opening region to specific tissues
  JOURNAL   EMBO J 16 (16), 5037-5045 (1997)
   PUBMED   9305645
REFERENCE   7  (bases 1 to 713)
  AUTHORS   Hong,N.A., Cado,D., Mitchell,J., Ortiz,B.D., Hsieh,S.N. and
            Winoto,A.
  TITLE     A targeted mutation at the T-cell receptor alpha/delta locus
            impairs T-cell development and reveals the presence of the nearby
            antiapoptosis gene Dad1
  JOURNAL   Mol Cell Biol 17 (4), 2151-2157 (1997)
   PUBMED   9121464
REFERENCE   8  (bases 1 to 713)
  AUTHORS   Wang,K., Gan,L., Kuo,C.L. and Hood,L.
  TITLE     A highly conserved apoptotic suppressor gene is located near the
            chicken T-cell receptor alpha chain constant region
  JOURNAL   Immunogenetics 46 (5), 376-382 (1997)
   PUBMED   9271627
REFERENCE   9  (bases 1 to 713)
  AUTHORS   Apte,S.S., Mattei,M.G., Seldin,M.F. and Olsen,B.R.
  TITLE     The highly conserved defender against the death 1 (DAD1) gene maps
            to human chromosome 14q11-q12 and mouse chromosome 14 and has plant
            and nematode homologs
  JOURNAL   FEBS Lett 363 (3), 304-306 (1995)
   PUBMED   7737422
REFERENCE   10 (bases 1 to 713)
  AUTHORS   Nakashima,T., Sekiguchi,T., Kuraoka,A., Fukushima,K., Shibata,Y.,
            Komiyama,S. and Nishimoto,T.
  TITLE     Molecular cloning of a human cDNA encoding a novel protein, DAD1,
            whose defect causes apoptotic cell death in hamster BHK21 cells
  JOURNAL   Mol Cell Biol 13 (10), 6367-6374 (1993)
   PUBMED   8413235
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CN833883.1, AK002446.1 and BC058116.1.
            
            On Aug 9, 2008 this sequence version replaced XM_001471644.1.
            
            Transcript Variant: This variant (1) represents the predominant
            transcript. Transcript variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BU936410.1, CB570814.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849379
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                CN833883.1         127-141
            16-695              AK002446.1         2-681
            696-713             BC058116.1         649-666
FEATURES             Location/Qualifiers
     source          1..713
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 27.7 cM"
     gene            1..713
                     /gene="Dad1"
                     /note="defender against cell death 1"
                     /db_xref="GeneID:13135"
                     /db_xref="MGI:MGI:101912"
     exon            1..298
                     /gene="Dad1"
                     /inference="alignment:Splign:2.1.0"
     CDS             88..429
                     /gene="Dad1"
                     /EC_number="2.4.99.18"
                     /note="DAD-1; oligosaccharyl transferase subunit DAD1"
                     /codon_start=1
                     /product="dolichyl-diphosphooligosaccharide--protein
                     glycosyltransferase subunit DAD1"
                     /protein_id="NP_001106829.1"
                     /db_xref="CCDS:CCDS27084.1"
                     /db_xref="GeneID:13135"
                     /db_xref="MGI:MGI:101912"
                     /translation="MSASVVSVISRFLEEYLSSTPQRLKLLDAYLLYILLTGALQFGY
                     CLLVGTFPFNSFLSGFISCVGSFILAVCLRIQINPQNKADFQGISPERAFADFLFAST
                     ILHLVVMNFVG"
     exon            299..468
                     /gene="Dad1"
                     /inference="alignment:Splign:2.1.0"
     exon            469..697
                     /gene="Dad1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      675..680
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dad1"
                     /note="hexamer: ATTAAA"
     polyA_site      697
                     /gene="Dad1"
                     /note="major polyA site"
ORIGIN      
        1 ggtgtgggcg tggctagggc ccgctaacgc gcacgcgcga gccacatcgt ctgtggtcgt
       61 ccggtatccg aagtccccgt gttcgtcatg tcggcgtctg tggtgtccgt catctcccgg
      121 ttcctggagg agtacttgag ctccactccg cagcggctga agttgctgga cgcctatctc
      181 ctttatatac tgctgaccgg ggcgctgcag ttcggctact gtctcctcgt gggcaccttc
      241 cccttcaact ctttcctctc tggcttcatc tcttgtgtgg gcagcttcat cctagcggtt
      301 tgcctgagaa tacagatcaa cccccagaac aaggcggact tccaaggcat ctctccggag
      361 cgagcctttg ctgacttcct ctttgccagc acgatcctgc accttgtcgt catgaacttc
      421 gttggctgaa ctccgtctcc ttaccgtgga gttggaggtt ggcggagcgc tcactctttg
      481 acgtcccctg gatcagcatt cttgagctgg cagcttgttg cacatggctt cttcagattc
      541 gtgcttgact acgagtctca ctggttgtga ggtggcacgt ccagagaact cccttcgctc
      601 tatcggacca actccacagt gtacggctgt taacacagaa tctgcctccc ctcactgtag
      661 cccttacttt ccatattaaa aacatttcag cctccaaaaa aaaaaaaaaa aaa
//
